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Oncaspar (Pegaspargase) - Pyrexia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Pyrexia (6)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Oncaspar (Pegaspargase) where reactions include pyrexia. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Oncaspar side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24

Patient: male, weighing 121.9 kg (268.2 pounds)

Reactions: Pruritus, Unresponsive To Stimuli, Device Related Infection, Pyrexia, Candidiasis, Abscess Limb, Ventricular Extrasystoles, Metabolic Acidosis, Dyspnoea, Hypotension, Pancytopenia, Tremor, Convulsion, Respiratory Failure, Fungal Infection, Ventricular Tachycardia, Sepsis, Respiratory Arrest, Pulse Absent, Sinus Tachycardia, Hypertension, Feeling Abnormal, Cardiac Arrest, Escherichia Infection, Infusion Related Reaction

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Epinephrine
    Dosage: 4 df, unk
    Indication: Cardiac Arrest
    Start date: 2012-07-14
    End date: 2012-07-14

Cyclophosphamide
    Dosage: daily for 5 days
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-19
    End date: 2012-06-23

Oncaspar
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-07-02
    End date: 2012-07-02

Epinephrine
    Dosage: unk
    Start date: 2012-07-14
    End date: 2012-07-14

Clolar
    Dosage: 74.4 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-19
    End date: 2012-06-23

Etoposide
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-19
    End date: 2012-06-23

Vincristine Sulfate
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-07-02
    End date: 2012-07-02

Other drugs received by patient: Colace; Bactrim; Stomatitis Mouthwash; Prilosec; Lortab; Cymbalta; Ondansetron; Ambien



Possible Oncaspar side effects in 17 year old female

Reported by a physician from United States on 2012-06-08

Patient: 17 year old female, weighing 47.6 kg (104.7 pounds)

Reactions: Blood Bilirubin Increased, Pyrexia, Caecitis, Loss of Consciousness, Oedema Peripheral, Pulmonary Oedema, Hypocalcaemia, Acute Respiratory Distress Syndrome, Melaena, Hypertriglyceridaemia, Epistaxis, Dysphagia, Anaemia, Hyperglycaemia, General Physical Health Deterioration, Eating Disorder, Tremor, Cerebral Infarction, Depressed Level of Consciousness, Neutropenia, Confusional State, Dyskinesia, Somnolence, Splenic Infarction, Hypokalaemia, Pleural Effusion, White Blood Cell Count Decreased, Cerebrovascular Accident, Ascites, Diarrhoea, Hypophagia, Hypoalbuminaemia, Sinus Tachycardia, Hypertension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 60mgm2 cyclic
    Administration route: Oral
    Indication: T-Cell Type Acute Leukaemia

Vincristine
    Dosage: 1.5mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Cyclophosphamide
    Dosage: 1000mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Methotrexate
    Indication: T-Cell Type Acute Leukaemia

Oncaspar
    Indication: T-Cell Type Acute Leukaemia

Nelarabine
    Dosage: 650mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-04-13

Cytarabine
    Dosage: 75mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Dalteparin Sodium
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Nystatin; Lansoprazole; Insulin Aspart; Piperacillin and Tazobactam; Vancomycin; Voriconazole



Possible Oncaspar side effects in 10 year old male

Reported by a physician from United States on 2012-05-24

Patient: 10 year old male, weighing 22.3 kg (49.1 pounds)

Reactions: Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL
    Dosage: 27 mg, qd on day 1 and 5
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-03-31
    End date: 2012-05-01

Methylprednisolone Acetate
    Dosage: 9.7 mg, q8h on day 4 to day 32
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-03

Etoposide
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-10

Afinitor
    Dosage: 2 mg, qd on day 1 to day 32
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-03-31
    End date: 2012-05-01

Oncaspar
    Dosage: 2275 iu, qd on days 4 to 32
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-03-31
    End date: 2012-05-01

Vincristine
    Dosage: 1.4 mg, qd on day 4, 11, 18 and 25
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-03-31
    End date: 2012-05-01

Cytoxan
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-10

Other drugs received by patient: Leucovorin Calcium; Ondansetron; Senna-Mint WAF; Colace; Sulfamethoxypyrazine / Trimethoprim; Ondansetron; Concerta; Calcium Carbonate; Clonidine



Possible Oncaspar side effects in 19 year old female

Reported by a physician from United States on 2012-04-24

Patient: 19 year old female, weighing 160.0 kg (352.0 pounds)

Reactions: Axillary Vein Thrombosis, Pyrexia, High Density Lipoprotein Decreased, Very LOW Density Lipoprotein Increased, Vena Cava Thrombosis, Thrombophlebitis, Blood Cholesterol Increased, Hypertriglyceridaemia

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Oncaspar
    Dosage: 4500 iu;x1; 2125 iu;x1;
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-12-01
    End date: 2011-12-01

Oncaspar
    Dosage: 4500 iu;x1; 2125 iu;x1;
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-01-17
    End date: 2012-01-17

Oncaspar
    Dosage: 4500 iu;x1; 2125 iu;x1;
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-02-14
    End date: 2012-02-14

Oncaspar



Possible Oncaspar side effects in 8 year old female

Reported by a pharmacist from United States on 2012-04-02

Patient: 8 year old female, weighing 26.0 kg (57.2 pounds)

Reactions: Hypersensitivity, Vomiting, Nausea, Chills, Pyrexia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Oncaspar



Possible Oncaspar side effects in 29 year old female

Reported by a individual with unspecified qualification from United Kingdom on 2011-10-20

Patient: 29 year old female

Reactions: Mucosal Inflammation, Hyperbilirubinaemia, Oral Pain, Pyrexia

Drug(s) suspected as cause:
Oncaspar
    Dosage: (1725 iu, d4+18) intravenous
    Start date: 2011-03-21
    End date: 2011-04-04

Palifermin (Palifermin)
    Dosage: (4.3 mg, per protocol) intravenous
    Indication: Stomatitis
    Start date: 2011-07-17
    End date: 2011-07-30

Palifermin (Palifermin)
    Dosage: (4.3 mg, per protocol) intravenous
    Indication: Prophylaxis
    Start date: 2011-07-17
    End date: 2011-07-30

Other drugs received by patient: Itraconazole; Allopurinol; Norethindrone; Difflan (Benzydamine Hydrochloride); Tazocin (Tazocin); Acyclovir; Enoxaparin Sodium; Acyclovir; Benzocaine + Codeine Mouthwash (Benzocaine, Codein); Cyclicine (Cyclicine); Acetaminophen; Codeine Sulfate; Piperacillin and Tazobactam; Chlorhexidine Gluconate; Cyclosporine; Nystatin; Itraconazole; Morphine Sulphate (Morphine Sulphate); Teicoplanin (Teicoplanin); Ondansetron

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