Taxol (Paclitaxel) - Death - Suspected Cause - Side Effect Reports

Possible Taxol side effects in female

Reported by a pharmacist from United States on 2012-08-16

Patient: female, weighing 41.5 kg (91.4 pounds)

Reactions: Agitation, Dyspnoea, Cardio-Respiratory Arrest, Cyanosis, Blood Pressure Immeasurable, Oxygen Saturation Decreased, Panic Reaction, Infusion Related Reaction

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Taxol

Possible Taxol side effects in 65 year old male

Reported by a health professional (non-physician/pharmacist) from Switzerland on 2012-08-10

Patient: 65 year old male

Reactions: Multi-Organ Failure, Gastrointestinal Haemorrhage, Dermatitis, Interstitial Lung Disease, Acute Respiratory Distress Syndrome

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Taxol
    Indication: Pharyngeal Cancer Stage Unspecified

Carboplatin
    Indication: Pharyngeal Cancer Stage Unspecified

Cetuximab
    Dosage: loading dose:600mg then 400mg
    Indication: Pharyngeal Cancer Stage Unspecified

Possible Taxol side effects in male

Reported by a physician from United Kingdom on 2012-08-06

Patient: male, weighing 62.4 kg (137.3 pounds)

Reactions: White Blood Cell Count Decreased, Bronchopneumonia, Nausea, Anaemia, Hyponatraemia, Hypoalbuminaemia, Fluid Intake Reduced, Platelet Count Decreased, Neutropenia, Decreased Appetite, Lethargy

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Taxol
    Dosage: 175 mg/m2, unk
    Indication: non-Small Cell Lung Cancer
    Start date: 2012-03-05
    End date: 2012-04-23

Pemetrexed
    Dosage: 500 mg/m2, unk
    Indication: non-Small Cell Lung Cancer
    Start date: 2012-03-05
    End date: 2012-04-23

Other drugs received by patient: Folic Acid; Vitamin B-12; Lansoprazole; Dexamethasone; Spiriva; Enoxaparin; Seretide; Phyllocontin; Fluconazole

Possible Taxol side effects in female

Reported by a physician from Spain on 2012-07-31

Patient: female, weighing 74.0 kg (162.8 pounds)

Reactions: Pulmonary Toxicity, Organising Pneumonia, Respiratory Failure

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Vinorelbine
    Indication: Breast Cancer Metastatic
    Start date: 2012-03-29
    End date: 2012-03-29

Herceptin
    Indication: Breast Cancer Metastatic
    Start date: 2012-02-16
    End date: 2012-03-01

Herceptin
    Start date: 2012-03-29
    End date: 2012-03-29

Taxol
    Indication: Breast Cancer Metastatic
    Start date: 2012-01-25
    End date: 2012-03-01

Possible Taxol side effects in

Reported by a consumer/non-health professional from Japan on 2012-07-30

Patient:

Reactions: Sudden Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Paraplatin AQ
    Indication: Lung Neoplasm Malignant

Taxol
    Indication: Lung Neoplasm Malignant

Possible Taxol side effects in female

Reported by a physician from Spain on 2012-07-24

Patient: female

Reactions: Pulmonary Toxicity, Respiratory Failure

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Taxol
    Indication: Breast Cancer Metastatic

Vinorelbine
    Indication: Breast Cancer Metastatic

Herceptin
    Indication: Breast Cancer Metastatic

Possible Taxol side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-24

Patient: female

Reactions: Death, Idiopathic Thrombocytopenic Purpura

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Breast Cancer Metastatic

Taxotere
    Indication: Breast Cancer Metastatic

Taxol
    Indication: Breast Cancer Metastatic

Possible Taxol side effects in male

Reported by a physician from United Kingdom on 2012-07-24

Patient: male, weighing 62.4 kg (137.3 pounds)

Reactions: White Blood Cell Count Decreased, Bronchopneumonia, Nausea, Anaemia, Hyponatraemia, Fluid Intake Reduced, Platelet Count Decreased, Hypoalbuminaemia, Neutropenia, Lethargy, Decreased Appetite

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Pemetrexed
    Dosage: 500 mg/m2, unk
    Indication: non-Small Cell Lung Cancer
    Start date: 2012-03-05
    End date: 2012-04-23

Taxol
    Dosage: 175 mg/m2, unk
    Indication: non-Small Cell Lung Cancer
    Start date: 2012-03-05
    End date: 2012-04-23

Other drugs received by patient: Phyllocontin; Vitamin B-12; Dexamethasone; Fluticasone Propionate / Salmeterol; Fluconazole; Folic Acid; Lansoprazole; Spiriva; Enoxaparin

Possible Taxol side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-23

Patient:

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Taxol
    Indication: Breast Cancer

Avastin
    Indication: Breast Cancer

Possible Taxol side effects in 71 year old female

Reported by a consumer/non-health professional from Japan on 2012-07-11

Patient: 71 year old female, weighing 46.0 kg (101.2 pounds)

Reactions: White Blood Cell Count Decreased, Abdominal Pain, Nausea, Hypotension, Pyrexia, Neutrophil Count Decreased, Renal Failure Acute

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Taxol
    Indication: Ovarian Cancer
    Start date: 2012-05-25
    End date: 2012-05-25

Carboplatin
    Indication: Ovarian Cancer
    Start date: 2012-05-25
    End date: 2012-05-25

Other drugs received by patient: Primperan TAB; Zantac; Inovan; Polaramine; Decadron; Neutrogin; Maxipime; Granisetron

Possible Taxol side effects in female

Reported by a physician from Japan on 2012-07-11

Patient: female, weighing 32.0 kg (70.4 pounds)

Reactions: Haemoptysis, Sensory Disturbance, Lung Infection, Posterior Reversible Encephalopathy Syndrome, Visual Impairment, Convulsion, Asphyxia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Taxol
    Dosage: discontinued.
    Start date: 2010-08-03
    End date: 2010-09-14

Avastin
    Indication: Lung Adenocarcinoma Recurrent
    Start date: 2010-07-13
    End date: 2010-09-14

Avastin
    Start date: 2010-09-21
    End date: 2010-09-21

Taxol
    Indication: Lung Adenocarcinoma Recurrent
    Start date: 2010-07-13
    End date: 2010-07-13

Possible Taxol side effects in 69 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-06

Patient: 69 year old male

Reactions: Hepatitis Cholestatic, Febrile Bone Marrow Aplasia, Septic Shock, Escherichia Bacteraemia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Atorvastatin
    Dosage: 40 mg, 1x/day
    Administration route: Oral
    End date: 2012-03-28

Taxol
    Dosage: 380 mg, cyclic, every 28 days
    Start date: 2012-02-27
    End date: 2012-02-27

Zantac
    Dosage: 50 mg, cyclic, every 28 days
    Start date: 2012-02-27
    End date: 2012-02-27

Carboplatin
    Dosage: 533 mg, cyclic, every 28 days
    Start date: 2012-02-27
    End date: 2012-02-27

Other drugs received by patient: Ondansetron HCL; Aldactone; Polaramine; Alimta; Lasix; Aspegic 1000; Neulasta; Methylprednisolone; Acetaminophen

Possible Taxol side effects in male

Reported by a physician from United Kingdom on 2012-07-05

Patient: male, weighing 62.4 kg (137.3 pounds)

Reactions: White Blood Cell Count Decreased, Nausea, Anaemia, Hyponatraemia, Death, Platelet Count Decreased, Fluid Intake Reduced, Hypoalbuminaemia, Neutropenia, Lethargy, Decreased Appetite

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Pemetrexed
    Dosage: 500 mg/m2, unk
    Indication: non-Small Cell Lung Cancer
    Start date: 2012-03-05

Taxol
    Dosage: 175 mg/m2, unk
    Indication: non-Small Cell Lung Cancer
    Start date: 2012-03-05

Other drugs received by patient: Lansoprazole; Dexamethasone Sodium Phosphate; Spiriva; Enoxaparin; Phyllocontin; Fluticasone Propionate / Salmeterol; Folic Acid; Vitamin B-12; Fluconazole

Possible Taxol side effects in male

Reported by a physician from Brazil on 2012-06-29

Patient: male, weighing 73.0 kg (160.6 pounds)

Reactions: Pulmonary Haemorrhage, Cytomegalovirus Chorioretinitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Dolutegravir
    Dosage: 50mg twice per day
    Indication: HIV Infection
    Start date: 2012-02-02

Darunavir Hydrate
    Dosage: 600mg twice per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2009-02-01
    End date: 2012-03-08

Taxol
    Dosage: 90mg weekly
    Indication: Kaposi's Sarcoma
    Start date: 2010-09-01

Etravirine
    Dosage: 200mg twice per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2011-01-01
    End date: 2012-03-08

Ganciclovir
    Dosage: 350mg twice per day
    Indication: Cytomegalovirus Chorioretinitis
    Start date: 2012-02-15
    End date: 2012-03-05

Ganciclovir
    Dosage: 350mg per day
    Start date: 2012-03-06
    End date: 2012-03-06

Ritonavir
    Dosage: 100mg twice per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2000-03-01
    End date: 2012-03-08

Combivir
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2012-02-02

Maraviroc
    Dosage: 150mg twice per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2011-01-01
    End date: 2012-03-08

Possible Taxol side effects in female

Reported by a individual with unspecified qualification from United States on 2012-06-29

Patient: female, weighing 131.5 kg (289.3 pounds)

Reactions: Atelectasis, Wheezing, Fatigue, Joint Range of Motion Decreased, Acute Myocardial Infarction, Back Pain, Hypotension, Musculoskeletal Pain, Condition Aggravated, Muscular Weakness, Pancytopenia, Renal Failure, Respiratory Failure, Arthralgia, Staphylococcal Infection, Dehydration, Asthenia, Cardiac Arrest, Septic Shock

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Taxol
    Dosage: 350 mg
    End date: 2011-02-04

Carboplatin
    Dosage: 724 mg
    End date: 2011-02-04

Other drugs received by patient: Celecoxib; Lasix; Verapamil Extended-Release; Cholecalciferol; Potassium Chloride; Vitamin; Fentanyl; Synthroid; Toprol-XL; Actos; Micardis HCT; Hydrocodone-Acetominophen

Possible Taxol side effects in 63 year old male

Reported by a consumer/non-health professional from United States on 2012-06-26

Patient: 63 year old male, weighing 69.0 kg (151.8 pounds)

Reactions: Abdominal Pain, Dyspnoea, Lung Infection, Sepsis, Neutrophil Count Decreased, Decreased Appetite

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cisplatin
    Dosage: last dose on 21may12;removed from protocol therapy on 06-jun-2012.
    Indication: Oesophageal Squamous Cell Carcinoma
    Start date: 2012-05-21

Taxol
    Dosage: last dose on 21may12; removed from protocol therapy on 06-jun-2012.
    Indication: Oesophageal Squamous Cell Carcinoma
    Start date: 2012-05-21

Other drugs received by patient: Celexa; Spiriva; Roxicet; Nicotine

Possible Taxol side effects in female

Reported by a physician from Netherlands on 2012-06-21

Patient: female

Reactions: Hypophagia, Leukopenia, Disease Progression

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Taxol
    Dosage: day 1.8 and 15 every 21 days
    Indication: Breast Cancer
    Start date: 2011-04-15
    End date: 2011-08-23

Doxorubicin HCL
    Indication: Breast Cancer
    Start date: 2012-04-05
    End date: 2012-04-05

Avastin
    Dosage: day 1 and 15 every 28 days + day 1 every 21 days (after discontinuation of paclitaxel)
    Indication: Breast Cancer
    Start date: 2011-04-15
    End date: 2012-03-13

Other drugs received by patient: Lisinopril Hydrochlorthiazid

Possible Taxol side effects in female

Reported by a individual with unspecified qualification from United States on 2012-06-18

Patient: female, weighing 38.5 kg (84.7 pounds)

Reactions: Renal Failure, Aplastic Anaemia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cisplatin
    Dosage: 63 mg
    End date: 2011-05-23

Taxol
    Dosage: 221 mg
    End date: 2011-05-23

Possible Taxol side effects in 56 year old female

Reported by a consumer/non-health professional from France on 2012-06-15

Patient: 56 year old female

Reactions: Haemorrhage, Disseminated Intravascular Coagulation, Hepatic Failure, Thrombocytopenia, Escherichia Sepsis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Adriamycin PFS

Taxol
    Indication: Breast Cancer
    Start date: 2012-01-24
    End date: 2012-02-16

Avastin
    Dosage: avastin 25 mg/ml, solution to dilute for infusion (bevacizumab) 50 mg/m2
    Indication: Breast Cancer
    Start date: 2012-01-24
    End date: 2012-02-16

Possible Taxol side effects in 58 year old female

Reported by a consumer/non-health professional from Japan on 2012-06-08

Patient: 58 year old female

Reactions: Hepatic Failure

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Paraplatin AQ
    Indication: Cervix Carcinoma
    Start date: 2012-05-15
    End date: 2012-05-15

Taxol
    Indication: Cervix Carcinoma
    Start date: 2012-05-15
    End date: 2012-05-15

Possible Taxol side effects in 56 year old female

Reported by a physician from France on 2012-06-08

Patient: 56 year old female

Reactions: Haemorrhage, Disseminated Intravascular Coagulation

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Breast Cancer
    Start date: 2012-01-24
    End date: 2012-02-16

Taxol
    Indication: Breast Cancer
    Start date: 2012-01-24
    End date: 2012-02-16

Other drugs received by patient: Ofloxacin; Adriamycin PFS; Sintrom; Rocephin; Tamoxifen Citrate

Possible Taxol side effects in female

Reported by a physician from United States on 2012-06-07

Patient: female, weighing 150.6 kg (331.2 pounds)

Reactions: Diarrhoea, Sepsis, Neutropenia, Thrombocytopenia, Renal Failure Acute

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Bevacizumab
    Dosage: 10 mg/kg, qd
    Indication: Metastatic Malignant Melanoma
    Start date: 2012-05-18
    End date: 2012-05-18

Afinitor
    Dosage: 5 mg, qw3 (m, w, f) all 4 weeks, repeat q28 days
    Administration route: Oral
    Indication: Metastatic Malignant Melanoma
    Start date: 2012-05-21
    End date: 2012-05-25

Taxol
    Dosage: 80 mg/m2, unk
    Indication: Metastatic Malignant Melanoma
    Start date: 2012-05-18
    End date: 2012-05-18

Carboplatin

Possible Taxol side effects in female

Reported by a physician from United States on 2012-06-07

Patient: female, weighing 150.6 kg (331.2 pounds)

Reactions: Diarrhoea, Sepsis, Neutropenia, Thrombocytopenia, Renal Failure Acute

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Carboplatin

Taxol
    Dosage: 80 mg/m2, unk
    Indication: Metastatic Malignant Melanoma
    Start date: 2012-05-18
    End date: 2012-05-18

Afinitor
    Dosage: 5 mg, qw3 (m, w, f) all 4 weeks, repeat q28 days
    Administration route: Oral
    Indication: Metastatic Malignant Melanoma
    Start date: 2012-05-21
    End date: 2012-05-25

Bevacizumab
    Dosage: 10 mg/kg, qd
    Indication: Metastatic Malignant Melanoma
    Start date: 2012-05-18
    End date: 2012-05-18

Possible Taxol side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-29

Patient: 54 year old male

Reactions: Death, Vomiting, Nausea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Erbitux
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-04-11

Carboplatin
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-04-11

Lortab
    Indication: Product Used FOR Unknown Indication

Atripla
    Indication: Product Used FOR Unknown Indication

Taxol
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-04-11

Fentanyl
    Indication: Product Used FOR Unknown Indication

Possible Taxol side effects in female

Reported by a physician from Algeria on 2012-05-25

Patient: female

Reactions: Vomiting, Dehydration, Convulsion, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Avastin
    Indication: Ovarian Cancer
    End date: 2012-04-22

Taxol
    Indication: Ovarian Cancer
    End date: 2012-04-22

Possible Taxol side effects in 54 year old male

Reported by a physician from United States on 2012-05-22

Patient: 54 year old male

Reactions: Death, Vomiting, Nausea, Cough

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Lortab

Fentanyl-100

Carboplatin
    Dosage: 545 mg total
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-04-11
    End date: 2011-01-01

Taxol
    Dosage: 269 mg total
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-04-11
    End date: 2011-01-01

Erbitux
    Dosage: 447.5 mg total
    Indication: non-Small Cell Lung Cancer
    Start date: 2011-04-11

Atripla

Possible Taxol side effects in male

Reported by a physician from United States on 2012-05-17

Patient: male

Reactions: Death, Malaise

Adverse event resulted in: death

Drug(s) suspected as cause:
Taxol

Zometa
    Start date: 2011-04-01

Erbitux

Possible Taxol side effects in female

Reported by a physician from United States on 2012-05-17

Patient: female, weighing 131.5 kg (289.3 pounds)

Reactions: Atelectasis, Wheezing, Fatigue, Joint Range of Motion Decreased, Acute Myocardial Infarction, Cardiac Failure Congestive, Back Pain, Musculoskeletal Pain, Cardiac Enzymes Increased, Pancytopenia, Renal Failure, Arthralgia, Respiratory Failure, Dehydration, Asthenia, Septic Shock, Cardiac Arrest, Staphylococcus Test Positive, Mobility Decreased

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Carboplatin
    Dosage: 724 mg
    End date: 2011-02-04

Taxol
    Dosage: 350 mg
    End date: 2011-02-04

Other drugs received by patient: Hydrocodone-Acetominophen; Lasix; Cholecalciferol; Toprol-XL; Verapamil Extended-Release; Vitamin; Synthroid; Potassium Chloride; Micardis HCT; Fentanyl-100; Actos; Celecoxib

Possible Taxol side effects in 73 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-05-16

Patient: 73 year old female

Reactions: Confusional State, Blood Alkaline Phosphatase Increased, Agitation, Neurological Decompensation, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, General Physical Health Deterioration, Liver Disorder, Convulsion, Gamma-Glutamyltransferase Increased, Dialysis, Aspartate Aminotransferase Increased, Renal Tubular Necrosis, Renal Failure Acute

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Endoxan. Mfr: NOT Specified
    Indication: Breast Cancer Metastatic
    Start date: 2011-08-01

Navelbine
    Dosage: 45 mg, iv
    Indication: Breast Cancer Metastatic
    Start date: 2011-10-01
    End date: 2011-11-01

Clastoban
    Indication: Product Used FOR Unknown Indication
    Start date: 2008-11-01

Taxol
    Indication: Breast Cancer Metastatic
    Start date: 2011-02-01

Other drugs received by patient: Plavix; Crestor; Irbesartan; Nexium

Possible Taxol side effects in 73 year old female

Reported by a consumer/non-health professional from France on 2012-05-14

Patient: 73 year old female

Reactions: Liver Injury, Anuria, Renal Failure Acute

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 2 tablets daily, administered every 2 weeks
    Indication: Breast Cancer Metastatic
    Start date: 2011-08-01

Clastoban
    Start date: 2008-11-01

Taxol
    Dosage: total of 6 courses
    Indication: Breast Cancer Metastatic
    Start date: 2011-02-01

Navelbine
    Indication: Breast Cancer Metastatic
    Start date: 2011-10-01
    End date: 2011-11-01

Other drugs received by patient: Nexium; Crestor; Aprovel; Plavix