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Vinorelbine (Vinorelbine) - Neutropenia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Neutropenia (25)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Vinorelbine where reactions include neutropenia. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Vinorelbine side effects in

Reported by a physician from United States on 2012-07-06

Patient:

Reactions: Respiratory Failure, Anaemia, Neutropenia, Thrombocytopenia, Infection

Drug(s) suspected as cause:
Doxorubicin Hydrochloride
    Dosage: administered on day 1 and day 8 of every 21 day cycle
    Indication: Diffuse Large B-Cell Lymphoma

Vinorelbine
    Dosage: administered on day 1 and day 8 of every 21 day cycle
    Indication: Diffuse Large B-Cell Lymphoma

Colony Stimulating Factor
    Dosage: on day 9 of each cycle
    Indication: Diffuse Large B-Cell Lymphoma

Rituximab
    Dosage: administered on day 1 and day 8 of every 21 day cycle
    Indication: Diffuse Large B-Cell Lymphoma

Gemcitabine
    Dosage: administered on day 1 and day 8 of every 21 day cycle
    Indication: Diffuse Large B-Cell Lymphoma



Possible Vinorelbine side effects in 20 year old female

Reported by a physician from Taiwan, Province of China on 2012-07-02

Patient: 20 year old female

Reactions: Refusal of Treatment by Patient, Hepatic Function Abnormal, Mental Status Changes, Disorientation, Respiratory Alkalosis, Somnolence, Convulsion, Hyperammonaemia, Depressed Level of Consciousness, Neutropenia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Vinorelbine
    Dosage: 20 mg/m**2;qd;
    Indication: B Precursor Type Acute Leukaemia

Gemcitabine Hydrochloride
    Dosage: 10 mg/m**2;
    Indication: B Precursor Type Acute Leukaemia

Other drugs received by patient: Vincristine; Cytarabine; Dexamethasone; Doxorubicin HCL; Asparaginase; Thiotepa; Mitoxantrone; Topotecan; Cisplatin



Possible Vinorelbine side effects in female

Reported by a physician from Chile on 2012-06-29

Patient: female, weighing 74.5 kg (163.9 pounds)

Reactions: Neutropenia

Drug(s) suspected as cause:
Lapatinib
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer Metastatic
    Start date: 2012-02-03

Vinorelbine
    Dosage: 20mgm2 cyclic
    Indication: Breast Cancer Metastatic
    Start date: 2012-02-03



Possible Vinorelbine side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-27

Patient:

Reactions: Respiratory Failure, Anaemia, Neutropenia, Thrombocytopenia, Infection

Drug(s) suspected as cause:
Vinorelbine
    Dosage: administered on day 1 and day 8 of every 21 day cycle
    Indication: Diffuse Large B-Cell Lymphoma

Doxorubicin Hydrochloride
    Dosage: administered on day 1 and day 8 of every 21 day cycle
    Indication: Diffuse Large B-Cell Lymphoma

Rituximab
    Dosage: administered on day 1 and day 8 of every 21 day cycle
    Indication: Diffuse Large B-Cell Lymphoma

Gemcitabine
    Dosage: administered on day 1 and day 8 of every 21 day cycle
    Indication: Diffuse Large B-Cell Lymphoma

Colony Stimulating Factor
    Dosage: on day 9 of each cycle
    Indication: Diffuse Large B-Cell Lymphoma



Possible Vinorelbine side effects in 39 year old female

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-06-22

Patient: 39 year old female

Reactions: Abdominal Pain, Alanine Aminotransferase Increased, Wrong Drug Administered, Accidental Overdose, Ileus Paralytic, Abdominal Pain Upper, Neurotoxicity, Myalgia, Hepatotoxicity, Diarrhoea, Colitis, Neutropenia, Thrombocytopenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Vinorelbine
    Dosage: 35 mg, unk
    Indication: Hodgkin's Disease

Vinblastine Sulfate
    Dosage: 35 mg, unk

Other drugs received by patient: Prednisolone; Ifosfamide; Gemcitabine



Possible Vinorelbine side effects in

Reported by a physician from United States on 2012-06-22

Patient:

Reactions: Thrombosis, Device Related Infection, Headache, Peripheral Sensory Neuropathy, Pericardial Effusion, Malaise, Dyspepsia, Granulocytopenia, Hypoxia, Pneumonitis, Blood Alkaline Phosphatase Increased, Hyperglycaemia, Anaemia, Hypotension, Dehydration, Neutropenia, Bone Pain, Pain, Hypokalaemia, Disease Progression, Death, Postoperative Wound Infection, Fatigue, Neutropenic Infection, Chest Pain, Depression, Lethargy, Vomiting, Dyspnoea, Alanine Aminotransferase Increased, Lymphopenia, Muscular Weakness, Febrile Neutropenia, Hypophosphataemia, Syncope, Diarrhoea, Arthralgia, Ejection Fraction Decreased, Hypermagnesaemia, Respiratory Tract Infection, Leukopenia, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Docetaxel
    Dosage: 60 mg/m2, unk
    Indication: Breast Cancer Metastatic

Vinorelbine
    Dosage: 27.5 mg/m2, per chemo regim
    Indication: Breast Cancer Metastatic

Filgrastim
    Dosage: 5 mug/kg, per chemo regim
    Indication: Breast Cancer Metastatic

Trastuzumab
    Dosage: 2 mg/kg, qwk

Trastuzumab
    Dosage: 4 mg/kg, one time dose
    Indication: Breast Cancer Metastatic



Possible Vinorelbine side effects in 76 year old female

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-05-25

Patient: 76 year old female

Reactions: Hyperbilirubinaemia, Dyspnoea, Neutropenia

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Cisplatin
    Indication: non-Small Cell Lung Cancer
    Start date: 2005-06-16

Cetuximab
    Dosage: 2nd inf on
    Indication: non-Small Cell Lung Cancer
    Start date: 2005-06-16

Vinorelbine
    Indication: non-Small Cell Lung Cancer
    Start date: 2005-06-16



Possible Vinorelbine side effects in 48 year old female

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-05-21

Patient: 48 year old female

Reactions: Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cisplatin
    Dosage: last dose:12jul2005
    Indication: non-Small Cell Lung Cancer
    Start date: 2005-05-30

Vinorelbine
    Indication: non-Small Cell Lung Cancer
    Start date: 2005-05-30



Possible Vinorelbine side effects in 61 year old female

Reported by a consumer/non-health professional from Germany on 2012-03-22

Patient: 61 year old female, weighing 45.0 kg (99.0 pounds)

Reactions: Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Cisplatin
    Dosage: 100mg:16feb10-10mar10, 35mg:09apr10-09apr10.
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-02-16
    End date: 2010-04-09

Cetuximab
    Dosage: 09feb10-09feb10,(77.1429mg) 16feb10-21may10.(340mg,1 in 1 week).
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-02-09
    End date: 2010-05-21

Vinorelbine
    Dosage: 33mg:16feb10-26mar10, 17mg:09apr10-21apr10.
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-02-16
    End date: 2010-04-21



Possible Vinorelbine side effects in 46 year old female

Reported by a consumer/non-health professional from Germany on 2012-03-21

Patient: 46 year old female, weighing 62.0 kg (136.4 pounds)

Reactions: Neutropenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Cisplatin
    Dosage: 131mgd1:17jul10-07aug10, 44mg,d1-3:08sep10-22sep10-ong.
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-07-17

Cetuximab
    Dosage: cetuximab intravenous infusion 435mg:17jul10-22oct10-ong
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-07-10

Vinorelbine
    Dosage: 44mg,d1 d8:17jul10-13aug10(27 days) 22mg,d1 d8:08sep10--22oct10 ong.
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-07-17



Possible Vinorelbine side effects in 57 year old male

Reported by a consumer/non-health professional from Germany on 2012-03-21

Patient: 57 year old male, weighing 62.0 kg (136.4 pounds)

Reactions: Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Cetuximab
    Dosage: 07nov09-07nov09,13nov09-27nov09;14d;430mg,04dec09-05feb10;63d;400mg,intravenous infusion
    Indication: non-Small Cell Lung Cancer
    Start date: 2009-11-07
    End date: 2010-02-05

Cisplatin
    Dosage: 13nov09-13nov09;d1,d8,04dec09-04dec09;108mg;d1,d8,30dec09-22jan10;23days;35mg;d1,8
    Indication: non-Small Cell Lung Cancer
    Start date: 2009-11-13
    End date: 2010-01-22

Vinorelbine
    Dosage: 13nov09-20nov09;7d;d1,d8,04dec09-unk;34mg;d1,8,30dec09-29jan10;22mg;30d;d1,8
    Indication: non-Small Cell Lung Cancer
    Start date: 2009-11-13
    End date: 2010-01-29



Possible Vinorelbine side effects in 63 year old male

Reported by a consumer/non-health professional from Germany on 2012-03-21

Patient: 63 year old male, weighing 65.0 kg (143.0 pounds)

Reactions: Bone Marrow Failure, Neutropenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Vinorelbine
    Dosage: last 19nov10.and continued.infusion. 40mg from 3sep10-30sep10(77d) 20mg from 21oct10-19nov10(77d)
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-09-03
    End date: 2010-11-19

Cisplatin
    Dosage: last 12nov10.and continued 120mg from 3sep10 - 24sep10(21d) 40mg from 21oct10 - 12nov10(70d)
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-09-03
    End date: 2010-11-12

Cetuximab
    Dosage: last dose:3dec10.and continued initial dose:640mg on 27aug10 03sep-03dec10
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-08-27
    End date: 2010-12-03



Possible Vinorelbine side effects in 57 year old male

Reported by a consumer/non-health professional from Germany on 2012-03-21

Patient: 57 year old male, weighing 62.0 kg (136.4 pounds)

Reactions: Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Cetuximab
    Dosage: 7nov09-7nov09=692mg,13nov09-27nov09=430mg,04dec09-5feb2010(400mg 1 in 1 week).
    Indication: non-Small Cell Lung Cancer
    Start date: 2009-11-07
    End date: 2010-02-05

Vinorelbine
    Dosage: 13nov09-20nov09,d1,8,04dec- 34mg every 3 week d,1,8,30dec09- 22mgevery 3weeks d,1,8
    Indication: non-Small Cell Lung Cancer
    Start date: 2009-11-13
    End date: 2010-01-29

Cisplatin
    Dosage: 13nov09-13nov09,d1,4dec09-4dec09=108mg every 3week d1,30dec09- 35 mg every 3weeksd1,
    Indication: non-Small Cell Lung Cancer
    Start date: 2009-11-13
    End date: 2010-01-22



Possible Vinorelbine side effects in 49 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-03-21

Patient: 49 year old male, weighing 55.0 kg (121.0 pounds)

Reactions: Neutropenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Vinorelbine
    Dosage: inter on 13jul11 initial dose:40 mg frm 03may11 - 31may11 20mg frm 15jun11 - 13jul11
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-05-03

Cetuximab
    Dosage: inter on 20jul11,iv infusion initial dose:640 mg on 25apr11 400mg frm 03may11 - 20jul11
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-04-25

Cisplatin
    Dosage: inter on 06jul11 initial dose:120 mg on 03may11 - 24may11 iv 40mg frm 15jun11 - 06jul11 iv drip
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-05-03



Possible Vinorelbine side effects in 68 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-03-21

Patient: 68 year old male, weighing 65.0 kg (143.0 pounds)

Reactions: Neutropenia, Leukopenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Vinorelbine
    Dosage: 43mg d1,d8,q3w 20mg d1,d8,q3w 29jun10-8jul10;9d 21jul-29jul1:34mg 8d 21aug-1sep10:20mg 29d
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-06-29

Cetuximab
    Dosage: cetuximab intravenous infusion 23jun10 29jun10-15sep10;78d (437 mg)
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-06-23

Cisplatin
    Dosage: 130mg q3w 40mg d1-d3 q3w 29jun10:130 mg;1d 21jul10-104mg 11aug10-1sep10:40mg 21d
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-06-29



Possible Vinorelbine side effects in 59 year old female

Reported by a consumer/non-health professional from Germany on 2012-03-20

Patient: 59 year old female, weighing 65.0 kg (143.0 pounds)

Reactions: Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Cetuximab
    Dosage: stat,inter on 30jul10,25jun10, 20jul10iv.625mg stat 14-14may10;400mgqw21may-25jun10. last 30jul10
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-05-14

Vinorelbine
    Dosage: frequency:stat,inter on 30jul10,therapy duration:70days 40mg d1,d8,21may2010
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-03-21

Cisplatin
    Dosage: stat,inter on 30jul10,therapy duration:70days. 120mg 21may-12jun10 44mg 5-30jul10 d1 d3 3wks
    Indication: non-Small Cell Lung Cancer
    Start date: 2010-05-21



Possible Vinorelbine side effects in 52 year old male

Reported by a consumer/non-health professional from Germany on 2012-03-20

Patient: 52 year old male, weighing 50.0 kg (110.0 pounds)

Reactions: non-Small Cell Lung Cancer, Bone Marrow Failure, Neoplasm Progression, Neutropenia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Cetuximab
    Dosage: 05-05jul11(630mg),12jul11-unk (394mg)56.2857 mg,09aug11-16aug11 (350mg)d1qw 50mg,no of cycles:2
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-07-05

Vinorelbine
    Dosage: d1,d8,12jul11-19jul11(7days),09aug11-16aug11 1.4286mg(30mg),no of cycles:2
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-07-12

Cisplatin
    Dosage: 12jul2011-12jul11:118mg d1 qw,09aug11-09aug11(1day) 4.2857 mg(90mg),no of cycles:2
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-07-12



Possible Vinorelbine side effects in 67 year old male

Reported by a health professional (non-physician/pharmacist) from China on 2012-03-14

Patient: 67 year old male

Reactions: Death, Hepatic Function Abnormal, Neutropenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Cisplatin
    Indication: Squamous Cell Carcinoma

Vinorelbine
    Indication: Squamous Cell Carcinoma

Other drugs received by patient: Cetuximab; Cetuximab



Possible Vinorelbine side effects in

Reported by a physician from United States on 2012-01-31

Patient:

Reactions: Death, Fatigue, Neutropenia, Disease Progression, Leukopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Trastuzumab
    Dosage: 2 mg/kg, qwk

Filgrastim
    Dosage: 5 mug/kg, per chemo regim
    Indication: Breast Cancer Metastatic

Vinorelbine
    Dosage: 27.5 mg, per chemo regim
    Indication: Breast Cancer Metastatic

Trastuzumab
    Dosage: 4 mg/kg, one time dose
    Indication: Breast Cancer Metastatic

Docetaxel
    Dosage: 60 mg, one time dose
    Indication: Breast Cancer Metastatic



Possible Vinorelbine side effects in female

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-01-17

Patient: female

Reactions: Neutropenia, Hypertransaminasaemia

Drug(s) suspected as cause:
Herceptin
    Indication: Breast Cancer
    Start date: 2011-10-19

Herceptin
    Start date: 2011-10-19

Zometa
    Indication: Breast Cancer
    Start date: 2011-10-19

Vinorelbine
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-10-19

Other drugs received by patient: Olmesartan Medoxomil



Possible Vinorelbine side effects in

Reported by a physician from United States on 2012-01-11

Patient:

Reactions: Fatigue, Neutropenia, Leukopenia

Drug(s) suspected as cause:
Vinorelbine
    Dosage: 27.5 mg, per chemo regim
    Indication: Breast Cancer Metastatic

Docetaxel
    Dosage: 60 mg, one time dose
    Indication: Breast Cancer Metastatic

Trastuzumab
    Dosage: 4 mg/kg, one time dose
    Indication: Breast Cancer Metastatic

Trastuzumab
    Dosage: 2 mg/kg, qwk

Neupogen
    Dosage: 5 mug/kg, per chemo regim
    Indication: Breast Cancer Metastatic



Possible Vinorelbine side effects in 49 year old female

Reported by a physician from United States on 2012-01-09

Patient: 49 year old female, weighing 105.5 kg (232.1 pounds)

Reactions: Dehydration, Neutropenia, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lapatinib
    Dosage: 1500mg per day
    Administration route: Oral
    Indication: Breast Cancer Metastatic
    Start date: 2011-04-07

Vinorelbine
    Dosage: 20mgm2 cyclic
    Indication: Breast Cancer Metastatic
    Start date: 2011-04-07

Diovan
    Dosage: 40mg per day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2007-01-01
    End date: 2011-04-20

Lisinopril
    Dosage: 10mg per day
    Administration route: Oral
    Indication: Hypertension
    Start date: 2007-01-01
    End date: 2011-04-20



Possible Vinorelbine side effects in female

Reported by a health professional (non-physician/pharmacist) from Italy on 2011-11-16

Patient: female

Reactions: Neutropenia, Hypertransaminasaemia

Drug(s) suspected as cause:
Zometa
    Dosage: 4 mg, (cyclic)
    Indication: Osteoporosis Prophylaxis
    Start date: 2011-05-06

Vinorelbine
    Dosage: 49 mg,(cyclic)
    Indication: Breast Cancer
    Start date: 2011-05-06

Other drugs received by patient: Telmisartan and Hydrochlorothiazide



Possible Vinorelbine side effects in 59 year old

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-01

Patient: 59 year old

Reactions: Sepsis, Neutropenia, Toxicity To Various Agents

Adverse event resulted in: death, disablity

Drug(s) suspected as cause:
Anthracycline (NO Pref. Name)
    Indication: Breast Cancer Metastatic

Capecitabine
    Indication: Breast Cancer Metastatic

Trastuzumab (Trastuzumab)
    Indication: Breast Cancer Metastatic

5-HT3 (NO Pref. Name)
    Indication: Breast Cancer Metastatic

Vinorelbine
    Indication: Breast Cancer Metastatic

Irinotecan Hydrochloride
    Dosage: 100 mg/m2
    Indication: Breast Cancer Metastatic

Docetaxel
    Indication: Breast Cancer Metastatic

Paclitaxel
    Indication: Breast Cancer Metastatic



Possible Vinorelbine side effects in female

Reported by a health professional (non-physician/pharmacist) from Italy on 2011-11-01

Patient: female

Reactions: Neutropenia, Hypertransaminasaemia

Drug(s) suspected as cause:
Vinorelbine
    Dosage: 49 mg,(cyclic)
    Indication: Breast Cancer
    Start date: 2011-05-06

Zometa
    Dosage: 4 mg, (cyclic)
    Indication: Osteoporosis Prophylaxis
    Start date: 2011-05-06

Other drugs received by patient: Telmisartan and Hydrochlorothiazide

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