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Index of reports
> Cases with Cytolytic Hepatitis (18)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Piperacillin and Tazobactam (Piperacillin / Tazobactam) where reactions include cytolytic hepatitis. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Piperacillin and Tazobactam side effects in 16 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-06-26
Patient: 16 year old male
Reactions: Cytolytic Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Zithromax
Dosage: 250 mg, 1x/day, from d-2 to the end of treatment
Administration route: Oral
Start date: 2012-03-29
End date: 2012-04-09
Zithromax
Dosage: 500 mg, 1x/day, d-1
Administration route: Oral
Indication: Lung Disorder
Start date: 2012-03-28
End date: 2012-03-28
Piperacillin and Tazobactam
Dosage: 4 g, 3x/day
Indication: Lung Disorder
Start date: 2012-04-01
End date: 2012-04-09
Other drugs received by patient: Rocephin
Possible Piperacillin and Tazobactam side effects in 16 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-06-08
Patient: 16 year old male
Reactions: Cytolytic Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: 4 g, 3x/day
Indication: Lung Disorder
Start date: 2012-04-01
End date: 2012-04-09
Zithromax
Dosage: 500 mg, 1x/day
Administration route: Oral
Indication: Lung Disorder
Start date: 2012-03-28
End date: 2012-03-28
Zithromax
Dosage: 250 mg, 1x/day
Administration route: Oral
Start date: 2012-03-29
End date: 2012-04-09
Other drugs received by patient: Rocephin
Possible Piperacillin and Tazobactam side effects in 24 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-05-16
Patient: 24 year old male
Reactions: Citrobacter Infection, Anti Factor V Antibody Positive, Pulmonary Alveolar Haemorrhage, Shock Haemorrhagic, Cytolytic Hepatitis, Coagulation Factor V Level Decreased, Cardiogenic Shock, Haemothorax, Klebsiella Infection, Renal Failure, Enterococcal Sepsis, Lung Disorder, Cervix Haematoma Uterine, Shock, Epistaxis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Amoxicillin
Dosage: intravenous
Start date: 2012-02-19
End date: 2012-02-29
Imipenem and Cilastatin
Dosage: intravenous
Start date: 2012-03-06
End date: 2012-03-09
Piperacillin and Tazobactam
Dosage: intravenous
Start date: 2012-03-06
End date: 2012-03-08
Tachosil
Dosage: 3 sponges in 2 days
Indication: Haemorrhage
Start date: 2012-03-09
End date: 2012-03-10
Gentamicin
Dosage: intravenous
Indication: Product Used FOR Unknown Indication
Start date: 2012-02-20
End date: 2012-02-29
Cefotaxime
Dosage: intravenous
Start date: 2012-03-08
End date: 2012-03-12
Possible Piperacillin and Tazobactam side effects in 53 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-03-30
Patient: 53 year old male
Reactions: Cytolytic Hepatitis, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: 4 g/day
Indication: Lung Disorder
Start date: 2012-01-05
End date: 2012-01-12
Lamictal
Dosage: 25 mg/day
Administration route: Oral
Indication: Convulsion
Start date: 2011-12-27
End date: 2012-01-09
Other drugs received by patient: Keppra
Possible Piperacillin and Tazobactam side effects in male
Reported by a health professional (non-physician/pharmacist) from France on 2012-03-19
Patient: male
Reactions: Cytolytic Hepatitis, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: 4 g/day
Indication: Lung Disorder
Start date: 2012-01-05
End date: 2012-01-12
Lamictal
Dosage: 25 mg/day
Administration route: Oral
Indication: Convulsion
Start date: 2011-12-27
End date: 2012-01-09
Other drugs received by patient: Keppra
Possible Piperacillin and Tazobactam side effects in 53 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-03-12
Patient: 53 year old male
Reactions: Cytolytic Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Lamictal
Dosage: 25 mg/day
Administration route: Oral
Indication: Convulsion
Start date: 2011-12-27
End date: 2012-01-09
Piperacillin and Tazobactam
Dosage: 4 g/day
Indication: Lung Disorder
Start date: 2012-01-05
End date: 2012-01-12
Other drugs received by patient: Keppra
Possible Piperacillin and Tazobactam side effects in 85 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-03-12
Patient: 85 year old female
Reactions: Cytolytic Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Tegretol
Dosage: unk
Start date: 2012-01-05
End date: 2012-01-25
Piperacillin and Tazobactam
Dosage: unk
Indication: Pneumonia Aspiration
Start date: 2012-01-23
End date: 2012-02-01
Ciprofloxacin
Dosage: unk
Indication: Pneumonia Aspiration
Start date: 2012-01-23
End date: 2012-01-25
Other drugs received by patient: Atorvastatin; Levofloxacin; Augmentin '125'
Possible Piperacillin and Tazobactam side effects in 85 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2012-03-05
Patient: 85 year old female
Reactions: Cytolytic Hepatitis, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ciprofloxacin
Dosage: unk
Start date: 2012-01-23
End date: 2012-01-25
Tegretol
Dosage: unk
Start date: 2012-01-05
End date: 2012-01-25
Piperacillin and Tazobactam
Dosage: unk
Start date: 2012-01-23
End date: 2012-02-01
Other drugs received by patient: Digoxin; Polyethylene Glycol; Amlodipine; Lamictal; Potassium Chloride; Procoralan; Pantoprazole
Possible Piperacillin and Tazobactam side effects in 45 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2011-12-23
Patient: 45 year old male
Reactions: Cytolytic Hepatitis, Cholestasis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: unk
Start date: 2011-11-16
End date: 2011-11-25
Meropenem
Dosage: unk
Start date: 2011-11-30
Other drugs received by patient: Diamox SRC; Vancomycin; Midazolam HCL; Lovenox; Lasix; Lasix; Lasix; Ticarcillin; Tracrium; Humalog; Diamox SRC; Gentamicin; Sufenta Preservative Free; Tracrium; Diamox SRC; Diamox SRC; Amikacin
Possible Piperacillin and Tazobactam side effects in 45 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2011-11-22
Patient: 45 year old female
Reactions: Lymphadenopathy, Cytolytic Hepatitis, Pancytopenia, Pyrexia, Drug Rash With Eosinophilia and Systemic Symptoms, Dermatitis Exfoliative, Eosinophilia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Gentamicin Sulfate
Indication: Sepsis
Start date: 2011-07-25
End date: 2011-08-04
Oxycodone HCL
Administration route: Oral
Start date: 2011-07-26
Levofloxacin
Start date: 2011-07-14
End date: 2011-07-22
Lovenox
Start date: 2011-07-26
End date: 2011-08-08
Targocid
Start date: 2011-07-25
End date: 2011-08-03
Piperacillin and Tazobactam
Start date: 2011-07-31
End date: 2011-08-12
Other drugs received by patient: Hydroxyzine
Possible Piperacillin and Tazobactam side effects in female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-11-14
Patient: female
Reactions: Hepatic Function Abnormal, Diarrhoea, Haemorrhage, Cytolytic Hepatitis, Acute Respiratory Distress Syndrome, Pancytopenia, Septic Shock
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Indication: Pyrexia
Start date: 2011-08-25
End date: 2011-09-04
Ganciclovir Sodium
Start date: 2011-08-30
End date: 2011-09-16
Amikacin
Indication: Pyrexia
Start date: 2011-08-25
End date: 2011-08-28
Tienam
Start date: 2011-10-02
Foscavir
Indication: Cytomegalovirus Infection
Start date: 2011-09-03
End date: 2011-09-09
Vancomycin HCL
Indication: Pyrexia
Start date: 2011-09-09
End date: 2011-09-13
Tienam
Indication: Pyrexia
Start date: 2011-09-09
End date: 2011-09-18
Amikacin
Start date: 2011-09-09
Foscavir
Start date: 2011-09-30
Piperacillin and Tazobactam
End date: 2011-10-02
Ganciclovir Sodium
Indication: Cytomegalovirus Infection
Other drugs received by patient: Cancidas; Cancidas; Imuran
Possible Piperacillin and Tazobactam side effects in 56 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2011-11-11
Patient: 56 year old male
Reactions: Cytolytic Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clarithromycin
Start date: 2008-06-29
End date: 2008-07-14
Acetaminophen
Start date: 2008-06-29
End date: 2008-07-17
Desloratadine
Administration route: Oral
Start date: 2008-07-09
Venofer
Start date: 2008-07-11
Acetaminophen
Administration route: Oral
Start date: 2008-07-18
Cipro
Start date: 2008-07-02
End date: 2008-07-04
TPN
Start date: 2008-07-11
Moxifloxacin HCL
Start date: 2008-06-29
End date: 2008-07-02
Levofloxacin
Start date: 2008-07-03
Primaxin
Indication: Pseudomonas Infection
Start date: 2008-07-18
Piperacillin and Tazobactam
Start date: 2008-07-07
End date: 2008-07-11
Zyvox
Administration route: Oral
Start date: 2008-07-14
Omeprazole
Administration route: Oral
Start date: 2008-07-17
Lovenox
Start date: 2008-07-05
Rocephin
Start date: 2008-06-29
End date: 2008-07-02
Other drugs received by patient: Fluconazole; Innohep; Solu-Medrol; Atarax (Alprazolam); Sucralfate
Possible Piperacillin and Tazobactam side effects in male
Reported by a health professional (non-physician/pharmacist) from France on 2011-11-08
Patient: male
Reactions: Hepatocellular Injury, Hairy Cell Leukaemia, Cytolytic Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: unk
Start date: 2008-07-07
End date: 2008-07-11
Ciprofloxacin
Dosage: 3 df per day
Start date: 2008-07-02
End date: 2008-07-04
Nutriflex ^braun^
Omeprazole
Dosage: 1 df per day
Administration route: Oral
Start date: 2008-07-17
Zyvox
Dosage: 3 df per day
Administration route: Oral
Indication: Prophylaxis
Start date: 2008-07-14
Moxifloxacin HCL
Dosage: 1 df per day
Start date: 2008-06-29
End date: 2008-07-02
Venofer
Dosage: 3 df per day
Start date: 2008-07-11
Tienam
Dosage: 3 df per day
Administration route: Oral
Indication: Prophylaxis
Start date: 2008-07-18
Clarithromycin
Dosage: 2 df per day
Indication: Pneumonia Legionella
Start date: 2008-06-29
End date: 2008-07-14
Paracetamol
Dosage: 4 df per day
Start date: 2008-06-29
End date: 2008-07-17
Rocephin
Dosage: 2 df per day
Start date: 2008-06-29
End date: 2008-07-02
Levofloxacin
Dosage: 2 df per day
Indication: Pneumonia Legionella
Start date: 2008-07-03
Lovenox
Dosage: 1 df per day
Start date: 2008-07-05
Desloratadine
Dosage: 1 df per day
Administration route: Oral
Start date: 2008-07-09
Acetaminophen
Dosage: 4 df per day
Administration route: Oral
Start date: 2008-07-18
Other drugs received by patient: Atarax; Sucralfate; Innohep; Solu-Medrol; Fluconazole
Possible Piperacillin and Tazobactam side effects in 56 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2011-11-04
Patient: 56 year old male
Reactions: Blood Bilirubin Increased, Gamma-Glutamyltransferase Increased, Cytolytic Hepatitis, Condition Aggravated, Rash Pruritic
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clarithromycin
Dosage: 1 g total daily
Indication: Pneumonia Legionella
Start date: 2008-06-29
End date: 2008-07-14
Lovenox
Dosage: 1 dosage form total daily
Start date: 2008-07-05
Piperacillin and Tazobactam
Dosage: 16 g total daily
Indication: Lung Infection
Start date: 2008-07-07
End date: 2008-07-11
Ciprofloxacin
Dosage: 3 dosage forms total daily
Indication: Pneumonia Legionella
Start date: 2008-07-02
End date: 2008-07-04
Tienam
Dosage: 3 dosages form
Administration route: Oral
Indication: Lung Infection
Start date: 2008-07-18
Rocephin
Dosage: 4 g; frequency unspecified
Indication: Pneumonia Legionella
Start date: 2008-06-29
End date: 2008-07-02
Moxifloxacin HCL
Dosage: 400 mg, 1x/day
Indication: Pneumonia Legionella
Start date: 2008-06-29
End date: 2008-07-02
Levofloxacin
Dosage: 10 mg total daily
Indication: Pneumonia Legionella
Start date: 2008-07-03
Venofer
Dosage: 300 mg total daily
Start date: 2008-07-11
Zyvox
Dosage: 3 dosages form total daily
Administration route: Oral
Start date: 2008-07-14
Desloratadine
Dosage: 1.0 df, 1x/day
Administration route: Oral
Start date: 2008-07-09
Nutriflex ^vifor^
Dosage: unknown
Acetaminophen
Dosage: 4 dosages form total daily
Administration route: Oral
Start date: 2008-07-18
Acetaminophen
Dosage: 40 mg total daily
Start date: 2008-06-29
End date: 2008-07-17
Omeprazole
Dosage: 1 df, 1x/day
Administration route: Oral
Start date: 2008-07-17
Other drugs received by patient: Sucralfate
Possible Piperacillin and Tazobactam side effects in 56 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2011-11-03
Patient: 56 year old male
Reactions: Cytolytic Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acetaminophen
Dosage: 4 df per day
Start date: 2008-06-29
End date: 2008-07-17
Venofer
Dosage: 3 df per day
Start date: 2008-07-11
Nutriflex ^braun^
Moxifloxacin HCL
Dosage: 1 df per day
Start date: 2008-06-29
End date: 2008-07-02
Ciprofloxacin
Dosage: 3 df per day
Start date: 2008-07-02
End date: 2008-07-04
Acetaminophen
Dosage: 4 df per day
Administration route: Oral
Start date: 2008-07-18
Clarithromycin
Dosage: 2 df per day
Indication: Pneumonia Legionella
Start date: 2008-06-29
End date: 2008-07-14
Zyvox
Dosage: 3 df per day
Administration route: Oral
Indication: Prophylaxis
Start date: 2008-07-14
Omeprazole
Dosage: 1 df per day
Administration route: Oral
Start date: 2008-07-17
Lovenox
Dosage: 1 df per day
Start date: 2008-07-05
Piperacillin and Tazobactam
Dosage: unk
Start date: 2008-07-07
End date: 2008-07-11
Rocephin
Dosage: 2 df per day
Start date: 2008-06-29
End date: 2008-07-02
Levofloxacin
Dosage: 2 df per day
Indication: Pneumonia Legionella
Start date: 2008-07-03
Desloratadine
Dosage: 1 df per day
Administration route: Oral
Start date: 2008-07-09
Tienam
Dosage: 3 df per day
Administration route: Oral
Indication: Prophylaxis
Start date: 2008-07-18
Other drugs received by patient: Innohep; Atarax; Fluconazole; Solu-Medrol; Sucralfate
Possible Piperacillin and Tazobactam side effects in 56 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2011-11-03
Patient: 56 year old male
Reactions: Superinfection, Pseudomonas Infection, Cytolytic Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Desloratadine
Dosage: 1 df; qd; po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2008-07-09
Clarithromycin
Dosage: 2 df; qd; iv
Indication: Legionella Infection
Start date: 2008-07-01
End date: 2008-07-14
Acetaminophen
Dosage: 4 df; qd; iv
Indication: Product Used FOR Unknown Indication
Start date: 2008-06-29
End date: 2008-07-17
Levofloxacin
Dosage: 2 df; qd; iv
Indication: Legionella Infection
Start date: 2008-07-01
Nutri-Flex (Glucosamine Fulfate, Hydrolyzed Gelatin, Methyl Sulfonyl M
Indication: Product Used FOR Unknown Indication
Zyvox
Dosage: 3 df; qd; po
Administration route: Oral
Indication: Staphylococcal Infection
Start date: 2008-07-14
Acetaminophen
Dosage: 4 df; qd; po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2008-07-18
Rocephin
Dosage: 2 df; qd; iv
Indication: Product Used FOR Unknown Indication
Start date: 2008-06-29
End date: 2008-07-02
Moxifloxacin Hydrochloride
Dosage: 1 df; qd; iv
Indication: Product Used FOR Unknown Indication
Start date: 2008-06-26
End date: 2008-07-02
Omeprazole
Dosage: 1 df; qd; po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2008-07-17
Ciprofloxacin
Dosage: 3 df; qd; iv
Indication: Product Used FOR Unknown Indication
Start date: 2008-06-29
End date: 2008-07-04
Piperacillin and Tazobactam
Dosage: 3 df; qd; iv
Indication: Superinfection
Start date: 2008-07-07
End date: 2008-07-11
Venofer
Dosage: 3 df; qd; iv
Indication: Product Used FOR Unknown Indication
Start date: 2008-07-11
Primaxin
Dosage: 3 df; qd; po
Administration route: Oral
Indication: Infection
Start date: 2008-07-18
Lovenox
Dosage: 2 df; qd; sc
Indication: Product Used FOR Unknown Indication
Start date: 2008-07-05
Possible Piperacillin and Tazobactam side effects in 56 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2011-10-24
Patient: 56 year old male
Reactions: Cytolytic Hepatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Acetaminophen
Dosage: 4 df per day
Start date: 2008-06-29
End date: 2008-07-17
Ciprofloxacin
Dosage: 3 df per day
Start date: 2008-07-02
End date: 2008-07-04
Levofloxacin
Dosage: 2 df per day
Indication: Pneumonia Legionella
Start date: 2008-07-03
Venofer
Dosage: 3 df per day
Start date: 2008-07-11
Acetaminophen
Dosage: 4 df per day
Administration route: Oral
Start date: 2008-07-18
Moxifloxacin HCL
Dosage: 1 df per day
Start date: 2008-06-29
End date: 2008-07-02
Nutriflex ^braun^
Zyvox
Dosage: 3 df per day
Administration route: Oral
Indication: Prophylaxis
Start date: 2008-07-14
Desloratadine
Dosage: 1 df per day
Administration route: Oral
Start date: 2008-07-09
Piperacillin and Tazobactam
Dosage: unk
Start date: 2008-07-07
End date: 2008-07-11
Omeprazole
Dosage: 1 df per day
Administration route: Oral
Start date: 2008-07-17
Tienam
Dosage: 3 df per day
Administration route: Oral
Indication: Prophylaxis
Start date: 2008-07-18
Rocephin
Dosage: 2 df per day
Start date: 2008-06-29
End date: 2008-07-02
Lovenox
Dosage: 1 df per day
Start date: 2008-07-05
Clarithromycin
Dosage: 2 df per day
Indication: Pneumonia Legionella
Start date: 2008-06-29
End date: 2008-07-14
Other drugs received by patient: Solu-Medrol; Fluconazole; Innohep; Sucralfate; Atarax
Possible Piperacillin and Tazobactam side effects in 64 year old female
Reported by a health professional (non-physician/pharmacist) from France on 2011-10-10
Patient: 64 year old female
Reactions: Cytolytic Hepatitis, Pyrexia, Eosinophilia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: unk
Indication: Inflammation
Start date: 2011-09-08
End date: 2011-09-09
Piperacillin and Tazobactam
Dosage: unk
Indication: Pyrexia
Start date: 2011-08-13
End date: 2011-08-15
Other drugs received by patient: Ciprofloxacin; Enalapril Maleate; Ciprofloxacin; Prednisone; Rapamune; Diamicron; Hyperium; Mycophenolate Mofetil (Cellcept); Levothyroxine Sodium; Atorvastatin Calcium; Prazosin HCL; Neoral; Ferrous Sulfate TAB; Amlodipine / Valsartan; Vitamin D
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