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Sevoflurane (Sevoflurane) - Torsade DE Pointes - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Torsade DE Pointes (14)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Sevoflurane where reactions include torsade de pointes. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Sevoflurane side effects in 70 year old female

Reported by a physician from Japan on 2012-08-02

Patient: 70 year old female, weighing 50.0 kg (110.0 pounds)

Reactions: Electrocardiogram QT Prolonged, Torsade DE Pointes, Drug Ineffective

Drug(s) suspected as cause:
Isoflurane
    Dosage: 1.0-1.5%
    Indication: Anaesthesia

Lidocaine
    Indication: Ventricular Extrasystoles

Sevoflurane
    Indication: Anaesthesia

Other drugs received by patient: Hydroxyzine; Propofol; Nitrous Oxide; Oxygen; Atropine; Vecuronium Bromide; Levodopa



Possible Sevoflurane side effects in female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-12-08

Patient: female, weighing 58.0 kg (127.6 pounds)

Reactions: Torsade DE Pointes

Drug(s) suspected as cause:
Sevoflurane

Other drugs received by patient: Fentanyl; Propofol; Fentanyl; Fentanyl; Nitrous Oxide; Vecuronium Bromide; Oxygen; Diuretics



Possible Sevoflurane side effects in 69 year old female

Reported by a health professional (non-physician/pharmacist) from Netherlands on 2011-12-07

Patient: 69 year old female, weighing 84.0 kg (184.8 pounds)

Reactions: Torsade DE Pointes

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Acetaminophen
    Dosage: 1000 mg
    Administration route: Oral

Amlodipine
    Dosage: 5 mg

Esomeprazole Sodium
    Dosage: 40 mg

Fluconazole

Piperacillin and Tazobactam
    Dosage: 4500 mg

Propofol
    Indication: Induction of Anaesthesia

Sevoflurane
    Indication: Maintenance of Anaesthesia

Sufentanil Citrate
    Indication: Induction of Anaesthesia



Possible Sevoflurane side effects in 69 year old female

Reported by a health professional (non-physician/pharmacist) from Netherlands on 2011-12-01

Patient: 69 year old female

Reactions: Torsade DE Pointes, Drug Interaction

Drug(s) suspected as cause:
Fluconazole
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Sevoflurane
    Dosage: unk
    Indication: Maintenance of Anaesthesia



Possible Sevoflurane side effects in female

Reported by a physician from Japan on 2011-11-28

Patient: female, weighing 55.3 kg (121.7 pounds)

Reactions: Torsade DE Pointes, Heart Rate Decreased, Extrasystoles, Blood Pressure Decreased, Arrhythmia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Ephedrine Hydrochloride
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-04-05

Sevoflurane
    Indication: Anaesthesia
    Start date: 2011-04-05
    End date: 2011-04-05

Sevoflurane
    Start date: 2011-04-05
    End date: 2011-04-05

Other drugs received by patient: Rocuronium Bromide; Propofol



Possible Sevoflurane side effects in 55 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-17

Patient: 55 year old female

Reactions: Torsade DE Pointes, Electrocardiogram QT Prolonged, Extrasystoles, Condition Aggravated

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Fentanyl
    Dosage: 0.1 mg, unk
    Indication: Induction of Anaesthesia

Nitrous Oxide
    Dosage: 3 l/min of nitrous oxide
    Indication: Maintenance of Anaesthesia

Propofol
    Dosage: 100 mg, unknown
    Indication: Induction of Anaesthesia

Sevoflurane
    Dosage: 1to 1.5 % of sevoflurane
    Indication: Maintenance of Anaesthesia

Vecuronium Bromide
    Dosage: 8 mg, unk
    Indication: Induction of Anaesthesia



Possible Sevoflurane side effects in 80 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-03

Patient: 80 year old female, weighing 55.0 kg (121.0 pounds)

Reactions: Torsade DE Pointes, Ventricular Arrhythmia, Bradycardia, Long QT Syndrome

Drug(s) suspected as cause:
Atropine
    Indication: Product Used FOR Unknown Indication

Remifentanil
    Dosage: 0.5 mg/kg
    Indication: Induction and Maintenance of Anaesthesia

Rocuronium Bromide
    Indication: Induction of Anaesthesia

Sevoflurane
    Dosage: 0.8-1%
    Indication: Maintenance of Anaesthesia

Thiamylal
    Indication: Induction of Anaesthesia

Other drugs received by patient: Atropine; Antiarrhythmics; Dopamine HCL; Oxygen



Possible Sevoflurane side effects in 80 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-11-01

Patient: 80 year old female, weighing 54.9 kg (120.8 pounds)

Reactions: Torsade DE Pointes, Ventricular Arrhythmia

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Atropine
    Dosage: unk

Remifentanil
    Dosage: unk, unk
    Indication: Anaesthesia

Rocuronium Bromide
    Dosage: unk, unk
    Indication: Induction of Anaesthesia

Sevoflurane
    Dosage: unk, unk
    Indication: Maintenance of Anaesthesia

Thiamylal
    Dosage: unk, unk
    Indication: Induction of Anaesthesia

Other drugs received by patient: Oxygen



Possible Sevoflurane side effects in 69 year old female

Reported by a physician from Netherlands on 2011-10-21

Patient: 69 year old female, weighing 84.0 kg (184.8 pounds)

Reactions: Torsade DE Pointes, Long QT Syndrome

Drug(s) suspected as cause:
Fluconazole
    Dosage: maximum of 100 mg infused
    Indication: Bone Abscess

Sevoflurane
    Dosage: 1.5-2% end expired
    Indication: Maintenance of Anaesthesia

Other drugs received by patient: Piperacillin and Tazobactam; Esomeprazole Sodium; Propofol; AIR; Acetaminophen; Sufentanil Citrate; Amlodipine; Oxygen



Possible Sevoflurane side effects in 68 year old female

Reported by a physician from Netherlands on 2011-10-20

Patient: 68 year old female, weighing 84.0 kg (184.8 pounds)

Reactions: Torsade DE Pointes, Cardiac Arrest

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Fluconazole
    Indication: Product Used FOR Unknown Indication
    Start date: 2009-06-15
    End date: 2009-06-17

Sevoflurane
    Indication: Induction of Anaesthesia
    Start date: 2009-06-17
    End date: 2009-06-17

Other drugs received by patient: Propofol; Piperacillin and Tazobactam; Sufentanil Citrate; Amlodipine; Nexium; Spironolactone; Acetaminophen; Sintrom



Possible Sevoflurane side effects in 55 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-18

Patient: 55 year old female

Reactions: Electrocardiogram QT Prolonged, Torsade DE Pointes, Extrasystoles, Condition Aggravated

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Fentanyl
    Dosage: unk
    Indication: Induction of Anaesthesia

Nitrous Oxide
    Dosage: 50% in oxygen
    Indication: Maintenance of Anaesthesia

Propofol
    Dosage: unk
    Indication: Induction of Anaesthesia

Sevoflurane
    Dosage: 1- 1.5 %
    Indication: Maintenance of Anaesthesia

Vecuronium Bromide
    Dosage: unk
    Indication: Induction of Anaesthesia



Possible Sevoflurane side effects in 80 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-17

Patient: 80 year old female, weighing 55.0 kg (121.0 pounds)

Reactions: Torsade DE Pointes, Ventricular Arrhythmia

Drug(s) suspected as cause:
Atropine
    Indication: Product Used FOR Unknown Indication

Remifentanil
    Dosage: 0.5 mug/sup-1/min/sup-1/
    Indication: Induction and Maintenance of Anaesthesia

Rocuronium Bromide
    Indication: Induction of Anaesthesia

Sevoflurane
    Indication: Maintenance of Anaesthesia

Thiamylal
    Indication: Induction of Anaesthesia

Other drugs received by patient: Oxygen



Possible Sevoflurane side effects in 55 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-12

Patient: 55 year old female, weighing 58.0 kg (127.6 pounds)

Reactions: Torsade DE Pointes, Electrocardiogram QT Prolonged, Ventricular Extrasystoles, Extrasystoles

Drug(s) suspected as cause:
Sevoflurane

Other drugs received by patient: Fentanyl; Diuretics; Nitrous Oxide; Oxygen; Propofol; Fentanyl; Vecuronium Bromide



Possible Sevoflurane side effects in 60 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2011-10-10

Patient: 60 year old female

Reactions: Torsade DE Pointes

Drug(s) suspected as cause:
Sevoflurane

Other drugs received by patient: Oxygen; Atenolol; Epidural Analgesics; Propofol; Fentanyl; Rocuronium Bromide; Remifentanil

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