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Vandetanib (Vandetanib) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Vandetanib and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (237)
Death (10)
Life Threatening Events (19)
Disability (2)

Reports by Reaction Type

Diarrhoea (49)Rash (27)Fatigue (25)Nausea (23)Acne (22)Electrocardiogram QT Prolonged (20)Blood Pressure Increased (18)Dizziness (15)Dyspnoea (13)Oral Pain (13)Decreased Appetite (12)Renal Failure (12)

Below are a few examples of reports where side effects / adverse reactions may be related to Vandetanib. For a complete list or a specific selection of reports, please use the links above.

Possible Vandetanib side effects in male

Reported by a physician from United Kingdom on 2012-08-27

Patient: male, weighing 70.0 kg (154.0 pounds)

Reactions: Pulmonary Embolism, Lower Respiratory Tract Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Gemcitabine Hydrochloride
    Indication: Pancreatic Carcinoma Metastatic
    Start date: 2012-06-13
    End date: 2012-07-25

Vandetanib
    Administration route: Oral
    Indication: Pancreatic Carcinoma Metastatic
    Start date: 2012-06-16
    End date: 2012-08-07

Other drugs received by patient: Perindopril; Metformin HCL; Zopiclone; Docusate Sodium; Omeprazole



Possible Vandetanib side effects in 759 month old male

Reported by a physician from France on 2012-08-09

Patient: 759 month old male, weighing 89.0 kg (195.8 pounds)

Reactions: Dysgeusia, Diarrhoea, Folliculitis, Optic Ischaemic Neuropathy, Hypertension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib

Other drugs received by patient: Rythmol; Previscan



Possible Vandetanib side effects in 56 year old male

Reported by a physician from Spain on 2012-08-06

Patient: 56 year old male, weighing 56.0 kg (123.2 pounds)

Reactions: Renal Failure, Hypoparathyroidism, Hypocalcaemia, Condition Aggravated

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib

Other drugs received by patient: Duragesic-100; Levothyroxine Sodium; Omeprazole



Possible Vandetanib side effects in male

Reported by a physician from United Kingdom on 2012-08-06

Patient: male, weighing 60.4 kg (132.9 pounds)

Reactions: Lower Respiratory Tract Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Adenocarcinoma Pancreas
    Start date: 2012-07-13
    End date: 2012-07-15

Gemcitabine Hydrochloride
    Indication: Adenocarcinoma Pancreas
    Start date: 2012-07-13
    End date: 2012-07-15



Possible Vandetanib side effects in 55 year old male

Reported by a consumer/non-health professional from United States on 2012-08-06

Patient: 55 year old male

Reactions: Speech Disorder, Neoplasm Malignant

Drug(s) suspected as cause:
Vandetanib



Possible Vandetanib side effects in 75 year old male

Reported by a physician from United Kingdom on 2012-07-23

Patient: 75 year old male, weighing 68.9 kg (151.6 pounds)

Reactions: Hyperglycaemia, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Gemcitabine
    Indication: Pancreatic Carcinoma
    Start date: 2012-05-08

Vandetanib
    Administration route: Oral
    Indication: Pancreatic Carcinoma
    Start date: 2012-06-05
    End date: 2012-06-19

Other drugs received by patient: Gliclazide; Oramorph SR; Paroxetine; Metformin Hydrochloride; Pravastatin Sodium; Felodipine



Possible Vandetanib side effects in 75 year old male

Reported by a physician from United Kingdom on 2012-07-23

Patient: 75 year old male, weighing 68.9 kg (151.6 pounds)

Reactions: Hyperglycaemia, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Pancreatic Carcinoma
    Start date: 2012-06-05
    End date: 2012-06-19

Gemcitabine
    Indication: Pancreatic Carcinoma
    Start date: 2012-05-08

Other drugs received by patient: Pravastatin Sodium; Felodipine; Oramorph SR; Paroxetine; Metformin Hydrochloride; Gliclazide



Possible Vandetanib side effects in 56 year old male

Reported by a physician from Spain on 2012-07-19

Patient: 56 year old male

Reactions: Renal Failure, Hypoparathyroidism, Hypocalcaemia, Adverse Event

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib



Possible Vandetanib side effects in female

Reported by a physician from Poland on 2012-07-11

Patient: female

Reactions: Renal Failure, Hypercalcaemia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Pamidronate Disodium
    Dosage: as required
    Indication: Metastases To Spine
    Start date: 2012-04-01
    End date: 2012-06-12

Vandetanib
    Administration route: Oral
    Start date: 2011-09-03

Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2011-08-16

Other drugs received by patient: Euthyrox N; Calperos; Magne B6; Pantoprazole; Euthyrox N; Loperamide; Alfadiol; Pramolan; Calperos; Potassium Chloride



Possible Vandetanib side effects in 75 year old male

Reported by a physician from United Kingdom on 2012-07-09

Patient: 75 year old male, weighing 68.9 kg (151.6 pounds)

Reactions: Hyperglycaemia, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Gemcitabine
    Indication: Pancreatic Carcinoma
    Start date: 2012-05-08

Vandetanib
    Administration route: Oral
    Indication: Pancreatic Carcinoma
    Start date: 2012-06-05
    End date: 2012-06-19

Other drugs received by patient: Metformin HCL; Pravastatin Sodium; Gliclazide; Felodipine; Oramorph SR; Paroxetine



Possible Vandetanib side effects in male

Reported by a physician from France on 2012-07-02

Patient: male

Reactions: Corneal Dystrophy

Drug(s) suspected as cause:
Vandetanib

Other drugs received by patient: Primperan TAB; Levothyroxine Sodium; Irbesartan and Hydrochlorothiazide; Imodium; UN-Alfa; Xanax



Possible Vandetanib side effects in female

Reported by a physician from Poland on 2012-06-29

Patient: female

Reactions: Renal Failure, Hypercalcaemia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Pamidronate Disodium
    Dosage: as required
    Indication: Metastases To Spine
    Start date: 2012-04-01
    End date: 2012-06-12

Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2011-08-16

Vandetanib
    Administration route: Oral
    Start date: 2011-09-03

Other drugs received by patient: Pramolan; Calperos; Loperamide; Euthyrox N; Pantoprazole; Alfadiol; Magne B6; Euthyrox N; Calperos; Potassium Chloride



Possible Vandetanib side effects in female

Reported by a physician from Poland on 2012-06-29

Patient: female

Reactions: Renal Failure, Hypercalcaemia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2011-08-16

Pamidronate Disodium
    Dosage: as required
    Indication: Metastases To Spine
    Start date: 2012-04-01
    End date: 2012-06-12

Vandetanib
    Administration route: Oral
    Start date: 2011-09-03

Other drugs received by patient: Loperamide; Pantoprazole; Magne B6; Calperos; Potassium Chloride; Euthyrox N; Calperos; Alfadiol; Euthyrox N; Pramolan



Possible Vandetanib side effects in female

Reported by a pharmacist from France on 2012-06-28

Patient: female, weighing 46.0 kg (101.2 pounds)

Reactions: Visual Acuity Reduced, Corneal Deposits

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Start date: 2007-11-01
    End date: 2010-11-01

Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2007-02-28
    End date: 2007-11-01

Vandetanib
    Administration route: Oral
    Start date: 2010-12-14
    End date: 2011-06-20

Vandetanib
    Administration route: Oral
    End date: 2012-05-16

Other drugs received by patient: Pravastatin; Levothyroxine Sodium; Potassium Chloride; UN-Alpha; Nicardipine Hydrochloride



Possible Vandetanib side effects in female

Reported by a physician from Belgium on 2012-06-26

Patient: female

Reactions: Large Intestine Perforation, Intestinal Obstruction

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2011-05-21
    End date: 2011-05-27

Vandetanib
    Administration route: Oral
    Start date: 2011-06-16
    End date: 2011-06-16

Vandetanib
    Dosage: dose reduced
    Administration route: Oral
    Start date: 2011-06-17
    End date: 2011-07-01

Other drugs received by patient: Lorazepam; Zometa; Alpha LEO; Loramet; Polyethylene Glycol; Pantoprazole; Targinact; Laxoberon; Calcium; Elthyrone; Litican; Oxycodone HCL; Imodium; Closan; Voltaren; Medrol; Redomex; MS Contin



Possible Vandetanib side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-26

Patient:

Reactions: Thrombocytopenia

Drug(s) suspected as cause:
Vandetanib
    Dosage: 100-300 mg daily
    Administration route: Oral
    Indication: Thyroid Cancer

Bortezomib
    Dosage: 1-1.3 mg/m2
    Indication: Thyroid Cancer



Possible Vandetanib side effects in male

Reported by a physician from Bulgaria on 2012-06-19

Patient: male

Reactions: Photosensitivity Reaction

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2012-01-13
    End date: 2012-02-20

Vandetanib
    Administration route: Oral
    Start date: 2012-02-26
    End date: 2012-04-27

Other drugs received by patient: Levothyroxine Sodium



Possible Vandetanib side effects in 72 year old female

Reported by a physician from United Kingdom on 2012-06-18

Patient: 72 year old female

Reactions: Haematocrit Increased

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2011-09-06
    End date: 2011-09-19

Vandetanib
    Administration route: Oral
    Start date: 2011-10-04
    End date: 2012-04-12

Other drugs received by patient: Calcichew D3; Amlodipine; Loperamide; Amlodipine; Levothyroxine Sodium; Aldonic Acid; Acetaminophen; Vitamin B Complex CAP



Possible Vandetanib side effects in female

Reported by a physician from Belgium on 2012-06-18

Patient: female

Reactions: Large Intestine Perforation, Intestinal Obstruction

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2011-05-21
    End date: 2011-05-27

Vandetanib
    Administration route: Oral
    Start date: 2011-06-16
    End date: 2011-06-16

Vandetanib
    Dosage: dose reduced
    Administration route: Oral
    Start date: 2011-06-17
    End date: 2011-07-01

Other drugs received by patient: Calcium; Alpha LEO; MS Contin; Closan; Laxoberon; Litican; Zometa; Voltaren; Redomex; Oxynorm; Imodium; Elthyrone; Pantoprazole; Targinact; Polyethylene Glycol; Medrol; Loramet; Lorazepam



Possible Vandetanib side effects in female

Reported by a pharmacist from France on 2012-06-14

Patient: female, weighing 46.0 kg (101.2 pounds)

Reactions: Visual Acuity Reduced, Corneal Deposits

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2007-02-28
    End date: 2007-11-01

Vandetanib
    Administration route: Oral
    Start date: 2007-11-01
    End date: 2010-11-01

Vandetanib
    Administration route: Oral
    Start date: 2010-12-14
    End date: 2011-06-20

Vandetanib
    Administration route: Oral
    End date: 2012-05-16

Other drugs received by patient: Nicardipine Hydrochloride; Levothyroxine Sodium; Pravastatin; UN-Alpha; Potassium Chloride



Possible Vandetanib side effects in 49 year old male

Reported by a physician from United States on 2012-05-29

Patient: 49 year old male, weighing 73.2 kg (161.0 pounds)

Reactions: ECG Signs of Myocardial Ischaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Midazolam
    Administration route: Oral
    Start date: 2012-05-02
    End date: 2012-05-02

Vandetanib
    Administration route: Oral
    Start date: 2012-05-17
    End date: 2012-05-17



Possible Vandetanib side effects in 49 year old male

Reported by a physician from United States on 2012-05-29

Patient: 49 year old male, weighing 73.2 kg (161.0 pounds)

Reactions: ECG Signs of Myocardial Ischaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Start date: 2012-05-17
    End date: 2012-05-17

Midazolam
    Administration route: Oral
    Start date: 2012-05-02
    End date: 2012-05-02



Possible Vandetanib side effects in 76 year old female

Reported by a physician from United Kingdom on 2012-05-25

Patient: 76 year old female, weighing 45.6 kg (100.3 pounds)

Reactions: Acute Coronary Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Pancreatic Carcinoma
    Start date: 2012-04-30
    End date: 2012-05-08

Gemcitabine
    Indication: Pancreatic Carcinoma
    Start date: 2012-04-30
    End date: 2012-04-30

Other drugs received by patient: Spiriva; Fluticasone Propionate / Salmeterol; Oramorph SR; Senna-Mint WAF; Lansoprazole; Buprenorphine; Albuterol; Aspirin



Possible Vandetanib side effects in female

Reported by a pharmacist from France on 2012-05-25

Patient: female, weighing 49.0 kg (107.8 pounds)

Reactions: Visual Acuity Reduced, Corneal Deposits

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Start date: 2010-12-14
    End date: 2012-05-16

Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2007-02-28
    End date: 2007-11-01

Vandetanib
    Administration route: Oral
    Start date: 2007-11-01
    End date: 2010-11-01



Possible Vandetanib side effects in male

Reported by a physician from Bulgaria on 2012-05-22

Patient: male

Reactions: Dermatitis Allergic

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2012-01-13
    End date: 2012-02-20

Vandetanib
    Administration route: Oral
    Start date: 2012-02-26
    End date: 2012-04-27

Other drugs received by patient: Levothyroxine Sodium



Possible Vandetanib side effects in male

Reported by a physician from Bulgaria on 2012-05-22

Patient: male

Reactions: Dermatitis Allergic

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Start date: 2012-02-26
    End date: 2012-04-27

Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2012-01-13
    End date: 2012-02-20

Other drugs received by patient: Levothyroxine Sodium



Possible Vandetanib side effects in male

Reported by a physician from United Kingdom on 2012-05-21

Patient: male

Reactions: Abscess Limb

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vandetanib
    Administration route: Oral
    Start date: 2011-12-19

Vandetanib
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2011-07-22
    End date: 2011-09-26

Vandetanib
    Administration route: Oral
    Start date: 2011-10-28
    End date: 2011-11-07

Vandetanib
    Administration route: Oral
    Start date: 2011-10-03
    End date: 2011-10-10

Other drugs received by patient: Plavix FC; Dothiepin Hydrochloride; Levothyroxine Sodium; Simvastatin; Dothiepin Hydrochloride; Diazepam; Omeprazole; Lactulose; Mucodyne; Bisoprilol



Possible Vandetanib side effects in 49 year old male

Reported by a consumer/non-health professional from United States on 2012-05-18

Patient: 49 year old male

Reactions: Blood Pressure Increased, Nausea, Musculoskeletal Discomfort, Dizziness, Hyperhidrosis

Drug(s) suspected as cause:
Vandetanib



Possible Vandetanib side effects in 40 year old female

Reported by a individual with unspecified qualification from United States on 2012-05-10

Patient: 40 year old female

Reactions: Brain Neoplasm Malignant, Pain, Neoplasm Progression, Blood Calcitonin Increased

Drug(s) suspected as cause:
Vandetanib

Other drugs received by patient: Nexavar; Sutent



Possible Vandetanib side effects in 40 year old female

Reported by a individual with unspecified qualification from United States on 2012-05-09

Patient: 40 year old female

Reactions: Brain Neoplasm Malignant, Hepatic Neoplasm Malignant, Pain, Neoplasm Progression, Blood Calcitonin Increased

Drug(s) suspected as cause:
Vandetanib

Other drugs received by patient: Nexavar; Sutent

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