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Pyrazinamide (Pyrazinamide) - Alanine Aminotransferase Increased - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Alanine Aminotransferase Increased (8)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Pyrazinamide where reactions include alanine aminotransferase increased. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Pyrazinamide side effects in male

Reported by a physician from Brazil on 2012-07-26

Patient: male

Reactions: Nausea, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased

Drug(s) suspected as cause:
Acetaminophen
    Dosage: unk
    Indication: Headache
    Start date: 2010-12-13

Acyclovir
    Dosage: 4000 unk, unk
    Indication: Herpes Zoster
    Start date: 2010-12-18
    End date: 2010-12-25

Azithromycin
    Dosage: 1500 unk, unk
    Indication: Prophylaxis
    Start date: 2010-11-04

Bactrim
    Dosage: 400 mg, unk
    Indication: Prophylaxis
    Start date: 2010-12-13

Efavirenz
    Dosage: unk
    Indication: HIV Infection
    Start date: 2010-11-25
    End date: 2011-01-01

Efavirenz
    Dosage: unk

Ethambutol Hydrochloride
    Dosage: unk
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2010-12-27

Ethambutol Hydrochloride
    Dosage: unk

Isoniazid
    Dosage: unk
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2011-01-01

Lamivudine
    Dosage: 300 mg, qd
    Indication: HIV Infection
    Start date: 2010-11-25

Prednisone
    Dosage: 40 mg, unk
    Indication: Meningitis
    Start date: 2010-10-16

Pyrazinamide
    Dosage: 1200 mg, unk
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2010-12-27

Rifampin
    Dosage: 450 mg, qd
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2011-01-01

Rifampin
    Dosage: 450 mg, qd

Tenofovir Disoproxil Fumarate
    Indication: HIV Infection



Possible Pyrazinamide side effects in 64 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11

Patient: 64 year old female

Reactions: Jaundice, Alanine Aminotransferase Increased, Drug Intolerance, Acute Hepatic Failure

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Pyrazinamide
    Indication: Meningitis Tuberculous

Rifampicin
    Indication: Meningitis Tuberculous

Other drugs received by patient: Ethambutol Hydrochloride; Moxifloxacin; Isoniazid



Possible Pyrazinamide side effects in 20 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11

Patient: 20 year old male

Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Acute Hepatic Failure, Liver Transplant Rejection, Drug Interaction

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Pyrazinamide

Other drugs received by patient possibly interacting with the suspect drug:
Azathioprine
    Indication: Immunosuppression

Cyclosporine
    Indication: Immunosuppression

Prednisolone
    Indication: Immunosuppression

Rifampicin
    Indication: Pulmonary Tuberculosis

Rifampicin

Other drugs received by patient: Ethambutol Hydrochloride; Isoniazid; Rifampicin; Streptomycin; Streptomycin; Ethambutol Hydrochloride



Possible Pyrazinamide side effects in 25 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11

Patient: 25 year old female

Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Drug Interaction, Acute Hepatic Failure, Liver Transplant Rejection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Pyrazinamide

Other drugs received by patient possibly interacting with the suspect drug:
Azathioprine
    Indication: Immunosuppression

Cyclosporine
    Indication: Immunosuppression

Prednisolone
    Indication: Immunosuppression

Rifampicin

Rifampicin
    Indication: Pulmonary Tuberculosis

Other drugs received by patient: Ofloxacin; Ofloxacin; Rifampicin; Ethambutol Hydrochloride; Isoniazid



Possible Pyrazinamide side effects in 20 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11

Patient: 20 year old female

Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Liver Transplant Rejection, Drug Interaction, Acute Hepatic Failure

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Pyrazinamide

Other drugs received by patient possibly interacting with the suspect drug:
Prednisolone
    Indication: Immunosuppression

Rifampicin

Rifampicin

Rifampicin
    Dosage: half of the dose every two days
    Indication: Pulmonary Tuberculosis

Tacrolimus
    Indication: Immunosuppression

Other drugs received by patient: Ethambutol Hydrochloride; Ethambutol Hydrochloride; Ethambutol Hydrochloride; Ofloxacin; Isoniazid; Ethambutol Hydrochloride; Rifampicin; Ofloxacin



Possible Pyrazinamide side effects in 7 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-14

Patient: 7 year old male

Reactions: Abdominal Pain, Jaundice, Alanine Aminotransferase Increased, International Normalised Ratio Increased, Cachexia, Gamma-Glutamyltransferase Increased, Hepatotoxicity, Aspartate Aminotransferase Increased, Ammonia Increased, Acute Hepatic Failure

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ethambutol Hydrochloride
    Indication: Tuberculosis

Isoniazid
    Indication: Tuberculosis

Pyrazinamide
    Indication: Tuberculosis

Rifampicin
    Indication: Tuberculosis

Other drugs received by patient: Ceftriaxone; Fluconazole; Pyridoxine HCL; Acetaminophen



Possible Pyrazinamide side effects in 8 month old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2011-10-20

Patient: 8 month old female

Reactions: Blood Bilirubin Increased, Immune Reconstitution Syndrome, Bovine Tuberculosis, Haemorrhage, Coagulopathy, Mental Status Changes, Hepatic Failure, Lymphadenitis, Hepatic Encephalopathy, Liver Function Test Abnormal, Brain Oedema, Hepatic Cirrhosis, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Vaccination Failure, Condition Aggravated, Toxicity To Various Agents, Convulsion, Acute Hepatic Failure, Hepatitis B

Adverse event resulted in: death

Drug(s) suspected as cause:
Amikacin
    Dosage: usp
    Indication: Tuberculosis

Ciprofloxacin
    Indication: Tuberculosis

Cotrim
    Indication: Tuberculosis

Ethambutol Hydrochloride
    Indication: Tuberculosis

Hepatitis B Vaccine
    Dosage: received at 6, 10 and 14 weeks of life
    Indication: Product Used FOR Unknown Indication

Isoniazid
    Indication: Tuberculosis

Lamivudine
    Indication: HIV Infection

Lamivudine

Lopinavir / Ritonavir

Lopinavir / Ritonavir
    Indication: HIV Infection

Pyrazinamide
    Indication: Tuberculosis

Rifampin
    Indication: Tuberculosis

Ritonavir
    Indication: HIV Infection

Ritonavir

Tice BCG
    Dosage: liquid intradermal
    Indication: Product Used FOR Unknown Indication

Zidovudine

Zidovudine
    Indication: HIV Infection



Possible Pyrazinamide side effects in 8 month old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2011-10-18

Patient: 8 month old female

Reactions: Blood Bilirubin Increased, Immune Reconstitution Syndrome, Bovine Tuberculosis, Haemorrhage, Coagulopathy, Mental Status Changes, Hepatic Failure, Lymphadenitis, Hepatic Encephalopathy, Liver Function Test Abnormal, Brain Oedema, Hepatic Cirrhosis, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Vaccination Failure, Condition Aggravated, Toxicity To Various Agents, Convulsion, Acute Hepatic Failure, Hepatitis B

Adverse event resulted in: death

Drug(s) suspected as cause:
Amikacin
    Dosage: usp
    Indication: Tuberculosis

Ciprofloxacin
    Indication: Tuberculosis

Cotrim
    Indication: Tuberculosis

Ethambutol Hydrochloride
    Indication: Tuberculosis

Hepatitis B Vaccine
    Dosage: received at 6, 10 and 14 weeks of life
    Indication: Product Used FOR Unknown Indication

Isoniazid
    Indication: Tuberculosis

Kaletra

Kaletra
    Indication: HIV Infection

Lamivudine

Lamivudine
    Indication: HIV Infection

Norvir
    Indication: HIV Infection

Norvir

Pyrazinamide
    Indication: Tuberculosis

Rifampin
    Indication: Tuberculosis

Tice BCG
    Dosage: liquid intradermal
    Indication: Product Used FOR Unknown Indication

Zidovudine
    Indication: HIV Infection

Zidovudine

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