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Phenytoin (Phenytoin) - Toxic Epidermal Necrolysis - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Toxic Epidermal Necrolysis (21)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Phenytoin where reactions include toxic epidermal necrolysis. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Phenytoin side effects in 63 year old female

Reported by a pharmacist from United States on 2012-08-16

Patient: 63 year old female

Reactions: Tubulointerstitial Nephritis, Toxic Epidermal Necrolysis

Drug(s) suspected as cause:
Phenytoin
    Dosage: 600 mg, daily
    Administration route: Oral

Phenytoin
    Dosage: 300 mg/day
    Administration route: Oral
    Indication: Postictal State

Other drugs received by patient: Chlorthalidone; Clonidine



Possible Phenytoin side effects in 16 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16

Patient: 16 year old male

Reactions: Sepsis, Toxic Epidermal Necrolysis, Rash Morbilliform, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 20 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16

Patient: 20 year old male

Reactions: Sepsis, Toxic Epidermal Necrolysis, Drug Rash With Eosinophilia and Systemic Symptoms, Dermatitis Exfoliative

Adverse event resulted in: death

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 10 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-06

Patient: 10 year old female

Reactions: Lymphadenopathy, Renal Failure, Toxic Epidermal Necrolysis, Dermatitis Exfoliative, Hepatitis, Nephritis, Eosinophilia

Drug(s) suspected as cause:
Phenytoin



Possible Phenytoin side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-06

Patient: 54 year old male

Reactions: Multi-Organ Failure, Toxic Epidermal Necrolysis, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Phenytoin
    Administration route: Oral
    Indication: Convulsion
    Start date: 2010-12-02

Omeprazole
    Start date: 2011-03-12



Possible Phenytoin side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-06

Patient: 54 year old male

Reactions: Multi-Organ Failure, Toxic Epidermal Necrolysis, Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Omeprazole
    Start date: 2011-03-12

Phenytoin
    Administration route: Oral
    Indication: Convulsion
    Start date: 2010-12-02



Possible Phenytoin side effects in 60 year old male

Reported by a physician from United Kingdom on 2012-06-30

Patient: 60 year old male

Reactions: Aphagia, Skin Exfoliation, Pain, Toxic Epidermal Necrolysis, Respiratory Failure, Dehydration, Oral Disorder, Rash Maculo-Papular, Eye Disorder, Blister

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Phenytoin
    Indication: Convulsion
    Start date: 2012-04-01

Dalteparin Sodium
    Indication: Deep Vein Thrombosis
    Start date: 2012-05-25
    End date: 2012-06-06



Possible Phenytoin side effects in 43 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-25

Patient: 43 year old female

Reactions: Coagulopathy, Mean Cell Volume Decreased, Prothrombin Time Prolonged, Activated Partial Thromboplastin Time Prolonged, Oral Candidiasis, C-Reactive Protein Increased, Fibrin D Dimer Increased, Cellulitis, Blood Lactate Dehydrogenase Increased, Toxic Epidermal Necrolysis, Blood Fibrinogen Increased, Blood Phosphorus Decreased, Prealbumin Decreased, Blood Urea Decreased, Platelet Count Decreased, Rash Maculo-Papular, Lymphocyte Percentage Decreased, Blood Calcium Decreased, Blood Creatinine Decreased, Haematocrit Decreased, Gamma-Glutamyltransferase Increased, International Normalised Ratio Decreased, Blood Sodium Decreased, Blood Glucose Increased, White Blood Cell Count Decreased, Neutrophil Percentage Increased, Vomiting, Swelling Face, Odynophagia, Respiratory Failure, Monocyte Percentage Decreased, Dysuria

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Phenytoin

Other drugs received by patient: Dexamethasone



Possible Phenytoin side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-05-18

Patient: 54 year old male

Reactions: Amylase Increased, Hyperbilirubinaemia, Blood Trypsin Increased, Alanine Aminotransferase Increased, Toxic Epidermal Necrolysis, Lymphocyte Stimulation Test Positive, Corneal Epithelium Defect, Blood Elastase Increased, Drug Rash With Eosinophilia and Systemic Symptoms, Gastric Haemorrhage, Multi-Organ Failure, Renal Impairment, Dialysis, Blood Disorder, Hypogammaglobulinaemia

Adverse event resulted in: death

Drug(s) suspected as cause:
Phenytoin
    Indication: Convulsion
    Start date: 2010-12-02

Omeprazole
    Indication: Melaena

Omeprazole
    Indication: Gastric Haemorrhage



Possible Phenytoin side effects in 52 year old male

Reported by a health professional (non-physician/pharmacist) from Netherlands on 2012-04-30

Patient: 52 year old male

Reactions: Pneumonia, Respiratory Failure, Toxic Epidermal Necrolysis, Bacterial Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Phenytoin

Other drugs received by patient: Vinorelbine; Dexamethasone; Cisplatin



Possible Phenytoin side effects in 65 year old male

Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-04-30

Patient: 65 year old male

Reactions: Toxic Epidermal Necrolysis

Adverse event resulted in: death

Drug(s) suspected as cause:
Dexamethasone
    Dosage: 16 mg;qd

Phenytoin
    Dosage: 300 mg;qd;po
    Administration route: Oral
    Indication: Convulsion



Possible Phenytoin side effects in 71 year old male

Reported by a pharmacist from United States on 2012-02-22

Patient: 71 year old male, weighing 78.0 kg (171.6 pounds)

Reactions: Skin Exfoliation, Hypotension, Toxic Epidermal Necrolysis, Stevens-Johnson Syndrome

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Phenytoin
    Dosage: 100 mg tid iv
    Indication: Convulsion
    Start date: 2012-02-16
    End date: 2012-02-17

Fosphenytoin
    Dosage: 1680 mg once iv
    Indication: Convulsion
    Start date: 2012-02-16
    End date: 2012-02-16



Possible Phenytoin side effects in

Reported by a consumer/non-health professional from Japan on 2012-01-09

Patient:

Reactions: Hepatic Function Abnormal, Respiratory Disorder, Gastrointestinal Haemorrhage, Haemorrhage, Disseminated Intravascular Coagulation, Apoptosis, Pyrexia, Multi-Organ Failure, Pneumocystis Jiroveci Pneumonia, Conjunctival Hyperaemia, Pulmonary Oedema, Stevens-Johnson Syndrome, Blister, Pneumonia Fungal, Corneal Defect, Toxic Epidermal Necrolysis, Rash, Renal Impairment, Epidermal Necrosis, Sepsis, Aspergillosis, Cytomegalovirus Infection, Blood Disorder, Cardiovascular Disorder

Adverse event resulted in: death

Drug(s) suspected as cause:
Clobazam
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Phenytoin
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Cefoperazone Sodium
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Meropenem
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Levofloxacin
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Digoxin
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Valproic Acid
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Piperacillin
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Farom
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Lasix
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Ciprofloxacin
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Aldactone
    Dosage: unk
    Indication: Product Used FOR Unknown Indication

Zonisamide
    Dosage: unk
    Indication: Product Used FOR Unknown Indication



Possible Phenytoin side effects in 42 year old female

Reported by a physician from United Kingdom on 2011-11-22

Patient: 42 year old female, weighing 75.0 kg (165.0 pounds)

Reactions: Toxic Epidermal Necrolysis, Herpes Zoster Disseminated, Rash, Pyrexia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Phenytoin
    Dosage: unk
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2011-08-30
    End date: 2011-10-14

Halaven
    Dosage: unk
    Indication: Breast Cancer Metastatic
    Start date: 2011-10-04
    End date: 2011-10-04

Other drugs received by patient: Paracetamol



Possible Phenytoin side effects in female

Reported by a physician from United Kingdom on 2011-11-11

Patient: female, weighing 75.0 kg (165.0 pounds)

Reactions: Toxic Epidermal Necrolysis, Pyrexia, Rash

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Halaven
    Dosage: unknown
    Start date: 2011-10-04
    End date: 2011-10-04

Phenytoin
    Dosage: unknown
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2011-08-30
    End date: 2011-10-14

Other drugs received by patient: Acetaminophen



Possible Phenytoin side effects in 42 year old female

Reported by a physician from United Kingdom on 2011-11-10

Patient: 42 year old female, weighing 75.0 kg (165.0 pounds)

Reactions: Herpes Zoster Disseminated, Toxic Epidermal Necrolysis, Pyrexia, Rash

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Phenytoin
    Dosage: unk
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2011-08-30
    End date: 2011-10-14

Halaven
    Dosage: unk
    Indication: Breast Cancer Metastatic
    Start date: 2011-10-04
    End date: 2011-10-04

Other drugs received by patient: Paracetamol



Possible Phenytoin side effects in 42 year old female

Reported by a physician from United Kingdom on 2011-11-08

Patient: 42 year old female, weighing 75.0 kg (165.0 pounds)

Reactions: Toxic Epidermal Necrolysis, Herpes Zoster Disseminated, Pyrexia, Rash

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Halaven
    Dosage: unk
    Indication: Breast Cancer Metastatic
    Start date: 2011-10-04
    End date: 2011-10-04

Phenytoin
    Dosage: unk
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2011-08-30
    End date: 2011-10-14

Other drugs received by patient: Paracetamol



Possible Phenytoin side effects in 42 year old female

Reported by a physician from United Kingdom on 2011-11-03

Patient: 42 year old female

Reactions: Body Temperature Increased, Herpes Zoster Disseminated, Toxic Epidermal Necrolysis, Rash

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Halaven
    Dosage: unk
    Indication: Breast Cancer Metastatic
    Start date: 2011-09-30

Phenytoin
    Dosage: unk
    Start date: 2011-08-01



Possible Phenytoin side effects in 14 year old female

Reported by a health professional (non-physician/pharmacist) from Spain on 2011-11-01

Patient: 14 year old female

Reactions: Toxic Epidermal Necrolysis

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Phenobarbital TAB
    Indication: Epilepsy

Phenytoin
    Indication: Epilepsy



Possible Phenytoin side effects in female

Reported by a physician from United Kingdom on 2011-10-27

Patient: female

Reactions: Toxic Epidermal Necrolysis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Halaven
    Dosage: unknown
    Start date: 2011-09-30

Phenytoin
    Dosage: unknown
    Start date: 2011-08-01



Possible Phenytoin side effects in female

Reported by a physician from NEW Zealand on 2011-08-22

Patient: female

Reactions: Hepatitis C, Toxic Epidermal Necrolysis, Lactic Acidosis, Thermal Burn

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Carbamazepine
    Indication: Product Used FOR Unknown Indication

Lamivudine (Epivir Hbv)
    Dosage: 100mg per day
    Administration route: Oral
    Indication: Hepatitis C
    End date: 2010-11-01

Phenytoin
    Dosage: 300mg per day
    Administration route: Oral
    Indication: Epilepsy
    Start date: 2008-01-01
    End date: 2010-11-01

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