This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Piperacillin and Tazobactam (Piperacillin / Tazobactam) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (401)
Death (89)
Life Threatening Events (66)
Disability (1)
Reports by Reaction Type
Renal Failure Acute (36),
Pruritus (35),
Rash Erythematous (34),
Paraesthesia (33),
Rash Maculo-Papular (31),
Skin Warm (23),
Product Contamination Microbial (20),
Thrombocytopenia (20),
Death (18),
Cytolytic Hepatitis (18),
Pyrexia (16),
Rash (16)
Below are a few examples of reports where side effects / adverse reactions may be related to Piperacillin and Tazobactam (Piperacillin / Tazobactam). For a complete list or a specific selection of reports, please use the links above.
Possible Piperacillin and Tazobactam side effects in 60 year old male
Reported by a health professional (non-physician/pharmacist) from China on 2012-08-24
Patient: 60 year old male
Reactions: Haemoglobin Decreased, Bone Marrow Failure, Platelet Count Decreased
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Other drugs received by patient: Gentamicin
Possible Piperacillin and Tazobactam side effects in 58 year old female
Reported by a pharmacist from United States on 2012-08-23
Patient: 58 year old female, weighing 149.0 kg (327.8 pounds)
Reactions: Product Quality Issue, Product Contamination
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: 4.5gm q6h iv
Indication: Cellulitis
Start date: 2012-08-01
End date: 2012-08-02
Piperacillin and Tazobactam
Dosage: 4.5gm q6h iv
Indication: Cellulitis
Possible Piperacillin and Tazobactam side effects in 24 year old male
Reported by a pharmacist from United States on 2012-08-22
Patient: 24 year old male, weighing 125.9 kg (277.0 pounds)
Reactions: Hepatitis Viral, Blood Bilirubin Increased, Bile Duct Stone, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Sepsis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Possible Piperacillin and Tazobactam side effects in
Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-08-22
Patient:
Reactions: Adverse Drug Reaction, Liver Disorder
Drug(s) suspected as cause:
Allopurinol
Indication: Product Used FOR Unknown Indication
Aminoglycoside Antibacterials
Indication: Product Used FOR Unknown Indication
Amoxicillin and Clavulanate Potassium
Indication: Product Used FOR Unknown Indication
AN Unknown Medication
Indication: Product Used FOR Unknown Indication
Anti-Psychotics
Indication: Product Used FOR Unknown Indication
Atazanavir
Indication: Product Used FOR Unknown Indication
Cephalosporins
Indication: Product Used FOR Unknown Indication
Clindamycin
Indication: Product Used FOR Unknown Indication
Fluconazole
Indication: Product Used FOR Unknown Indication
Herbal Medicines
Indication: Product Used FOR Unknown Indication
Itraconazole
Indication: Product Used FOR Unknown Indication
Nucleoside Reverse Transcriptase Inhibitors
Indication: Product Used FOR Unknown Indication
Piperacillin and Tazobactam
Indication: Product Used FOR Unknown Indication
Propyl-Thiouracil
Indication: Product Used FOR Unknown Indication
Protease Inhibitors
Indication: Product Used FOR Unknown Indication
Topiramate
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Tramadol Hydrochloride and Acetaminophen
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Piperacillin and Tazobactam side effects in 71 year old male
Reported by a pharmacist from United States on 2012-08-21
Patient: 71 year old male
Reactions: Thrombocytopenia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Indication: Urinary Tract Infection
Start date: 2012-07-13
End date: 2012-07-19
Piperacillin and Tazobactam
Indication: Sepsis
Start date: 2012-07-13
End date: 2012-07-19
Possible Piperacillin and Tazobactam side effects in 48 year old female
Reported by a physician from United Kingdom on 2012-08-17
Patient: 48 year old female, weighing 98.0 kg (215.6 pounds)
Reactions: Type IV Hypersensitivity Reaction, Petechiae, Withdrawal Syndrome, Thrombocytopenia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Other drugs received by patient: Dalteparin Sodium; Folic Acid; Ferrous Sulfate TAB; Acetaminophen; Cyclizine; Codeine Sulfate
Possible Piperacillin and Tazobactam side effects in 46 year old male
Reported by a physician from Malaysia on 2012-08-17
Patient: 46 year old male
Reactions: Jaundice, Alanine Aminotransferase Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Other drugs received by patient: Bisoprolol; Aspirin; Digoxin
Possible Piperacillin and Tazobactam side effects in 70 year old male
Reported by a physician from China on 2012-08-16
Patient: 70 year old male
Reactions: Atrioventricular Block Complete
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Indication: Infection Prophylaxis
Piperacillin and Tazobactam
Dosage: unk
Indication: Diabetic Foot Infection
Start date: 2012-04-12
End date: 2012-04-16
Other drugs received by patient: Phosphatidyl Choline; Tinidazole; Diammonium Glycyrrhizinate; Alprostadil; Amlodipine; Valsartan; Insulin Glargine; Ginkgo Biloba; Acetylsalicylic Acid; Insulin Aspart
Possible Piperacillin and Tazobactam side effects in 41 year old male
Reported by a pharmacist from United States on 2012-08-14
Patient: 41 year old male, weighing 92.6 kg (203.7 pounds)
Reactions: Tubulointerstitial Nephritis, Blood Urea Increased, Pain, Procedural Site Reaction, Rash, Blood Creatinine Increased, Erythema
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Possible Piperacillin and Tazobactam side effects in male
Reported by a pharmacist from United States on 2012-08-14
Patient: male, weighing 60.8 kg (133.8 pounds)
Reactions: Tubulointerstitial Nephritis
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Possible Piperacillin and Tazobactam side effects in 72 year old female
Reported by a physician from Honduras on 2012-08-13
Patient: 72 year old female
Reactions: Oedema
Adverse event resulted in: death
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Possible Piperacillin and Tazobactam side effects in female
Reported by a physician from Italy on 2012-08-11
Patient: female
Reactions: Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ceftriaxone Sodium
Indication: Pneumonitis
Start date: 2012-06-28
End date: 2012-07-05
Clarithromycin
Dosage: 2 units daily
Indication: Pneumonitis
Start date: 2012-07-03
End date: 2012-07-05
Piperacillin and Tazobactam
Dosage: 3 unitsdaily
Indication: Pneumonia
Start date: 2012-07-06
End date: 2012-07-18
Targocid
Indication: Pneumonia
Start date: 2012-07-06
End date: 2012-07-18
Ultravist 150
Dosage: 80 milliliter total
Indication: Computerised Tomogram
Start date: 2012-07-05
End date: 2012-07-05
Other drugs received by patient: Bisoprolol Fumarate; Omeprazole
Possible Piperacillin and Tazobactam side effects in 56 year old male
Reported by a pharmacist from United States on 2012-08-10
Patient: 56 year old male
Reactions: Tubulointerstitial Nephritis, Renal Impairment, Drug Interaction, Rash
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Other drugs received by patient possibly interacting with the suspect drug:
Meropenem
Dosage: unk
Indication: Nosocomial Infection
Possible Piperacillin and Tazobactam side effects in 58 year old male
Reported by a pharmacist from United States on 2012-08-09
Patient: 58 year old male, weighing 95.5 kg (210.1 pounds)
Reactions: Renal Failure Acute
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: 3.375 gm qid iv
Start date: 2011-08-30
End date: 2011-09-07
Vancomycin
Dosage: 1500 mg bid iv
Start date: 2011-08-30
End date: 2011-09-04
Possible Piperacillin and Tazobactam side effects in 65 year old male
Reported by a pharmacist from United States on 2012-08-09
Patient: 65 year old male, weighing 83.6 kg (183.9 pounds)
Reactions: Anaphylactic Reaction
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Cefazolin
Dosage: 2 gm once iv
Start date: 2011-10-28
End date: 2011-10-28
Piperacillin and Tazobactam
Dosage: 3.75 gm once iv
Start date: 2011-10-28
End date: 2011-10-28
Possible Piperacillin and Tazobactam side effects in
Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-08-03
Patient:
Reactions: Adverse Drug Reaction, Liver Disorder
Drug(s) suspected as cause:
Allopurinol
Indication: Product Used FOR Unknown Indication
Aminoglycoside Antibacterials
Indication: Product Used FOR Unknown Indication
Amoxicillin and Clavulanate Potassium
Indication: Product Used FOR Unknown Indication
AN Unknown Medication
Indication: Product Used FOR Unknown Indication
Anti-Psychotics
Indication: Product Used FOR Unknown Indication
Atazanavir
Indication: Product Used FOR Unknown Indication
Cephalosporins
Indication: Product Used FOR Unknown Indication
Clindamycin
Indication: Product Used FOR Unknown Indication
Fluconazole
Indication: Product Used FOR Unknown Indication
Herbal Medicines
Indication: Product Used FOR Unknown Indication
Itraconazole
Indication: Product Used FOR Unknown Indication
Nucleoside Reverse Transcriptase Inhibitors
Indication: Product Used FOR Unknown Indication
Piperacillin and Tazobactam
Indication: Product Used FOR Unknown Indication
Propyl-Thiouracil
Indication: Product Used FOR Unknown Indication
Protease Inhibitors
Indication: Product Used FOR Unknown Indication
Topiramate
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Tramadol Hydrochloride and Acetaminophen
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Piperacillin and Tazobactam side effects in female
Reported by a consumer/non-health professional from Italy on 2012-08-03
Patient: female
Reactions: Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ceftriaxone Sodium
Indication: Pneumonitis
Start date: 2012-06-28
End date: 2012-07-05
Clarithromycin
Dosage: 2 units daily
Indication: Pneumonitis
Start date: 2012-07-03
End date: 2012-07-05
Piperacillin and Tazobactam
Dosage: 3 units once daily
Indication: Pneumonia
Start date: 2012-07-06
End date: 2012-07-18
Targocid
Indication: Pneumonia
Start date: 2012-07-06
End date: 2012-07-18
Ultravist 150
Dosage: 80 milliliter total
Indication: Computerised Tomogram
Start date: 2012-07-05
End date: 2012-07-05
Other drugs received by patient: Omeprazole; Bisoprolol Fumarate
Possible Piperacillin and Tazobactam side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-02
Patient:
Reactions: Thrombocytopenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Aspirin
Cefepime
Heparin Sodium
Meropenem
Nitro-DUR
Pepcid
Administration route: Oral
Piperacillin and Tazobactam
Vancomycin
Zocor
Administration route: Oral
Possible Piperacillin and Tazobactam side effects in 29 year old male
Reported by a health professional (non-physician/pharmacist) from Australia on 2012-08-02
Patient: 29 year old male
Reactions: Hyperoxaluria, Renal Tubular Necrosis, Crystal Nephropathy, Renal Failure Acute
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Amikacin
Ganciclovir
Moxifloxacin
Piperacillin and Tazobactam
Trimethoprim + Sulfamethoxazole
Vancomycin
Voriconazole
Other drugs received by patient: Mycophenolate Mofetil; Creon [amylase,lipase,pancreatin,protease]; Basiliximab; Methylprednisolone; Tacrolimus; Corticosteroids; Insulin
Possible Piperacillin and Tazobactam side effects in 58 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-01
Patient: 58 year old male
Reactions: Multi-Organ Failure, Drug Ineffective
Adverse event resulted in: death
Drug(s) suspected as cause:
Caspofungin Acetate
Indication: Systemic Candida
Caspofungin Acetate
Indication: Pneumocystis Jiroveci Pneumonia
Caspofungin Acetate
Dosage: unk
Indication: Bronchopulmonary Aspergillosis
Ciprofloxacin HCL
Dosage: unk
Indication: Bronchopulmonary Aspergillosis
Ciprofloxacin HCL
Indication: Systemic Candida
Ciprofloxacin HCL
Indication: Pneumocystis Jiroveci Pneumonia
Fluconazole
Indication: Pneumocystis Jiroveci Pneumonia
Fluconazole
Indication: Systemic Candida
Fluconazole
Dosage: unk
Indication: Bronchopulmonary Aspergillosis
Piperacillin and Tazobactam
Dosage: unk
Indication: Pneumonia
Voriconazole
Dosage: unk
Indication: Bronchopulmonary Aspergillosis
Voriconazole
Indication: Systemic Candida
Voriconazole
Indication: Pneumocystis Jiroveci Pneumonia
Possible Piperacillin and Tazobactam side effects in 56 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-31
Patient: 56 year old male
Reactions: Tubulointerstitial Nephritis, Renal Impairment, Drug Interaction, Rash
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Other drugs received by patient possibly interacting with the suspect drug:
Meropenem
Dosage: unk
Possible Piperacillin and Tazobactam side effects in 60 year old male
Reported by a pharmacist from United States on 2012-07-30
Patient: 60 year old male, weighing 138.6 kg (304.9 pounds)
Reactions: Dyspnoea, Hypotension, Tachycardia, Anaphylactic Reaction, Chills, Respiratory Depression
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: 2.25gm other iv
Indication: Pneumonia
Start date: 2012-06-16
End date: 2012-06-18
Vancomycin
Dosage: 2500mg other iv
Indication: Upper Respiratory Tract Infection
Start date: 2012-06-16
End date: 2012-06-16
Possible Piperacillin and Tazobactam side effects in 48 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-30
Patient: 48 year old female, weighing 98.0 kg (215.6 pounds)
Reactions: Petechiae, Thrombocytopenia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Other drugs received by patient: Folic Acid; Cyclizine (Cyclizine); Codein (Codeine Phosphate); Dalteparin Sodium; Ferrous Sulfate TAB; Acetaminophen
Possible Piperacillin and Tazobactam side effects in 79 year old male
Reported by a pharmacist from United States on 2012-07-30
Patient: 79 year old male, weighing 79.1 kg (174.0 pounds)
Reactions: Cardio-Respiratory Arrest, Anaphylactic Reaction
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: 3.375 gm qid iv
Start date: 2012-05-10
End date: 2012-05-10
Vancomycin
Dosage: 1 gm every day iv
Indication: Cellulitis
Start date: 2012-05-10
End date: 2012-05-10
Possible Piperacillin and Tazobactam side effects in 33 year old male
Reported by a pharmacist from United States on 2012-07-30
Patient: 33 year old male, weighing 105.5 kg (232.1 pounds)
Reactions: Rash
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Possible Piperacillin and Tazobactam side effects in 90 year old male
Reported by a physician from Greece on 2012-07-27
Patient: 90 year old male, weighing 70.0 kg (154.0 pounds)
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Colimycine
Dosage: 1000000 unk, 4x/day
Indication: Abdominal Infection
Start date: 2009-05-26
End date: 2009-05-28
Daptomycin
Dosage: 350 mg, 1x/day
Indication: Abdominal Infection
Start date: 2009-05-24
End date: 2009-05-25
Innohep
Dosage: unk
Indication: Anticoagulant Therapy
Start date: 2009-05-19
Levophed
Dosage: 3 amp/24hrs
Start date: 2009-05-19
Metronidazole
Dosage: 500 mg, 3x/day
Start date: 2009-05-19
End date: 2009-05-23
Moxifloxacin
Dosage: 400 mg, 2x/day
Indication: Abdominal Infection
Start date: 2009-05-16
End date: 2009-05-18
Netilmicin
Dosage: 300 mg, 1x/day
Indication: Abdominal Infection
Start date: 2009-05-29
End date: 2009-06-08
Piperacillin and Tazobactam
Dosage: 4.5 mg, 3x/day
Start date: 2009-05-16
End date: 2009-05-25
Tigecycline
Dosage: 50 mg, 2x/day
Start date: 2009-05-28
End date: 2009-06-09
Possible Piperacillin and Tazobactam side effects in female
Reported by a consumer/non-health professional from Italy on 2012-07-26
Patient: female
Reactions: Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ceftriaxone Sodium
Indication: Pneumonitis
Start date: 2012-06-28
End date: 2012-07-05
Clarithromycin
Dosage: 2 units daily
Indication: Pneumonitis
Start date: 2012-07-03
End date: 2012-07-05
Piperacillin and Tazobactam
Dosage: 3 units once daily
Indication: Pneumonia
Start date: 2012-07-06
End date: 2012-07-18
Targocid
Indication: Pneumonia
Start date: 2012-07-06
End date: 2012-07-18
Ultravist 150
Dosage: 80 milliliter total
Indication: Computerised Tomogram
Start date: 2012-07-05
End date: 2012-07-05
Other drugs received by patient: Omeprazole; Bisoprolol Fumarate
Possible Piperacillin and Tazobactam side effects in 47 year old male
Reported by a physician from Korea, Republic of on 2012-07-25
Patient: 47 year old male
Reactions: Septic Shock
Adverse event resulted in: death
Drug(s) suspected as cause:
Piperacillin and Tazobactam
Dosage: 3 g, 3x/day
Indication: Soft Tissue Infection
Piperacillin and Tazobactam
Dosage: 2.25 g, 3x/day
Indication: Cellulitis
Possible Piperacillin and Tazobactam side effects in 80 year old male
Reported by a pharmacist from United States on 2012-07-25
Patient: 80 year old male, weighing 90.2 kg (198.4 pounds)
Reactions: Abdominal Pain, Clostridial Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Ciprofloxacin
Dosage: 400 mg bid iv
Indication: Abscess
Start date: 2012-05-02
End date: 2012-05-09
Piperacillin and Tazobactam
Dosage: 4.5 mg tid iv
Indication: Abscess
Start date: 2012-04-20
End date: 2012-05-02
Possible Piperacillin and Tazobactam side effects in 53 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-07-24
Patient: 53 year old male
Reactions: Drug Rash With Eosinophilia and Systemic Symptoms, Nephropathy
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clindamycin HCL
Dosage: unk
Indication: Infection
Start date: 2012-05-11
End date: 2012-05-24
Piperacillin and Tazobactam
Dosage: unk
Indication: Infection
Start date: 2012-05-11
End date: 2012-06-05
Other drugs received by patient: Vancomycin; Azactam
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