Index of reports
> Cases with Alanine Aminotransferase Increased (8)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Pyrazinamide where reactions include alanine aminotransferase increased. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Pyrazinamide side effects in male
Reported by a physician from Brazil on 2012-07-26
Patient: male
Reactions: Nausea, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased
Drug(s) suspected as cause:
Acetaminophen
Dosage: unk
Indication: Headache
Start date: 2010-12-13
Acyclovir
Dosage: 4000 unk, unk
Indication: Herpes Zoster
Start date: 2010-12-18
End date: 2010-12-25
Azithromycin
Dosage: 1500 unk, unk
Indication: Prophylaxis
Start date: 2010-11-04
Bactrim
Dosage: 400 mg, unk
Indication: Prophylaxis
Start date: 2010-12-13
Efavirenz
Dosage: unk
Indication: HIV Infection
Start date: 2010-11-25
End date: 2011-01-01
Efavirenz
Dosage: unk
Ethambutol Hydrochloride
Dosage: unk
Indication: Tuberculosis
Start date: 2010-10-16
End date: 2010-12-27
Ethambutol Hydrochloride
Dosage: unk
Isoniazid
Dosage: unk
Indication: Tuberculosis
Start date: 2010-10-16
End date: 2011-01-01
Lamivudine
Dosage: 300 mg, qd
Indication: HIV Infection
Start date: 2010-11-25
Prednisone
Dosage: 40 mg, unk
Indication: Meningitis
Start date: 2010-10-16
Pyrazinamide
Dosage: 1200 mg, unk
Indication: Tuberculosis
Start date: 2010-10-16
End date: 2010-12-27
Rifampin
Dosage: 450 mg, qd
Indication: Tuberculosis
Start date: 2010-10-16
End date: 2011-01-01
Rifampin
Dosage: 450 mg, qd
Tenofovir Disoproxil Fumarate
Indication: HIV Infection
Possible Pyrazinamide side effects in 64 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11
Patient: 64 year old female
Reactions: Jaundice, Alanine Aminotransferase Increased, Drug Intolerance, Acute Hepatic Failure
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Indication: Meningitis Tuberculous
Rifampicin
Indication: Meningitis Tuberculous
Other drugs received by patient: Ethambutol Hydrochloride; Moxifloxacin; Isoniazid
Possible Pyrazinamide side effects in 20 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11
Patient: 20 year old male
Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Acute Hepatic Failure, Liver Transplant Rejection, Drug Interaction
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient possibly interacting with the suspect drug: Azathioprine
Indication: Immunosuppression
Cyclosporine
Indication: Immunosuppression
Prednisolone
Indication: Immunosuppression
Rifampicin
Indication: Pulmonary Tuberculosis
Rifampicin
Other drugs received by patient: Ethambutol Hydrochloride; Isoniazid; Rifampicin; Streptomycin; Streptomycin; Ethambutol Hydrochloride
Possible Pyrazinamide side effects in 25 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11
Patient: 25 year old female
Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Drug Interaction, Acute Hepatic Failure, Liver Transplant Rejection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient possibly interacting with the suspect drug: Azathioprine
Indication: Immunosuppression
Cyclosporine
Indication: Immunosuppression
Prednisolone
Indication: Immunosuppression
Rifampicin
Rifampicin
Indication: Pulmonary Tuberculosis
Other drugs received by patient: Ofloxacin; Ofloxacin; Rifampicin; Ethambutol Hydrochloride; Isoniazid
Possible Pyrazinamide side effects in 20 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11
Patient: 20 year old female
Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Liver Transplant Rejection, Drug Interaction, Acute Hepatic Failure
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Pyrazinamide
Other drugs received by patient possibly interacting with the suspect drug: Prednisolone
Indication: Immunosuppression
Rifampicin
Rifampicin
Rifampicin
Dosage: half of the dose every two days
Indication: Pulmonary Tuberculosis
Tacrolimus
Indication: Immunosuppression
Other drugs received by patient: Ethambutol Hydrochloride; Ethambutol Hydrochloride; Ethambutol Hydrochloride; Ofloxacin; Isoniazid; Ethambutol Hydrochloride; Rifampicin; Ofloxacin
Possible Pyrazinamide side effects in 7 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-14
Patient: 7 year old male
Reactions: Abdominal Pain, Jaundice, Alanine Aminotransferase Increased, International Normalised Ratio Increased, Cachexia, Gamma-Glutamyltransferase Increased, Hepatotoxicity, Aspartate Aminotransferase Increased, Ammonia Increased, Acute Hepatic Failure
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ethambutol Hydrochloride
Indication: Tuberculosis
Isoniazid
Indication: Tuberculosis
Pyrazinamide
Indication: Tuberculosis
Rifampicin
Indication: Tuberculosis
Other drugs received by patient: Ceftriaxone; Fluconazole; Pyridoxine HCL; Acetaminophen
Possible Pyrazinamide side effects in 8 month old female
Reported by a health professional (non-physician/pharmacist) from Canada on 2011-10-20
Patient: 8 month old female
Reactions: Blood Bilirubin Increased, Immune Reconstitution Syndrome, Bovine Tuberculosis, Haemorrhage, Coagulopathy, Mental Status Changes, Hepatic Failure, Lymphadenitis, Hepatic Encephalopathy, Liver Function Test Abnormal, Brain Oedema, Hepatic Cirrhosis, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Vaccination Failure, Condition Aggravated, Toxicity To Various Agents, Convulsion, Acute Hepatic Failure, Hepatitis B
Adverse event resulted in: death
Drug(s) suspected as cause:
Amikacin
Dosage: usp
Indication: Tuberculosis
Ciprofloxacin
Indication: Tuberculosis
Cotrim
Indication: Tuberculosis
Ethambutol Hydrochloride
Indication: Tuberculosis
Hepatitis B Vaccine
Dosage: received at 6, 10 and 14 weeks of life
Indication: Product Used FOR Unknown Indication
Isoniazid
Indication: Tuberculosis
Lamivudine
Indication: HIV Infection
Lamivudine
Lopinavir / Ritonavir
Lopinavir / Ritonavir
Indication: HIV Infection
Pyrazinamide
Indication: Tuberculosis
Rifampin
Indication: Tuberculosis
Ritonavir
Indication: HIV Infection
Ritonavir
Tice BCG
Dosage: liquid intradermal
Indication: Product Used FOR Unknown Indication
Zidovudine
Zidovudine
Indication: HIV Infection
Possible Pyrazinamide side effects in 8 month old female
Reported by a health professional (non-physician/pharmacist) from Canada on 2011-10-18
Patient: 8 month old female
Reactions: Blood Bilirubin Increased, Immune Reconstitution Syndrome, Bovine Tuberculosis, Haemorrhage, Coagulopathy, Mental Status Changes, Hepatic Failure, Lymphadenitis, Hepatic Encephalopathy, Liver Function Test Abnormal, Brain Oedema, Hepatic Cirrhosis, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Vaccination Failure, Condition Aggravated, Toxicity To Various Agents, Convulsion, Acute Hepatic Failure, Hepatitis B
Adverse event resulted in: death
Drug(s) suspected as cause:
Amikacin
Dosage: usp
Indication: Tuberculosis
Ciprofloxacin
Indication: Tuberculosis
Cotrim
Indication: Tuberculosis
Ethambutol Hydrochloride
Indication: Tuberculosis
Hepatitis B Vaccine
Dosage: received at 6, 10 and 14 weeks of life
Indication: Product Used FOR Unknown Indication
Isoniazid
Indication: Tuberculosis
Kaletra
Kaletra
Indication: HIV Infection
Lamivudine
Lamivudine
Indication: HIV Infection
Norvir
Indication: HIV Infection
Norvir
Pyrazinamide
Indication: Tuberculosis
Rifampin
Indication: Tuberculosis
Tice BCG
Dosage: liquid intradermal
Indication: Product Used FOR Unknown Indication
Zidovudine
Indication: HIV Infection
Zidovudine
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