Index of reports
> Cases with Toxic Epidermal Necrolysis (21)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Phenytoin where reactions include toxic epidermal necrolysis. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Phenytoin side effects in 63 year old female
Reported by a pharmacist from United States on 2012-08-16
Patient: 63 year old female
Reactions: Tubulointerstitial Nephritis, Toxic Epidermal Necrolysis
Drug(s) suspected as cause:
Phenytoin
Dosage: 600 mg, daily
Administration route: Oral
Phenytoin
Dosage: 300 mg/day
Administration route: Oral
Indication: Postictal State
Other drugs received by patient: Chlorthalidone; Clonidine
Possible Phenytoin side effects in 16 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16
Patient: 16 year old male
Reactions: Sepsis, Toxic Epidermal Necrolysis, Rash Morbilliform, Drug Rash With Eosinophilia and Systemic Symptoms
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Phenytoin
Possible Phenytoin side effects in 20 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16
Patient: 20 year old male
Reactions: Sepsis, Toxic Epidermal Necrolysis, Drug Rash With Eosinophilia and Systemic Symptoms, Dermatitis Exfoliative
Adverse event resulted in: death
Drug(s) suspected as cause:
Phenytoin
Possible Phenytoin side effects in 10 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-06
Patient: 10 year old female
Reactions: Lymphadenopathy, Renal Failure, Toxic Epidermal Necrolysis, Dermatitis Exfoliative, Hepatitis, Nephritis, Eosinophilia
Drug(s) suspected as cause:
Phenytoin
Possible Phenytoin side effects in 54 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-06
Patient: 54 year old male
Reactions: Multi-Organ Failure, Toxic Epidermal Necrolysis, Drug Rash With Eosinophilia and Systemic Symptoms
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Phenytoin
Administration route: Oral
Indication: Convulsion
Start date: 2010-12-02
Omeprazole
Start date: 2011-03-12
Possible Phenytoin side effects in 54 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-06
Patient: 54 year old male
Reactions: Multi-Organ Failure, Toxic Epidermal Necrolysis, Drug Rash With Eosinophilia and Systemic Symptoms
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Omeprazole
Start date: 2011-03-12
Phenytoin
Administration route: Oral
Indication: Convulsion
Start date: 2010-12-02
Possible Phenytoin side effects in 60 year old male
Reported by a physician from United Kingdom on 2012-06-30
Patient: 60 year old male
Reactions: Aphagia, Skin Exfoliation, Pain, Toxic Epidermal Necrolysis, Respiratory Failure, Dehydration, Oral Disorder, Rash Maculo-Papular, Eye Disorder, Blister
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Phenytoin
Indication: Convulsion
Start date: 2012-04-01
Dalteparin Sodium
Indication: Deep Vein Thrombosis
Start date: 2012-05-25
End date: 2012-06-06
Possible Phenytoin side effects in 43 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-25
Patient: 43 year old female
Reactions: Coagulopathy, Mean Cell Volume Decreased, Prothrombin Time Prolonged, Activated Partial Thromboplastin Time Prolonged, Oral Candidiasis, C-Reactive Protein Increased, Fibrin D Dimer Increased, Cellulitis, Blood Lactate Dehydrogenase Increased, Toxic Epidermal Necrolysis, Blood Fibrinogen Increased, Blood Phosphorus Decreased, Prealbumin Decreased, Blood Urea Decreased, Platelet Count Decreased, Rash Maculo-Papular, Lymphocyte Percentage Decreased, Blood Calcium Decreased, Blood Creatinine Decreased, Haematocrit Decreased, Gamma-Glutamyltransferase Increased, International Normalised Ratio Decreased, Blood Sodium Decreased, Blood Glucose Increased, White Blood Cell Count Decreased, Neutrophil Percentage Increased, Vomiting, Swelling Face, Odynophagia, Respiratory Failure, Monocyte Percentage Decreased, Dysuria
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Phenytoin
Other drugs received by patient: Dexamethasone
Possible Phenytoin side effects in 54 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-05-18
Patient: 54 year old male
Reactions: Amylase Increased, Hyperbilirubinaemia, Blood Trypsin Increased, Alanine Aminotransferase Increased, Toxic Epidermal Necrolysis, Lymphocyte Stimulation Test Positive, Corneal Epithelium Defect, Blood Elastase Increased, Drug Rash With Eosinophilia and Systemic Symptoms, Gastric Haemorrhage, Multi-Organ Failure, Renal Impairment, Dialysis, Blood Disorder, Hypogammaglobulinaemia
Adverse event resulted in: death
Drug(s) suspected as cause:
Phenytoin
Indication: Convulsion
Start date: 2010-12-02
Omeprazole
Indication: Melaena
Omeprazole
Indication: Gastric Haemorrhage
Possible Phenytoin side effects in 52 year old male
Reported by a health professional (non-physician/pharmacist) from Netherlands on 2012-04-30
Patient: 52 year old male
Reactions: Pneumonia, Respiratory Failure, Toxic Epidermal Necrolysis, Bacterial Sepsis
Adverse event resulted in: death
Drug(s) suspected as cause:
Phenytoin
Other drugs received by patient: Vinorelbine; Dexamethasone; Cisplatin
Possible Phenytoin side effects in 65 year old male
Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-04-30
Patient: 65 year old male
Reactions: Toxic Epidermal Necrolysis
Adverse event resulted in: death
Drug(s) suspected as cause:
Dexamethasone
Dosage: 16 mg;qd
Phenytoin
Dosage: 300 mg;qd;po
Administration route: Oral
Indication: Convulsion
Possible Phenytoin side effects in 71 year old male
Reported by a pharmacist from United States on 2012-02-22
Patient: 71 year old male, weighing 78.0 kg (171.6 pounds)
Reactions: Skin Exfoliation, Hypotension, Toxic Epidermal Necrolysis, Stevens-Johnson Syndrome
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Phenytoin
Dosage: 100 mg tid iv
Indication: Convulsion
Start date: 2012-02-16
End date: 2012-02-17
Fosphenytoin
Dosage: 1680 mg once iv
Indication: Convulsion
Start date: 2012-02-16
End date: 2012-02-16
Possible Phenytoin side effects in
Reported by a consumer/non-health professional from Japan on 2012-01-09
Patient:
Reactions: Hepatic Function Abnormal, Respiratory Disorder, Gastrointestinal Haemorrhage, Haemorrhage, Disseminated Intravascular Coagulation, Apoptosis, Pyrexia, Multi-Organ Failure, Pneumocystis Jiroveci Pneumonia, Conjunctival Hyperaemia, Pulmonary Oedema, Stevens-Johnson Syndrome, Blister, Pneumonia Fungal, Corneal Defect, Toxic Epidermal Necrolysis, Rash, Renal Impairment, Epidermal Necrosis, Sepsis, Aspergillosis, Cytomegalovirus Infection, Blood Disorder, Cardiovascular Disorder
Adverse event resulted in: death
Drug(s) suspected as cause:
Clobazam
Dosage: unk
Indication: Product Used FOR Unknown Indication
Phenytoin
Dosage: unk
Indication: Product Used FOR Unknown Indication
Cefoperazone Sodium
Dosage: unk
Indication: Product Used FOR Unknown Indication
Meropenem
Dosage: unk
Indication: Product Used FOR Unknown Indication
Levofloxacin
Dosage: unk
Indication: Product Used FOR Unknown Indication
Digoxin
Dosage: unk
Indication: Product Used FOR Unknown Indication
Valproic Acid
Dosage: unk
Indication: Product Used FOR Unknown Indication
Piperacillin
Dosage: unk
Indication: Product Used FOR Unknown Indication
Farom
Dosage: unk
Indication: Product Used FOR Unknown Indication
Lasix
Dosage: unk
Indication: Product Used FOR Unknown Indication
Ciprofloxacin
Dosage: unk
Indication: Product Used FOR Unknown Indication
Aldactone
Dosage: unk
Indication: Product Used FOR Unknown Indication
Zonisamide
Dosage: unk
Indication: Product Used FOR Unknown Indication
Possible Phenytoin side effects in 42 year old female
Reported by a physician from United Kingdom on 2011-11-22
Patient: 42 year old female, weighing 75.0 kg (165.0 pounds)
Reactions: Toxic Epidermal Necrolysis, Herpes Zoster Disseminated, Rash, Pyrexia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Phenytoin
Dosage: unk
Administration route: Oral
Indication: Epilepsy
Start date: 2011-08-30
End date: 2011-10-14
Halaven
Dosage: unk
Indication: Breast Cancer Metastatic
Start date: 2011-10-04
End date: 2011-10-04
Other drugs received by patient: Paracetamol
Possible Phenytoin side effects in female
Reported by a physician from United Kingdom on 2011-11-11
Patient: female, weighing 75.0 kg (165.0 pounds)
Reactions: Toxic Epidermal Necrolysis, Pyrexia, Rash
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Halaven
Dosage: unknown
Start date: 2011-10-04
End date: 2011-10-04
Phenytoin
Dosage: unknown
Administration route: Oral
Indication: Epilepsy
Start date: 2011-08-30
End date: 2011-10-14
Other drugs received by patient: Acetaminophen
Possible Phenytoin side effects in 42 year old female
Reported by a physician from United Kingdom on 2011-11-10
Patient: 42 year old female, weighing 75.0 kg (165.0 pounds)
Reactions: Herpes Zoster Disseminated, Toxic Epidermal Necrolysis, Pyrexia, Rash
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Phenytoin
Dosage: unk
Administration route: Oral
Indication: Epilepsy
Start date: 2011-08-30
End date: 2011-10-14
Halaven
Dosage: unk
Indication: Breast Cancer Metastatic
Start date: 2011-10-04
End date: 2011-10-04
Other drugs received by patient: Paracetamol
Possible Phenytoin side effects in 42 year old female
Reported by a physician from United Kingdom on 2011-11-08
Patient: 42 year old female, weighing 75.0 kg (165.0 pounds)
Reactions: Toxic Epidermal Necrolysis, Herpes Zoster Disseminated, Pyrexia, Rash
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Halaven
Dosage: unk
Indication: Breast Cancer Metastatic
Start date: 2011-10-04
End date: 2011-10-04
Phenytoin
Dosage: unk
Administration route: Oral
Indication: Epilepsy
Start date: 2011-08-30
End date: 2011-10-14
Other drugs received by patient: Paracetamol
Possible Phenytoin side effects in 42 year old female
Reported by a physician from United Kingdom on 2011-11-03
Patient: 42 year old female
Reactions: Body Temperature Increased, Herpes Zoster Disseminated, Toxic Epidermal Necrolysis, Rash
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Halaven
Dosage: unk
Indication: Breast Cancer Metastatic
Start date: 2011-09-30
Phenytoin
Dosage: unk
Start date: 2011-08-01
Possible Phenytoin side effects in 14 year old female
Reported by a health professional (non-physician/pharmacist) from Spain on 2011-11-01
Patient: 14 year old female
Reactions: Toxic Epidermal Necrolysis
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Phenobarbital TAB
Indication: Epilepsy
Phenytoin
Indication: Epilepsy
Possible Phenytoin side effects in female
Reported by a physician from United Kingdom on 2011-10-27
Patient: female
Reactions: Toxic Epidermal Necrolysis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Halaven
Dosage: unknown
Start date: 2011-09-30
Phenytoin
Dosage: unknown
Start date: 2011-08-01
Possible Phenytoin side effects in female
Reported by a physician from NEW Zealand on 2011-08-22
Patient: female
Reactions: Hepatitis C, Toxic Epidermal Necrolysis, Lactic Acidosis, Thermal Burn
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Carbamazepine
Indication: Product Used FOR Unknown Indication
Lamivudine (Epivir Hbv)
Dosage: 100mg per day
Administration route: Oral
Indication: Hepatitis C
End date: 2010-11-01
Phenytoin
Dosage: 300mg per day
Administration route: Oral
Indication: Epilepsy
Start date: 2008-01-01
End date: 2010-11-01
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