This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Zosyn (Piperacillin / Tazobactam) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (195)
Death (45)
Life Threatening Events (40)
Disability (5)
Reports by Reaction Type
Hepatic Function Abnormal (16),
Pyrexia (14),
Interstitial Lung Disease (14),
Drug Interaction (11),
Renal Failure Acute (11),
Liver Disorder (10),
Rash (10),
Diarrhoea (10),
Renal Impairment (9),
Alopecia (9),
Pneumonia Aspiration (8),
Skin Exfoliation (8)
Below are a few examples of reports where side effects / adverse reactions may be related to Zosyn (Piperacillin / Tazobactam). For a complete list or a specific selection of reports, please use the links above.
Possible Zosyn side effects in 38 year old female
Reported by a physician from Japan on 2012-08-27
Patient: 38 year old female, weighing 72.0 kg (158.4 pounds)
Reactions: Interstitial Lung Disease
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient: Metformin HCL; Mucodyne; Humalog; Lantus; Astomin
Possible Zosyn side effects in 73 year old male
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: 73 year old male, weighing 70.3 kg (154.6 pounds)
Reactions: Dyspnoea, Diarrhoea, Clostridium Difficile Colitis, Gallbladder Disorder
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zosyn
Possible Zosyn side effects in 63 year old male
Reported by a physician from Japan on 2012-08-24
Patient: 63 year old male
Reactions: Lung Infection Pseudomonal
Adverse event resulted in: death
Drug(s) suspected as cause:
Meropenem
Dosage: 3 g, 1x/day
Indication: Febrile Neutropenia
Zosyn
Dosage: 4.5 g, 3x/day
Zosyn
Dosage: 4.5 g, 3x/day
Indication: Febrile Neutropenia
Other drugs received by patient: Fluconazole; Daunorubicin HCL; Novantrone; Etoposide; Cytarabine; Teicoplanin; Vfend
Possible Zosyn side effects in 61 year old male
Reported by a pharmacist from United States on 2012-08-15
Patient: 61 year old male, weighing 88.0 kg (193.6 pounds)
Reactions: LIP Swelling, Pruritus, Vomiting, Nausea, Anaphylactic Reaction, Rash
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient: Ciprofloxacin; Enalapril Maleate; Cyanocobalamin; Nifedipine; Insulin; Esomeprazole Sodium; Hydralazine HCL; Ferrous Sulfate TAB
Possible Zosyn side effects in 83 year old female
Reported by a physician from Japan on 2012-08-14
Patient: 83 year old female
Reactions: Haemorrhagic Diathesis, Drug Interaction, Prothrombin Time Prolonged
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient possibly interacting with the suspect drug:
Warfarin Sodium
Dosage: 1 mg, 1x/day
Administration route: Oral
Indication: Atrial Fibrillation
Start date: 2012-05-09
End date: 2012-05-19
Other drugs received by patient: Aspirin; Amobantes; Tulobuterol
Possible Zosyn side effects in 84 year old male
Reported by a physician from Japan on 2012-08-10
Patient: 84 year old male
Reactions: Anaphylactic Shock
Adverse event resulted in: death
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient: Montelukast Sodium; Famotidine; Mucodyne; Fluticasone Propionate; Coniel; Magnesium Oxide; Uniphyl; Tamsulosin HCL; Neophyllin; Losartan Potassium and Hydrochlorothiazide
Possible Zosyn side effects in 66 year old female
Reported by a pharmacist from Japan on 2012-08-03
Patient: 66 year old female, weighing 47.0 kg (103.4 pounds)
Reactions: Ocular Hyperaemia, Rhinorrhoea, Nasal Congestion, Oropharyngeal Discomfort
Drug(s) suspected as cause:
Zosyn
Possible Zosyn side effects in 66 year old female
Reported by a pharmacist from Japan on 2012-07-31
Patient: 66 year old female, weighing 47.0 kg (103.4 pounds)
Reactions: Ocular Hyperaemia, Rhinorrhoea, Nasal Congestion, Oropharyngeal Discomfort
Drug(s) suspected as cause:
Zosyn
Possible Zosyn side effects in 1 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-25
Patient: 1 year old male, weighing 18.0 kg (39.6 pounds)
Reactions: Pneumonia Fungal, Electrocardiogram QT Prolonged, Renal Disorder, Malnutrition, Disseminated Intravascular Coagulation, Clostridium Colitis, Gastric Ulcer, Pneumonia Cytomegaloviral, Liver Disorder, Hypokalaemia, Pneumocystis Jiroveci Pneumonia, Pneumonia Bacterial, Pancreatitis, Acute Respiratory Distress Syndrome
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Ambisome
Dosage: uncertainty
Bactrim
Dosage: unk
Cellcept
Dosage: uncertainty
Administration route: Oral
Cyclosporine
Dosage: uncertainty
Decadron
Dosage: 12 mg, unk
Administration route: Oral
Indication: Idiopathic Thrombocytopenic Purpura
Start date: 2011-05-20
End date: 2011-06-17
Funguard
Dosage: uncertainty
Meropenem
Dosage: unk
Indication: Prophylaxis
Rituxan
Romiplostim
Dosage: 1 mg/kg, qwk
Indication: Idiopathic Thrombocytopenic Purpura
Start date: 2011-06-01
End date: 2011-06-08
Romiplostim
Dosage: 2 mg/kg, qwk
Start date: 2011-06-15
End date: 2011-06-15
Romiplostim
Dosage: 3 mg/kg, qwk
Start date: 2011-06-24
End date: 2012-06-24
Romiplostim
Dosage: 5 mg/kg, qwk
Start date: 2011-08-09
End date: 2011-08-09
Romiplostim
Dosage: 5 mg/kg, qwk
Start date: 2011-07-21
End date: 2011-08-06
Romiplostim
Dosage: 10 mg/kg, qwk
Start date: 2011-10-17
Romiplostim
Dosage: 9 mg/kg, qwk
Start date: 2011-09-08
End date: 2011-09-08
Romiplostim
Dosage: 4 mg/kg, qwk
Start date: 2011-07-11
End date: 2011-07-11
Romiplostim
Dosage: 8 mg/kg, qwk
Start date: 2011-09-01
End date: 2011-09-01
Romiplostim
Dosage: 3 mg/kg, qwk
Start date: 2012-06-21
End date: 2012-06-21
Romiplostim
Dosage: 6 mg/kg, qwk
Start date: 2011-08-16
End date: 2011-08-16
Romiplostim
Dosage: 7 mg/kg, qwk
Start date: 2011-08-24
End date: 2011-08-24
Romiplostim
Dosage: 10 mg/kg, qwk
Start date: 2011-09-15
End date: 2011-10-13
Zosyn
Dosage: unk
Other drugs received by patient: Prednisolone; Prednisolone; Fungizone; Prednisolone; Prednisolone; Prednisolone; Famotidine; Danazol; Danazol; Immune Globulin (Human); Cefazolin Sodium; Prednisolone; Prednisolone; Prednisolone; Prednisolone
Possible Zosyn side effects in
Reported by a pharmacist from United States on 2012-07-25
Patient:
Reactions: NO Adverse Event
Drug(s) suspected as cause:
Zosyn
Possible Zosyn side effects in
Reported by a pharmacist from United States on 2012-07-24
Patient:
Reactions: NO Adverse Event
Drug(s) suspected as cause:
Zosyn
Possible Zosyn side effects in male
Reported by a consumer/non-health professional from United States on 2012-07-24
Patient: male
Reactions: Jaundice, Weight Decreased, Deafness, Drug Withdrawal Syndrome Neonatal, Constipation, Failure To Thrive, Speech Disorder, Tethered Cord Syndrome, Type 1 Diabetes Mellitus, Gastrooesophageal Reflux Disease, Spina Bifida, Ear Infection, Meningomyelocele, Anxiety, Feeding Disorder Neonatal, Attention Deficit / Hyperactivity Disorder
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dexamethasone
Indication: Foetal Exposure During Pregnancy
Januvia
Indication: Foetal Exposure During Pregnancy
Lantus
Indication: Foetal Exposure During Pregnancy
Metformin Hydrochloride
Indication: Foetal Exposure During Pregnancy
Novolog
Indication: Foetal Exposure During Pregnancy
Prozac
Indication: Foetal Exposure During Pregnancy
Seroquel
Indication: Foetal Exposure During Pregnancy
Terbutaline
Indication: Foetal Exposure During Pregnancy
Topamax
Indication: Foetal Exposure During Pregnancy
Start date: 2006-08-03
End date: 2006-10-06
Zoloft
Indication: Foetal Exposure During Pregnancy
Zosyn
Indication: Foetal Exposure During Pregnancy
Other drugs received by patient: Multi-Vitamins
Possible Zosyn side effects in 91 year old male
Reported by a physician from Japan on 2012-07-20
Patient: 91 year old male, weighing 50.0 kg (110.0 pounds)
Reactions: Renal Disorder, Liver Disorder
Drug(s) suspected as cause:
Zosyn
Dosage: 2.25 g, 3x/day
End date: 2011-03-22
Zosyn
Dosage: 4.5 g, 3x/day
Indication: Pneumonia
Start date: 2011-03-12
Other drugs received by patient: Clarithromycin
Possible Zosyn side effects in 57 year old female
Reported by a pharmacist from United States on 2012-07-19
Patient: 57 year old female
Reactions: Renal Impairment
Drug(s) suspected as cause:
Carboplatin
Indication: Neoplasm Malignant
Start date: 2012-06-26
Taxol
Indication: Neoplasm Malignant
Start date: 2012-06-26
Vancomycin
Indication: Neoplasm Malignant
Start date: 2012-06-29
Zosyn
Indication: Neoplasm Malignant
Start date: 2012-06-20
Possible Zosyn side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-18
Patient: female, weighing 94.8 kg (208.5 pounds)
Reactions: Back Pain, Pruritus, Skin Exfoliation, Alopecia, Blister, Stevens-Johnson Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient: Vancomycin; Insulin; Diflucan; Tobramycin; Dilantin
Possible Zosyn side effects in 38 year old female
Reported by a pharmacist from Japan on 2012-07-16
Patient: 38 year old female, weighing 72.0 kg (158.4 pounds)
Reactions: Lung Disorder
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient: Mucodyne; Astomin; Lantus; Humalog; Metformin HCL
Possible Zosyn side effects in 1 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-13
Patient: 1 year old male, weighing 18.0 kg (39.6 pounds)
Reactions: Electrocardiogram QT Prolonged, Pneumonia Fungal, Renal Disorder, Disseminated Intravascular Coagulation, Malnutrition, Gastric Ulcer, Clostridium Colitis, Pneumonia Cytomegaloviral, Hypokalaemia, Liver Disorder, Pneumocystis Jiroveci Pneumonia, Pneumonia Bacterial, Pancreatitis, Acute Respiratory Distress Syndrome
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Ambisome
Dosage: uncertainty
Bactrim
Dosage: unk
Cellcept
Dosage: uncertainty
Administration route: Oral
Cyclosporine
Dosage: uncertainty
Decadron
Dosage: 12 mg, unk
Administration route: Oral
Indication: Idiopathic Thrombocytopenic Purpura
Start date: 2011-05-20
End date: 2011-06-17
Funguard
Dosage: uncertainty
Meropenem
Dosage: unk
Indication: Prophylaxis
Rituxan
Romiplostim
Dosage: 3 mg/kg, qwk
Start date: 2011-06-24
End date: 2012-06-24
Romiplostim
Dosage: 10 mg/kg, qwk
Start date: 2011-09-15
End date: 2011-10-13
Romiplostim
Dosage: 2 mg/kg, qwk
Start date: 2011-06-15
End date: 2011-06-15
Romiplostim
Dosage: 5 mg/kg, qwk
Start date: 2011-07-21
End date: 2011-08-06
Romiplostim
Dosage: 6 mg/kg, qwk
Start date: 2011-08-16
End date: 2011-08-16
Romiplostim
Dosage: 5 mg/kg, qwk
Start date: 2011-08-09
End date: 2011-08-09
Romiplostim
Dosage: 10 mg/kg, qwk
Start date: 2011-10-17
Romiplostim
Dosage: 8 mg/kg, qwk
Start date: 2011-09-01
End date: 2011-09-01
Romiplostim
Dosage: 9 mg/kg, qwk
Start date: 2011-09-08
End date: 2011-09-08
Romiplostim
Dosage: 4 mg/kg, qwk
Start date: 2011-07-11
End date: 2011-07-11
Romiplostim
Dosage: 1 mg/kg, qwk
Indication: Idiopathic Thrombocytopenic Purpura
Start date: 2011-06-01
End date: 2011-06-08
Romiplostim
Dosage: 3 mg/kg, qwk
Start date: 2012-06-21
End date: 2012-06-21
Romiplostim
Dosage: 7 mg/kg, qwk
Start date: 2011-08-24
End date: 2011-08-24
Zosyn
Dosage: unk
Other drugs received by patient: Danazol; Famotidine; Prednisolone; Prednisolone; Danazol; Prednisolone; Cefazolin Sodium; Prednisolone; Immune Globulin (Human); Prednisolone; Fungizone; Prednisolone; Prednisolone; Prednisolone; Prednisolone
Possible Zosyn side effects in
Reported by a pharmacist from United States on 2012-07-11
Patient:
Reactions: Malaise, Circumstance or Information Capable of Leading To Medication Error
Drug(s) suspected as cause:
Zosyn
Possible Zosyn side effects in 63 year old male
Reported by a physician from Japan on 2012-07-11
Patient: 63 year old male
Reactions: Lung Infection Pseudomonal
Adverse event resulted in: death
Drug(s) suspected as cause:
Meropenem
Dosage: 3 g, 1x/day
Indication: Febrile Neutropenia
Zosyn
Dosage: 4.5 g, 3x/day
Indication: Febrile Neutropenia
Zosyn
Dosage: 4.5 g, 3x/day
Other drugs received by patient: Etoposide; Vfend; Fluconazole; Novantrone; Teicoplanin; Cytarabine; Daunorubicin HCL
Possible Zosyn side effects in female
Reported by a physician from United States on 2012-07-11
Patient: female, weighing 94.8 kg (208.5 pounds)
Reactions: Back Pain, Pruritus, Skin Exfoliation, Alopecia, Blister, Stevens-Johnson Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient: Insulin; Dilantin; Diflucan; Tobramycin; Vancomycin
Possible Zosyn side effects in 35 year old female
Reported by a physician from Japan on 2012-07-03
Patient: 35 year old female, weighing 75.0 kg (165.0 pounds)
Reactions: Tubulointerstitial Nephritis
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Flurbiprofen
Dosage: 50 mg/ day
Indication: Febrile Neutropenia
Start date: 2011-10-21
End date: 2011-10-21
Loxoprofen
Dosage: 60-120 mg/ day
Administration route: Oral
Indication: Febrile Neutropenia
Start date: 2011-10-22
End date: 2011-10-31
Meropenem
Dosage: 2-3 g/ day
Indication: Febrile Neutropenia
Start date: 2011-10-26
End date: 2011-11-03
Vancomycin
Dosage: 2 g/ day
Indication: Febrile Neutropenia
Start date: 2011-10-27
End date: 2011-11-04
Zosyn
Dosage: unk
Start date: 2011-11-05
End date: 2011-11-07
Zosyn
Dosage: 4.5 g, 3x/day
Indication: Device Related Infection
Start date: 2011-10-17
End date: 2011-10-21
Other drugs received by patient: Norgestrel and Ethinyl Estradiol; Prednisolone Sodium Succinate INJ; Cytarabine; Maxipime; Amikacin; Ambisome; Funguard
Possible Zosyn side effects in female
Reported by a pharmacist from United States on 2012-07-03
Patient: female
Reactions: Renal Impairment, Nephropathy Toxic, Drug Interaction
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient possibly interacting with the suspect drug:
Vancomycin Hychloride
Dosage: unk
Possible Zosyn side effects in male
Reported by a pharmacist from United States on 2012-07-03
Patient: male
Reactions: Renal Impairment, Nephropathy Toxic, Drug Interaction
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient possibly interacting with the suspect drug:
Vancomycin Hychloride
Dosage: unk
Possible Zosyn side effects in female
Reported by a pharmacist from United States on 2012-07-03
Patient: female
Reactions: Renal Impairment, Nephropathy Toxic, Drug Interaction
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient possibly interacting with the suspect drug:
Vancomycin Hychloride
Dosage: unk
Indication: Subcutaneous Abscess
Possible Zosyn side effects in 88 year old female
Reported by a physician from Japan on 2012-06-29
Patient: 88 year old female, weighing 46.0 kg (101.2 pounds)
Reactions: Hepatic Function Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zosyn
Dosage: 9 g, unk
Indication: Pneumonia
Start date: 2012-04-03
End date: 2012-04-04
Zosyn
Dosage: 13.5 g, unk
Indication: Urinary Tract Infection
Start date: 2012-04-05
End date: 2012-04-17
Other drugs received by patient: Famotidine; Silvinol; Equa; Furosemide; Diart; Nicorandil; Lacb R
Possible Zosyn side effects in 63 year old male
Reported by a physician from Japan on 2012-06-27
Patient: 63 year old male
Reactions: Lung Infection Pseudomonal
Adverse event resulted in: death
Drug(s) suspected as cause:
Zosyn
Dosage: 4.5 g, 3x/day
Indication: Febrile Neutropenia
Zosyn
Dosage: 4.5 g, 3x/day
Other drugs received by patient: Daunorubicin HCL; Meropenem; Vfend; Fluconazole; Novantrone; Vfend; Cytarabine; Etoposide; Teicoplanin
Possible Zosyn side effects in 75 year old female
Reported by a physician from Japan on 2012-06-22
Patient: 75 year old female, weighing 37.0 kg (81.4 pounds)
Reactions: Interstitial Lung Disease, Hypokalaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zosyn
Other drugs received by patient: Lansoprazole; Amlodipine; Zolpidem; Ketoprofen; Magmitt; Alosenn; Loxonin; Olmesartan Medoxomil
Possible Zosyn side effects in 14 year old female
Reported by a physician from United States on 2012-06-21
Patient: 14 year old female
Reactions: Anaemia, Pyrexia, Thrombocytopenia, Leukopenia
Drug(s) suspected as cause:
Zosyn
Dosage: 2.25 g, every 8 hours
Start date: 2012-04-12
End date: 2012-04-17
Zosyn
Dosage: 3.375 g, every 6 hours
Start date: 2012-04-17
End date: 2012-04-24
Possible Zosyn side effects in male
Reported by a pharmacist from United States on 2012-06-20
Patient: male
Reactions: Injection Site Erythema, Injection Site Extravasation, Injection Site Pain
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zosyn
Possible Zosyn side effects in 76 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-06-20
Patient: 76 year old male, weighing 53.0 kg (116.6 pounds)
Reactions: Pruritus Generalised, Oedema, Anaphylactic Shock, Erythema, Cough
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Lactec
Dosage: unk
Start date: 2012-02-16
End date: 2012-02-16
Zosyn
Dosage: 4.5 g, unk
Indication: Antibiotic Prophylaxis
Start date: 2012-02-16
End date: 2012-02-16
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