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Tasigna (Nilotinib) - Blast Crisis in Myelogenous Leukaemia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Blast Crisis in Myelogenous Leukaemia ()

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Tasigna (Nilotinib) where reactions include blast crisis in myelogenous leukaemia. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Tasigna side effects in female

Reported by a physician from United Kingdom on 2012-05-21

Patient: female, weighing 50.0 kg (110.0 pounds)

Reactions: Electrocardiogram ST Segment Depression, Pulmonary Hypertension, Blood Bilirubin Increased, Rales, Pyrexia, Device Related Infection, Tricuspid Valve Incompetence, Cardiomegaly, Palpitations, Skin Haemorrhage, Blood Creatinine Increased, Cardiac Failure Congestive, Gingival Bleeding, Left Ventricular END-Diastolic Pressure Decreased, Blast Crisis in Myelogenous Leukaemia, Angina Pectoris, Hypotension, Anaemia, Haematotoxicity, Platelet Count Decreased, Aortic Valve Incompetence, Left Ventricular Failure, Chest Pain, Thrombocytopenia, Blood Glucose Increased, White Blood Cell Count Decreased, Dyspnoea AT Rest, Cardiogenic Shock, Chronic Myeloid Leukaemia, Heart Rate Increased, Mitral Valve Incompetence, Shock, Leukopenia

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
RED Blood Cells

Tasigna
    Dosage: 800 mg, bid
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2007-04-25
    End date: 2007-04-28

Other drugs received by patient: Isosorbide Mononitrate; Metoprolol Tartrate



Possible Tasigna side effects in female

Reported by a physician from France on 2012-05-18

Patient: female, weighing 55.0 kg (121.0 pounds)

Reactions: Arrhythmia Supraventricular, Blast Cell Count Increased, Escherichia Urinary Tract Infection, Drug Ineffective, Blast Crisis in Myelogenous Leukaemia, Lung Infection, Myocardial Ischaemia, Tachycardia, Atrial Fibrillation, Febrile Infection, Cardiac Disorder, Neoplasm Malignant, Neutropenia, Asthenia, White Blood Cell Count Increased

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Tasigna
    Dosage: 800mg daily
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2007-08-14
    End date: 2007-09-07

Tasigna
    Dosage: no treatment
    Start date: 2007-09-08
    End date: 2007-09-18

Tasigna
    Dosage: 400mg daily
    Administration route: Oral
    Start date: 2007-09-19
    End date: 2007-09-23

Other drugs received by patient: Diltiazem; Valsartan; Hydrochlorothiazide; Fluindione



Possible Tasigna side effects in female

Reported by a physician from Japan on 2012-05-14

Patient: female

Reactions: Chronic Myeloid Leukaemia Transformation, Drug Ineffective, Blast Crisis in Myelogenous Leukaemia, Platelet Count Decreased

Drug(s) suspected as cause:
Tasigna

Other drugs received by patient: Prednisolone; Flomox; Lansoprazole; Oncovin



Possible Tasigna side effects in male

Reported by a physician from Japan on 2012-05-11

Patient: male, weighing 53.0 kg (116.6 pounds)

Reactions: Dizziness Postural, Pineal Neoplasm, Encephalitis, Device Related Infection, Headache, Cerebral Ventricle Dilatation, Loss of Consciousness, Blast Cells Present, Cerebrospinal Fluid Reservoir Placement, Neck Pain, Brain Oedema, Dizziness, Intracranial Pressure Increased, Hydrocephalus, Candidiasis, Bone Marrow Transplant, Blast Crisis in Myelogenous Leukaemia, Ear Disorder, Pancytopenia, CSF Cell Count Increased, Condition Aggravated, Acute Lymphocytic Leukaemia Recurrent, Leukaemic Infiltration Brain, Ventricular Drainage, Staphylococcal Infection, Meningitis Fungal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Tasigna
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2006-08-05
    End date: 2006-08-25

Tasigna
    Dosage: 200 mg, qd
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2006-08-02
    End date: 2006-08-04

Other drugs received by patient: Flomax; Asverin; Myser; Posterisan; Famotidine; Sodium Bicarbonate; Sodium Alginate; Veen D; Zovirax; Negmin; Urso 250; Dasen; Adona; Cotrim; Indomethacin; Levofloxacin; NEO-Minophagen C; Loxonin; Phenobarbital TAB; Solita T; Selbex; Pentazocine Lactate; Venilon; Cefazolin; Valtrex; Transamine CAP; Diflucan; Famotidine



Possible Tasigna side effects in female

Reported by a physician from Thailand on 2012-04-24

Patient: female

Reactions: Confusional State, Pancreatitis Acute, Blast Crisis in Myelogenous Leukaemia, Pyrexia, Somnolence, Loss of Consciousness, Abdominal Pain Upper, Cerebral Haemorrhage, Neoplasm Malignant, Renal Failure Acute, Shock

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Tasigna



Possible Tasigna side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-06

Patient: female

Reactions: Blast Crisis in Myelogenous Leukaemia, Drug Ineffective, Epistaxis

Drug(s) suspected as cause:
Tasigna

Other drugs received by patient: Acyclovir; Amlodipine; Hydroxyurea; Voriconazole; Clonazepam; Levothyroxine Sodium; Pantoprazole; Sertraline Hydrochloride



Possible Tasigna side effects in 43 year old male

Reported by a consumer/non-health professional from United States on 2012-03-26

Patient: 43 year old male

Reactions: Blast Crisis in Myelogenous Leukaemia

Drug(s) suspected as cause:
Tasigna



Possible Tasigna side effects in 64 year old female

Reported by a consumer/non-health professional from United States on 2012-03-26

Patient: 64 year old female

Reactions: Blast Crisis in Myelogenous Leukaemia

Drug(s) suspected as cause:
Tasigna
    Dosage: 400 mg, bid, oral
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2010-10-12

Gleevec
    Start date: 2010-08-16
    End date: 2010-11-23



Possible Tasigna side effects in 71 year old female

Reported by a consumer/non-health professional from United States on 2012-03-26

Patient: 71 year old female

Reactions: Blast Crisis in Myelogenous Leukaemia

Drug(s) suspected as cause:
Tasigna



Possible Tasigna side effects in

Reported by a physician from United States on 2012-03-26

Patient:

Reactions: Blast Crisis in Myelogenous Leukaemia

Drug(s) suspected as cause:
Tasigna



Possible Tasigna side effects in female

Reported by a consumer/non-health professional from United States on 2012-03-15

Patient: female

Reactions: Drug Ineffective, Blast Crisis in Myelogenous Leukaemia, Epistaxis

Drug(s) suspected as cause:
Tasigna

Other drugs received by patient: Clonazepam; Sertraline Hydrochloride; Voriconazole; Amlodipine; Acyclovir; Hydroxyurea; Levothyroxine Sodium; Pantoprazole



Possible Tasigna side effects in

Reported by a physician from Brazil on 2012-02-15

Patient:

Reactions: Death, Blast Crisis in Myelogenous Leukaemia

Adverse event resulted in: death

Drug(s) suspected as cause:
Tasigna



Possible Tasigna side effects in male

Reported by a physician from Japan on 2012-02-08

Patient: male

Reactions: Chronic Myeloid Leukaemia Transformation, Blast Crisis in Myelogenous Leukaemia

Adverse event resulted in: death

Drug(s) suspected as cause:
Tasigna

Other drugs received by patient: Bisoprolol Fumarate; Prednisolone; Cinalong; Rabeprazole Sodium; Usro; Allopurinol



Possible Tasigna side effects in female

Reported by a physician from Malaysia on 2011-12-05

Patient: female

Reactions: Bronchopulmonary Aspergillosis, Haemorrhage, Blast Crisis in Myelogenous Leukaemia, Bone Pain, Acute Leukaemia, Febrile Neutropenia, Neoplasm Progression, Pyrexia, Leukostasis, Neoplasm Malignant, Thrombocytopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Tasigna
    Dosage: 400 mg, bid
    Administration route: Oral

Tasigna
    Dosage: 400 mg, bid
    Administration route: Oral
    End date: 2011-09-14

Tasigna
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    Start date: 2011-03-03

Tasigna
    Dosage: 200 mg, qd
    Administration route: Oral

Other drugs received by patient: Diamicron; Voriconazole; Folic Acid; Oxycontin; Metformin HCL



Possible Tasigna side effects in female

Reported by a physician from Japan on 2011-12-01

Patient: female

Reactions: Drug Ineffective, Blast Crisis in Myelogenous Leukaemia, Platelet Count Decreased, Gene Mutation Identification Test Positive

Drug(s) suspected as cause:
Tasigna

Other drugs received by patient: Lansoprazole; Flomox; Prednisolone; Oncovin



Possible Tasigna side effects in male

Reported by a physician from Japan on 2011-12-01

Patient: male

Reactions: Chronic Myeloid Leukaemia Transformation, Blast Crisis in Myelogenous Leukaemia

Adverse event resulted in: death

Drug(s) suspected as cause:
Tasigna

Other drugs received by patient: Prednisolone; Usro; Rabeprazole Sodium; Bisoprolol Fumarate; Allopurinol; Cinalong



Possible Tasigna side effects in female

Reported by a physician from Malaysia on 2011-10-04

Patient: female

Reactions: Pneumonia Fungal, Haemorrhage, Blast Crisis in Myelogenous Leukaemia, Acute Leukaemia, Bone Pain, Febrile Neutropenia, Leukostasis, Thrombocytopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Tasigna
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Chronic Myeloid Leukaemia
    End date: 2011-09-14

Tasigna
    Dosage: 200 mg, qd
    Administration route: Oral

Other drugs received by patient: Voriconazole; Folic Acid; Metformin HCL; Diamicron; Oxycontin

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