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Index of reports
> Cases with Blast Crisis in Myelogenous Leukaemia ()
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Tasigna (Nilotinib) where reactions include blast crisis in myelogenous leukaemia. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Tasigna side effects in female
Reported by a physician from United Kingdom on 2012-05-21
Patient: female, weighing 50.0 kg (110.0 pounds)
Reactions: Electrocardiogram ST Segment Depression, Pulmonary Hypertension, Blood Bilirubin Increased, Rales, Pyrexia, Device Related Infection, Tricuspid Valve Incompetence, Cardiomegaly, Palpitations, Skin Haemorrhage, Blood Creatinine Increased, Cardiac Failure Congestive, Gingival Bleeding, Left Ventricular END-Diastolic Pressure Decreased, Blast Crisis in Myelogenous Leukaemia, Angina Pectoris, Hypotension, Anaemia, Haematotoxicity, Platelet Count Decreased, Aortic Valve Incompetence, Left Ventricular Failure, Chest Pain, Thrombocytopenia, Blood Glucose Increased, White Blood Cell Count Decreased, Dyspnoea AT Rest, Cardiogenic Shock, Chronic Myeloid Leukaemia, Heart Rate Increased, Mitral Valve Incompetence, Shock, Leukopenia
Adverse event resulted in: death, life threatening event, hospitalization
Drug(s) suspected as cause:
RED Blood Cells
Tasigna
Dosage: 800 mg, bid
Administration route: Oral
Indication: Chronic Myeloid Leukaemia
Start date: 2007-04-25
End date: 2007-04-28
Other drugs received by patient: Isosorbide Mononitrate; Metoprolol Tartrate
Possible Tasigna side effects in female
Reported by a physician from France on 2012-05-18
Patient: female, weighing 55.0 kg (121.0 pounds)
Reactions: Arrhythmia Supraventricular, Blast Cell Count Increased, Escherichia Urinary Tract Infection, Drug Ineffective, Blast Crisis in Myelogenous Leukaemia, Lung Infection, Myocardial Ischaemia, Tachycardia, Atrial Fibrillation, Febrile Infection, Cardiac Disorder, Neoplasm Malignant, Neutropenia, Asthenia, White Blood Cell Count Increased
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Tasigna
Dosage: 800mg daily
Administration route: Oral
Indication: Chronic Myeloid Leukaemia
Start date: 2007-08-14
End date: 2007-09-07
Tasigna
Dosage: no treatment
Start date: 2007-09-08
End date: 2007-09-18
Tasigna
Dosage: 400mg daily
Administration route: Oral
Start date: 2007-09-19
End date: 2007-09-23
Other drugs received by patient: Diltiazem; Valsartan; Hydrochlorothiazide; Fluindione
Possible Tasigna side effects in female
Reported by a physician from Japan on 2012-05-14
Patient: female
Reactions: Chronic Myeloid Leukaemia Transformation, Drug Ineffective, Blast Crisis in Myelogenous Leukaemia, Platelet Count Decreased
Drug(s) suspected as cause:
Tasigna
Other drugs received by patient: Prednisolone; Flomox; Lansoprazole; Oncovin
Possible Tasigna side effects in male
Reported by a physician from Japan on 2012-05-11
Patient: male, weighing 53.0 kg (116.6 pounds)
Reactions: Dizziness Postural, Pineal Neoplasm, Encephalitis, Device Related Infection, Headache, Cerebral Ventricle Dilatation, Loss of Consciousness, Blast Cells Present, Cerebrospinal Fluid Reservoir Placement, Neck Pain, Brain Oedema, Dizziness, Intracranial Pressure Increased, Hydrocephalus, Candidiasis, Bone Marrow Transplant, Blast Crisis in Myelogenous Leukaemia, Ear Disorder, Pancytopenia, CSF Cell Count Increased, Condition Aggravated, Acute Lymphocytic Leukaemia Recurrent, Leukaemic Infiltration Brain, Ventricular Drainage, Staphylococcal Infection, Meningitis Fungal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tasigna
Dosage: 400 mg, qd
Administration route: Oral
Start date: 2006-08-05
End date: 2006-08-25
Tasigna
Dosage: 200 mg, qd
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Start date: 2006-08-02
End date: 2006-08-04
Other drugs received by patient: Flomax; Asverin; Myser; Posterisan; Famotidine; Sodium Bicarbonate; Sodium Alginate; Veen D; Zovirax; Negmin; Urso 250; Dasen; Adona; Cotrim; Indomethacin; Levofloxacin; NEO-Minophagen C; Loxonin; Phenobarbital TAB; Solita T; Selbex; Pentazocine Lactate; Venilon; Cefazolin; Valtrex; Transamine CAP; Diflucan; Famotidine
Possible Tasigna side effects in female
Reported by a physician from Thailand on 2012-04-24
Patient: female
Reactions: Confusional State, Pancreatitis Acute, Blast Crisis in Myelogenous Leukaemia, Pyrexia, Somnolence, Loss of Consciousness, Abdominal Pain Upper, Cerebral Haemorrhage, Neoplasm Malignant, Renal Failure Acute, Shock
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Tasigna
Possible Tasigna side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-06
Patient: female
Reactions: Blast Crisis in Myelogenous Leukaemia, Drug Ineffective, Epistaxis
Drug(s) suspected as cause:
Tasigna
Other drugs received by patient: Acyclovir; Amlodipine; Hydroxyurea; Voriconazole; Clonazepam; Levothyroxine Sodium; Pantoprazole; Sertraline Hydrochloride
Possible Tasigna side effects in 71 year old female
Reported by a consumer/non-health professional from United States on 2012-03-26
Patient: 71 year old female
Reactions: Blast Crisis in Myelogenous Leukaemia
Drug(s) suspected as cause:
Tasigna
Possible Tasigna side effects in
Reported by a physician from United States on 2012-03-26
Patient:
Reactions: Blast Crisis in Myelogenous Leukaemia
Drug(s) suspected as cause:
Tasigna
Possible Tasigna side effects in 43 year old male
Reported by a consumer/non-health professional from United States on 2012-03-26
Patient: 43 year old male
Reactions: Blast Crisis in Myelogenous Leukaemia
Drug(s) suspected as cause:
Tasigna
Possible Tasigna side effects in 64 year old female
Reported by a consumer/non-health professional from United States on 2012-03-26
Patient: 64 year old female
Reactions: Blast Crisis in Myelogenous Leukaemia
Drug(s) suspected as cause:
Tasigna
Dosage: 400 mg, bid, oral
Administration route: Oral
Indication: Chronic Myeloid Leukaemia
Start date: 2010-10-12
Gleevec
Start date: 2010-08-16
End date: 2010-11-23
Possible Tasigna side effects in female
Reported by a consumer/non-health professional from United States on 2012-03-15
Patient: female
Reactions: Drug Ineffective, Blast Crisis in Myelogenous Leukaemia, Epistaxis
Drug(s) suspected as cause:
Tasigna
Other drugs received by patient: Clonazepam; Sertraline Hydrochloride; Voriconazole; Amlodipine; Acyclovir; Hydroxyurea; Levothyroxine Sodium; Pantoprazole
Possible Tasigna side effects in
Reported by a physician from Brazil on 2012-02-15
Patient:
Reactions: Death, Blast Crisis in Myelogenous Leukaemia
Adverse event resulted in: death
Drug(s) suspected as cause:
Tasigna
Possible Tasigna side effects in male
Reported by a physician from Japan on 2012-02-08
Patient: male
Reactions: Chronic Myeloid Leukaemia Transformation, Blast Crisis in Myelogenous Leukaemia
Adverse event resulted in: death
Drug(s) suspected as cause:
Tasigna
Other drugs received by patient: Bisoprolol Fumarate; Prednisolone; Cinalong; Rabeprazole Sodium; Usro; Allopurinol
Possible Tasigna side effects in female
Reported by a physician from Malaysia on 2011-12-05
Patient: female
Reactions: Bronchopulmonary Aspergillosis, Haemorrhage, Blast Crisis in Myelogenous Leukaemia, Bone Pain, Acute Leukaemia, Febrile Neutropenia, Neoplasm Progression, Pyrexia, Leukostasis, Neoplasm Malignant, Thrombocytopenia
Adverse event resulted in: death
Drug(s) suspected as cause:
Tasigna
Dosage: 400 mg, bid
Administration route: Oral
Tasigna
Dosage: 400 mg, bid
Administration route: Oral
End date: 2011-09-14
Tasigna
Administration route: Oral
Indication: Chronic Myeloid Leukaemia
Start date: 2011-03-03
Tasigna
Dosage: 200 mg, qd
Administration route: Oral
Other drugs received by patient: Diamicron; Voriconazole; Folic Acid; Oxycontin; Metformin HCL
Possible Tasigna side effects in male
Reported by a physician from Japan on 2011-12-01
Patient: male
Reactions: Chronic Myeloid Leukaemia Transformation, Blast Crisis in Myelogenous Leukaemia
Adverse event resulted in: death
Drug(s) suspected as cause:
Tasigna
Other drugs received by patient: Prednisolone; Usro; Rabeprazole Sodium; Bisoprolol Fumarate; Allopurinol; Cinalong
Possible Tasigna side effects in female
Reported by a physician from Japan on 2011-12-01
Patient: female
Reactions: Drug Ineffective, Blast Crisis in Myelogenous Leukaemia, Platelet Count Decreased, Gene Mutation Identification Test Positive
Drug(s) suspected as cause:
Tasigna
Other drugs received by patient: Lansoprazole; Flomox; Prednisolone; Oncovin
Possible Tasigna side effects in female
Reported by a physician from Malaysia on 2011-10-04
Patient: female
Reactions: Pneumonia Fungal, Haemorrhage, Blast Crisis in Myelogenous Leukaemia, Acute Leukaemia, Bone Pain, Febrile Neutropenia, Leukostasis, Thrombocytopenia
Adverse event resulted in: death
Drug(s) suspected as cause:
Tasigna
Dosage: 400 mg, bid
Administration route: Oral
Indication: Chronic Myeloid Leukaemia
End date: 2011-09-14
Tasigna
Dosage: 200 mg, qd
Administration route: Oral
Other drugs received by patient: Voriconazole; Folic Acid; Metformin HCL; Diamicron; Oxycontin
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