This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Tobramycin and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (80)
Death (6)
Life Threatening Events (5)
Disability (2)
Reports by Reaction Type
Intraocular Pressure Increased (7),
Decreased Appetite (7),
Vision Blurred (7),
Drug Ineffective (6),
Pyrexia (6),
Eye Oedema (5),
Visual Acuity Reduced (5),
Angioedema (5),
Drug Hypersensitivity (5),
Ageusia (5),
Ocular Hyperaemia (5),
Thrombocytopenia (4)
Below are a few examples of reports where side effects / adverse reactions may be related to Tobramycin. For a complete list or a specific selection of reports, please use the links above.
Possible Tobramycin side effects in 46 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-27
Patient: 46 year old female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Tobramycin
Dosage: unk
Prilosec
Dosage: unk
Codeine Sulfate
Dosage: unk
Prevacid
Dosage: unk
Benadryl
Dosage: unk
Keflex
Dosage: unk
Demerol
Dosage: unk
Possible Tobramycin side effects in 13 year old female
Reported by a individual with unspecified qualification from United Kingdom on 2012-08-03
Patient: 13 year old female
Reactions: Aphagia, Renal Impairment, Malaise, Disseminated Intravascular Coagulation, Abnormal Behaviour, Pyrexia, Serum Sickness, Feeling Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targocid
Dosage: 400 mg (1x 1 / d)
Indication: Hypogammaglobulinaemia
Start date: 2012-05-28
End date: 2012-06-11
Targocid
Dosage: 400 mg (1x 1 / d)
Indication: Staphylococcal Infection
Start date: 2012-05-28
End date: 2012-06-11
Ceftazidime
Dosage: 4.5 g (2x 1/d)
Indication: Staphylococcal Infection
Start date: 2012-05-30
Tobramycin
Dosage: 450 mg (1x 1/d)
Indication: Staphylococcal Infection
Start date: 2012-05-28
End date: 2012-06-08
Other drugs received by patient: Taurine; Azithromycin; Acetaminophen; Colecalciferol; Vitamin E; Dornase Alfa; Fluticasone and Salmeterol; Pancrelipase; Albuterol Sulate; Theophylline; Omeprazole; Vitamin D; Phytonadione; Ursodiol; Vitamin A
Possible Tobramycin side effects in 64 year old female
Reported by a consumer/non-health professional from United States on 2012-07-12
Patient: 64 year old female
Reactions: Pruritus, Ocular Hyperaemia, Swelling, Toxicity To Various Agents, Discomfort
Drug(s) suspected as cause:
Tobramycin
Possible Tobramycin side effects in male
Reported by a pharmacist from United States on 2012-07-02
Patient: male, weighing 108.0 kg (237.6 pounds)
Reactions: Dialysis, Escherichia Infection, Haemodialysis, Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tobramycin
Vancomycin
Possible Tobramycin side effects in
Reported by a individual with unspecified qualification from United States on 2012-06-12
Patient:
Reactions: Circumstance or Information Capable of Leading To Medication Error, Intercepted Medication Error
Drug(s) suspected as cause:
Clindamycin
Dosage: injectable
Tobramycin
Dosage: injectable
Possible Tobramycin side effects in female
Reported by a physician from United States on 2012-05-28
Patient: female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Tobramycin
Dosage: unk
Potassium Penicillin G
Dosage: unk
Possible Tobramycin side effects in 21 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-23
Patient: 21 year old female
Reactions: Bartter's Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tobramycin
Dosage: 7 mg/kg, daily on hospital day 3, intravenous (not otherwise specified)
Indication: Product Used FOR Unknown Indication
Rifampin
Indication: Product Used FOR Unknown Indication
Amiloride HCL
Dosage: 10 mg, daily
Indication: Electrolyte Depletion
Possible Tobramycin side effects in female
Reported by a pharmacist from United States on 2012-05-16
Patient: female
Reactions: Convulsion
Drug(s) suspected as cause:
Tobramycin
Dosage: twice a day
Indication: Pseudomonas Infection
Zoledronic Acid
Dosage: unk
Possible Tobramycin side effects in 21 year old female
Reported by a physician from United States on 2012-05-11
Patient: 21 year old female
Reactions: Pseudo-Bartter Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tobramycin
Dosage: 7 mg/kg daily
Tobramycin
Other drugs received by patient: Rifampicin
Possible Tobramycin side effects in female
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-05-09
Patient: female, weighing 11.3 kg (24.9 pounds)
Reactions: Croup Infectious, Hypertension
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dexamethasone
Dosage: 6 mg, ix
Administration route: Oral
Start date: 2011-08-17
End date: 2011-08-17
Tobramycin
Dosage: code not broken
Indication: Pseudomonas Infection
Start date: 2010-06-11
End date: 2010-07-08
Dexamethasone
Dosage: 6.5 mg, die
Administration route: Oral
Start date: 2011-08-14
End date: 2011-08-16
Blinded NO Treatment Received
Dosage: code not broken
Indication: Pseudomonas Infection
Start date: 2010-06-11
End date: 2010-07-08
Placebo
Dosage: code not broken
Indication: Pseudomonas Infection
Start date: 2010-06-11
End date: 2010-07-08
Epinephrine
Dosage: 5 ml 1/600 neb prn
Start date: 2011-08-14
End date: 2011-08-15
Other drugs received by patient: Tempra; Vitamin E; Cephalexin; Creon; Motilium; TRI-VI-SOL; Sodium Chloride
Possible Tobramycin side effects in 55 year old male
Reported by a consumer/non-health professional from France on 2012-05-09
Patient: 55 year old male
Reactions: Grand MAL Convulsion, Overdose, Metabolic Acidosis, Hypotension
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Ciprofloxacin Hydrochloride
Dosage: daily dose 400 mg
Indication: Product Used FOR Unknown Indication
Start date: 2009-12-22
End date: 2009-12-23
Tobramycin
Dosage: unk
Indication: Product Used FOR Unknown Indication
Start date: 2009-12-20
Ciprofloxacin Hydrochloride
Dosage: daily dose 400 mg
Start date: 2009-12-26
End date: 2010-01-01
Ciprofloxacin Hydrochloride
Dosage: 400 mg, bid
Start date: 2009-12-24
End date: 2009-12-26
Imipenem and Cilastatin Sodium
Dosage: 500 mg, bid
Start date: 2010-01-24
End date: 2010-01-24
Ciprofloxacin Hydrochloride
Dosage: daily dose 200 mg
Start date: 2010-01-02
End date: 2010-01-21
Other drugs received by patient: Nicardipine Hydrochloride; Gentamicin; Imovane; Fluconazole; Previscan
Possible Tobramycin side effects in 84 year old female
Reported by a consumer/non-health professional from United States on 2012-05-07
Patient: 84 year old female, weighing 65.8 kg (144.7 pounds)
Reactions: Ocular Hyperaemia, Drug Hypersensitivity, Localised Oedema, Eye Pruritus
Drug(s) suspected as cause:
Tobramycin
Possible Tobramycin side effects in female
Reported by a physician from Hungary on 2012-04-30
Patient: female
Reactions: Neutrophil Count Increased, C-Reactive Protein Increased, Burkholderia Test Positive, Pseudomonas Infection, Sputum Discoloured, Asphyxia, White Blood Cell Count Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tobramycin
Possible Tobramycin side effects in 22 year old female
Reported by a health professional (non-physician/pharmacist) from Germany on 2012-04-27
Patient: 22 year old female
Reactions: Lymphadenopathy, Drug Ineffective, Tachycardia, Rales, Pyrexia, Serum Ferritin Increased, Shift To THE Left, C-Reactive Protein Increased, Still's Disease Adult Onset, Tachypnoea, Splenomegaly, Pharyngitis, Clubbing, Procalcitonin Increased, Dyspnoea, Rash, Computerised Tomogram Abnormal, Oropharyngeal Discomfort, Candida Test Positive, Tonsillar Disorder, Increased Viscosity of Nasal Secretion, Bacterial Disease Carrier, Arthralgia, Respiratory Failure, Rhonchi, Arthritis, Aspergillus Test Positive, Inflammation
Drug(s) suspected as cause:
Tobramycin
Other drugs received by patient: Pancreatic Enzymes; Penicillin V; Clarithromycin; Colistin Sulfate; Fluticasone Propionate / Salmeterol; Tiotropium Bromide; Meropenem
Possible Tobramycin side effects in 16 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-04-24
Patient: 16 year old female
Reactions: Arthralgia, Oedema Peripheral, Pain, Pyrexia, Feeling Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tobramycin
Other drugs received by patient: Meropenem
Possible Tobramycin side effects in female
Reported by a physician from Canada on 2012-04-23
Patient: female, weighing 11.3 kg (24.9 pounds)
Reactions: Hypertension, Croup Infectious
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tobramycin
Dosage: double blinded
Indication: Pseudomonas Infection
Start date: 2010-06-11
End date: 2010-07-08
Dexamethasone
Dosage: 6 mg, ix
Administration route: Oral
Start date: 2011-08-17
End date: 2011-08-17
Blinded Placebo
Dosage: double blinded
Indication: Pseudomonas Infection
Start date: 2010-06-11
End date: 2010-07-08
Dexamethasone
Dosage: 6.5 mg, die
Administration route: Oral
Start date: 2011-08-14
End date: 2011-08-16
Epinephrine
Dosage: 5 ml 1/600 neb prn
Start date: 2011-08-14
End date: 2011-08-15
Blinded NO Treatment Received
Dosage: double blinded
Indication: Pseudomonas Infection
Start date: 2010-06-11
End date: 2010-07-08
Other drugs received by patient: Sodium Chloride; Motilium; Cephalexin; TRI-VI-SOL; Tempra; Creon; Vitamin E
Possible Tobramycin side effects in 63 year old female
Reported by a consumer/non-health professional from United States on 2012-04-20
Patient: 63 year old female
Reactions: Scratch, Pneumonia, Wrist Fracture, Fungal Sepsis, Fall, Malaise, Staphylococcal Infection, Septic Shock, Renal Failure Acute, Ligament Sprain, Infarction
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Vancomycin
Indication: Product Used FOR Unknown Indication
Tobramycin
Indication: Product Used FOR Unknown Indication
Tigecycline
Indication: Product Used FOR Unknown Indication
Humira
Indication: Crohn's Disease
Other drugs received by patient: Zoloft; Vicodin; Lomotil; Bentyl; Potassium Chloride; Soma; Norvasc; Aciphex; Bupropion HCL; Quinapril and Hydrochlorothiazide; Ambien; Bystolic; Furosemide
Possible Tobramycin side effects in female
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-04-18
Patient: female, weighing 11.3 kg (24.9 pounds)
Reactions: Hypertension, Croup Infectious
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tobramycin
Dosage: double blinded
Indication: Pseudomonas Infection
Start date: 2010-06-11
End date: 2010-07-08
Blinded NO Treatment Received
Dosage: double blinded
Indication: Pseudomonas Infection
Start date: 2010-06-11
End date: 2010-07-08
Dexamethasone
Dosage: 0.5 mg, qd
Administration route: Oral
Start date: 2011-08-14
End date: 2011-08-16
Epinephrine
Dosage: 5 ml 1/600 neb prn
Start date: 2011-08-14
End date: 2011-08-15
Dexamethasone
Dosage: 6 mg, ix
Administration route: Oral
Start date: 2011-08-17
End date: 2011-08-17
Placebo
Dosage: double blinded
Indication: Pseudomonas Infection
Start date: 2010-06-11
End date: 2010-07-08
Other drugs received by patient: Vitamin E; Sodium Chloride; Tempra; Motilium; Creon; TRI-VI-SOL
Possible Tobramycin side effects in female
Reported by a physician from Canada on 2012-04-18
Patient: female, weighing 5.9 kg (13.1 pounds)
Reactions: Pseudomonas Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Placebo
Dosage: double blinded
Indication: Pseudomonas Infection
Start date: 2011-04-19
End date: 2011-05-04
Placebo
Dosage: double blinded
Start date: 2011-05-05
End date: 2011-05-09
Placebo
Dosage: double blinded
Start date: 2011-05-09
End date: 2011-05-19
Tobramycin
Dosage: double blinded
Start date: 2011-05-09
End date: 2011-05-19
Tobramycin
Dosage: double blinded
Start date: 2011-05-05
End date: 2011-05-09
Blinded NO Treatment Received
Dosage: double blinded
Start date: 2011-05-09
End date: 2011-05-19
Blinded NO Treatment Received
Dosage: double blinded
Indication: Pseudomonas Infection
Start date: 2011-04-19
End date: 2011-05-04
Tobramycin
Dosage: double blinded
Indication: Pseudomonas Infection
Start date: 2011-04-19
End date: 2011-05-04
Blinded NO Treatment Received
Dosage: double blinded
Start date: 2011-05-05
End date: 2011-05-09
Possible Tobramycin side effects in 69 year old male
Reported by a pharmacist from United States on 2012-04-18
Patient: 69 year old male, weighing 70.3 kg (154.7 pounds)
Reactions: Renal Tubular Necrosis, Toxicity To Various Agents, Renal Failure Acute, Haemodialysis
Drug(s) suspected as cause:
Tobramycin
Possible Tobramycin side effects in 78 year old female
Reported by a physician from Canada on 2012-04-18
Patient: 78 year old female
Reactions: Neuropathy Peripheral, Angioedema, Febrile Neutropenia, Rash Maculo-Papular
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Tobramycin
Indication: Febrile Neutropenia
Start date: 2010-11-04
End date: 2010-11-05
Revlimid
Dosage: 25 milligram
Administration route: Oral
Indication: Myelodysplastic Syndrome
Start date: 2010-10-29
End date: 2010-11-09
Ancef
Indication: Febrile Neutropenia
Start date: 2010-11-04
End date: 2010-11-05
Other drugs received by patient: Velcade
Possible Tobramycin side effects in 66 year old female
Reported by a physician from United States on 2012-04-11
Patient: 66 year old female
Reactions: Corneal Thinning, Ulcerative Keratitis, Corneal Epithelium Defect, Pseudomonas Test Positive, Corneal Infiltrates, Hypopyon, Keratitis Bacterial, Corneal Oedema, Iritis, Keratitis
Drug(s) suspected as cause:
Prednisolone Acetate
Dosage: (every 2 hours ophthalmic)
Ceftazidime
Dosage: (50 mg/ml qid)
Tobramycin
Dosage: (14 mg/ml every 30 minutes), (four times a day)
Possible Tobramycin side effects in female
Reported by a consumer/non-health professional from Canada on 2012-04-02
Patient: female
Reactions: Eye Infection, Laser Therapy, Eye Pain
Drug(s) suspected as cause:
Xalatan
Dosage: 1 drop in each eye daily
Indication: Glaucoma
Azarga
Dosage: unk
End date: 2011-06-01
Tobramycin
Dosage: 1 gtt, 4x/day
Indication: Eye Infection
Possible Tobramycin side effects in 68 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-30
Patient: 68 year old female
Reactions: Drug Ineffective, Cataract Operation Complication, Eye Oedema, Intraocular Pressure Increased, Vision Blurred, Polyarthritis
Drug(s) suspected as cause:
Celebrex
Dosage: 200 mg; qd
Indication: Polyarthritis
Acetazolamide
Dosage: 125 mg;qd
Indication: Eye Oedema
Ketorolac Tromethamine
Dosage: oph
Indication: Eye Oedema
Tobramycin
Dosage: oph
Indication: Eye Oedema
End date: 2011-10-01
Omnipred
Dosage: oph
Administration route: Oral
Indication: Eye Oedema
Propylene Glycol
Dosage: oph
Indication: Eye Oedema
Naproxen
Indication: Polyarthritis
End date: 2011-12-01
Simvastatin
Indication: Blood Cholesterol Increased
End date: 2011-10-01
Cortisone
Dosage: qid
Indication: Eye Oedema
Start date: 2011-05-01
Lipitor
Dosage: 20 mg;qd;po
Administration route: Oral
Indication: Blood Cholesterol Increased
Start date: 2011-10-01
Pred Forte
Dosage: oph
Indication: Eye Oedema
Other drugs received by patient: Thiazide; Levoxyl
Possible Tobramycin side effects in female
Reported by a physician from United States on 2012-03-23
Patient: female, weighing 52.2 kg (114.7 pounds)
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Codeine
Dosage: unk
Gemfibrozil
Dosage: unk
Timoptic
Dosage: unk
Minitran
Dosage: unk
Ergomar
Dosage: unk
Alphagan
Dosage: unk
Celexa
Dosage: unk
Velocef
Dosage: unk
Tobramycin
Dosage: unk
Valium
Dosage: unk
Phenergan HCL
Dosage: unk
E.E.S.
Dosage: unk
Tetanus Toxoid
Dosage: unk
Ciprofloxacin
Dosage: unk
Azopt
Dosage: unk
Lipitor
Dosage: unk
Vicodin
Dosage: unk
Darvon
Dosage: unk
Possible Tobramycin side effects in 68 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-22
Patient: 68 year old female, weighing 90.7 kg (199.6 pounds)
Reactions: Drug Ineffective, Pain, Eye Oedema, Intraocular Pressure Increased, Visual Acuity Reduced, Vision Blurred
Drug(s) suspected as cause:
Pred Forte
Indication: Eye Oedema
Tobramycin
Indication: Eye Oedema
Propylene Glycol
Indication: Eye Oedema
Naproxen
Indication: Arthritis
End date: 2011-12-01
Simvastatin
Indication: Blood Cholesterol Increased
End date: 2011-10-01
Lipitor
Administration route: Oral
Indication: Blood Cholesterol Increased
Naproxen
End date: 2011-12-01
Celebrex
Indication: Polyarthritis
Acetazolamide
Indication: Eye Oedema
Ketorolac Tromethamine
Indication: Eye Oedema
Omnipred
Indication: Eye Oedema
Cortisone Acetate
Indication: Eye Oedema
Start date: 2011-05-01
Other drugs received by patient: Thiazide; Levoxyl
Possible Tobramycin side effects in 53 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-03-16
Patient: 53 year old female
Reactions: Thrombocytopenia
Adverse event resulted in: death
Drug(s) suspected as cause:
Tobramycin
Start date: 2011-12-24
End date: 2012-01-12
Vancomycin
Start date: 2011-12-19
End date: 2012-01-12
Ceftazidime
Start date: 2011-12-24
End date: 2012-01-12
Cancidas
Start date: 2011-12-27
End date: 2012-01-12
Ambisome
Start date: 2012-01-04
End date: 2012-01-12
Other drugs received by patient: Prednisone TAB; Aspirin; Atorvastatin; Propranolol; Ramipril; Insulin; Clonazepam
Possible Tobramycin side effects in 69 year old male
Reported by a pharmacist from United States on 2012-03-15
Patient: 69 year old male, weighing 139.5 kg (306.9 pounds)
Reactions: Chemical Eye Injury
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tobramycin
Possible Tobramycin side effects in 68 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-03-14
Patient: 68 year old female, weighing 90.7 kg (199.5 pounds)
Reactions: Drug Ineffective, Visual Impairment, Intraocular Pressure Increased, Eye Oedema, Vision Blurred, Eye Disorder, Cataract Operation
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Tobramycin
Indication: Oedema
Simvastatin
Indication: Blood Cholesterol Increased
Systane [macrogol,propylene Glycol]
Indication: Oedema
Pred Forte
Indication: Oedema
Celebrex
Dosage: 200 mg, qd
Indication: Polyarthritis
Naproxen Sodium
Indication: Polyarthritis
Acetazolamide
Dosage: 125 mg, qd
Indication: Oedema
Lipitor
Dosage: 20 mg, qd
Administration route: Oral
Indication: Blood Cholesterol Increased
Ketorolac Tromethamine
Indication: Oedema
Other drugs received by patient: Thiazide Derivatives; Levoxyl
Possible Tobramycin side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-09
Patient: female, weighing 90.8 kg (199.8 pounds)
Reactions: Drug Ineffective, Eye Oedema, Visual Impairment, Intraocular Pressure Increased, Vision Blurred, Eye Disorder, Cataract Operation
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Lipitor
Administration route: Oral
Indication: Blood Cholesterol Increased
Ketorolac Tromethamine
Indication: Oedema
Simvastatin
Indication: Blood Cholesterol Increased
Tobramycin
Indication: Oedema
Acetazolamide
Indication: Oedema
Celebrex
Indication: Polyarthritis
Naproxen
Indication: Polyarthritis
Pred Forte
Indication: Oedema
Propylene Glycol
Indication: Oedema
Other drugs received by patient: Levoxyl; Thiazide
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