This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Rebif (Interferon Beta-1A) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (5972)
Death (182)
Life Threatening Events (109)
Disability (167)
Reports by Reaction Type
Injection Site Erythema (716),
Multiple Sclerosis Relapse (680),
Injection Site Pain (519),
Influenza Like Illness (489),
Fall (424),
Fatigue (364),
Headache (363),
Injection Site Haematoma (335),
Pain (268),
Depression (265),
Urinary Tract Infection (265),
Hypoaesthesia (221)
Below are a few examples of reports where side effects / adverse reactions may be related to Rebif (Interferon Beta-1A). For a complete list or a specific selection of reports, please use the links above.
Possible Rebif side effects in male
Reported by a physician from Brazil on 2012-08-27
Patient: male
Reactions: Labyrinthitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in female
Reported by a consumer/non-health professional from Brazil on 2012-08-27
Patient: female
Reactions: Angina Pectoris, Stent Placement, Cardiovascular Disorder, Multiple Sclerosis Relapse
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Diltiazem; Isosorbide; Atorvastatin; Losartan Potassium; Vastarel; Aspirin; Clopidegrel
Possible Rebif side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: male
Reactions: Injection Site Pain, Hernia, Arthritis
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: TAR Shampoo with INL Rinse
Possible Rebif side effects in female
Reported by a consumer/non-health professional from Brazil on 2012-08-27
Patient: female
Reactions: Intervertebral Disc Protrusion, Paraesthesia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Ibuprofen
Possible Rebif side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female
Reactions: Rectal Haemorrhage, Deep Vein Thrombosis
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Coumadin
Indication: Thrombosis
Rebif
Indication: Multiple Sclerosis
Start date: 2009-11-19
End date: 2010-01-01
Rebif
Start date: 2010-01-01
Possible Rebif side effects in female
Reported by a health professional (non-physician/pharmacist) from Ireland on 2012-08-27
Patient: female
Reactions: Syncope, Chills, Headache, Treatment Noncompliance, Lower Respiratory Tract Infection, Feeling Cold, Cough
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ciprager
Indication: Depression
Diamicron MR
Indication: Blood Glucose
Januvia
Indication: Blood Glucose
Rebif
Indication: Relapsing-Remitting Multiple Sclerosis
Start date: 2011-07-18
End date: 2012-02-06
Rebif
Start date: 2012-03-01
Other drugs received by patient: Lopraz (Omeprazole); Fluticasone Propionate / Salmeterol; Epilin (Epilim); Florinef; Valproic Acid; Cardiac Medication
Possible Rebif side effects in female
Reported by a consumer/non-health professional from United Kingdom on 2012-08-27
Patient: female
Reactions: Optic Neuritis
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female
Reactions: Nausea, Constipation, Fatigue, Injection Site Erythema, Diarrhoea, Fibromyalgia, Depression, Hypertension, Influenza Like Illness
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Indication: Multiple Sclerosis
Start date: 2010-07-27
Rebif
Possible Rebif side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-27
Patient: male
Reactions: Injection Site Induration, Hypothyroidism, Injection Site Warmth, Multiple Sclerosis Relapse, Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Plavix; Odansetron; Promethazine
Possible Rebif side effects in 32 year old female
Reported by a consumer/non-health professional from France on 2012-08-27
Patient: 32 year old female
Reactions: Injection Site Haematoma, Urinary Tract Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Cortisone Acetate
Possible Rebif side effects in female
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-27
Patient: female
Reactions: Optic Neuritis
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Crestor; Vitamin D; Irbesartan
Possible Rebif side effects in 47 year old female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: 47 year old female, weighing 49.0 kg (107.8 pounds)
Reactions: Abnormal Dreams, Burning Sensation, Thinking Abnormal, Nausea, Trigeminal Neuralgia, Insomnia, Emotional Disorder, Multiple Sclerosis, Crying
Drug(s) suspected as cause:
Betaseron
Dosage: unk
Indication: Multiple Sclerosis
Start date: 2004-01-01
Betaseron
Indication: Trigeminal Neuralgia
Chantix
Dosage: unk
Administration route: Oral
Indication: Smoking Cessation Therapy
Chantix
Dosage: unk
Administration route: Oral
Chantix
Dosage: unk
Administration route: Oral
Neurontin
Dosage: 600 mg, daily
Administration route: Oral
Indication: Multiple Sclerosis
Start date: 2004-01-01
Neurontin
Indication: Trigeminal Neuralgia
Rebif
Dosage: 44 ug, 3x/week
Indication: Multiple Sclerosis
Start date: 2004-01-01
Rebif
Indication: Trigeminal Neuralgia
Other drugs received by patient: Hydrocodone; Estradiol
Possible Rebif side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female
Reactions: Fatigue, Injection Site Erythema, Type 2 Diabetes Mellitus, Injection Site Haematoma, Pain, Cognitive Disorder
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female, weighing 64.0 kg (140.8 pounds)
Reactions: White Blood Cell Count Decreased, Injection Site Erythema, Systemic Lupus Erythematosus, Injection Site Pain, Lymphoma, Type 1 Diabetes Mellitus, Influenza Like Illness
Drug(s) suspected as cause:
Rebif
Indication: Multiple Sclerosis
End date: 2010-02-01
Rebif
Start date: 2012-03-07
Other drugs received by patient: Steroids
Possible Rebif side effects in male
Reported by a consumer/non-health professional from Brazil on 2012-08-27
Patient: male
Reactions: Back Pain, Dyspnoea, Haemorrhage, Drug Ineffective, Pain, Headache, Erythema, Suicidal Ideation, Multiple Sclerosis Relapse, Pruritus Generalised, Oral Discomfort, Visual Impairment, Nervousness
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Motilium; Calcium; Dorflex; Alprazolam
Possible Rebif side effects in female
Reported by a consumer/non-health professional from Brazil on 2012-08-27
Patient: female
Reactions: Glaucoma
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female
Reactions: Crohn's Disease, Liver Disorder
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female
Reactions: Type 2 Diabetes Mellitus, Injection Site Pain, Headache, Muscle Rigidity, Muscle Spasms
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in male
Reported by a consumer/non-health professional from Brazil on 2012-08-27
Patient: male
Reactions: Glaucoma
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Dorflex
Possible Rebif side effects in 46 year old male
Reported by a consumer/non-health professional from France on 2012-08-27
Patient: 46 year old male
Reactions: Drug-Induced Liver Injury
Drug(s) suspected as cause:
Allopurinol
Indication: Gout
Colchicine
Indication: Gout
Rebif
Indication: Product Used FOR Unknown Indication
Start date: 1996-01-01
End date: 2012-08-16
Possible Rebif side effects in female
Reported by a physician from Italy on 2012-08-27
Patient: female
Reactions: Proteinuria, Nephroangiosclerosis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Levothyroxine Sodium
Possible Rebif side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female
Reactions: Thyroxine Decreased, Hepatic Enzyme Increased
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-27
Patient: female
Reactions: Blood Pressure Increased, Urinary Tract Infection, Encephalopathy, Pyrexia, Multiple Sclerosis, Neuralgia, Injection Site Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Indication: Multiple Sclerosis
Start date: 2006-05-17
End date: 2006-12-05
Rebif
Start date: 2007-10-05
End date: 2012-07-01
Possible Rebif side effects in female
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-27
Patient: female
Reactions: Anaemia, Thrombocytopenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in female
Reported by a consumer/non-health professional from Canada on 2012-08-27
Patient: female
Reactions: Weight Decreased, Injection Site Haemorrhage, Injection Site Pain, Cerebrovascular Insufficiency
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: female, weighing 50.0 kg (110.0 pounds)
Reactions: Cardiac Septal Defect, Muscle Strain, Hypersensitivity, Injection Site Haematoma, Injection Site Induration, Injection Site Pain
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Naproxen
Possible Rebif side effects in female
Reported by a physician from United States on 2012-08-27
Patient: female, weighing 88.0 kg (193.6 pounds)
Reactions: Injection Site Discolouration, Injection Site Mass, Pain in Extremity, Axillary Mass, Fall, Ligament Sprain
Drug(s) suspected as cause:
Rebif
Possible Rebif side effects in 72 year old female
Reported by a consumer/non-health professional from Greece on 2012-08-27
Patient: 72 year old female
Reactions: HIP Fracture, Fall
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Miorel; Modafanil; Cymbalta; Vitamin TAB
Possible Rebif side effects in female
Reported by a consumer/non-health professional from Brazil on 2012-08-27
Patient: female
Reactions: Weight Increased, Hypoaesthesia, Headache, Paraesthesia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Acetaminophen; Escitalopram; Trilax
Possible Rebif side effects in female
Reported by a consumer/non-health professional from Brazil on 2012-08-27
Patient: female
Reactions: Fall, Multiple Sclerosis Relapse
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Rebif
Other drugs received by patient: Acetaminophen; Ascorbic Acid
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