Index of reports
> Cases with Toxicity To Various Agents (53)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Phenytoin where reactions include toxicity to various agents. The selected reports were submitted to the FDA during the sample period of about a year.
Reports 1 - 30 of 53 Next >>
Possible Phenytoin side effects in female
Reported by a health professional (non-physician/pharmacist) from Peru on 2012-07-27
Patient: female
Reactions: Choreoathetosis, Hallucination, Visual, Dyskinesia, Toxicity To Various Agents
Drug(s) suspected as cause:
Phenytoin
Other drugs received by patient: Valproic Acid
Possible Phenytoin side effects in female
Reported by a health professional (non-physician/pharmacist) from Peru on 2012-07-27
Patient: female
Reactions: Chorea, Dyskinesia, Toxicity To Various Agents
Drug(s) suspected as cause:
Phenytoin
Dosage: 200 mg, 1x/day
Indication: Epilepsy
Phenytoin
Dosage: 300 mg, 1x/day
Possible Phenytoin side effects in 4 year old
Reported by a health professional (non-physician/pharmacist) from India on 2012-07-18
Patient: 4 year old
Reactions: Toxicity To Various Agents, Accidental Exposure
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Phenytoin
Possible Phenytoin side effects in 21 year old male
Reported by a health professional (non-physician/pharmacist) from India on 2012-07-10
Patient: 21 year old male
Reactions: Headache, Pyrexia, Treatment Noncompliance, Cerebellar Atrophy, Speech Disorder, Nystagmus, Anticonvulsant Drug Level Increased, Coordination Abnormal, Vomiting, Ataxia, Toxicity To Various Agents, Grand MAL Convulsion, Intention Tremor, Hypotonia, Vision Blurred, Gait Disturbance
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Phenytoin
Other drugs received by patient: Methaqualone TAB
Possible Phenytoin side effects in 37 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-06
Patient: 37 year old female
Reactions: Accidental Death, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Phenytoin
Indication: Product Used FOR Unknown Indication
Keppra
Indication: Product Used FOR Unknown Indication
Fluoxetine
Indication: Product Used FOR Unknown Indication
Methadone Hydrochloride
Indication: Product Used FOR Unknown Indication
Possible Phenytoin side effects in 53 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-02
Patient: 53 year old female
Reactions: Hypothermia, Toxicity To Various Agents
Drug(s) suspected as cause:
Phenytoin
Dosage: unk
Indication: Schizoaffective Disorder
Risperidone
Dosage: unk
Indication: Schizoaffective Disorder
Possible Phenytoin side effects in 21 year old male
Reported by a health professional (non-physician/pharmacist) from India on 2012-06-25
Patient: 21 year old male
Reactions: Cerebellar Ataxia, Drug Interaction, Toxicity To Various Agents, Speech Disorder, Intention Tremor, Nystagmus, Hypotonia, Vision Blurred, Gait Disturbance, Coordination Abnormal
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Phenytoin
Dosage: 300 mg;qd;po
Administration route: Oral
Indication: Epilepsy
Methaqualone (Methaqualone)
Dosage: 250 mg;bid
Possible Phenytoin side effects in 21 year old male
Reported by a physician from India on 2012-06-22
Patient: 21 year old male
Reactions: Ataxia, Drug Interaction, Toxicity To Various Agents, Cerebellar Atrophy, Grand MAL Convulsion, Dysarthria, Anticonvulsant Drug Level Above Therapeutic, Intention Tremor, Nystagmus, Hypotonia, Vision Blurred, Gait Disturbance, Coordination Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Methaqualone TAB
Dosage: 250 mg;bid;
Phenytoin
Dosage: 300 mg;qd; 300 mg;qd;
Indication: Epilepsy
Phenytoin
Dosage: 300 mg;qd; 300 mg;qd;
Indication: Epilepsy
Possible Phenytoin side effects in 53 year old male
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-06-21
Patient: 53 year old male
Reactions: Electrocardiogram ST Segment Depression, Anaesthetic Complication, Coronary Artery Disease, Drug Interaction, Toxicity To Various Agents, Electrocardiogram QRS Complex Abnormal, Electrocardiogram ST Segment Elevation, Haemodynamic Instability
Drug(s) suspected as cause:
Valproate Sodium
Dosage: unk, intravenous
Indication: Status Epilepticus
Phenytoin
Dosage: unk
Indication: Status Epilepticus
Other drugs received by patient: Inotropic Agents
Possible Phenytoin side effects in 53 year old male
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-06-14
Patient: 53 year old male
Reactions: Electrocardiogram ST Segment Depression, Coronary Artery Disease, Drug Interaction, Toxicity To Various Agents, Electrocardiogram ST Segment Elevation, Haemodynamic Instability
Drug(s) suspected as cause:
Valproate Sodium
Dosage: intravenous (otherwise not specified)
Indication: Status Epilepticus
Phenytoin
Indication: Status Epilepticus
Other drugs received by patient: Inotropic Agents
Possible Phenytoin side effects in 53 year old male
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-05-29
Patient: 53 year old male
Reactions: Electrocardiogram Abnormal, Drug Interaction, Toxicity To Various Agents
Drug(s) suspected as cause:
Phenytoin
Other drugs received by patient possibly interacting with the suspect drug: Valproic Acid
Indication: Status Epilepticus
Possible Phenytoin side effects in
Reported by a consumer/non-health professional from United States on 2012-05-09
Patient:
Reactions: Product Substitution Issue, Product Quality Issue, Drug Level Increased, Anticonvulsant Drug Level Increased, Unevaluable Event, Toxicity To Various Agents, Suicidal Ideation
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dilantin
Dosage: unk
Indication: Convulsion
Start date: 1997-01-01
Phenytoin
Dosage: unk
Indication: Convulsion
Possible Phenytoin side effects in 21 year old male
Reported by a health professional (non-physician/pharmacist) from India on 2012-04-24
Patient: 21 year old male
Reactions: Vestibular Disorder, Drug Interaction, Toxicity To Various Agents, Cerebellar Syndrome
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Phenytoin
Other drugs received by patient possibly interacting with the suspect drug: Mandrax
Possible Phenytoin side effects in 52 year old female
Reported by a physician from Turkey on 2012-04-20
Patient: 52 year old female
Reactions: Pneumonia Aspiration, Supraventricular Tachycardia, Coma, Toxicity To Various Agents, Electroencephalogram Abnormal, Neurotoxicity, Renal Failure, Respiratory Failure, Dehydration, Acute Respiratory Distress Syndrome, Hyperthyroidism
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Diuretics
Indication: Hypertension
Lithium Carbonate
Indication: Bipolar Disorder
Propranolol
Indication: Supraventricular Tachycardia
Insuline Glargine
Indication: Diabetes Mellitus
Irbesartane
Indication: Hypertension
Phenytoin
Dosage: 300 mg
Indication: Convulsion
Dexamethasone
Indication: Supraventricular Tachycardia
Dexamethasone
Dosage: 2 mg
Indication: Hyperthyroidism
Chlorpromazine
Dosage: 200 mg
Indication: Bipolar Disorder
Propranolol
Dosage: 160 mg
Indication: Hyperthyroidism
Propyl-Thiouracil
Indication: Supraventricular Tachycardia
Propyl-Thiouracil
Dosage: 600 mg
Indication: Hyperthyroidism
Possible Phenytoin side effects in 42 year old male
Reported by a pharmacist from United States on 2012-04-16
Patient: 42 year old male, weighing 111.0 kg (244.2 pounds)
Reactions: Nystagmus, Ataxia, Toxicity To Various Agents, Accidental Overdose
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Phenytoin
Possible Phenytoin side effects in 54 year old male
Reported by a pharmacist from United States on 2012-04-05
Patient: 54 year old male, weighing 80.9 kg (178.0 pounds)
Reactions: Product Substitution Issue, Asterixis, Ataxia, Gait Disturbance, Toxicity To Various Agents, Fall, RIB Fracture
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Phenytoin
Possible Phenytoin side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-03
Patient:
Reactions: Pneumonia, Overdose, Toxicity To Various Agents
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Phenytoin
Methadone HCL
Possible Phenytoin side effects in male
Reported by a physician from United States on 2012-04-02
Patient: male, weighing 2.4 kg (5.3 pounds)
Reactions: Metabolic Acidosis, Ventricular Arrhythmia, Drug Interaction, Atrioventricular Block, Toxicity To Various Agents, Sinus Bradycardia, Long QT Syndrome Congenital
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Lidocaine
Dosage: 1 mg/kg; 10 ug/kg; 40 ug/kg; 1 mg/kg;2 times; 50 ug/kg; 1 mg/kg; iv
Indication: Ventricular Tachycardia
Amiodarone HCL
Dosage: 1 mg/kg; 3 mg;11 times; 1 mg/kg;3 times;
Indication: Torsade DE Pointes
Phenytoin
Dosage: 8 mg/kg; 5 mg/kg;
Indication: Ventricular Tachycardia
Other drugs received by patient: Potassium; Dopamine HCL; Vecuronium Bromide; Fentanyl Citrate; Magnesium; Calcium Gluconate; 5% Albumin; Esmolol HCL; Milrinone; Isoproterenol HCL
Possible Phenytoin side effects in 59 year old male
Reported by a individual with unspecified qualification from Japan on 2012-03-28
Patient: 59 year old male
Reactions: Drug Level Increased, Nausea, Condition Aggravated, Drug Interaction, Toxicity To Various Agents, Treatment Noncompliance, Convulsion, Dyslalia, Anxiety, Insomnia, Hypophagia, Dizziness, Gastrooesophageal Reflux Disease
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Phenytoin
Dosage: 300 mg (100 mg, 3 in 1 d) 200 mg (200 mg, 1 d), 225 mg (225 mg, 1 d)
Administration route: Oral
Indication: Epilepsy
Start date: 1994-01-01
End date: 2012-02-02
Phenytoin
Dosage: 300 mg (100 mg, 3 in 1 d) 200 mg (200 mg, 1 d), 225 mg (225 mg, 1 d)
Administration route: Oral
Indication: Epilepsy
Start date: 2012-02-03
End date: 2012-02-17
Phenytoin
Dosage: 300 mg (100 mg, 3 in 1 d) 200 mg (200 mg, 1 d), 225 mg (225 mg, 1 d)
Administration route: Oral
Indication: Epilepsy
Start date: 2012-02-18
Lansoprazole
Dosage: 15 mg (15 mg, 1 in 1 d)
Administration route: Oral
Indication: Gastrooesophageal Reflux Disease
Start date: 2011-09-02
End date: 2012-02-09
Possible Phenytoin side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-09
Patient: male, weighing 113.4 kg (249.4 pounds)
Reactions: Drug Hypersensitivity, Ataxia, Anticonvulsant Drug Level Decreased, Toxicity To Various Agents, Thermal Burn, Suicidal Ideation, Balance Disorder, Depression
Drug(s) suspected as cause:
Phenytoin
Dosage: unk
Indication: Convulsion
Dilantin-125
Dosage: 400 mg, unk
Administration route: Oral
Indication: Convulsion
Dilantin-125
Dosage: 100 mg,5 per day
Keppra
Indication: Convulsion
Start date: 2010-06-06
End date: 2010-06-16
Topamax
Dosage: frequency: 2x/day,
Indication: Convulsion
Start date: 2010-01-01
Possible Phenytoin side effects in 64 year old female
Reported by a individual with unspecified qualification from Canada on 2012-03-08
Patient: 64 year old female
Reactions: Colon Cancer Metastatic, Ataxia, Hyperreflexia, Drug Interaction, Anticonvulsant Drug Level Decreased, Toxicity To Various Agents, Somnolence, Balance Disorder, Dizziness, Gait Disturbance
Drug(s) suspected as cause:
Fluorouracil
Indication: Colon Cancer
Phenytoin
Indication: Epilepsy
Other drugs received by patient: Calcium Carbonate; Venlafaxine; Etidronate Disodium; Irinotecan HCL; Docusate Sodium; Leucovorin Calcium; Cetuximab
Possible Phenytoin side effects in male
Reported by a physician from United States on 2012-02-24
Patient: male, weighing 2.4 kg (5.3 pounds)
Reactions: Neurotoxicity, Nasopharyngitis, Drug Interaction, Toxicity To Various Agents, Cardiac Disorder
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Esmolol HCL
Dosage: 66;30;200;250;500 mcg/kg/min, intravenous drip
Indication: Ventricular Arrhythmia
Fentanyl Citrate
Dosage: 5 ug/kg, microgram/kilogram,
Indication: Anaesthesia
Fentanyl Citrate
Dosage: 5 ug/kg, microgram/kilogram,
Indication: Arrhythmia
Phenytoin
Dosage: 8;5mg/kg milligram(s)/kilogram, intravenous bolus
Indication: Ventricular Arrhythmia
Lidocaine HCL
Dosage: 1;40;50 mg/kg milligram(s)/kilogram, intravenous bolus
Indication: Ventricular Arrhythmia
Amiodarone HCL
Dosage: 1;3mg/dose, intravenous bolus
Indication: Ventricular Arrhythmia
Magnesium Sulfate
Dosage: i25 mg/kg per dose, ntravenous bolus
Indication: Ventricular Arrhythmia
Other drugs received by patient: Potassium Chloride; Sodium Hydrogen Carbonate; Albumin (Human); Clcium Gluconate; Vecuronium Bromide; Isoproterenol Hydrochloride; Milrinone
Possible Phenytoin side effects in 64 year old female
Reported by a physician from Japan on 2012-02-13
Patient: 64 year old female
Reactions: Toxicity To Various Agents, Convulsion
Drug(s) suspected as cause:
Phenytoin
Other drugs received by patient: Valproic Acid; Pazufloxacin; Ceftazidime; Clindamycin
Possible Phenytoin side effects in 66 year old male
Reported by a pharmacist from United States on 2012-02-10
Patient: 66 year old male, weighing 84.9 kg (186.8 pounds)
Reactions: Chills, Sedation, Toxicity To Various Agents, Cough, Convulsion
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Phenytoin
Possible Phenytoin side effects in male
Reported by a physician from United States on 2012-01-31
Patient: male, weighing 113.4 kg (249.4 pounds)
Reactions: Drug Hypersensitivity, Anticonvulsant Drug Level Decreased, Ataxia, Toxicity To Various Agents, Thermal Burn, Suicidal Ideation, Balance Disorder, Depression
Drug(s) suspected as cause:
Dilantin-125
Dosage: 100 mg,5 per day
Topamax
Dosage: frequency: 2x/day,
Indication: Convulsion
Start date: 2010-01-01
Phenytoin
Dosage: unk
Indication: Convulsion
Dilantin-125
Dosage: 400 mg, unk
Administration route: Oral
Indication: Convulsion
Keppra
Indication: Convulsion
Start date: 2010-06-06
End date: 2010-06-16
Possible Phenytoin side effects in 49 year old female
Reported by a physician from United States on 2012-01-25
Patient: 49 year old female
Reactions: Respiratory Arrest, Toxicity To Various Agents, Intentional Drug Misuse, Cardiac Arrest
Adverse event resulted in: death
Drug(s) suspected as cause:
Alprazolam
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Phenytoin
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Topiramate
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Acetaminophen and Hydrocodone Bitartrate
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Possible Phenytoin side effects in 64 year old female
Reported by a physician from Canada on 2012-01-17
Patient: 64 year old female
Reactions: Drug Interaction, Hyperreflexia, Ataxia, Toxicity To Various Agents, Somnolence, Anticonvulsant Drug Level Below Therapeutic, Anticonvulsant Drug Level Above Therapeutic, Balance Disorder, Dizziness, Gait Disturbance
Drug(s) suspected as cause:
Fluorouracil
Indication: Chemotherapy
Phenytoin
Dosage: 200 mg; tid; po
Administration route: Oral
Indication: Epilepsy
Other drugs received by patient: Venlafaxine HCL Extended-Release; Irinotecan HCL; Etidronate and Calcium Carbonate; Leucovorin Calcium; Docusate Sodium
Possible Phenytoin side effects in 73 year old female
Reported by a physician from United States on 2012-01-17
Patient: 73 year old female
Reactions: Intentional Drug Misuse, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Omeprazole
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Sertraline Hydrochloride
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Hydroxyzine
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Antihyperlipidemic
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Gabapentin
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Phenytoin
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Metoprolol Tartrate
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Possible Phenytoin side effects in 73 year old female
Reported by a physician from United States on 2012-01-17
Patient: 73 year old female
Reactions: Intentional Drug Misuse, Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Hydroxyzine
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Phenytoin
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Omeprazole
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Antihyperlipidemic
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Metoprolol Tartrate
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Gabapentin
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Sertraline Hydrochloride
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Possible Phenytoin side effects in 52 year old male
Reported by a physician from United States on 2012-01-17
Patient: 52 year old male
Reactions: Toxicity To Various Agents
Adverse event resulted in: death
Drug(s) suspected as cause:
Levetiracetam
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Phenytoin
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
Barbiturate (Barbiturate)
Indication: Product Used FOR Unknown Indication
End date: 2010-01-01
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