This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Targretin (Bexarotene) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (28)
Death (8)
Disability (2)
Reports by Reaction Type
Dehydration (7),
Lung Infection (3),
Anaemia (3),
Febrile Neutropenia (3),
Haematochezia (3),
Abdominal Pain (2),
Tinnitus (2),
Coagulopathy (2),
Deafness (2),
Cardiac Failure Congestive (2),
Renal Failure Acute (2),
General Physical Health Deterioration (2)
Possible Targretin side effects in 69 year old male
Reported by a physician from Switzerland on 2012-08-27
Patient: 69 year old male
Reactions: Mucosal Inflammation, Agranulocytosis, Glomerular Filtration Rate Decreased, Skin Lesion, Toxic Epidermal Necrolysis, Pancytopenia, Melaena, Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Mefenamic Acid
Dosage: as necessary
Administration route: Oral
Indication: Pain
Start date: 2012-07-05
End date: 2012-07-22
Methotrexate
Indication: Product Used FOR Unknown Indication
Start date: 2012-07-18
Doxorubicin HCL
Dosage: total cumulates dose 880mg
Indication: Product Used FOR Unknown Indication
End date: 2012-07-05
Mefenamic Acid
Dosage: as necessary
Administration route: Oral
Indication: Pyrexia
Start date: 2012-07-05
End date: 2012-07-22
Targretin
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Aspirin
Administration route: Oral
Indication: Product Used FOR Unknown Indication
End date: 2012-07-22
Novalgine
Dosage: as necessary
Administration route: Oral
Indication: Pain
Start date: 2012-07-05
End date: 2012-07-22
Methotrexate
Start date: 2012-07-11
Novalgine
Dosage: as necessary
Administration route: Oral
Indication: Pyrexia
Start date: 2012-07-05
End date: 2012-07-22
Other drugs received by patient: Hydrocortisone; Acetaminophen; Fenofibrate; Levothyroxine Sodium; Metformin HCL; Carvedilol
Possible Targretin side effects in 65 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-06-22
Patient: 65 year old male, weighing 58.0 kg (127.6 pounds)
Reactions: Vomiting, Psychomotor Retardation, Flatulence, General Physical Health Deterioration, Blood Chloride Increased, Disorientation, Hypernatraemia, Haemoconcentration, Hypercalcaemia, Cachexia, Dehydration, Protein Total Increased, Haemoglobin Increased, Renal Failure Acute
Adverse event resulted in: death
Drug(s) suspected as cause:
Targretin
Indication: Mycosis Fungoides
Start date: 2009-11-01
End date: 2011-12-05
Emend
Administration route: Oral
Indication: Vomiting
Start date: 2011-09-01
Roferon-A
Dosage: miu
Indication: Mycosis Fungoides
Start date: 2010-11-01
Other drugs received by patient: Nutritional Supplements; Levothyroxine Sodium; Xerial 50; Amitriptyline Hydrochloride; Lexomil
Possible Targretin side effects in male
Reported by a physician from France on 2012-05-25
Patient: male, weighing 67.0 kg (147.4 pounds)
Reactions: Aphthous Stomatitis, Tinnitus, Deafness, Vertigo
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Targretin
Other drugs received by patient: Levothyroxine Sodium; Valsartan; Fenofibrate
Possible Targretin side effects in female
Reported by a pharmacist from United States on 2012-05-23
Patient: female
Reactions: Abdominal Pain Lower, Blood Urine Present, Decreased Appetite
Drug(s) suspected as cause:
Targretin
Possible Targretin side effects in male
Reported by a physician from Italy on 2012-04-24
Patient: male
Reactions: Skin Exfoliation, Fibrin D Dimer Increased, Pain, Transaminases Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targretin
Possible Targretin side effects in 66 year old female
Reported by a physician from France on 2012-04-12
Patient: 66 year old female
Reactions: Pneumonia Cryptococcal
Drug(s) suspected as cause:
Alemtuzumab
Dosage: unknown
Start date: 2010-07-01
End date: 2010-07-01
Targretin
Dosage: unknown
Administration route: Oral
Start date: 2006-01-01
Chlorambucil
Dosage: unknown
Start date: 2006-01-01
Methotrexate
Dosage: unknown
Start date: 2006-01-01
Alemtuzumab
Dosage: unknown
Start date: 2011-04-01
End date: 2011-04-01
Interferon
Dosage: unknown
Start date: 2006-01-01
Alemtuzumab
Dosage: unknown
Start date: 2009-03-01
End date: 2009-03-01
Possible Targretin side effects in 67 year old male
Reported by a physician from France on 2012-03-21
Patient: 67 year old male
Reactions: Tinnitus, Vertigo, Deafness
Drug(s) suspected as cause:
Targretin
Possible Targretin side effects in male
Reported by a physician from France on 2012-03-12
Patient: male, weighing 65.0 kg (143.0 pounds)
Reactions: Apathy, Dyspepsia, Acne, Hypothyroidism, Depression, Asthenia
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Targretin
Administration route: Oral
Indication: Mycosis Fungoides
Start date: 2011-09-10
End date: 2012-01-23
Targretin
Administration route: Oral
Start date: 2012-01-24
Possible Targretin side effects in male
Reported by a consumer/non-health professional from United States on 2012-02-27
Patient: male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Targretin
Possible Targretin side effects in male
Reported by a physician from United States on 2012-01-31
Patient: male, weighing 67.0 kg (147.4 pounds)
Reactions: Neoplasm Malignant, Anaemia
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Targretin
Other drugs received by patient: Simvastatin; Fish OIL; Tricor; Iron
Possible Targretin side effects in 83 year old female
Reported by a physician from Germany on 2012-01-30
Patient: 83 year old female
Reactions: Cardiac Failure
Drug(s) suspected as cause:
Targretin
Possible Targretin side effects in 65 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-01-27
Patient: 65 year old male
Reactions: Dehydration
Adverse event resulted in: death
Drug(s) suspected as cause:
Targretin
Indication: Mycosis Fungoides
Start date: 2009-11-01
End date: 2011-12-05
Interferon Alfa
Dosage: miu
Indication: Mycosis Fungoides
Start date: 2010-11-01
Emend
Indication: Vomiting
Start date: 2011-09-01
Other drugs received by patient: Levothyroxine Sodium; Amitriptyline HCL; Lexomil; Xerial 50
Possible Targretin side effects in 83 year old female
Reported by a individual with unspecified qualification from Germany on 2012-01-25
Patient: 83 year old female
Reactions: Cardiac Failure
Drug(s) suspected as cause:
Targretin
Possible Targretin side effects in male
Reported by a physician from Germany on 2012-01-09
Patient: male
Reactions: Delirium
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targretin
Administration route: Oral
Targretin
Administration route: Oral
Start date: 2008-01-01
Targretin
Administration route: Oral
Start date: 2005-02-01
End date: 2008-01-01
Other drugs received by patient: Amlodipine; Ramipril; Pantoprazole; Maprotiline; Metoclopramide
Possible Targretin side effects in male
Reported by a physician from France on 2012-01-06
Patient: male, weighing 43.0 kg (94.6 pounds)
Reactions: Dehydration
Adverse event resulted in: death
Drug(s) suspected as cause:
Targretin
Administration route: Oral
Start date: 2011-11-01
End date: 2011-12-05
Roferon-A
Dosage: 300 mui
Start date: 2011-11-01
Emend
Indication: Vomiting
Start date: 2011-09-01
Other drugs received by patient: Dexeryl; Amitriptyline HCL; Lexomil; Levothyroxine Sodium; Xerial 50
Possible Targretin side effects in male
Reported by a physician from France on 2012-01-06
Patient: male, weighing 43.0 kg (94.6 pounds)
Reactions: Dehydration
Adverse event resulted in: death
Drug(s) suspected as cause:
Interferon Alfa
Indication: Mycosis Fungoides
Start date: 2010-11-01
End date: 2011-12-05
Emend
Indication: Vomiting
Start date: 2011-09-01
End date: 2011-11-18
Targretin
Indication: Mycosis Fungoides
Start date: 2009-11-01
End date: 2011-12-05
Other drugs received by patient: Levothyroxine Sodium; Amitriptyline HCL; Dexeryl (France); Lexomil; Xerial (France)
Possible Targretin side effects in male
Reported by a physician from France on 2012-01-05
Patient: male, weighing 43.0 kg (94.6 pounds)
Reactions: Dehydration
Adverse event resulted in: death
Drug(s) suspected as cause:
Interferon Alfa
Indication: Mycosis Fungoides
Emend
Indication: Vomiting
Targretin
Indication: Mycosis Fungoides
End date: 2011-12-05
Other drugs received by patient: Lexomil; Dexeryl (France); Levothyroxine Sodium; Amitriptyline HCL; Xerial (France)
Possible Targretin side effects in 79 year old male
Reported by a physician from United States on 2011-12-20
Patient: 79 year old male, weighing 64.0 kg (140.8 pounds)
Reactions: Lung Infection, Febrile Neutropenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targretin
Administration route: Oral
Start date: 2011-11-12
Decitabine
Indication: Acute Myeloid Leukaemia
Start date: 2011-11-14
End date: 2011-11-18
Other drugs received by patient: Coreg; Multi-Vitamin; Allopurinol; Lovaza; Lisinopril; Zocor
Possible Targretin side effects in female
Reported by a physician from France on 2011-12-05
Patient: female
Reactions: Anaemia, Coagulopathy
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Bicnu
Dosage: unknown
Indication: Mycosis Fungoides
Start date: 2011-03-01
End date: 2011-06-01
Targretin
Dosage: unknown
Administration route: Oral
Indication: Mycosis Fungoides
Start date: 2011-01-01
End date: 2011-01-01
Other drugs received by patient: Fluticasone Propionate; Tiotropium; Clopidogrel; Folic Acid; Albuterol Sulfate Autohaler; FER; Betamethasone Cream; Dexeryl; Almitrine; Atorvastatin; Levothyroxine Sodium; Lyrica; Zolpidem; Trimeprazine TAB; Gluconate DE Zinc; Acetaminophen
Possible Targretin side effects in 69 year old female
Reported by a physician from France on 2011-12-02
Patient: 69 year old female
Reactions: Haematochezia, Dermatitis Atopic, Neoplasm Malignant, Anaemia, Coagulopathy, General Physical Health Deterioration
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Carmustine
Dosage: september to october 2007 stopped for atopic eczema march to june 2011,diluted at 10%
Indication: Mycosis Fungoides
Start date: 2011-03-01
End date: 2011-06-01
Targretin
Dosage: september 2008 for 3 months (also stopped due to inefficiency and dyslipidemia)
Administration route: Oral
Indication: Mycosis Fungoides
Start date: 2011-01-01
End date: 2011-07-27
Other drugs received by patient: Trimeprazine Tartrate; Vectarion; Speciafoldine; Ferrous Sulfate TAB; Diprosone; Zolpidem; Atorvastatin Calcium; Acetaminophen; Dexeryl; Plavix; Fluticasone Propionate / Salmeterol; Spiriva; Rubozinc; Anafranil; Levothyroxine Sodium; Lyrica; Ventolin; Fenofibrate
Possible Targretin side effects in male
Reported by a physician from United States on 2011-12-02
Patient: male, weighing 105.0 kg (231.0 pounds)
Reactions: Haematochezia, Cardiac Failure Congestive
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targretin
Administration route: Oral
Start date: 2011-08-10
End date: 2011-09-06
Targretin
Administration route: Oral
Start date: 2011-10-05
Targretin
Administration route: Oral
Start date: 2011-09-22
End date: 2011-10-04
Possible Targretin side effects in 78 year old male
Reported by a physician from United States on 2011-11-14
Patient: 78 year old male, weighing 99.0 kg (217.8 pounds)
Reactions: Lung Infection, Sepsis, Febrile Neutropenia
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Decitabine
Indication: Acute Myeloid Leukaemia
Start date: 2011-08-17
End date: 2011-10-14
Targretin
Administration route: Oral
Indication: Acute Myeloid Leukaemia
Start date: 2011-08-15
End date: 2011-10-14
Other drugs received by patient: Amitriptyline HCL; Amoxicillin; Fenofibrate; Prilosec; Furosemide; Valaciclovir; Fluconazole; Lipitor; Atenolol; Levothyroxine Sodium; Celebrex; Cipro; Hydromorphone HCL; Hydrochlorothiazide
Possible Targretin side effects in 71 year old male
Reported by a individual with unspecified qualification on 2011-11-07
Patient: 71 year old male
Reactions: Exostosis
Drug(s) suspected as cause:
Targretin
Possible Targretin side effects in male
Reported by a physician from United States on 2011-11-04
Patient: male, weighing 55.0 kg (121.0 pounds)
Reactions: Abdominal Pain, Dehydration
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targretin
Possible Targretin side effects in 78 year old male
Reported by a physician from United States on 2011-11-01
Patient: 78 year old male, weighing 97.0 kg (213.4 pounds)
Reactions: Lung Infection, Febrile Neutropenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targretin
Administration route: Oral
Indication: Acute Myeloid Leukaemia
Start date: 2011-08-15
End date: 2011-10-14
Decitabine
Indication: Acute Myeloid Leukaemia
Start date: 2011-08-17
End date: 2011-10-14
Other drugs received by patient: Fluconazole; Atenolol; Celebrex; Prilosec; Hydromorphone HCL; Fenofibrate; Levothyroxine Sodium; Ciprofloxacin; Valaciclovir; Lipitor; Amoxicillin; Amitriptyline HCL; Furosemide; Hydrochlorothiazide
Possible Targretin side effects in male
Reported by a physician from United States on 2011-10-24
Patient: male, weighing 55.0 kg (121.0 pounds)
Reactions: Abdominal Pain, Dehydration
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targretin
Possible Targretin side effects in female
Reported by a health professional (non-physician/pharmacist) from France on 2011-10-14
Patient: female, weighing 81.0 kg (178.2 pounds)
Reactions: Drug Ineffective, Oedema Peripheral, Erythema, Hypertriglyceridaemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targretin
Administration route: Oral
Targretin
Administration route: Oral
Indication: Mycosis Fungoides
Targretin
Administration route: Oral
Start date: 2011-01-28
Other drugs received by patient: Xerial 10; Lipanthyl 160
Possible Targretin side effects in male
Reported by a physician from United States on 2011-10-10
Patient: male, weighing 105.0 kg (231.0 pounds)
Reactions: Haematochezia, Cardiac Failure Congestive
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Targretin
Administration route: Oral
Start date: 2011-09-22
Targretin
Administration route: Oral
Start date: 2011-08-10
End date: 2011-09-06
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