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Nexavar (Sorafenib) - Death - Suspected Cause - Side Effect Reports

 
 



Index of reports > Death (538)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Nexavar (Sorafenib) death. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 538   Next >>

Possible Nexavar side effects in 35 year old male

Reported by a physician from Japan on 2012-08-27

Patient: 35 year old male, weighing 68.3 kg (150.3 pounds)

Reactions: Hepatic Function Abnormal

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2010-06-18
    End date: 2010-06-19

Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-06-11
    End date: 2010-06-17

Other drugs received by patient: Fentanyl-100; Oxycontin; Restamin; Primperan TAB; Omeprazole; Magmitt; Enteronon R; Cefazolin Sodium; Ketoprofen; Celecoxib; Pursennid; Zometa; Baraclude; Prochlorperazine; Acetaminophen; Wystal; Enteronon R; Oxycodone Hydrochloride; Primperan TAB; Primperan TAB



Possible Nexavar side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male

Reactions: Death, Adverse Drug Reaction, Toxicity To Various Agents

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 73 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-24

Patient: 73 year old female, weighing 48.0 kg (105.6 pounds)

Reactions: Hyperbilirubinaemia, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Palmar-Plantar Erythrodysaesthesia Syndrome, General Physical Health Deterioration, Encephalopathy, Dizziness, Hypertension, Decreased Appetite

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-01-08
    End date: 2010-01-10

Nexavar
    Dosage: 800 mg, qd
    Administration route: Oral
    Start date: 2010-01-13
    End date: 2010-01-19

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2010-01-20
    End date: 2010-03-02

Other drugs received by patient: Aldactone; Shakuyakukanzoutou; Omeprazole; Urso 250; Medicon; Allegra; Acetaminophen; Onealfa



Possible Nexavar side effects in 78 year old female

Reported by a physician from Czech Republic on 2012-08-24

Patient: 78 year old female, weighing 58.0 kg (127.6 pounds)

Reactions: Cardiac Failure, Malnutrition

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400mg daily
    Administration route: Oral
    Start date: 2010-06-03
    End date: 2010-06-17

Nexavar
    Dosage: 800mg daily
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-04-20
    End date: 2010-06-02

Other drugs received by patient: Enalapril Maleate; Furosemide; Spironolactone; Furosemidum; Furosemidum



Possible Nexavar side effects in 58 year old female

Reported by a consumer/non-health professional from United States on 2012-08-24

Patient: 58 year old female, weighing 89.5 kg (197.0 pounds)

Reactions: Migraine, Respiratory Failure, Mitral Valve Incompetence

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-03-11
    End date: 2010-04-08

Nexavar
    Dosage: cycle 8 - as used dose: 400-200 mg
    Administration route: Oral
    Start date: 2010-08-03
    End date: 2010-08-05

Nexavar
    Dosage: cycle 10-due to subject error
    Administration route: Oral
    Start date: 2010-09-19
    End date: 2010-09-20

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-01-15
    End date: 2010-02-08

Nexavar
    Dosage: cycle 10 - as used does: 400-200 mg
    Administration route: Oral
    Start date: 2010-09-21

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Thyroid Cancer Metastatic
    Start date: 2009-12-17
    End date: 2010-01-15

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-02-08
    End date: 2010-03-11

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-04-08
    End date: 2010-04-13

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-05-21
    End date: 2010-06-23

Nexavar
    Dosage: cycle 9 - as used dose: 400-200 mg
    Administration route: Oral
    Start date: 2010-08-05
    End date: 2010-09-01

Nexavar
    Dosage: cycle 12 : 400+200 mg qd
    Administration route: Oral
    Start date: 2010-09-23
    End date: 2010-11-26

Other drugs received by patient: Synthroid; Lisinopril; Trazodone Hydrochloride; Pristiq; Ativan; Vitamin D; Lomotil [diphenoxylate Hydrochloride]; Dilaudid; Ambien; Hyzaar; Prednisone TAB; Valium; Sodium Chloride; Lorazepam; Calcium Carbonate; Procardia XL; Fiorinal W / Codeine; Fioricet W / Codeine; Procardia XL; Sodium Chloride



Possible Nexavar side effects in 55 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-23

Patient: 55 year old male

Reactions: Jaundice, Abdominal Pain, Hyperkalaemia, Chills, Mental Status Changes, Pyrexia, Loss of Consciousness, Death, Hepatic Encephalopathy, Fatigue, Cholangitis, Pleural Effusion, Thrombocytopenia, Renal Failure Acute, Nausea, Malnutrition, Urinary Tract Infection, Anaemia, Hyponatraemia, Rash, Bacteraemia, Dehydration, Ammonia Increased

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, bid
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-05-25
    End date: 2012-06-05

Nexavar
    Dosage: 400 mg, bid
    Start date: 2012-06-01

Other drugs received by patient: Lorazepam; Diphenoxylate HCL and Atropine Sulfate; Lortab; Lasix; Albuterol; Aldactone; Protonix



Possible Nexavar side effects in 59 year old male

Reported by a physician from France on 2012-08-23

Patient: 59 year old male, weighing 120.0 kg (264.0 pounds)

Reactions: Fatigue, Hepatic Neoplasm Malignant, Hepatic Failure, Encephalopathy, Hepatic Cirrhosis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Propranolol; Glucophage; Lorazepam



Possible Nexavar side effects in 58 year old female

Reported by a physician from Korea, Republic of on 2012-08-22

Patient: 58 year old female, weighing 37.0 kg (81.4 pounds)

Reactions: Fanconi Syndrome, Lung Infection

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Capecitabine
    Dosage: 2900 mg, qd
    Indication: Gastric Cancer
    Start date: 2012-03-08
    End date: 2012-03-22

Capecitabine
    Dosage: 2900 mg, qd
    Start date: 2012-03-28
    End date: 2012-04-09

Cisplatin
    Dosage: 118 mg
    Start date: 2012-03-28
    End date: 2012-03-28

Cisplatin
    Dosage: 118 mg
    Indication: Gastric Cancer
    Start date: 2012-03-08
    End date: 2012-03-08

Nexavar
    Dosage: 400 mg, bid
    Indication: Gastric Cancer
    Start date: 2012-06-30
    End date: 2012-07-14

Other drugs received by patient: Enoxaparin; Levofloxacin; Nystatin; Nystatin; Enoxaparin; Enoxaparin; Piperacillin / Tazobactam; Bromhexin; Ceftriaxone; Ambroxol; Meropenem; Moxifloxacin; Azithromycin; Ceftriaxone; Acetylcysteine; Azithromycin



Possible Nexavar side effects in 73 year old male

Reported by a physician from Japan on 2012-08-20

Patient: 73 year old male, weighing 52.0 kg (114.4 pounds)

Reactions: Malaise, Hepatic Neoplasm Malignant, Diarrhoea, Pyrexia, Altered State of Consciousness

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 69 year old male

Reported by a physician from Japan on 2012-08-17

Patient: 69 year old male

Reactions: Liver Abscess, Septic Shock

Adverse event resulted in: death

Drug(s) suspected as cause:
Baraclude
    Dosage: 0.5 mg, qd
    Administration route: Oral
    Indication: Hepatitis B

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-05-11
    End date: 2012-06-26



Possible Nexavar side effects in 53 year old male

Reported by a consumer/non-health professional from United States on 2012-08-17

Patient: 53 year old male

Reactions: Confusional State, Agitation, Dysphagia, Pain, Anaemia, Failure To Thrive, Hypokalaemia, Death, Fatigue, Fluid Intake Reduced, Asthenia, Decreased Appetite, Deep Vein Thrombosis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg am, 200 mg pm x 21days
    Indication: Colorectal Cancer Metastatic
    Start date: 2012-06-22
    End date: 2012-08-07

Xeloda
    Dosage: 1500 mg am, 1650 mg pm x 14 days
    Indication: Colorectal Cancer Metastatic
    Start date: 2012-06-22
    End date: 2012-08-01

Other drugs received by patient: Roxicodone; Compazine; Ferrous Fumarate; MS Contin; Phenergan HCL; Prinzide; Multi-Vitamin; Compazine



Possible Nexavar side effects in 58 year old female

Reported by a consumer/non-health professional from United States on 2012-08-17

Patient: 58 year old female, weighing 89.5 kg (197.0 pounds)

Reactions: Migraine, Respiratory Failure, Mitral Valve Incompetence

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-02-08
    End date: 2010-03-11

Nexavar
    Dosage: cycle 10-due to subject error
    Administration route: Oral
    Start date: 2010-09-19
    End date: 2010-09-20

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-04-08
    End date: 2010-04-13

Nexavar
    Dosage: cycle 12 : 400+200 mg qd
    Administration route: Oral
    Start date: 2010-09-23
    End date: 2010-11-26

Nexavar
    Dosage: cycle 8 - as used dose: 400-200 mg
    Administration route: Oral
    Start date: 2010-08-03
    End date: 2010-08-05

Nexavar
    Dosage: cycle 10 - as used does: 400-200 mg
    Administration route: Oral
    Start date: 2010-09-21

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Thyroid Cancer Metastatic
    Start date: 2009-12-17
    End date: 2010-01-15

Nexavar
    Dosage: cycle 9 - as used dose: 400-200 mg
    Administration route: Oral
    Start date: 2010-08-05
    End date: 2010-09-01

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-03-11
    End date: 2010-04-08

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-05-21
    End date: 2010-06-23

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2010-01-15
    End date: 2010-02-08

Other drugs received by patient: Synthroid; Dilaudid; Lisinopril; Lorazepam; Lomotil [diphenoxylate Hydrochloride]; Pristiq; Procardia XL; Valium; Sodium Chloride; Sodium Chloride; Ativan; Hyzaar; Prednisone TAB; Fioricet W / Codeine; Procardia XL; Calcium Carbonate; Trazodone Hydrochloride; Fiorinal W / Codeine; Ambien; Vitamin D



Possible Nexavar side effects in 54 year old male

Reported by a physician from Japan on 2012-08-13

Patient: 54 year old male, weighing 40.5 kg (89.1 pounds)

Reactions: Blood Bilirubin Increased, Blood Alkaline Phosphatase Increased, Pneumonia, Hepatic Function Abnormal, Anaemia, Constipation, Ascites, Diarrhoea, Platelet Count Decreased, Metastases To Bone, Liver Carcinoma Ruptured, Bilirubin Conjugated Increased, Decreased Appetite

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-08-10
    End date: 2009-09-10

Nexavar
    Dosage: 600 mg, qd
    Administration route: Oral
    Start date: 2009-09-12
    End date: 2009-09-25

Other drugs received by patient: Fentanyl-100; TPN; Zolpidem; Bismuth Subnitrate; Voltaren; Lansoprazole; Albumin Tannate; Oxycodone Hydrochloride; Elemenmic



Possible Nexavar side effects in 64 year old male

Reported by a physician from Italy on 2012-08-10

Patient: 64 year old male, weighing 90.0 kg (198.0 pounds)

Reactions: Hepatic Failure

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 56 year old male

Reported by a physician from United States on 2012-08-10

Patient: 56 year old male

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 64 year old male

Reported by a pharmacist from Japan on 2012-08-09

Patient: 64 year old male, weighing 62.0 kg (136.4 pounds)

Reactions: Diarrhoea, Hepatic Neoplasm Malignant, Hyperammonaemia, Eczema, Decreased Appetite, Ascites

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg/day
    Administration route: Oral
    Start date: 2009-09-09
    End date: 2009-10-01

Nexavar
    Dosage: 400 mg/day
    Administration route: Oral
    Start date: 2009-10-28
    End date: 2009-10-30

Nexavar
    Dosage: 600 mg/day
    Administration route: Oral
    Start date: 2009-10-02
    End date: 2009-10-27

Nexavar
    Dosage: 800 mg/day
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-08-06
    End date: 2009-09-08

Other drugs received by patient: Lamivudine; Mucosta; Aldactone; Lasix; Oxycontin; Rabeprazole Sodium; Loxoprofen; Fentanyl-100; Pastaron; Ensure [minerals Nos,vitamins Nos]; Hepsera; Hypoca; Morphine; Aldactone



Possible Nexavar side effects in 68 year old female

Reported by a physician from Japan on 2012-08-09

Patient: 68 year old female, weighing 49.0 kg (107.8 pounds)

Reactions: Hepatic Neoplasm Malignant, Disseminated Intravascular Coagulation, Sepsis, Duodenal Ulcer, Melaena, Haemorrhagic Ascites

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Diclofenac Sodium
    Dosage: 25 mg, unk
    Indication: Product Used FOR Unknown Indication
    Start date: 2009-06-22

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-06-16
    End date: 2009-06-23

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2009-06-24
    End date: 2009-06-28

Other drugs received by patient: Aldactone; Lasix; Fentanyl-100



Possible Nexavar side effects in 59 year old female

Reported by a physician from Korea, Republic of on 2012-08-09

Patient: 59 year old female, weighing 48.0 kg (105.6 pounds)

Reactions: Fanconi Syndrome, Lung Infection

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Capecitabine

Cisplatin

Nexavar
    Dosage: 400 mg, bid
    Indication: Gastric Cancer
    Start date: 2012-06-30
    End date: 2012-07-14



Possible Nexavar side effects in 67 year old female

Reported by a physician from Japan on 2012-08-08

Patient: 67 year old female

Reactions: Hepatic Failure, Ascites

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 62 year old male

Reported by a physician from Japan on 2012-08-08

Patient: 62 year old male, weighing 57.0 kg (125.4 pounds)

Reactions: Fatigue, Dyspnoea, Diarrhoea, Bone Marrow Failure, Acute Respiratory Distress Syndrome, Decreased Appetite

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 800 mg
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-03-10
    End date: 2012-03-20

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2012-04-01
    End date: 2012-05-01

Nexavar
    Dosage: 400 mg, qod
    Start date: 2012-04-28
    End date: 2012-04-30

Nexavar
    Dosage: 200 mg, bid
    Start date: 2012-03-29
    End date: 2012-04-27

Other drugs received by patient: Silece; Risperidone; Zometa; Fentanyl Citrate; Lyrica; Loxonin; Lamivudine; Hepsera



Possible Nexavar side effects in 48 year old male

Reported by a physician from Taiwan, Province of China on 2012-08-08

Patient: 48 year old male, weighing 67.7 kg (148.9 pounds)

Reactions: Hepatic Function Abnormal, Sepsis, Hepatic Failure, Constipation, Acute Respiratory Failure, Oesophageal Varices Haemorrhage

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-10-05
    End date: 2011-10-25

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2011-11-15
    End date: 2011-11-15

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2011-10-26
    End date: 2011-11-14

Other drugs received by patient: Entecavir; Lactulose; Metoclopramide; Ultracet; Oxybutynin Chloride; Tamsulosin HCL; Esomeprazole



Possible Nexavar side effects in 74 year old male

Reported by a physician from Japan on 2012-08-08

Patient: 74 year old male

Reactions: Intra-Abdominal Haemorrhage, Haematemesis, Loss of Consciousness, Upper Gastrointestinal Haemorrhage, Liver Carcinoma Ruptured, Melaena, Cardiac Arrest, Catheter Site Pain

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-10-29
    End date: 2009-11-23

Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-11-24
    End date: 2009-11-28

Other drugs received by patient: Novorapid; Novolin R; Norfloxacin; Tokisyakuyakusan; Magmitt; Lamivudine



Possible Nexavar side effects in 77 year old female

Reported by a physician from Japan on 2012-08-08

Patient: 77 year old female

Reactions: Abdominal Pain, Vomiting, Portal Venous GAS, Intestinal Haemorrhage, Malaise, Pneumatosis Intestinalis, Blood Creatinine Increased, Thrombocytopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Indication: Renal Cell Carcinoma
    Start date: 2011-05-23

Nexavar
    Dosage: daily dose 600 mg
    Administration route: Oral
    End date: 2011-06-01



Possible Nexavar side effects in 59 year old male

Reported by a physician from Japan on 2012-08-08

Patient: 59 year old male

Reactions: Hepatic Failure

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 72 year old male

Reported by a physician from Japan on 2012-08-08

Patient: 72 year old male

Reactions: Hepatic Failure

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 72 year old male

Reported by a physician from Japan on 2012-08-08

Patient: 72 year old male

Reactions: Hepatic Failure

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 65 year old male

Reported by a physician from Japan on 2012-08-08

Patient: 65 year old male, weighing 73.0 kg (160.6 pounds)

Reactions: Hepatic Failure, Liver Disorder

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, daily
    Administration route: Oral
    Start date: 2012-04-12
    End date: 2012-05-15

Nexavar
    Dosage: 800 mg,daily
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-03-06
    End date: 2012-04-11

Other drugs received by patient: Claritin; Lasix; Spironolactone; Livact



Possible Nexavar side effects in 65 year old female

Reported by a physician from Australia on 2012-08-07

Patient: 65 year old female, weighing 79.8 kg (175.6 pounds)

Reactions: Influenza

Adverse event resulted in: death

Drug(s) suspected as cause:
Erlotinib Hydrochloride
    Dosage: 50 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    End date: 2012-07-26

Erlotinib Hydrochloride
    Dosage: 50 mg, qd
    Administration route: Oral
    Start date: 2012-07-30

Nexavar
    Dosage: 400 mg, qod
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    End date: 2012-07-26

Nexavar
    Dosage: unk
    Start date: 2012-07-30

Other drugs received by patient: Valium; Amlodipine; Temazepam; Vitaminorum; Irbesartan; Thiamine HCL; Seretide MDI; Magnesium Aspartate Hydrochloride; Human Insulin; Motilium; Alendronate Sodium; Propranolol; Doxepin HCL; Lactulose



Possible Nexavar side effects in 59 year old male

Reported by a physician from United States on 2012-08-06

Patient: 59 year old male

Reactions: Death, Hepatic Neoplasm Malignant

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 55 year old male

Reported by a physician from Japan on 2012-08-06

Patient: 55 year old male

Reactions: Jaundice Cholestatic

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



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