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Vincristine (Vincristine) - Septic Shock - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Septic Shock ()

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Vincristine where reactions include septic shock. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of    Next >>

Possible Vincristine side effects in 49 year old male

Reported by a physician from Norway on 2012-08-27

Patient: 49 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Bone Marrow Failure, Pyrexia, Lung Infiltration, Septic Shock, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Bleomycin Sulfate
    Dosage: on day 8
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: for escalated cycles on day 1
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: for standard cycles on day 1

Doxorubicin Hydrochloride
    Dosage: for escalated cycles on day 1
    Indication: Hodgkin's Disease

Doxorubicin Hydrochloride
    Dosage: on day 1,for standard cycles

Etoposide
    Dosage: for the escalated cycles on day 1 to 3

Etoposide
    Dosage: for the escalated cycles on day 1 to 3

Etoposide
    Dosage: for the standard cycles, day 1 to 3
    Indication: Hodgkin's Disease

Prednisolone
    Dosage: on day 1 to 14 every 21 day cycle treatment for 6 cycles
    Administration route: Oral
    Indication: Hodgkin's Disease

Procarbazine Hydrochloride
    Dosage: day 1 to 7
    Administration route: Oral
    Indication: Hodgkin's Disease

Vincristine
    Dosage: on day 8
    Indication: Hodgkin's Disease



Possible Vincristine side effects in 49 year old male

Reported by a physician from Norway on 2012-08-27

Patient: 49 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Bone Marrow Failure, Septic Shock, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Bleomycin Sulfate
    Dosage: 10000 iu, day 8 (2 escalated cycles)
    Indication: Hodgkin's Disease

Bleomycin Sulfate
    Dosage: 10000 iu, day 8 (4 standard cycles)

Cyclophosphamide
    Dosage: 650 mg/m2, day 1 (4 standard cycles)

Cyclophosphamide
    Dosage: 1250 mg/m2, day 1 (2 escalated cycles)
    Indication: Hodgkin's Disease

Doxorubicin HCL
    Dosage: 25 mg/m2, day 1 (4 standard cycles)

Doxorubicin HCL
    Dosage: 35 mg/m2, day 1 (2 escalated cycles)
    Indication: Hodgkin's Disease

Etoposide
    Dosage: 100 mg/m2, day 1-3 (4 standard cycles)

Etoposide
    Dosage: 200 mg/m2, day 1-3 (2 escalated cycles)
    Indication: Hodgkin's Disease

Prednisolone
    Dosage: 40 mg/m2, day 1-14 (4 standard cycles)
    Administration route: Oral

Prednisolone
    Dosage: 40 mg/m2, day 1-14 (2 escalated cycles)
    Administration route: Oral
    Indication: Hodgkin's Disease

Procarbazine Hydrochloride
    Dosage: 100 mg/m2, day 1-7 (2 escalated cycles)
    Administration route: Oral
    Indication: Hodgkin's Disease

Procarbazine Hydrochloride
    Dosage: 100 mg/m2, day 1-7 (4 standard cycles)
    Administration route: Oral

Vincristine
    Dosage: 1.4 mg/m2, day 8 (2 escalated cycles)
    Indication: Hodgkin's Disease

Vincristine
    Dosage: 1.4 mg/m2, day 8 (4 standard cycles)



Possible Vincristine side effects in 49 year old male

Reported by a physician from Norway on 2012-08-24

Patient: 49 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Bone Marrow Failure, Pyrexia, Lung Infiltration, Septic Shock, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Bleomycin Sulfate
    Dosage: on day 8
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: for escalated cycles on day 1
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: for standard cycles on day 1

Doxorubicin Hydrochloride
    Dosage: on day 1,for standard cycles

Doxorubicin Hydrochloride
    Dosage: for escalated cycles on day 1
    Indication: Hodgkin's Disease

Etoposide
    Dosage: for the escalated cycles on day 1 to 3

Etoposide
    Dosage: for the escalated cycles on day 1 to 3

Etoposide
    Dosage: for the standard cycles, day 1 to 3
    Indication: Hodgkin's Disease

Prednisolone
    Dosage: on day 1 to 14 every 21 day cycle treatment for 6 cycles
    Administration route: Oral
    Indication: Hodgkin's Disease

Procarbazine Hydrochloride
    Dosage: day 1 to 7
    Administration route: Oral
    Indication: Hodgkin's Disease

Vincristine
    Dosage: on day 8
    Indication: Hodgkin's Disease



Possible Vincristine side effects in 18 year old female

Reported by a physician from Slovenia on 2012-08-23

Patient: 18 year old female

Reactions: Pulmonary Haemorrhage, Gastrointestinal Haemorrhage, Injection Site Haemorrhage, Sepsis, Shock Haemorrhagic, Acute Respiratory Distress Syndrome, Bone Marrow Failure, Staphylococcal Bacteraemia, Septic Shock

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia

Heparin

Vincristine
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia



Possible Vincristine side effects in 49 year old male

Reported by a physician from Norway on 2012-08-23

Patient: 49 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Bone Marrow Failure, Pyrexia, Septic Shock, Lung Infiltration

Adverse event resulted in: death

Drug(s) suspected as cause:
Bleomycin Baxter 15 000 IE Lyofilisat TIL Injeksjonsv?ske / Infusjonsv?s

Cyclophosphamide

Cyclophosphamide

Doxorubicin Hydrochloride

Doxorubicin Hydrochloride

Etoposide

Etoposide

Prednisolone
    Administration route: Oral

Procarbazine Hydrochloride
    Administration route: Oral

Vincristine



Possible Vincristine side effects in 17 year old male

Reported by a physician from Poland on 2012-08-23

Patient: 17 year old male

Reactions: Rhabdomyolysis, Disseminated Intravascular Coagulation, Pancytopenia, Pyrexia, Renal Failure, Neutropenia, Clostridial Infection, Septic Shock

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cefepime

Doxorubicin Hydrochloride
    Indication: Ewing's Sarcoma

Etoposide
    Indication: Ewing's Sarcoma Metastatic

Ifosfamide
    Indication: Ewing's Sarcoma Metastatic

Meropenem

Metronidazole

Netromycin

Vancocin Hydrochloride

Vincristine
    Indication: Ewing's Sarcoma Metastatic

Other drugs received by patient: Fluconazole; Caspofungin Acetate



Possible Vincristine side effects in male

Reported by a physician from United States on 2012-08-22

Patient: male, weighing 55.2 kg (121.4 pounds)

Reactions: Unresponsive To Stimuli, Moaning, Neutropenia, Septic Shock, Cardiac Arrest

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Start date: 2009-08-21

Methotrexate Sodium

Prednisone

Vincristine
    End date: 2012-08-10



Possible Vincristine side effects in 9 year old male

Reported by a physician from United States on 2012-08-17

Patient: 9 year old male

Reactions: Respiratory Failure, Disseminated Cryptococcosis, Septic Shock

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Dexamethasone
    Dosage: daily
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Pegaspargase
    Dosage: single dose
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: weekly
    Indication: Acute Lymphocytic Leukaemia



Possible Vincristine side effects in

Reported by a individual with unspecified qualification from France on 2012-08-15

Patient:

Reactions: Septic Shock

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide

Cyclophosphamide
    Dosage: 3 g/m^2

Cyclophosphamide

Doxorubicin Hydrochloride

Prednisone TAB
    Administration route: Oral

Vincristine



Possible Vincristine side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-13

Patient: female

Reactions: Septic Shock, Splenic Infarction

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Nodal Marginal Zone B-Cell Lymphoma
    Start date: 2012-06-29
    End date: 2012-06-29

Prednisone TAB
    Dosage: 1 tablet
    Administration route: Oral
    Indication: Nodal Marginal Zone B-Cell Lymphoma
    Start date: 2012-06-28

Vincristine
    Dosage: 1 unit
    Indication: Nodal Marginal Zone B-Cell Lymphoma
    Start date: 2012-06-29
    End date: 2012-06-29

Other drugs received by patient: Aspirin; Acetaminophen; Fasturtec; Pravastatine Arrow; Venlafaxine; Potassium Chloride; Ramipril; Nexium; Bisoprolol Fumarate



Possible Vincristine side effects in 17 year old male

Reported by a physician from Poland on 2012-08-01

Patient: 17 year old male

Reactions: Renal Failure, Rhabdomyolysis, Disseminated Intravascular Coagulation, Pancytopenia, Neutropenia, Clostridial Infection, Septic Shock

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Doxorubicin Hydrochloride
    Indication: Ewing's Sarcoma

Etoposide
    Indication: Ewing's Sarcoma Metastatic

Ifosfamide
    Indication: Ewing's Sarcoma Metastatic

Vincristine
    Indication: Ewing's Sarcoma Metastatic



Possible Vincristine side effects in 49 year old male

Reported by a health professional (non-physician/pharmacist) from Norway on 2012-07-31

Patient: 49 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Bone Marrow Failure, Lung Infiltration, Septic Shock

Adverse event resulted in: death

Drug(s) suspected as cause:
Bleomycin Sulfate
    Dosage: 10000 iu
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: 650mg/m2
    Indication: Hodgkin's Disease

Doxorubicin Hydrochloride
    Dosage: 25 mg/m2, unk
    Indication: Hodgkin's Disease

Etoposide
    Dosage: 100 mg/m2, unk
    Indication: Hodgkin's Disease

Prednisolone
    Dosage: 40 mg/m2
    Administration route: Oral
    Indication: Hodgkin's Disease

Procarbazine Hydrochloride
    Dosage: 100 mg/m2, unk
    Administration route: Oral
    Indication: Hodgkin's Disease

Vincristine
    Dosage: 1.4 mg/m2, unk
    Indication: Hodgkin's Disease



Possible Vincristine side effects in 17 year old male

Reported by a physician from Poland on 2012-07-27

Patient: 17 year old male

Reactions: Renal Failure, Rhabdomyolysis, Disseminated Intravascular Coagulation, Pancytopenia, Neutropenia, Septic Shock, Clostridial Infection

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Doxorubicin Hydrochloride
    Indication: Ewing's Sarcoma

Etoposide
    Indication: Ewing's Sarcoma Metastatic

Ifosfamide
    Indication: Ewing's Sarcoma Metastatic

Vincristine
    Indication: Ewing's Sarcoma Metastatic



Possible Vincristine side effects in

Reported by a physician from Italy on 2012-07-27

Patient:

Reactions: Anaemia, Skin Toxicity, Febrile Neutropenia, Mucosal Inflammation, Neurotoxicity, Respiratory Failure, Sepsis, Neutropenia, Cardiotoxicity, Septic Shock, Thrombocytopenia, Myocardial Infarction, Diffuse Large B-Cell Lymphoma

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Diffuse Large B-Cell Lymphoma

Doxorubicin HCL
    Indication: Diffuse Large B-Cell Lymphoma

Epirubicin Hydrochloride
    Indication: Diffuse Large B-Cell Lymphoma

Mabthera
    Indication: Diffuse Large B-Cell Lymphoma

Prednisone and Prednisone
    Indication: Diffuse Large B-Cell Lymphoma

Vincristine
    Indication: Diffuse Large B-Cell Lymphoma



Possible Vincristine side effects in 17 year old male

Reported by a health professional (non-physician/pharmacist) from Poland on 2012-07-23

Patient: 17 year old male

Reactions: Abdominal Pain, Rhabdomyolysis, Pain in Extremity, Disseminated Intravascular Coagulation, Chromaturia, Pancytopenia, Pyrexia, Renal Failure, Renal Impairment, Diarrhoea, Clostridial Infection, Septic Shock

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Cefepime
    Indication: Pyrexia

Doxorubicin HCL
    Indication: Ewing's Sarcoma Metastatic

Etoposide
    Indication: Ewing's Sarcoma Metastatic

Ifosfamide
    Indication: Ewing's Sarcoma Metastatic

Netilmicin Sulfate
    Indication: Pyrexia

Vincristine
    Indication: Ewing's Sarcoma Metastatic



Possible Vincristine side effects in

Reported by a physician from Italy on 2012-07-20

Patient:

Reactions: Anaemia, Febrile Neutropenia, Toxicity To Various Agents, Diffuse Large B-Cell Lymphoma Recurrent, Mucosal Inflammation, Neurotoxicity, Sepsis, Adverse Event, Cardiotoxicity, Neutropenia, Thrombocytopenia, Diffuse Large B-Cell Lymphoma, Lymphoma, Septic Shock

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 750 mg/m2 on day 1 for chop and 750 mg/m2 on day 2 for r-chop
    Indication: Diffuse Large B-Cell Lymphoma

Doxorubicin HCL
    Dosage: 50 mg/m2 on day 1 for chop and 50 mg/m2 on day 2 for r-chop
    Indication: Diffuse Large B-Cell Lymphoma

Prednisone
    Dosage: 100 mg on days 1-5 for chop and r-chop
    Administration route: Oral
    Indication: Diffuse Large B-Cell Lymphoma

Rituximab
    Dosage: 375 mg/m2 on day 1 for r-chop
    Indication: Diffuse Large B-Cell Lymphoma

Vincristine
    Dosage: 1.4 mg/m2 on day 1 for chop and 1.4 mg/m2 on day 2 for r-chop upto a maximum dose of 2 mg
    Indication: Diffuse Large B-Cell Lymphoma

Other drugs received by patient: Neupogen



Possible Vincristine side effects in male

Reported by a physician from United States on 2012-07-16

Patient: male, weighing 27.7 kg (60.9 pounds)

Reactions: Hypotension, Tachycardia, Respiratory Distress, Heart Rate Decreased, Pulmonary Oedema, Septic Shock, Oxygen Saturation Decreased, Pulseless Electrical Activity

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytarabine
    Dosage: 70 mg

Dexamethasone
    Dosage: 78 mg

Methotrexate
    Dosage: 15 mg

PEG-L-Asparaginase (Pegaspargase, Oncospar) 2500 IU
    Dosage: 2500iu

Vincristine
    Dosage: 3 mg



Possible Vincristine side effects in 61 year old male

Reported by a consumer/non-health professional from Germany on 2012-07-13

Patient: 61 year old male

Reactions: Candida Pneumonia, Bronchopneumonia, Febrile Neutropenia, Respiratory Distress, Organising Pneumonia, Respiratory Failure, Interstitial Lung Disease, Pseudomonal Sepsis, Opportunistic Infection, Stenotrophomonas Sepsis, Tracheitis, Septic Shock, Sinusitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Campath
    Dosage: 30 mg, qd
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-08

Campath
    Dosage: 30 mg, qd
    Start date: 2010-02-22
    End date: 2010-02-23

Cyclophosphamide
    Dosage: 1380 mg, unk
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-07

Cyclophosphamide
    Dosage: 690 mg, unk
    Start date: 2010-02-22
    End date: 2010-02-22

Doxorubicin HCL
    Dosage: 92 mg, unk
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-07

Doxorubicin HCL
    Dosage: 46 mg, unk
    Start date: 2010-02-22
    End date: 2010-02-22

Pegfilgrastim
    Dosage: 6 mg, qd
    Start date: 2010-03-01
    End date: 2010-03-01

Pegfilgrastim
    Dosage: 3 mg, qd
    Indication: T-Cell Lymphoma

Posaconazole
    Indication: Prophylaxis

Prednisone
    Dosage: 100 mg, unk
    Administration route: Oral
    Start date: 2010-02-22
    End date: 2010-02-26

Prednisone
    Dosage: 100 mg, unk
    Administration route: Oral
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-11

Vincristine
    Dosage: 2 mg, unk
    Start date: 2010-02-22
    End date: 2010-02-22

Vincristine
    Dosage: 2 mg, unk
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-07



Possible Vincristine side effects in 61 year old male

Reported by a consumer/non-health professional from Germany on 2012-07-10

Patient: 61 year old male

Reactions: Respiratory Failure, Bronchopneumonia, Pseudomonal Sepsis, Febrile Neutropenia, Septic Shock, Tracheitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Campath
    Dosage: 30 mg, qd
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-08

Campath
    Dosage: 30 mg, qd
    Start date: 2010-02-22
    End date: 2010-02-23

Cyclophosphamide
    Dosage: 1380 mg, unk
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-07

Cyclophosphamide
    Dosage: 690 mg, unk
    Start date: 2010-02-22
    End date: 2010-02-22

Doxorubicin HCL
    Dosage: 46 mg, unk
    Start date: 2010-02-22
    End date: 2010-02-22

Doxorubicin HCL
    Dosage: 92 mg, unk
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-07

Pegfilgrastim
    Dosage: 3 mg, qd
    Indication: T-Cell Lymphoma

Pegfilgrastim
    Dosage: 6 mg, qd
    Start date: 2010-03-01
    End date: 2010-03-01

Posaconazole
    Indication: Prophylaxis

Prednisone
    Dosage: 100 mg, unk
    Administration route: Oral
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-11

Prednisone
    Dosage: 100 mg, unk
    Administration route: Oral
    Start date: 2010-02-22
    End date: 2010-02-26

Vincristine
    Dosage: 2 mg, unk
    Indication: T-Cell Lymphoma
    Start date: 2010-01-07
    End date: 2010-01-07

Vincristine
    Dosage: 2 mg, unk
    Start date: 2010-02-22
    End date: 2010-02-22



Possible Vincristine side effects in male

Reported by a consumer/non-health professional from Germany on 2012-07-10

Patient: male, weighing 60.0 kg (132.0 pounds)

Reactions: Candida Pneumonia, Bronchopneumonia, Tachycardia, Atrial Fibrillation, Febrile Neutropenia, General Physical Health Deterioration, Lactic Acidosis, Respiratory Distress, Respiratory Failure, Skin Lesion, Pseudomonal Sepsis, Tracheitis, Septic Shock

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Campath
    Dosage: 30 mg, qd
    Indication: Peripheral T-Cell Lymphoma Unspecified
    Start date: 2010-01-07
    End date: 2010-01-08

Campath
    Dosage: 30 mg, qd
    Start date: 2010-02-22
    End date: 2010-02-23

Cyclophosphamide
    Dosage: 690 mg, once
    Start date: 2010-02-22
    End date: 2010-02-22

Cyclophosphamide
    Dosage: 1380 mg, unk
    Indication: Peripheral T-Cell Lymphoma Unspecified
    Start date: 2010-01-07
    End date: 2010-01-07

Doxorubicin HCL
    Dosage: 92 mg, unk
    Indication: Peripheral T-Cell Lymphoma Unspecified
    Start date: 2010-01-07
    End date: 2010-01-07

Doxorubicin HCL
    Dosage: 46 mg, once
    Start date: 2010-02-22
    End date: 2010-02-22

Pegfilgrastim
    Dosage: 6 mg, once
    Start date: 2010-03-01
    End date: 2010-03-01

Pegfilgrastim
    Dosage: 3 mg, qd
    Indication: Peripheral T-Cell Lymphoma Unspecified

Prednisone
    Dosage: 100 mg, unk
    Administration route: Oral
    Indication: Peripheral T-Cell Lymphoma Unspecified
    Start date: 2010-01-07
    End date: 2010-01-11

Prednisone
    Dosage: 100 mg, qdx5
    Administration route: Oral
    Start date: 2010-02-22
    End date: 2010-02-26

Vasopressin
    Dosage: unk
    Indication: Blood Pressure Management

Vincristine
    Dosage: 2 mg, qd
    Start date: 2010-02-22
    End date: 2010-02-22

Vincristine
    Dosage: 2 mg, unk
    Indication: Peripheral T-Cell Lymphoma Unspecified
    Start date: 2010-01-07
    End date: 2010-01-07

Other drugs received by patient: Zienam; Posaconazole; Taranic; Zienam; Taranic; Candiohermal; Candiohermal



Possible Vincristine side effects in 51 year old male

Reported by a physician from Turkey on 2012-06-22

Patient: 51 year old male

Reactions: Drug Ineffective, Pancytopenia, Escherichia Bacteraemia, Disease Progression, Hepatotoxicity, Embolism Venous, Septic Shock, Renal Failure Acute

Drug(s) suspected as cause:
Adriamycin PFS
    Indication: Multiple Myeloma

Aspirin
    Indication: Thrombosis Prophylaxis

Bortezomib
    Indication: Multiple Myeloma

Cyclophosphamide
    Indication: Multiple Myeloma

Dexamethasone
    Dosage: 40 mg
    Administration route: Oral
    Indication: Multiple Myeloma

Dexamethasone

Melphalan Hydrochloride
    Indication: Bone Marrow Conditioning Regimen

Thalidomide
    Dosage: 200 mg
    Indication: Multiple Myeloma

Vincristine
    Dosage: 0.4 mg
    Indication: Multiple Myeloma



Possible Vincristine side effects in 49 year old male

Reported by a physician from Norway on 2012-06-14

Patient: 49 year old male

Reactions: Off Label Use, Pneumocystis Jiroveci Pneumonia, Bone Marrow Failure, Pyrexia, Lung Infiltration, Septic Shock, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Bleomycin Sulfate

Cyclophosphamide

Doxorubicin HCL

Etoposide

Prednisolone
    Administration route: Oral

Procarbazine Hydrochloride
    Administration route: Oral

Vincristine



Possible Vincristine side effects in 49 year old male

Reported by a health professional (non-physician/pharmacist) from Norway on 2012-06-11

Patient: 49 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Bone Marrow Failure, Pyrexia, Lung Infiltration, Septic Shock, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Bleomycin Sulfate
    Dosage: on d8
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: 650mg/m2 standard cycles 1250 for the escalated cycles
    Indication: Hodgkin's Disease

Doxorubicin HCL
    Dosage: 35mg/m2,on d1 for escalated cycles
    Indication: Hodgkin's Disease

Etoposide
    Dosage: 100mg/m2 for the standard cycles d1 to 3; 200mg/m2 for the escalated cycles from d1-3 iv
    Indication: Hodgkin's Disease

Prednisolone
    Dosage: on days 1 to 14 in every 21 day cycle treatment for 6 cycles
    Administration route: Oral
    Indication: Hodgkin's Disease

Procarbazine Hydrochloride
    Dosage: day1-7
    Administration route: Oral
    Indication: Hodgkin's Disease

Vincristine
    Dosage: on d8
    Indication: Hodgkin's Disease



Possible Vincristine side effects in 49 year old male

Reported by a physician from Norway on 2012-06-08

Patient: 49 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Bone Marrow Failure, Septic Shock, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Bleomycin Sulfate
    Dosage: 10000 iu, day 8 (4 standard cycles)

Bleomycin Sulfate
    Dosage: 10000 iu, day 8 (2 escalated cycles)
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: 1250 mg/m2, day 1 (2 escalated cycles)
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: 650 mg/m2, day 1 (4 standard cycles)

Doxorubicin HCL
    Dosage: 35 mg/m2, day 1 (2 escalated cycles)
    Indication: Hodgkin's Disease

Doxorubicin HCL
    Dosage: 25 mg/m2, day 1 (4 standard cycles)

Etoposide
    Dosage: 200 mg/m2, day 1-3 (2 escalated cycles)
    Indication: Hodgkin's Disease

Etoposide
    Dosage: 100 mg/m2, day 1-3 (4 standard cycles)

Prednisolone
    Dosage: 40 mg/m2, day 1-14 (2 escalated cycles)
    Administration route: Oral
    Indication: Hodgkin's Disease

Prednisolone
    Dosage: 40 mg/m2, day 1-14 (4 standard cycles)
    Administration route: Oral

Procarbazine Hydrochloride
    Dosage: 100 mg/m2, day 1-7 (4 standard cycles)
    Administration route: Oral

Procarbazine Hydrochloride
    Dosage: 100 mg/m2, day 1-7 (2 escalated cycles)
    Administration route: Oral
    Indication: Hodgkin's Disease

Vincristine
    Dosage: 1.4 mg/m2, day 8 (2 escalated cycles)
    Indication: Hodgkin's Disease

Vincristine
    Dosage: 1.4 mg/m2, day 8 (4 standard cycles)



Possible Vincristine side effects in 49 year old male

Reported by a physician from Norway on 2012-06-05

Patient: 49 year old male

Reactions: Pneumocystis Jiroveci Pneumonia, Bone Marrow Failure, Pyrexia, Lung Infiltration, Septic Shock, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Bleomycin Sulfate
    Dosage: on day 8
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: for standard cycles on day 1
    Indication: Hodgkin's Disease

Cyclophosphamide
    Dosage: for escalated cycles on day 1

Doxorubicin HCL
    Dosage: for escalated cycles on day 1

Doxorubicin HCL
    Dosage: for standard cycles
    Indication: Hodgkin's Disease

Etoposide
    Dosage: for the standard cycles, day 1 to 3

Etoposide
    Dosage: for the escalated cycles on day 1 to 3
    Indication: Hodgkin's Disease

Prednisolone
    Dosage: on day 1 to 14
    Administration route: Oral
    Indication: Hodgkin's Disease

Procarbazine Hydrochloride
    Dosage: day 1 to 7
    Administration route: Oral
    Indication: Hodgkin's Disease

Vincristine
    Dosage: on day 8
    Indication: Hodgkin's Disease



Possible Vincristine side effects in 49 year old female

Reported by a health professional (non-physician/pharmacist) from Taiwan, Province of China on 2012-05-30

Patient: 49 year old female

Reactions: Multi-Organ Failure, Lymphocytosis, Acute Lymphocytic Leukaemia, Refractory Anaemia, Pneumonia, Septic Shock

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 100 mg
    Administration route: Oral
    Indication: Anaemia

Cyclophosphamide
    Indication: Breast Cancer

Cyclophosphamide
    Indication: Leukocytosis
    Start date: 2009-07-01

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2009-07-01

Dexamethasone
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2009-07-01

Doxorubicin HCL
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2009-07-01

Epirubicin
    Indication: Breast Cancer

Fluorouracil
    Indication: Breast Cancer

Methotrexate
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2009-07-01

Prednisolone
    Indication: Leukocytosis

Prednisolone
    Dosage: 15 mg
    Indication: Anaemia

Vincristine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2009-07-01



Possible Vincristine side effects in female

Reported by a individual with unspecified qualification from United States on 2012-05-25

Patient: female, weighing 14.9 kg (32.8 pounds)

Reactions: Anaemia, Hyponatraemia, Rash, Pyrexia, Ascites, Abdominal Pain Upper, Abdominal Compartment Syndrome, Respiratory Failure, Pneumonia Herpes Viral, Bone Marrow Failure, Neutropenia, Thrombocytopenia, Cardiac Arrest, Septic Shock, Infection in AN Immunocompromised Host

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Dexamethasone
    Dosage: 17.5 ml

Mercaptopurine
    Dosage: 460 mg

Methotrexate
    Dosage: 24.5 mg

Vincristine
    Dosage: .99 mg



Possible Vincristine side effects in

Reported by a physician from United States on 2012-05-21

Patient:

Reactions: Off Label Use, Cholecystitis, Septic Shock

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Sarcoma

Doxorubicin HCL
    Indication: Sarcoma

Etoposide
    Indication: Sarcoma

Vincristine
    Indication: Sarcoma



Possible Vincristine side effects in

Reported by a health professional (non-physician/pharmacist) from France on 2012-05-10

Patient:

Reactions: Septic Shock

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Chronic Lymphocytic Leukaemia

Doxorubicin HCL
    Indication: Chronic Lymphocytic Leukaemia

Granulocyte Colony Stimulating Factor
    Indication: Chronic Lymphocytic Leukaemia

Prednisone TAB
    Administration route: Oral
    Indication: Chronic Lymphocytic Leukaemia

Vincristine
    Indication: Chronic Lymphocytic Leukaemia



Possible Vincristine side effects in 18 year old male

Reported by a physician from United States on 2012-04-03

Patient: 18 year old male, weighing 126.4 kg (278.1 pounds)

Reactions: White Blood Cell Count Decreased, Abdominal Pain, Metabolic Acidosis, Clostridium Test Positive, Urine Output Decreased, Hypotension, Hyponatraemia, Capillary Leak Syndrome, Platelet Count Decreased, Septic Shock

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cytarabine
    Dosage: 70 mg;x1;inth
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-02-24

Doxorubicin HCL
    Dosage: 60 mg/m**2;x1;iv
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-02-24
    End date: 2012-02-24

Hydrocortisone
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: inth
    Indication: Acute Lymphocytic Leukaemia

Oncaspar
    Dosage: 2500 iu;x1;iv
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-02-24
    End date: 2012-03-02

Prednisone TAB
    Dosage: 20 mg/m**2;qd;po
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-02-24
    End date: 2012-03-04

Velcade
    Dosage: 1.3 mg/m**2; qd; iv
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-02-24
    End date: 2012-03-02

Vincristine
    Dosage: 1.5 mg/m**2;qd;iv
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-02-24
    End date: 2012-03-02



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