Index of reports
> Cases with Torsade DE Pointes (14)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Sevoflurane where reactions include torsade de pointes. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Sevoflurane side effects in 70 year old female
Reported by a physician from Japan on 2012-08-02
Patient: 70 year old female, weighing 50.0 kg (110.0 pounds)
Reactions: Electrocardiogram QT Prolonged, Torsade DE Pointes, Drug Ineffective
Drug(s) suspected as cause:
Isoflurane
Dosage: 1.0-1.5%
Indication: Anaesthesia
Lidocaine
Indication: Ventricular Extrasystoles
Sevoflurane
Indication: Anaesthesia
Other drugs received by patient: Hydroxyzine; Propofol; Nitrous Oxide; Oxygen; Atropine; Vecuronium Bromide; Levodopa
Possible Sevoflurane side effects in female
Reported by a health professional (non-physician/pharmacist) from Japan on 2011-12-08
Patient: female, weighing 58.0 kg (127.6 pounds)
Reactions: Torsade DE Pointes
Drug(s) suspected as cause:
Sevoflurane
Other drugs received by patient: Fentanyl; Propofol; Fentanyl; Fentanyl; Nitrous Oxide; Vecuronium Bromide; Oxygen; Diuretics
Possible Sevoflurane side effects in 69 year old female
Reported by a health professional (non-physician/pharmacist) from Netherlands on 2011-12-07
Patient: 69 year old female, weighing 84.0 kg (184.8 pounds)
Reactions: Torsade DE Pointes
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Acetaminophen
Dosage: 1000 mg
Administration route: Oral
Amlodipine
Dosage: 5 mg
Esomeprazole Sodium
Dosage: 40 mg
Fluconazole
Piperacillin and Tazobactam
Dosage: 4500 mg
Propofol
Indication: Induction of Anaesthesia
Sevoflurane
Indication: Maintenance of Anaesthesia
Sufentanil Citrate
Indication: Induction of Anaesthesia
Possible Sevoflurane side effects in 69 year old female
Reported by a health professional (non-physician/pharmacist) from Netherlands on 2011-12-01
Patient: 69 year old female
Reactions: Torsade DE Pointes, Drug Interaction
Drug(s) suspected as cause:
Fluconazole
Dosage: unk
Indication: Product Used FOR Unknown Indication
Sevoflurane
Dosage: unk
Indication: Maintenance of Anaesthesia
Possible Sevoflurane side effects in female
Reported by a physician from Japan on 2011-11-28
Patient: female, weighing 55.3 kg (121.7 pounds)
Reactions: Torsade DE Pointes, Heart Rate Decreased, Extrasystoles, Blood Pressure Decreased, Arrhythmia
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Ephedrine Hydrochloride
Indication: Product Used FOR Unknown Indication
Start date: 2011-04-05
Sevoflurane
Indication: Anaesthesia
Start date: 2011-04-05
End date: 2011-04-05
Sevoflurane
Start date: 2011-04-05
End date: 2011-04-05
Other drugs received by patient: Rocuronium Bromide; Propofol
Possible Sevoflurane side effects in 55 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-17
Patient: 55 year old female
Reactions: Torsade DE Pointes, Electrocardiogram QT Prolonged, Extrasystoles, Condition Aggravated
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Fentanyl
Dosage: 0.1 mg, unk
Indication: Induction of Anaesthesia
Nitrous Oxide
Dosage: 3 l/min of nitrous oxide
Indication: Maintenance of Anaesthesia
Propofol
Dosage: 100 mg, unknown
Indication: Induction of Anaesthesia
Sevoflurane
Dosage: 1to 1.5 % of sevoflurane
Indication: Maintenance of Anaesthesia
Vecuronium Bromide
Dosage: 8 mg, unk
Indication: Induction of Anaesthesia
Possible Sevoflurane side effects in 80 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-03
Patient: 80 year old female, weighing 55.0 kg (121.0 pounds)
Reactions: Torsade DE Pointes, Ventricular Arrhythmia, Bradycardia, Long QT Syndrome
Drug(s) suspected as cause:
Atropine
Indication: Product Used FOR Unknown Indication
Remifentanil
Dosage: 0.5 mg/kg
Indication: Induction and Maintenance of Anaesthesia
Rocuronium Bromide
Indication: Induction of Anaesthesia
Sevoflurane
Dosage: 0.8-1%
Indication: Maintenance of Anaesthesia
Thiamylal
Indication: Induction of Anaesthesia
Other drugs received by patient: Atropine; Antiarrhythmics; Dopamine HCL; Oxygen
Possible Sevoflurane side effects in 80 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-01
Patient: 80 year old female, weighing 54.9 kg (120.8 pounds)
Reactions: Torsade DE Pointes, Ventricular Arrhythmia
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Atropine
Dosage: unk
Remifentanil
Dosage: unk, unk
Indication: Anaesthesia
Rocuronium Bromide
Dosage: unk, unk
Indication: Induction of Anaesthesia
Sevoflurane
Dosage: unk, unk
Indication: Maintenance of Anaesthesia
Thiamylal
Dosage: unk, unk
Indication: Induction of Anaesthesia
Other drugs received by patient: Oxygen
Possible Sevoflurane side effects in 69 year old female
Reported by a physician from Netherlands on 2011-10-21
Patient: 69 year old female, weighing 84.0 kg (184.8 pounds)
Reactions: Torsade DE Pointes, Long QT Syndrome
Drug(s) suspected as cause:
Fluconazole
Dosage: maximum of 100 mg infused
Indication: Bone Abscess
Sevoflurane
Dosage: 1.5-2% end expired
Indication: Maintenance of Anaesthesia
Other drugs received by patient: Piperacillin and Tazobactam; Esomeprazole Sodium; Propofol; AIR; Acetaminophen; Sufentanil Citrate; Amlodipine; Oxygen
Possible Sevoflurane side effects in 68 year old female
Reported by a physician from Netherlands on 2011-10-20
Patient: 68 year old female, weighing 84.0 kg (184.8 pounds)
Reactions: Torsade DE Pointes, Cardiac Arrest
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Fluconazole
Indication: Product Used FOR Unknown Indication
Start date: 2009-06-15
End date: 2009-06-17
Sevoflurane
Indication: Induction of Anaesthesia
Start date: 2009-06-17
End date: 2009-06-17
Other drugs received by patient: Propofol; Piperacillin and Tazobactam; Sufentanil Citrate; Amlodipine; Nexium; Spironolactone; Acetaminophen; Sintrom
Possible Sevoflurane side effects in 55 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-18
Patient: 55 year old female
Reactions: Electrocardiogram QT Prolonged, Torsade DE Pointes, Extrasystoles, Condition Aggravated
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Fentanyl
Dosage: unk
Indication: Induction of Anaesthesia
Nitrous Oxide
Dosage: 50% in oxygen
Indication: Maintenance of Anaesthesia
Propofol
Dosage: unk
Indication: Induction of Anaesthesia
Sevoflurane
Dosage: 1- 1.5 %
Indication: Maintenance of Anaesthesia
Vecuronium Bromide
Dosage: unk
Indication: Induction of Anaesthesia
Possible Sevoflurane side effects in 80 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-17
Patient: 80 year old female, weighing 55.0 kg (121.0 pounds)
Reactions: Torsade DE Pointes, Ventricular Arrhythmia
Drug(s) suspected as cause:
Atropine
Indication: Product Used FOR Unknown Indication
Remifentanil
Dosage: 0.5 mug/sup-1/min/sup-1/
Indication: Induction and Maintenance of Anaesthesia
Rocuronium Bromide
Indication: Induction of Anaesthesia
Sevoflurane
Indication: Maintenance of Anaesthesia
Thiamylal
Indication: Induction of Anaesthesia
Other drugs received by patient: Oxygen
Possible Sevoflurane side effects in 55 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-12
Patient: 55 year old female, weighing 58.0 kg (127.6 pounds)
Reactions: Torsade DE Pointes, Electrocardiogram QT Prolonged, Ventricular Extrasystoles, Extrasystoles
Drug(s) suspected as cause:
Sevoflurane
Other drugs received by patient: Fentanyl; Diuretics; Nitrous Oxide; Oxygen; Propofol; Fentanyl; Vecuronium Bromide
Possible Sevoflurane side effects in 60 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-10
Patient: 60 year old female
Reactions: Torsade DE Pointes
Drug(s) suspected as cause:
Sevoflurane
Other drugs received by patient: Oxygen; Atenolol; Epidural Analgesics; Propofol; Fentanyl; Rocuronium Bromide; Remifentanil
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