Ibuprofen as a Possible Preventer of Post Bronchoscopy Fever
Information source: Shaare Zedek Medical Center
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Post Bronchoscopy Fever
Intervention: ibuprofen (Drug); placebo (Drug)
Phase: Phase 2
Status: Not yet recruiting
Sponsored by: Shaare Zedek Medical Center Overall contact:
Leon j Joseph, MB ChB, Phone: 00 972 2 666 6292, Email: leonj@doctors.org.uk
Summary
Scientific background: Bronchoscopy is a procedure commonly performed in the management of
persistent respiratory illness. In the last decades this exam has become a routine and safe
procedure even in children and there are few side-effects. However, one known side effect is
transient fever and even high fever a few hours after the bronchoscopy. This side effect is
not dangerous but very uncomfortable for the patients and it would be interesting to try to
reduce this phenomena. This fever is due to a release of cytokines during the
broncho-alveolar lavage procedure and not to sepsis. In a previous study a single dose of
dexamethasone was shown to prevent the fever post bronchoscopy with no apparent detriment to
the child. It is well known that steroids are immunosuppressive. Even though the
post-bronchoscopy fever is not caused by an infection, it seems preferable to use other
anti-inflammatory drugs to fight this very inconvenient side effect.
Ibuprofen (Nurofen*) is known as an effective medication to reduce fever in infectious
illnesses and is even considered as superior to paracetamol. It has no immunosuppressive
effect and is usually well tolerated by children with very few side effects when taken in
the normal therapeutic dose of 10mg/Kg. The investigators postulate that a dose of Nurofen
prior to bronchoscopy could significantly reduce fever post bronchoscopy.
Clinical Details
Official title: Ibuprofen as a Possible Preventer of Post Bronchoscopy Fever
Study design: N/A
Eligibility
Minimum age: N/A.
Maximum age: 12 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- under twelve years of age
- all patients undergoing bronchoscopy and bronchoalveolar lavage
Exclusion Criteria:
- children with immune deficiency
- allergy to NSAIDS
- previous exacerbation of asthma due to NSAIDS
- fever on the day of the examination
- current antibiotic treatment
Locations and Contacts
Leon j Joseph, MB ChB, Phone: 00 972 2 666 6292, Email: leonj@doctors.org.uk
Shaare Zedek Medical Center POB 3235, Jerusalem 91031, Israel
Additional Information
Related publications: Picard E, Schwartz S, Goldberg S, Glick T, Villa Y, Kerem E. A prospective study of fever and bacteremia after flexible fiberoptic bronchoscopy in children. Chest. 2000 Feb;117(2):573-7. Fonseca MT, Camargos PA, Abou Taam R, Le Bourgeois M, Scheinmann P, de Blic J. Incidence rate and factors related to post-bronchoalveolar lavage fever in children. Respiration. 2007;74(6):653-8. Epub 2007 Aug 29.
Last updated: August 6, 2009
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