This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Zaroxolyn (Metolazone) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (14)
Death (1)
Life Threatening Events (3)
Reports by Reaction Type
Hyponatraemia (6),
Bronchitis (6),
Confusional State (4),
Dyspnoea (4),
Cardiac Failure Congestive (3),
Heart Rate Decreased (3),
Renal Failure (3),
Micturition Disorder (3),
Dysuria (3),
Gait Disturbance (3),
Asthenia (3),
Cardiac Discomfort (2)
Possible Zaroxolyn side effects in 87 year old male
Reported by a physician from United States on 2012-08-08
Patient: 87 year old male, weighing 84.8 kg (186.6 pounds)
Reactions: Renal Failure
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Spironolactone
Indication: Cardiac Failure Congestive
Start date: 2009-01-21
Tafamidis Meglumine
Administration route: Oral
Indication: Amyloidosis
Start date: 2008-12-05
Torsemide
Indication: Cardiac Failure Congestive
Start date: 2010-08-25
Zaroxolyn
Indication: Cardiac Failure Congestive
Start date: 2012-01-29
Other drugs received by patient: Ambien; Synthroid; Coumadin; Lipitor; Allopurinol; Colchicine; Colchicine
Possible Zaroxolyn side effects in 87 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-31
Patient: 87 year old male, weighing 84.8 kg (186.6 pounds)
Reactions: Renal Failure, Cardiac Failure Congestive
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Spironolactone
Dosage: 12.5 mg (12.5 mg,1 in 1 d),oral
Administration route: Oral
Indication: Cardiac Failure Congestive
Start date: 2009-01-21
Tafamidis Meglumine
Dosage: 20 mg (20 mg, 1 in 1 d),oral
Administration route: Oral
Indication: Amyloidosis
Start date: 2008-12-05
Torsemide
Dosage: 200 mg (100 mg,2 in 1 d),oral
Administration route: Oral
Indication: Cardiac Failure Congestive
Start date: 2010-08-25
Zaroxolyn
Dosage: as needed (2.5 mg),oral
Administration route: Oral
Indication: Cardiac Failure Congestive
Start date: 2010-01-29
Other drugs received by patient: Ambien; Synthroid; Colchicine; Lipitor; Allopurinol; Coumadin
Possible Zaroxolyn side effects in 87 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-23
Patient: 87 year old male, weighing 84.8 kg (186.6 pounds)
Reactions: Renal Failure, Peritoneal Dialysis, Condition Aggravated, Cardiac Failure Congestive
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Spironolactone
Indication: Cardiac Failure Congestive
Start date: 2009-01-21
Tafamidis Meglumine
Dosage: 20mg (20 mg, 1 in 1 d),oral
Administration route: Oral
Indication: Amyloidosis
Start date: 2008-12-05
Torsemide
Indication: Cardiac Failure Congestive
Start date: 2010-08-25
Zaroxolyn
Indication: Cardiac Failure Congestive
Start date: 2012-01-29
Other drugs received by patient: Ambien; Warfarin Sodium; Colchicine (Colchidine); Allopurinol; Synthroid; Lipitor
Possible Zaroxolyn side effects in 90 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-16
Patient: 90 year old female
Reactions: Multiple Drug Overdose Accidental, Bradycardia, Shock
Drug(s) suspected as cause:
Atenolol
Dosage: 200 mg, once oral, (2 mg, daily oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Diltiazem HCL
Dosage: 960 mg,one oral, 240 mg, daily, oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Furosemide
Dosage: 160 mg, once, oral (40 mg, daily, oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Glyburide
Dosage: 20 mg once oral (5 mg, daily, oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Hydralazine HCL
Dosage: 100 mg once oral (25 mg daily oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Lisinopril
Dosage: 20 mg, once oral (5 mg, daily oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Potassium Chloride
Dosage: 80 mg once oral, (20 mg, daily oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Warfarin Sodium
Dosage: 8 mg, once, oral, 2 mg daily oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Zaroxolyn
Dosage: 20 mg once oral (5 mg daily, oral)
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Zaroxolyn side effects in 90 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-09
Patient: 90 year old female
Reactions: Bradycardia, Accidental Overdose, Shock
Adverse event resulted in: death
Drug(s) suspected as cause:
Atenolol
Administration route: Oral
Atenolol
Administration route: Oral
Diltiazem HCL
Dosage: controlled delivery
Administration route: Oral
Diltiazem HCL
Administration route: Oral
Furosemide
Administration route: Oral
Furosemide
Administration route: Oral
Glyburide
Administration route: Oral
Glyburide
Administration route: Oral
Hydralazine Hydrochloride
Administration route: Oral
Hydralazine Hydrochloride
Administration route: Oral
Lisinopril
Administration route: Oral
Lisinopril
Administration route: Oral
Potassium Chloride
Administration route: Oral
Potassium Chloride
Administration route: Oral
Warfarin Sodium
Administration route: Oral
Warfarin Sodium
Administration route: Oral
Zaroxolyn
Administration route: Oral
Zaroxolyn
Administration route: Oral
Possible Zaroxolyn side effects in 65 year old male
Reported by a consumer/non-health professional from United States on 2012-05-15
Patient: 65 year old male, weighing 99.8 kg (219.5 pounds)
Reactions: Dyspnoea, Body Height Abnormal, Heart Rate Decreased, Micturition Disorder, Dysuria, Gait Disturbance, Blood Pressure Abnormal, Asthenia, Myocardial Infarction
Drug(s) suspected as cause:
Revatio
Administration route: Oral
Indication: Lung Disorder
End date: 2012-04-11
Revatio
Administration route: Oral
Indication: Pulmonary Embolism
End date: 2012-04-11
Zaroxolyn
Administration route: Oral
Indication: Hypertension
End date: 2012-03-30
Other drugs received by patient: Allopurinol; Tracleer
Possible Zaroxolyn side effects in male
Reported by a consumer/non-health professional from United States on 2012-05-03
Patient: male, weighing 99.8 kg (219.5 pounds)
Reactions: Body Height Decreased, Dyspnoea, Cardiac Discomfort, Heart Rate Decreased, Micturition Disorder, Dysuria, Gait Disturbance, Asthenia
Drug(s) suspected as cause:
Revatio
Dosage: 20 mg, 3x/day
Administration route: Oral
Indication: Pulmonary Embolism
End date: 2012-04-11
Zaroxolyn
Dosage: 2.5 mg, 1x/day
Administration route: Oral
Indication: Hypertension
End date: 2012-03-30
Other drugs received by patient: Allopurinol; Tracleer
Possible Zaroxolyn side effects in male
Reported by a consumer/non-health professional from United States on 2012-04-20
Patient: male, weighing 99.8 kg (219.5 pounds)
Reactions: Body Height Decreased, Heart Rate Decreased, Dyspnoea, Cardiac Discomfort, Micturition Disorder, Dysuria, Pulmonary Oedema, Gait Disturbance, Asthenia, Cardiac Failure Congestive
Drug(s) suspected as cause:
Revatio
Dosage: 20 mg, 3x/day
Administration route: Oral
Indication: Pulmonary Embolism
End date: 2012-04-11
Zaroxolyn
Dosage: 2.5 mg, 1x/day
Administration route: Oral
Indication: Hypertension
End date: 2012-03-30
Other drugs received by patient: Tracleer; Allopurinol
Possible Zaroxolyn side effects in 76 year old female
Reported by a physician from Israel on 2012-02-16
Patient: 76 year old female
Reactions: Confusional State, Hyponatraemia, Bronchitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Apidra
Dosage: 14 iu
Indication: Type 2 Diabetes Mellitus
Lantus
Dosage: 21 iu
Indication: Type 2 Diabetes Mellitus
Saxagliptin / Placebo
Indication: Type 2 Diabetes Mellitus
Start date: 2010-08-12
End date: 2011-03-10
Zaroxolyn
Start date: 2010-12-01
Other drugs received by patient: Enoxaparin Sodium; Aldactone; Angiotensin Receptor Blocker; Hypertension Agent; Aspirin; Cadex; Coumadin; Bondormin; Clopidogrel Bisulfate; Prilosec; Calcium Antagonist; Vaben; Statin; Diuretics; Proscar
Possible Zaroxolyn side effects in 76 year old female
Reported by a physician from Israel on 2012-01-20
Patient: 76 year old female
Reactions: Confusional State, Hyponatraemia, Bronchitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Apidra
Dosage: 14 iu
Indication: Type 2 Diabetes Mellitus
Lantus
Dosage: 21 iu
Indication: Type 2 Diabetes Mellitus
Saxagliptin / Placebo
Indication: Type 2 Diabetes Mellitus
Start date: 2010-08-12
End date: 2011-03-10
Zaroxolyn
Start date: 2010-12-01
Other drugs received by patient: Calcium Antagonist; Coumadin; Prilosec; Aldactone; Bondormin; Statin; Diuretics; Aspirin; Clopidogrel Bisulfate; Enoxaparin Sodium; Hypertension Agent; Vaben; Angiotensin Receptor Blocker; Cadex; Proscar
Possible Zaroxolyn side effects in 76 year old female
Reported by a physician from Israel on 2011-12-22
Patient: 76 year old female
Reactions: Confusional State, Hyponatraemia, Bronchitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Apidra
Dosage: 14 iu
Indication: Type 2 Diabetes Mellitus
Lantus
Dosage: 21 iu
Indication: Type 2 Diabetes Mellitus
Saxagliptin / Placebo
Indication: Type 2 Diabetes Mellitus
Start date: 2010-08-12
End date: 2011-03-10
Zaroxolyn
Start date: 2010-12-01
Other drugs received by patient: Hypertension Agent; Clopidogrel Bisulfate; Bondormin; Calcium Antagonist; Prilosec; Proscar; Cadex; Coumadin; Vaben; Diuretics; Statin; Aldactone; Angiotensin Receptor Blocker; Aspirin; Enoxaparin Sodium
Possible Zaroxolyn side effects in 76 year old female
Reported by a physician from Israel on 2011-12-15
Patient: 76 year old female
Reactions: Confusional State, Hyponatraemia, Bronchitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Apidra
Dosage: 14 iu
Indication: Type 2 Diabetes Mellitus
Lantus
Dosage: 21 iu
Indication: Type 2 Diabetes Mellitus
Saxagliptin / Placebo
Indication: Type 2 Diabetes Mellitus
Start date: 2010-08-12
End date: 2011-03-10
Zaroxolyn
Start date: 2010-12-01
Other drugs received by patient: Statin; Enoxaparin Sodium; Prilosec; Calcium Antagonist; Proscar; Bondormin; Aldactone; Aspirin; Diuretics; Clopidogrel Bisulfate; Angiotensin Receptor Blocker; Hypertension Agent; Cadex; Coumadin; Vaben
Possible Zaroxolyn side effects in 76 year old female
Reported by a physician from Israel on 2011-10-18
Patient: 76 year old female
Reactions: Hyponatraemia, Bronchitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Apidra
Dosage: 14 iu
Indication: Type 2 Diabetes Mellitus
Lantus
Dosage: 21 iu
Indication: Type 2 Diabetes Mellitus
Saxagliptin / Placebo
Indication: Type 2 Diabetes Mellitus
Start date: 2010-08-12
End date: 2011-03-10
Zaroxolyn
Start date: 2010-12-01
Other drugs received by patient: Calcium Antagonist; Hypertension Agent; Statin; Clopidogrel Bisulfate; Diuretics; Angiotensin Receptor Blocker; Aspirin
Possible Zaroxolyn side effects in female
Reported by a physician from Israel on 2011-10-04
Patient: female
Reactions: Dyspnoea, Hyponatraemia, Pyrexia, Bronchitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Apidra
Dosage: 14 iu
Indication: Type 2 Diabetes Mellitus
Lantus
Dosage: 21 iu
Indication: Type 2 Diabetes Mellitus
Saxagliptin / Placebo
Indication: Type 2 Diabetes Mellitus
Start date: 2010-08-12
End date: 2011-03-10
Zaroxolyn
Start date: 2010-12-01
Other drugs received by patient: Diuretics; Hypertension Agent; Statin; Calcium Antagonist; Angiotensin Receptor Blocker; Acetylsalicylic Acid SRT; Clopidogrel Bisulfate
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