This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Skelaxin (Metaxalone) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (91)
Death (4)
Reports by Reaction Type
Drug Ineffective (21),
Headache (10),
Abdominal Discomfort (10),
Nausea (10),
Insomnia (10),
Cardiac Disorder (9),
Dizziness (9),
Drug Hypersensitivity (9),
Rash (9),
Pain (8),
Hypersensitivity (7),
Weight Increased (7)
Below are a few examples of reports where side effects / adverse reactions may be related to Skelaxin (Metaxalone). For a complete list or a specific selection of reports, please use the links above.
Possible Skelaxin side effects in 50 year old female
Reported by a physician from United States on 2012-08-27
Patient: 50 year old female
Reactions: Memory Impairment, Ankle Fracture, Feeling Abnormal, Loss of Consciousness
Drug(s) suspected as cause:
MS Contin
Dosage: 30 mg, 2x/day
Flexeril
Dosage: unk
Tramadol HCL
Dosage: 50 mg, every 4 hrs
Avinza
Dosage: 60 mg, 1x/day
Morphine
Dosage: 15 mg, every 4 hrs
Skelaxin
Dosage: unk
Possible Skelaxin side effects in 50 year old female
Reported by a physician from United States on 2012-08-24
Patient: 50 year old female
Reactions: Syncope, Hospitalisation, Sedation, Ankle Fracture
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Avinza
Dosage: 60 mg, am
Indication: Product Used FOR Unknown Indication
MS Contin
Dosage: 30 mg, q12h
Indication: Product Used FOR Unknown Indication
Tramadol HCL
Dosage: 50 mg, q4h
Indication: Product Used FOR Unknown Indication
Morphine Sulfate
Dosage: 15 mg, q4h
Indication: Product Used FOR Unknown Indication
Skelaxin
Dosage: unk
Indication: Product Used FOR Unknown Indication
Flexeril
Indication: Product Used FOR Unknown Indication
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-23
Patient: female
Reactions: Spinal Disorder, Cardiac Disorder
Drug(s) suspected as cause:
Skelaxin
Dosage: 800 mg, 3x/day
Administration route: Oral
Indication: Muscle Spasms
Neurontin
Dosage: 600 mg, 3x/day
Administration route: Oral
Indication: Neuropathy Peripheral
Possible Skelaxin side effects in 52 year old male
Reported by a consumer/non-health professional from United States on 2012-08-22
Patient: 52 year old male, weighing 73.9 kg (162.6 pounds)
Reactions: Atrial Fibrillation
Drug(s) suspected as cause:
Skelaxin
Other drugs received by patient: Percocet; Diazepam
Possible Skelaxin side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-20
Patient: male
Reactions: Hypokinesia, Pain
Drug(s) suspected as cause:
Skelaxin
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-14
Patient: female
Reactions: Confusional State, Agitation, Nightmare, Drug Ineffective, Hyperglycaemia, Rash, Toxicity To Various Agents, Convulsion, Tremor, Weight Increased, Bipolar Disorder, Chest Pain
Drug(s) suspected as cause:
Trileptal
Tizanidine Hydrochloride
Indication: Migraine
Depakote
Darvocet-N 50
Skelaxin
Prozac
Paxil
Lunesta
Beta Blocking Agents
Topamax
Zonegran
Valium
Indication: Agitation
Reglan
Abilify
Elavil
Zyprexa
Tegretol
Requip
MAO Inhibitors
Remeron
Buspar
Adderall
Erythromycin
Ritalin
Effexor
Sumatriptan
Wellbutrin
Tofranil
Zoloft
Daytrana
Antidepressants
Steroids NOS
Desyrel
Neurontin
Sinequan
Seroquel
Pamelor
Other drugs received by patient: Aspirin; Vitamin B-Complex, Other Combinations; Ensure; Caltrate +D; ONE A DAY
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-10
Patient: female
Reactions: Spinal Disorder, Cardiac Disorder
Drug(s) suspected as cause:
Neurontin
Dosage: 600 mg, 3x/day
Administration route: Oral
Indication: Neuropathy Peripheral
Skelaxin
Dosage: 800 mg, 3x/day
Administration route: Oral
Indication: Muscle Spasms
Possible Skelaxin side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-07
Patient: male
Reactions: Drug Ineffective, Neuralgia
Drug(s) suspected as cause:
Skelaxin
Dosage: 800mg
Indication: Neuralgia
Start date: 2009-10-05
End date: 2009-10-01
Gabapentin
Dosage: 300 mg, 2x/day
Indication: Neuralgia
Start date: 2009-11-18
End date: 2009-12-18
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-31
Patient: female, weighing 86.2 kg (189.6 pounds)
Reactions: Malaise, Alopecia
Drug(s) suspected as cause:
Lyrica
Dosage: 150 mg,daily
Administration route: Oral
Indication: Nervous System Disorder
Start date: 2012-03-01
End date: 2012-07-01
Lyrica
Dosage: 150 mg/day
Administration route: Oral
Indication: Spinal Osteoarthritis
Start date: 2012-07-25
Skelaxin
Dosage: 800 mg, daily
Indication: Spinal Osteoarthritis
Start date: 2012-03-01
Possible Skelaxin side effects in
Reported by a consumer/non-health professional from United States on 2012-07-31
Patient:
Reactions: Drug Ineffective
Drug(s) suspected as cause:
Skelaxin
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-31
Patient: female, weighing 83.9 kg (184.6 pounds)
Reactions: Procedural Pain, Hypersensitivity, Contusion, Fall
Drug(s) suspected as cause:
Skelaxin
Administration route: Oral
Indication: Muscle Relaxant Therapy
Start date: 2012-06-11
End date: 2012-06-01
Benadryl
Administration route: Oral
Indication: Urticaria
Start date: 2012-06-20
End date: 2012-06-01
Stelara
Indication: Psoriasis
Start date: 2012-03-01
Hydrocodone
Administration route: Oral
Indication: Procedural Pain
Start date: 2012-06-11
End date: 2012-06-01
Hydroxyzine HCL
Administration route: Oral
Indication: Urticaria
Start date: 2012-06-01
Tramadol Hydrochloride
Administration route: Oral
Indication: Procedural Pain
Start date: 2012-06-11
Corticosteroids
Dosage: given once
Indication: Urticaria
Start date: 2012-06-01
End date: 2012-06-01
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-30
Patient: female, weighing 77.0 kg (169.4 pounds)
Reactions: Weight Decreased, Pain, Musculoskeletal Discomfort, Headache, Hypoaesthesia, Paraesthesia, Muscle Strain, Insomnia, Musculoskeletal Stiffness, Feeling Abnormal
Drug(s) suspected as cause:
Cyclobenzaprine
Indication: Muscle Tightness
Cyclobenzaprine
Dosage: 10 mg, 2x/day
Indication: Brachial Plexopathy
Start date: 2012-05-16
End date: 2012-05-20
Cyclobenzaprine
Indication: Nerve Compression
Lortab
Dosage: unk
Indication: Pain
Start date: 2012-01-01
Skelaxin
Dosage: 800 mg, 4x/day
Indication: Brachial Plexopathy
Start date: 2012-05-20
End date: 2012-01-01
Skelaxin
Indication: Nerve Compression
Skelaxin
Indication: Muscle Tightness
Other drugs received by patient: Klonopin; Klonopin; Effexor XR
Possible Skelaxin side effects in female
Reported by a physician from United States on 2012-07-27
Patient: female
Reactions: Sexual Dysfunction
Drug(s) suspected as cause:
Tramadol Hydrochloride
Dosage: unk
Lyrica
Dosage: unk
Skelaxin
Dosage: unk
Possible Skelaxin side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-23
Patient: male
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Skelaxin
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-20
Patient: female
Reactions: Burning Sensation, Breast Pain, Dyspnoea
Drug(s) suspected as cause:
Aldactone
Dosage: unk
Lyrica
Dosage: unk
Skelaxin
Dosage: unk
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-12
Patient: female, weighing 80.0 kg (176.0 pounds)
Reactions: Intervertebral Disc Protrusion, Arthralgia, Oedema Peripheral
Drug(s) suspected as cause:
Skelaxin
Dosage: 800 mg, 4x/day
Administration route: Oral
Indication: Fibromyalgia
Lyrica
Dosage: 75 mg, 2x/day
Administration route: Oral
Indication: Fibromyalgia
Other drugs received by patient: Cymbalta; Xanax; Oxycontin; Naproxen
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-11
Patient: female, weighing 83.9 kg (184.6 pounds)
Reactions: Procedural Pain, Contusion, Hypersensitivity, Fall
Drug(s) suspected as cause:
Benadryl
Administration route: Oral
Indication: Urticaria
Start date: 2012-06-20
End date: 2012-06-01
Stelara
Indication: Psoriasis
Start date: 2012-03-01
Hydrocodone Bitartrate
Administration route: Oral
Indication: Procedural Pain
Start date: 2012-06-11
End date: 2012-06-01
Hydroxyzine HCL
Administration route: Oral
Indication: Urticaria
Start date: 2012-06-01
Tramadol HCL
Administration route: Oral
Indication: Procedural Pain
Start date: 2012-06-11
Corticosteroids
Dosage: given once
Indication: Urticaria
Start date: 2012-06-01
End date: 2012-06-01
Skelaxin
Administration route: Oral
Indication: Muscle Relaxant Therapy
Start date: 2012-06-11
End date: 2012-06-01
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-11
Patient: female
Reactions: Confusional State, Agitation, Nightmare, Drug Ineffective, Hyperglycaemia, Toxicity To Various Agents, Rash, Convulsion, Tremor, Weight Increased, Bipolar Disorder, Chest Pain
Drug(s) suspected as cause:
Tegretol
Requip
Neurontin
Darvocet-N 50
Remeron
Reglan
Depakote
Imitrex
Zonegran
Erythromycin
Ritalin
Sinequan
Elavil
Adderall 5
Wellbutrin
Pamelor
Prozac
Buspar
Lunesta
Trileptal
Topamax
Beta Blocking Agents
Abilify
Valium
Indication: Agitation
Steroids NOS
Seroquel
MAO Inhibitors
Tofranil
Zoloft
Paxil
Daytrana
Effexor
Skelaxin
Antidepressants
Tizanidine Hydrochloride
Desyrel
Zyprexa
Other drugs received by patient: Vitamin B-Complex, Other Combinations; Caltrate +D; Ensure; ONE A DAY; Aspirin
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-22
Patient: female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Zomig
Dosage: unk
Keflex
Dosage: unk
Skelaxin
Dosage: unk
Clindamycin HCL
Dosage: unk
Tramadol HCL
Dosage: unk
Butorphanol
Dosage: unk
Frova
Dosage: unk
Lyrica
Dosage: unk
Prochlorperazine
Dosage: unk
Talwin
Dosage: unk
Ciprofloxacin HCL
Dosage: unk
Cyproheptadine HCL
Dosage: unk
Benadryl
Dosage: 2% spray
Scopolamine
Dosage: unk
Naproxen
Dosage: unk
Valium
Dosage: unk
Reglan
Dosage: unk
Ketorolac Tromethamine
Dosage: unk
Lidocaine Hydrochloride
Dosage: unk
Lovenox
Dosage: unk
Augmentin '125'
Dosage: unk
Dihydroergotamine Mesylate
Dosage: unk
Celebrex
Dosage: unk
Doxycycline Monohydrate
Dosage: unk
Possible Skelaxin side effects in 66 year old female
Reported by a consumer/non-health professional from United States on 2012-06-11
Patient: 66 year old female
Reactions: Hypersensitivity
Adverse event resulted in: death
Drug(s) suspected as cause:
Skelaxin
Dilantin
Cytotec
Dosage: unk
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-08
Patient: female
Reactions: Agitation, Confusional State, Nightmare, Drug Ineffective, Hyperglycaemia, Rash, Toxicity To Various Agents, Tremor, Convulsion, Weight Increased, Bipolar Disorder, Chest Pain
Drug(s) suspected as cause:
Skelaxin
Elavil
Prozac
Reglan
Tegretol
Depakote
Steroids NOS
Zonegran
MAO Inhibitors
Pamelor
Paxil
Requip
Sinequan
Abilify
Remeron
Tofranil
Buspar
Topamax
Imitrex
Darvocet-N 50
Seroquel
Tizanidine Hydrochloride
Adderall 5
Neurontin
Beta Blocking Agents
Desyrel
Zoloft
Ritalin
Trileptal
Valium
Indication: Agitation
Lunesta
Daytrana
Erythromycin
Effexor
Antidepressants
Wellbutrin
Zyprexa
Other drugs received by patient: Aspirin; Caltrate +D; ONE A DAY; Vitamin B-Complex, Other Combinations; Ensure
Possible Skelaxin side effects in 66 year old female
Reported by a consumer/non-health professional from United States on 2012-06-07
Patient: 66 year old female
Reactions: Hypersensitivity
Adverse event resulted in: death
Drug(s) suspected as cause:
Skelaxin
Dilantin
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-07
Patient: female, weighing 80.0 kg (176.0 pounds)
Reactions: Intervertebral Disc Protrusion, Arthralgia, Oedema Peripheral
Drug(s) suspected as cause:
Skelaxin
Dosage: 800 mg, 4x/day
Administration route: Oral
Indication: Fibromyalgia
Lyrica
Dosage: 75 mg, 2x/day
Administration route: Oral
Indication: Fibromyalgia
Other drugs received by patient: Xanax; Cymbalta; Naproxen; Oxycontin
Possible Skelaxin side effects in female
Reported by a physician from United States on 2012-06-06
Patient: female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Daypro
Dosage: unk
Erythromycin
Dosage: unk
Tetracycline Hydrochloride
Dosage: unk
Chondroitin / Glucosamine
Dosage: unk
Mobic
Dosage: unk
Azithromycin
Dosage: unk
Chloroquine
Dosage: unk
Ceftin
Dosage: unk
Claritin-D
Dosage: unk
Plaquenil
Dosage: unk
Sudafed 12 Hour
Dosage: unk
Skelaxin
Dosage: unk
Methotrexate Sodium
Dosage: unk
Parafon Forte
Dosage: unk
Ultram
Dosage: unk
Prednisone TAB
Dosage: unk
Lincocin
Dosage: unk
Ciprofloxacin
Dosage: unk
Benzylpenicillin Potassium
Dosage: unk
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-05
Patient: female, weighing 78.9 kg (173.6 pounds)
Reactions: Vomiting, Nausea, Injection Site Haemorrhage, Pain, Musculoskeletal Chest Pain, Headache, Cardiac Disorder, Abdominal Discomfort, Fungal Oesophagitis, Gastrointestinal Fungal Infection, Dizziness
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Remicade
Dosage: 1 in 8 week
Indication: Rheumatoid Arthritis
Start date: 2011-09-22
End date: 2011-12-29
Skelaxin
Dosage: 800 mg, qd
Indication: Bone Disorder
Start date: 2012-01-01
Other drugs received by patient: Calcium; Calcium Carbonate; Reclast; Citracal + D
Possible Skelaxin side effects in 59 year old female
Reported by a individual with unspecified qualification from United States on 2012-06-05
Patient: 59 year old female, weighing 65.3 kg (143.7 pounds)
Reactions: Pharyngeal Oedema, Swelling Face, Pruritus, Dyspnoea, Oedema Peripheral
Drug(s) suspected as cause:
Skelaxin
Dosage: 1 tab 800 mg 1 at bedtime oral
Administration route: Oral
Start date: 2012-02-11
End date: 2012-02-15
Medrol
Dosage: dose pk on 3rd day reaction oral
Administration route: Oral
Indication: Accident
Start date: 2012-02-10
End date: 2012-02-12
Medrol
Dosage: dose pk on 3rd day reaction oral
Administration route: Oral
Indication: Head Injury
Start date: 2012-02-10
End date: 2012-02-12
Possible Skelaxin side effects in female
Reported by a consumer/non-health professional from United States on 2012-06-04
Patient: female, weighing 78.9 kg (173.6 pounds)
Reactions: Vomiting, Nausea, Injection Site Haemorrhage, Pain, Musculoskeletal Chest Pain, Headache, Cardiac Disorder, Abdominal Discomfort, Fungal Oesophagitis, Gastrointestinal Fungal Infection, Dizziness
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Skelaxin
Dosage: 800 mg, qd
Indication: Bone Disorder
Start date: 2012-01-01
Remicade
Dosage: 1 in 8 week
Indication: Rheumatoid Arthritis
Start date: 2011-09-22
End date: 2011-12-29
Other drugs received by patient: Citracal + D; Reclast; Calcium; Calcium Carbonate
Possible Skelaxin side effects in 66 year old female
Reported by a consumer/non-health professional from United States on 2012-06-01
Patient: 66 year old female
Reactions: Hypersensitivity
Adverse event resulted in: death
Drug(s) suspected as cause:
Skelaxin
Possible Skelaxin side effects in 46 year old female
Reported by a physician from United States on 2012-05-30
Patient: 46 year old female, weighing 54.4 kg (119.7 pounds)
Reactions: Blood Alkaline Phosphatase Increased, Blood Bilirubin Increased, Nausea, Alanine Aminotransferase Increased, Blood Calcium Decreased, Anxiety, Alcohol Intolerance, Drug Tolerance Decreased, Malaise, Blood Potassium Decreased, Aspartate Aminotransferase Increased, Asthenia, Blood Glucose Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Skelaxin
Possible Skelaxin side effects in female
Reported by a physician from United States on 2012-05-29
Patient: female, weighing 71.7 kg (157.6 pounds)
Reactions: Dyspnoea, Drug Hypersensitivity
Drug(s) suspected as cause:
Lyrica
Dosage: unk
Indication: Fibromyalgia
Paxil
Dosage: unk
Indication: Mental Disorder
Codeine Sulfate
Dosage: unk
Indication: Gallbladder Pain
Aspirin
Dosage: unk
Prozac
Dosage: unk
Indication: Mental Disorder
Skelaxin
Dosage: unk
Indication: Fibromyalgia
Potassium Penicillin G
Dosage: unk
Indication: Cholecystitis Infective
Ultram
Dosage: unk
Indication: Fibromyalgia
Other drugs received by patient: Seroquel; Buspar
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