Effect of Antidepressants on Back Pain
Information source: Department of Veterans Affairs
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Back Pain; Sciatica
Intervention: Fluoxetine (Drug); Desipramine (Drug); Benztropine (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: Department of Veterans Affairs Official(s) and/or principal investigator(s):
Mark A Slater, Ph.D
Edmund V Capparelli, Pharm.D.
Mark Wallace, M.D.
Steve R Garfin, M.D.
Summary
The purpose of this study is to determine whether different types of antidepressant medicines
relieve back pain that has lasted at least six months on a daily basis. Study participants
will be assigned to treatment with either a antidepressant acting on the serotonin system in
the brain (fluoxetine), one acting on the noradrenoline system (desipramine, or to a control
medication not expected to relieve pain (benztropine). Each participant will be seen at
least nine times during their 12 weeks on medication. This is a phase 2/3, outpatient
study.
Clinical Details
Official title: Efficacy of Antidepressants in Chronic Back Pain
Study design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
- Chronic back pain (pain on a daily basis for six months or longer)
- Age 18-65
- No major medical illness
Locations and Contacts
Department of Veterans Affairs, San Diego, California 92161, United States
Additional Information
Starting date: April 1999
Ending date: March 2002
Last updated: June 23, 2005
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