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Tykerb (Lapatinib) - Life Threatening Events - Suspected Cause - Side Effect Reports

 
 



Index of reports > Life Threatening Events (24)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Tykerb (Lapatinib) life threatening events. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Tykerb side effects in 60 year old female

Reported by a physician from Canada on 2012-08-20

Patient: 60 year old female

Reactions: Vomiting, Nausea, Diarrhoea, Neoplasm Malignant, Dehydration, Disease Progression, Renal Failure Acute

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb
    Administration route: Oral

Xeloda
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Tykerb
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Hydromorphone Hydrochloride; Retinol; Prevacid; Micardis; Verapamil HCL; Celebrex; Colace; Vitamin D; Antihypertensive Medications; Actonel; Senokot



Possible Tykerb side effects in female

Reported by a health professional (non-physician/pharmacist) from Australia on 2012-08-06

Patient: female

Reactions: Dyspnoea, Vomiting, Nausea, Headache, Pericardial Effusion, Dysgeusia, Diarrhoea, Chest Pain, Pulmonary Thrombosis, Decreased Appetite

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Xeloda
    Indication: Breast Cancer
    Start date: 2012-01-23
    End date: 2012-07-01

Tykerb
    Indication: Breast Cancer
    Start date: 2012-01-23
    End date: 2012-07-01



Possible Tykerb side effects in 76 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-20

Patient: 76 year old female

Reactions: Disease Progression

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb

Other drugs received by patient: Antiemetics



Possible Tykerb side effects in female

Reported by a physician from Japan on 2012-06-20

Patient: female, weighing 39.0 kg (85.8 pounds)

Reactions: Monoplegia, Interstitial Lung Disease, Lymphangiosis Carcinomatosa, Decreased Appetite

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2010-09-09
    End date: 2010-09-30

Xeloda
    Dosage: 1500mg per day
    Administration route: Oral
    Start date: 2010-09-09
    End date: 2010-09-22



Possible Tykerb side effects in female

Reported by a physician from Japan on 2012-05-22

Patient: female, weighing 56.0 kg (123.2 pounds)

Reactions: Interstitial Lung Disease

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Tykerb

Other drugs received by patient: Alloid G; Urso 250; Gemzar; Xeloda; Mucosta; Herceptin; Loxonin; Glycyron



Possible Tykerb side effects in female

Reported by a physician from Japan on 2012-05-22

Patient: female, weighing 34.0 kg (74.8 pounds)

Reactions: Pneumonia, Dehydration, Decreased Appetite, Infectious Pleural Effusion

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Xeloda
    Dosage: 2400mg per day
    Administration route: Oral
    Start date: 2010-06-03
    End date: 2010-11-24

Phenytoin Sodium CAP
    Indication: Product Used FOR Unknown Indication

Tykerb
    Dosage: 1000mg per day
    Administration route: Oral
    Start date: 2010-12-01
    End date: 2010-12-07

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Start date: 2010-03-14
    End date: 2010-05-19

Tykerb
    Dosage: 750mg per day
    Administration route: Oral
    Start date: 2010-11-25
    End date: 2010-11-30

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2010-01-12
    End date: 2010-03-09

Xeloda
    Dosage: 2400mg per day
    Administration route: Oral
    Start date: 2011-01-06
    End date: 2011-07-28

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Start date: 2010-06-03
    End date: 2010-11-24

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Start date: 2010-12-15
    End date: 2011-07-28

Xeloda
    Dosage: 2400mg per day
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-01-12
    End date: 2010-03-09

Xeloda
    Dosage: 2400mg per day
    Administration route: Oral
    Start date: 2010-03-14
    End date: 2010-05-19

Xeloda
    Dosage: 1800mg per day
    Administration route: Oral
    Start date: 2010-11-25
    End date: 2011-01-05

Other drugs received by patient: Depakene; Betamethasone; Phenytoin Sodium CAP; Gabapentin; Zonisamide; Famotidine



Possible Tykerb side effects in female

Reported by a physician from Japan on 2012-05-16

Patient: female, weighing 34.0 kg (74.8 pounds)

Reactions: Pneumonia, Dehydration, Decreased Appetite, Infectious Pleural Effusion

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb
    Dosage: 750mg per day
    Administration route: Oral
    Start date: 2010-11-25
    End date: 2010-11-30

Tykerb
    Dosage: 1000mg per day
    Administration route: Oral
    Start date: 2010-12-01
    End date: 2010-12-07

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Start date: 2010-12-15
    End date: 2011-07-28

Xeloda
    Dosage: 2400mg per day
    Administration route: Oral
    Start date: 2010-06-03
    End date: 2010-11-24

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Start date: 2010-03-14
    End date: 2010-05-19

Xeloda
    Dosage: 2400mg per day
    Administration route: Oral
    Start date: 2010-03-14
    End date: 2010-05-19

Xeloda
    Dosage: 2400mg per day
    Administration route: Oral
    Start date: 2011-01-06
    End date: 2011-07-28

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2010-01-12
    End date: 2010-03-09

Xeloda
    Dosage: 2400mg per day
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-01-12
    End date: 2010-03-09

Xeloda
    Dosage: 1800mg per day
    Administration route: Oral
    Start date: 2010-11-25
    End date: 2011-01-05

Phenytoin Sodium CAP
    Indication: Product Used FOR Unknown Indication

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Start date: 2010-06-03
    End date: 2010-11-24

Other drugs received by patient: Betamethasone; Gabapentin; Depakene; Phenytoin Sodium CAP; Zonisamide; Famotidine



Possible Tykerb side effects in 59 year old female

Reported by a consumer/non-health professional from United States on 2012-05-08

Patient: 59 year old female, weighing 86.4 kg (190.1 pounds)

Reactions: Sudden Cardiac Death, Nausea, Cardiac Disorder, Apparent Death, Diarrhoea, Cardiac Failure, Electrolyte Imbalance, Stress Cardiomyopathy

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb

Other drugs received by patient: Xeloda



Possible Tykerb side effects in female

Reported by a physician from Japan on 2012-05-01

Patient: female, weighing 56.0 kg (123.2 pounds)

Reactions: Interstitial Lung Disease

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Tykerb

Other drugs received by patient: Urso 250; Xeloda; Glycyron; Loxonin; Gemzar; Mucosta; Herceptin; Alloid G



Possible Tykerb side effects in 45 year old female

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-04-12

Patient: 45 year old female

Reactions: Vomiting, Nausea, Gastrointestinal Toxicity, Hepatitis, Transaminases Increased, Abdominal Pain Upper, Diarrhoea, Liver Function Test Abnormal

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb



Possible Tykerb side effects in 81 year old female

Reported by a consumer/non-health professional from United States on 2012-04-11

Patient: 81 year old female, weighing 65.5 kg (144.1 pounds)

Reactions: Thrombosis, Intestinal Ischaemia, Diarrhoea, International Normalised Ratio Increased, Coagulopathy, Hypoxia, Intestinal Infarction

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Coumadin
    Indication: Atrial Fibrillation
    End date: 2012-02-21

Tykerb
    Dosage: 250mg three times per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-02-01
    End date: 2012-02-19

Other drugs received by patient: Xeloda



Possible Tykerb side effects in 59 year old female

Reported by a consumer/non-health professional from United States on 2012-04-10

Patient: 59 year old female, weighing 86.4 kg (190.1 pounds)

Reactions: Nausea, Sudden Cardiac Death, Cardiac Disorder, Apparent Death, Diarrhoea, Cardiac Failure, Electrolyte Imbalance, Stress Cardiomyopathy

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb

Other drugs received by patient: Xeloda



Possible Tykerb side effects in 81 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-20

Patient: 81 year old female

Reactions: Intestinal Ischaemia, Thrombosis, Diarrhoea, Coagulopathy, International Normalised Ratio Increased, Hypoxia

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Coumadin
    Indication: Product Used FOR Unknown Indication

Tykerb
    Dosage: 250mg three times per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-02-01
    End date: 2012-02-19

Other drugs received by patient: Xeloda



Possible Tykerb side effects in female

Reported by a physician from Japan on 2012-03-20

Patient: female, weighing 56.0 kg (123.2 pounds)

Reactions: Hepatic Function Abnormal, Palmar-Plantar Erythrodysaesthesia Syndrome, Femoral Neck Fracture, Hepatic Enzyme Increased

Adverse event resulted in: life threatening event, disablity

Drug(s) suspected as cause:
Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2010-10-12
    End date: 2011-06-21

Xeloda
    Dosage: 1800mg per day
    Administration route: Oral
    Start date: 2010-10-12
    End date: 2011-06-14

Other drugs received by patient: Lendormin; Cortril; Famotidine; Chinese Medicine; Decadron; Chinese Medicine; Desmopressin Acetate



Possible Tykerb side effects in female

Reported by a physician from Indonesia on 2012-03-14

Patient: female

Reactions: Hepatic Failure

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Tykerb



Possible Tykerb side effects in female

Reported by a physician from Japan on 2012-03-02

Patient: female, weighing 56.0 kg (123.2 pounds)

Reactions: Hepatic Function Abnormal, Palmar-Plantar Erythrodysaesthesia Syndrome, Femoral Neck Fracture, Hepatic Enzyme Increased

Adverse event resulted in: life threatening event, disablity

Drug(s) suspected as cause:
Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2010-10-12
    End date: 2011-06-21

Xeloda
    Dosage: 1800mg per day
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2010-10-12
    End date: 2011-06-14

Other drugs received by patient: Desmopressin Acetate; Cortril; Chinese Medicine; Lendormin; Chinese Medicine; Decadron; Famotidine



Possible Tykerb side effects in female

Reported by a physician from Brazil on 2012-02-15

Patient: female

Reactions: Vomiting, Gastrointestinal Toxicity, Diarrhoea, Nausea, Transaminases Increased, Hepatitis, Abdominal Pain Upper

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb



Possible Tykerb side effects in 81 year old female

Reported by a physician from Japan on 2011-12-29

Patient: 81 year old female

Reactions: Interstitial Lung Disease

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Tykerb

Other drugs received by patient: Tagamet; Timoptol; Depakene; Xalatan; Xeloda; Trusopt; Betamethasone



Possible Tykerb side effects in female

Reported by a physician from Japan on 2011-11-28

Patient: female, weighing 50.1 kg (110.2 pounds)

Reactions: Cardiac Failure, Hypotension, Acute Myocardial Infarction

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2011-08-04
    End date: 2011-08-11

Magmitt
    Administration route: Oral
    Indication: Constipation

Capecitabine
    Dosage: 3000mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2011-08-04
    End date: 2011-08-12

Other drugs received by patient: Gasmotin; Zolpidem; Claritin; Lipitor; Mohrus Tape; Methylcobal; Lansoprazole; Zetia; Posterisan



Possible Tykerb side effects in female

Reported by a physician from Japan on 2011-11-23

Patient: female, weighing 56.0 kg (123.2 pounds)

Reactions: Weight Decreased, Colitis, Decreased Appetite

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Xeloda
    Dosage: 3000mg per day
    Administration route: Oral
    Start date: 2010-05-28
    End date: 2010-10-14

Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2010-05-23

Xeloda
    Dosage: 3000mg per day
    Administration route: Oral
    Start date: 2010-10-29
    End date: 2010-12-10



Possible Tykerb side effects in 63 year old female

Reported by a consumer/non-health professional from United States on 2011-11-11

Patient: 63 year old female, weighing 87.7 kg (192.9 pounds)

Reactions: Subdural Haematoma, Haematocrit Decreased, Haematoma Evacuation, Ecchymosis, Pneumocephalus, Fall, Extradural Haematoma

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer

Warfarin Sodium
    Dosage: 3mg per day
    Administration route: Oral
    Indication: Cardioversion
    End date: 2011-10-01

Other drugs received by patient: Keppra; Zyprexa; Dilantin; Toprol-XL; Levophed; Haldol; Vitamin D; Femara; Amiodarone HCL; Lamictal



Possible Tykerb side effects in 63 year old female

Reported by a pharmacist from United States on 2011-10-26

Patient: 63 year old female

Reactions: Depressed Level of Consciousness, Fall, Haematoma

Adverse event resulted in: life threatening event, hospitalization, disablity

Drug(s) suspected as cause:
Tykerb

Other drugs received by patient: Femara



Possible Tykerb side effects in female

Reported by a physician from Japan on 2011-10-04

Patient: female, weighing 50.1 kg (110.2 pounds)

Reactions: Cardiac Failure, Hypotension, Acute Myocardial Infarction

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2011-08-04
    End date: 2011-08-11

Magmitt
    Administration route: Oral
    Indication: Constipation

Capecitabine
    Dosage: 3000mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2011-08-04
    End date: 2011-08-12

Other drugs received by patient: Claritin; Lansoprazole; Zolpidem; Posterisan; Zetia; Mohrus Tape; Methylcobal; Gasmotin; Lipitor



Possible Tykerb side effects in female

Reported by a physician from Japan on 2011-10-03

Patient: female, weighing 50.1 kg (110.2 pounds)

Reactions: Cardiac Failure, Hypotension, Acute Myocardial Infarction

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Tykerb
    Dosage: 1250mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2011-08-04
    End date: 2011-08-11

Capecitabine
    Dosage: 3000mg per day
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2011-08-04
    End date: 2011-08-12

Other drugs received by patient: Claritin; Magmitt; Methylcobal; Posterisan; Lansoprazole; Gasmotin; Zolpidem; Zetia; Mohrus Tape; Lipitor

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