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Xeloda (Capecitabine) - Palmar-Plantar Erythrodysaesthesia Syndrome - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Palmar-Plantar Erythrodysaesthesia Syndrome (231)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Xeloda (Capecitabine) where reactions include palmar-plantar erythrodysaesthesia syndrome. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 231   Next >>

Possible Xeloda side effects in female

Reported by a physician from Japan on 2012-08-24

Patient: female, weighing 49.0 kg (107.8 pounds)

Reactions: Stomatitis, Disseminated Intravascular Coagulation, Pancytopenia, Palmar-Plantar Erythrodysaesthesia Syndrome, Ketoacidosis, Diarrhoea, Cerebral Infarction, Altered State of Consciousness

Adverse event resulted in: life threatening event, disablity

Drug(s) suspected as cause:
Xeloda

Other drugs received by patient: Tamoxifen Citrate



Possible Xeloda side effects in 62 year old male

Reported by a physician from Poland on 2012-08-23

Patient: 62 year old male

Reactions: Kwashiorkor, Carcinoembryonic Antigen Increased, Increased Appetite, Nausea, Anaemia, General Physical Health Deterioration, Palmar-Plantar Erythrodysaesthesia Syndrome, Ascites, Apathy, Death, Neutropenia, Thrombocytopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Cisplatin
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-12-14

Xeloda
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-12-14

Other drugs received by patient: Diaprel MR



Possible Xeloda side effects in male

Reported by a physician from Japan on 2012-08-23

Patient: male, weighing 70.0 kg (154.0 pounds)

Reactions: Ureteric Obstruction, Palmar-Plantar Erythrodysaesthesia Syndrome, Extravasation of Urine

Drug(s) suspected as cause:
Avastin
    Dosage: dosage is uncertain.
    Indication: Colon Cancer
    Start date: 2009-11-24
    End date: 2010-03-01

Avastin
    Indication: Colon Cancer Recurrent
    Start date: 2010-11-22
    End date: 2011-08-22

Avastin
    Start date: 2011-10-31
    End date: 2011-12-12

Xeloda
    Administration route: Oral
    Start date: 2010-09-27
    End date: 2011-08-22

Xeloda
    Administration route: Oral
    Indication: Colon Cancer Recurrent
    Start date: 2010-07-13
    End date: 2010-01-01

Other drugs received by patient: Loxoprofen; Loxoprofen; Oxaliplatin; Levoleucovorin Calcium; Fluorouracil; Fluorouracil; Oxycodone HCL; TS-1; Irinotecan HCL; Fluorouracil; Levoleucovorin Calcium; Loxoprofen; Oxaliplatin; Fluorouracil; Oxycodone HCL



Possible Xeloda side effects in female

Reported by a health professional (non-physician/pharmacist) from Australia on 2012-08-21

Patient: female

Reactions: Defaecation Urgency, Pruritus, Coagulopathy, Central Nervous System Lesion, Palmar-Plantar Erythrodysaesthesia Syndrome, Hypoaesthesia, Neoplasm, Nail Infection, Diarrhoea, Dysphonia, Oral Pain, Skin Lesion, Gastrointestinal Sounds Abnormal, Brain Neoplasm, Eye Disorder

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Tamoxifen Citrate
    Indication: Product Used FOR Unknown Indication

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer Metastatic
    Start date: 2011-10-14

Xeloda
    Dosage: 500mg per day
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-10-14



Possible Xeloda side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-21

Patient:

Reactions: Mucosal Inflammation, Diarrhoea, Palmar-Plantar Erythrodysaesthesia Syndrome

Drug(s) suspected as cause:
Xeloda



Possible Xeloda side effects in 73 year old male

Reported by a pharmacist from Canada on 2012-08-20

Patient: 73 year old male

Reactions: LIP Swelling, Pruritus, Angioedema, Eosinophil Count Abnormal, Urticaria, Palmar-Plantar Erythrodysaesthesia Syndrome, Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Xeloda

Other drugs received by patient: Insulin; Atacand; Nexium; Carvedilol; Furosemide; Amlodipine; Digoxin; Aspirin; Risedronate Sodium



Possible Xeloda side effects in female

Reported by a physician from Germany on 2012-08-20

Patient: female, weighing 76.3 kg (167.8 pounds)

Reactions: Palmar-Plantar Erythrodysaesthesia Syndrome, Rash

Adverse event resulted in: death

Drug(s) suspected as cause:
Cetuximab and Cetuximab
    Dosage: frequency reported as day 1.
    Indication: Colorectal Cancer Metastatic

Irinotecan Hydrochloride
    Dosage: frequency reported as day 1.
    Indication: Colorectal Cancer Metastatic

Xeloda
    Administration route: Oral
    Indication: Colorectal Cancer Metastatic

Xeloda
    Dosage: dose: 3 pills in am and 4 pills in the pm
    Administration route: Oral

Other drugs received by patient: Budenofalk; Zofran; Dexamethasone; Mesalamine



Possible Xeloda side effects in female

Reported by a consumer/non-health professional from Australia on 2012-08-16

Patient: female

Reactions: Fatigue, Pain in Extremity, Palmar-Plantar Erythrodysaesthesia Syndrome, Impaired Gastric Emptying, Gait Disturbance, Skin Fissures

Drug(s) suspected as cause:
Xeloda
    Indication: Product Used FOR Unknown Indication

Xeloda



Possible Xeloda side effects in

Reported by a consumer/non-health professional from Poland on 2012-08-16

Patient:

Reactions: Coagulopathy, Palmar-Plantar Erythrodysaesthesia Syndrome, Thrombocytopenia

Drug(s) suspected as cause:
Xeloda



Possible Xeloda side effects in 35 year old female

Reported by a physician from Poland on 2012-08-14

Patient: 35 year old female

Reactions: Paronychia, Blood Bilirubin Increased, Herpes Zoster Disseminated, Palmar-Plantar Erythrodysaesthesia Syndrome, Metastasis, Diarrhoea, Metastases To Central Nervous System, Neurological Symptom

Drug(s) suspected as cause:
Trastuzumab
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-09-01

Trastuzumab
    Start date: 2008-11-01
    End date: 2009-11-01

Xeloda
    Administration route: Oral
    Start date: 2012-04-01

Xeloda
    Dosage: treatment resumed after 3 weeks .
    Administration route: Oral
    Start date: 2011-01-01
    End date: 2011-07-01

Xeloda
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-05-07

Xeloda
    Dosage: dose reduction by 10 percent
    Administration route: Oral
    Start date: 2010-07-01
    End date: 2011-04-01

Xeloda
    Dosage: 50 percent reduced dose
    Administration route: Oral
    Start date: 2011-10-01
    End date: 2011-12-01

Other drugs received by patient: Cytoxan; Paclitaxel; Lapatinib; Adriamycin PFS; Goserelin



Possible Xeloda side effects in female

Reported by a consumer/non-health professional from Mexico on 2012-08-13

Patient: female, weighing 68.0 kg (149.6 pounds)

Reactions: Hysterectomy, Fatigue, Malaise, Palmar-Plantar Erythrodysaesthesia Syndrome, Musculoskeletal Stiffness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Xeloda
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-06-21
    End date: 2012-07-05

Xeloda
    Administration route: Oral
    Start date: 2012-08-06



Possible Xeloda side effects in 24 year old male

Reported by a physician from Russian Federation on 2012-08-13

Patient: 24 year old male, weighing 49.0 kg (107.8 pounds)

Reactions: Palmar-Plantar Erythrodysaesthesia Syndrome

Drug(s) suspected as cause:
Avastin
    Indication: Rectal Cancer
    Start date: 2012-05-18
    End date: 2012-06-14

Xeloda
    Administration route: Oral
    Indication: Rectal Cancer
    Start date: 2012-06-08
    End date: 2012-06-14

Other drugs received by patient: Oxaliplatin



Possible Xeloda side effects in

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-13

Patient:

Reactions: Abdominal Pain, Blood Bilirubin Increased, Thrombosis, Anal Examination Abnormal, Hypokalaemia, Fatigue, Proteinuria, Abdominal Distension, Decreased Appetite, Nausea, Palmar-Plantar Erythrodysaesthesia Syndrome, Hyponatraemia, Small Intestinal Obstruction, Hypophosphataemia, Diarrhoea, Alopecia, Dehydration, Neutropenia, Hypertension, Vascular Access Complication

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Dosage: given on day 1
    Indication: Colorectal Cancer Metastatic

Irinotecan Hydrochloride and Irinotecan Hydrochloride
    Dosage: given on day 1
    Indication: Colorectal Cancer Metastatic

Xeloda
    Dosage: 1000 mg/m2 twice daily for age below 65 years,750 mg/m2 twice daily for age above 65 years
    Administration route: Oral
    Indication: Colorectal Cancer Metastatic



Possible Xeloda side effects in female

Reported by a physician from Argentina on 2012-08-10

Patient: female

Reactions: Palmar-Plantar Erythrodysaesthesia Syndrome, Nail Disorder, Disease Progression

Drug(s) suspected as cause:
Xeloda

Other drugs received by patient: Paclitaxel



Possible Xeloda side effects in female

Reported by a physician from Germany on 2012-08-10

Patient: female, weighing 61.0 kg (134.2 pounds)

Reactions: Palmar-Plantar Erythrodysaesthesia Syndrome, Pancytopenia, Febrile Neutropenia, Febrile Infection, Mucosal Inflammation, Agranulocytosis, Diarrhoea, Sepsis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Xeloda

Other drugs received by patient: Herceptin; Carboplatin



Possible Xeloda side effects in

Reported by a individual with unspecified qualification from Italy on 2012-08-08

Patient:

Reactions: Stomatitis, Anaemia, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Liver Disorder, Mucosal Inflammation, Fatigue, Diarrhoea, Neutropenia, Thrombocytopenia, Leukopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lapatinib
    Indication: Breast Cancer Metastatic

Xeloda
    Indication: Breast Cancer Metastatic



Possible Xeloda side effects in female

Reported by a physician from United States on 2012-08-07

Patient: female, weighing 72.9 kg (160.4 pounds)

Reactions: Mucosal Inflammation, Blood Bilirubin Increased, Malaise, Dyspnoea, Dehydration, Palmar-Plantar Erythrodysaesthesia Syndrome, Constipation, Ascites

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ramucirumab
    Indication: Breast Cancer
    Start date: 2012-06-15

Xeloda
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-06-15

Other drugs received by patient: Tramadol HCL; Ativan; Compazine; Lisinopril



Possible Xeloda side effects in

Reported by a physician from Spain on 2012-08-07

Patient:

Reactions: Abdominal Pain, Dyspnoea, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Mucosal Inflammation, Death, Fatigue, Diarrhoea, Neutropenia, Hypertension, Asthenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Blinded Sorafenib and Blinded Sorafenib
    Administration route: Oral
    Indication: Breast Cancer

Xeloda
    Dosage: drug was used for 14 days every 21 days.
    Administration route: Oral
    Indication: Breast Cancer



Possible Xeloda side effects in

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-08-06

Patient:

Reactions: Vomiting, Anaemia, Pulmonary Embolism, Febrile Neutropenia, Palmar-Plantar Erythrodysaesthesia Syndrome, Peripheral Sensory Neuropathy, Mucosal Inflammation, Diarrhoea, Proteinuria, Neutropenia, Leukopenia

Drug(s) suspected as cause:
Avastin
    Dosage: fluorouracil based regimen
    Indication: Colorectal Cancer Metastatic

Avastin
    Dosage: capecitabine-based regimen

Fluorouracil
    Dosage: on day 1

Fluorouracil
    Indication: Colorectal Cancer Metastatic

Irinotecan Hydrochloride
    Dosage: dose: 150/180 mg/m2 on day 1
    Indication: Colorectal Cancer Metastatic

Leucovorin Calcium
    Dosage: on day 1
    Indication: Colorectal Cancer Metastatic

Oxaliplatin
    Dosage: on day 1
    Indication: Colorectal Cancer Metastatic

Xeloda
    Indication: Colorectal Cancer Metastatic



Possible Xeloda side effects in female

Reported by a consumer/non-health professional from Mexico on 2012-08-06

Patient: female, weighing 46.0 kg (101.2 pounds)

Reactions: Fatigue, Pancreatic Carcinoma, Palmar-Plantar Erythrodysaesthesia Syndrome, Depression

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Xeloda
    Administration route: Oral
    Indication: Pancreatic Carcinoma
    Start date: 2011-10-01

Xeloda
    Administration route: Oral
    Start date: 2011-11-01

Other drugs received by patient: Gemcitabine Hydrochloride; Cinnarizine; Aspirin; Irbesartan



Possible Xeloda side effects in male

Reported by a physician from Japan on 2012-08-06

Patient: male, weighing 70.0 kg (154.0 pounds)

Reactions: Ureteric Obstruction, Palmar-Plantar Erythrodysaesthesia Syndrome, Extravasation of Urine

Drug(s) suspected as cause:
Avastin
    Dosage: dosage is uncertain.
    Indication: Colon Cancer Recurrent
    Start date: 2009-11-24
    End date: 2010-03-01

Avastin
    Start date: 2010-11-22
    End date: 2011-08-22

Avastin
    Start date: 2011-10-31
    End date: 2011-12-12

Xeloda
    Administration route: Oral
    Indication: Colon Cancer Recurrent
    Start date: 2010-07-13
    End date: 2010-01-01

Xeloda
    Administration route: Oral
    Start date: 2010-09-27
    End date: 2011-08-22

Other drugs received by patient: Levoleucovorin Calcium; Oxycodone HCL; Levoleucovorin Calcium; Oxaliplatin; Loxoprofen; Oxaliplatin; Irinotecan HCL; Fluorouracil; Fluorouracil; Fluorouracil; Loxoprofen; Fluorouracil; Loxoprofen; TS-1; Oxycodone HCL



Possible Xeloda side effects in female

Reported by a health professional (non-physician/pharmacist) from Australia on 2012-08-03

Patient: female

Reactions: Central Nervous System Lesion, Palmar-Plantar Erythrodysaesthesia Syndrome, Hypoaesthesia, Nail Infection, Diarrhoea, Oral Pain, Skin Lesion, Eye Disorder, Brain Neoplasm

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Tykerb
    Administration route: Oral
    Indication: Breast Cancer Metastatic
    Start date: 2011-10-14

Xeloda
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-10-14



Possible Xeloda side effects in female

Reported by a physician from United States on 2012-07-31

Patient: female, weighing 59.5 kg (130.8 pounds)

Reactions: Death, Hyperaesthesia, Pain in Extremity, Skin Exfoliation, Palmar-Plantar Erythrodysaesthesia Syndrome

Adverse event resulted in: death

Drug(s) suspected as cause:
Xeloda

Other drugs received by patient: Allegra; Potassium; Probiotic (Unk Ingredients); Lovenox; Torsemide; Nexium; Diuretic (Unk Ingredients); Valtrex; Lorazepam



Possible Xeloda side effects in female

Reported by a physician from United States on 2012-07-27

Patient: female, weighing 59.5 kg (130.8 pounds)

Reactions: Death, Hyperaesthesia, Skin Exfoliation, Pain in Extremity, Palmar-Plantar Erythrodysaesthesia Syndrome

Adverse event resulted in: death

Drug(s) suspected as cause:
Xeloda

Other drugs received by patient: Probiotic (Unk Ingredients); Lovenox; Diuretic (Unk Ingredients); Allegra; Potassium Chloride; Valtrex; Nexium; Torsemide



Possible Xeloda side effects in 80 year old female

Reported by a physician from Lebanon on 2012-07-26

Patient: 80 year old female

Reactions: Skin Exfoliation, Pancytopenia, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, Mucosal Inflammation, Diarrhoea, Skin Discolouration, Neutropenia, Thrombocytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Xeloda



Possible Xeloda side effects in 41 year old female

Reported by a pharmacist from Canada on 2012-07-26

Patient: 41 year old female

Reactions: Breast Cancer, Stomatitis, Skin Exfoliation, Metastases To Liver, Palmar-Plantar Erythrodysaesthesia Syndrome, Condition Aggravated, Erythema

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Tykerb
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Xeloda
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Docusate Sodium; Senokot; Tylenol with Codeine #3 (United States)



Possible Xeloda side effects in

Reported by a health professional (non-physician/pharmacist) from Austria on 2012-07-26

Patient:

Reactions: Neuropathy Peripheral, Embolism, Diarrhoea, Palmar-Plantar Erythrodysaesthesia Syndrome

Drug(s) suspected as cause:
Avastin
    Dosage: day 1 of a 2 week cycle for 6 cycles
    Indication: Colorectal Cancer Metastatic

Oxaliplatin
    Dosage: day 1 of a 2 week cycle for 6 cycles
    Indication: Colorectal Cancer Metastatic

Xeloda
    Dosage: day 1-7 of a 2 week cycle for 6 cycles
    Indication: Colorectal Cancer Metastatic



Possible Xeloda side effects in 46 year old female

Reported by a physician from Canada on 2012-07-26

Patient: 46 year old female

Reactions: Musculoskeletal Disorder, Palmar-Plantar Erythrodysaesthesia Syndrome, DRY Skin, Erythema

Drug(s) suspected as cause:
Tykerb
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Xeloda
    Indication: Product Used FOR Unknown Indication



Possible Xeloda side effects in 63 year old male

Reported by a consumer/non-health professional from China on 2012-07-25

Patient: 63 year old male, weighing 74.0 kg (162.8 pounds)

Reactions: Productive Cough, Palmar-Plantar Erythrodysaesthesia Syndrome, Immunodeficiency, Oropharyngeal Pain, Rash Macular, Diarrhoea, Skin Discolouration, Ear Pain, Toothache, Asthenia, Metastases To Lung, Lethargy

Drug(s) suspected as cause:
Xeloda
    Administration route: Oral
    Start date: 2012-03-01
    End date: 2012-07-13

Xeloda
    Administration route: Oral
    Indication: Hepatic Cancer Metastatic
    Start date: 2007-11-01
    End date: 2008-01-01

Xeloda
    Administration route: Oral
    Start date: 2010-01-01

Xeloda
    Administration route: Oral
    Start date: 2009-01-01

Other drugs received by patient: Adefovir Dipivoxil; Lamivudine; Nexavar



Possible Xeloda side effects in 57 year old female

Reported by a pharmacist from United States on 2012-07-25

Patient: 57 year old female

Reactions: Palmar-Plantar Erythrodysaesthesia Syndrome

Drug(s) suspected as cause:
Xeloda



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