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Nexavar (Sorafenib) - Palmar-Plantar Erythrodysaesthesia Syndrome - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Palmar-Plantar Erythrodysaesthesia Syndrome (282)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Nexavar (Sorafenib) where reactions include palmar-plantar erythrodysaesthesia syndrome. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 282   Next >>

Possible Nexavar side effects in 62 year old male

Reported by a physician from Japan on 2012-08-27

Patient: 62 year old male

Reactions: Diarrhoea, Cerebral Infarction, Palmar-Plantar Erythrodysaesthesia Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-06-21
    End date: 2010-10-11

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2010-10-12
    End date: 2010-11-19



Possible Nexavar side effects in 73 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-24

Patient: 73 year old female, weighing 48.0 kg (105.6 pounds)

Reactions: Hyperbilirubinaemia, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased, Palmar-Plantar Erythrodysaesthesia Syndrome, General Physical Health Deterioration, Encephalopathy, Dizziness, Hypertension, Decreased Appetite

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-01-08
    End date: 2010-01-10

Nexavar
    Dosage: 800 mg, qd
    Administration route: Oral
    Start date: 2010-01-13
    End date: 2010-01-19

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2010-01-20
    End date: 2010-03-02

Other drugs received by patient: Aldactone; Shakuyakukanzoutou; Omeprazole; Urso 250; Medicon; Allegra; Acetaminophen; Onealfa



Possible Nexavar side effects in 63 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-21

Patient: 63 year old female, weighing 48.1 kg (105.8 pounds)

Reactions: Blood Creatine Phosphokinase Increased, Angina Unstable, Palmar-Plantar Erythrodysaesthesia Syndrome, Wound Infection, Blood Creatine Phosphokinase MB Increased, Malaise, C-Reactive Protein Increased, Diarrhoea, Impaired Healing, Hepatectomy, Chest Pain, Platelet Count Decreased, Skin Necrosis, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-01-07
    End date: 2011-01-28

Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Indication: Metastases To Lung
    Start date: 2011-03-05
    End date: 2011-03-24

Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Start date: 2011-03-17

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2011-04-22
    End date: 2011-08-22

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2011-10-25
    End date: 2011-10-30

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2011-08-31
    End date: 2011-10-23

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2011-11-03

Other drugs received by patient: Urepearl; Epirubicin Hydrochloride; Famotidine; Amlodipine; Miriplatin



Possible Nexavar side effects in 67 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-20

Patient: 67 year old female

Reactions: Adverse Drug Reaction, Oropharyngeal Pain, Constipation, Pharyngeal Oedema, Hair Texture Abnormal, Oedema Peripheral, DRY Mouth, Blister, LIP DRY, Pain in Extremity, Palmar-Plantar Erythrodysaesthesia Syndrome, Ear Infection, Antibiotic Therapy, Arthralgia, Diarrhoea, Limb Injury, Joint Swelling, Alopecia, Hair Disorder

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2009-07-09

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar



Possible Nexavar side effects in 22 year old male

Reported by a physician from Spain on 2012-08-20

Patient: 22 year old male

Reactions: Mucosal Inflammation, Pulmonary Tuberculosis, Alopecia, Palmar-Plantar Erythrodysaesthesia Syndrome, Erythema Multiforme

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2009-01-01

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Angiosarcoma
    Start date: 2009-10-01

Nexavar
    Dosage: 200 mg, every 36 hours
    Administration route: Oral
    Start date: 2011-01-01



Possible Nexavar side effects in 65 year old male

Reported by a consumer/non-health professional from United States on 2012-08-07

Patient: 65 year old male, weighing 72.6 kg (159.6 pounds)

Reactions: Glossodynia, Dyspnoea, Visual Field Defect, Pain in Extremity, Pain, Musculoskeletal Pain, Palmar-Plantar Erythrodysaesthesia Syndrome, Fatigue, Vitreous Floaters, Dizziness, Vision Blurred, Lacrimation Increased, Blood Pressure Abnormal, Asthenia, Arthritis

Drug(s) suspected as cause:
Nexavar
    Dosage: unk
    Indication: Metastatic Renal Cell Carcinoma
    Start date: 2012-04-24
    End date: 2012-05-21

Sutent
    Dosage: 50 mg, cyclic (50mg for the first 42 day cycle)
    Indication: Metastatic Renal Cell Carcinoma
    Start date: 2012-06-26

Other drugs received by patient: Symbicort; Nasonex; Ascorbic Acid; Refresh; Lotemax; Mucinex; Mobic; Chondroitin / Glucosamine; Proventil Gentlehaler



Possible Nexavar side effects in 63 year old female

Reported by a physician from Japan on 2012-08-06

Patient: 63 year old female, weighing 48.1 kg (105.8 pounds)

Reactions: Blood Creatine Phosphokinase Increased, Angina Unstable, Palmar-Plantar Erythrodysaesthesia Syndrome, Wound Infection, Blood Creatine Phosphokinase MB Increased, Malaise, C-Reactive Protein Increased, Diarrhoea, Impaired Healing, Hepatectomy, Chest Pain, Platelet Count Decreased, Skin Necrosis, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 200-400 mg
    Administration route: Oral
    Start date: 2011-08-01

Nexavar
    Dosage: daily dose 600 mg
    Administration route: Oral
    Indication: Metastases To Lung
    Start date: 2011-03-05
    End date: 2011-03-24

Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Start date: 2011-03-17

Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-01-07
    End date: 2011-01-28

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2011-04-22

Other drugs received by patient: Amlodipine; Miriplatin; Epirubicin Hydrochloride; Famotidine; Urepearl



Possible Nexavar side effects in 64 year old male

Reported by a physician from Japan on 2012-08-02

Patient: 64 year old male

Reactions: Cerebral Infarction, Palmar-Plantar Erythrodysaesthesia Syndrome

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 70 year old male

Reported by a health professional (non-physician/pharmacist) from Puerto Rico on 2012-08-02

Patient: 70 year old male

Reactions: Palmar-Plantar Erythrodysaesthesia Syndrome, Gangrene, TOE Amputation, Infected Skin Ulcer

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 59 year old male

Reported by a physician from Japan on 2012-08-02

Patient: 59 year old male

Reactions: Sepsis, Palmar-Plantar Erythrodysaesthesia Syndrome, Platelet Count Decreased, Jaundice Cholestatic, Hypertension

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-10-07
    End date: 2009-10-01

Nexavar
    Dosage: 400 mg, unk
    Administration route: Oral
    Start date: 2009-10-01
    End date: 2009-12-01



Possible Nexavar side effects in 73 year old female

Reported by a physician from Japan on 2012-08-02

Patient: 73 year old female

Reactions: Hepatic Neoplasm Malignant, Palmar-Plantar Erythrodysaesthesia Syndrome, Jaundice Cholestatic, Duodenal Stenosis, Liver Disorder

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg - dose reduced
    Start date: 2012-01-01
    End date: 2012-01-01

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-09-09

Other drugs received by patient: Warfarin Potassium



Possible Nexavar side effects in 61 year old male

Reported by a health professional (non-physician/pharmacist) from Belgium on 2012-08-02

Patient: 61 year old male

Reactions: Abdominal Pain, Phlebitis, Chest Discomfort, Glossodynia, Palmar-Plantar Erythrodysaesthesia Syndrome, Pyrexia, Abdominal Pain Upper, Abscess Intestinal, Oral Pain, Dizziness, Vision Blurred, Enterocolitis, Hypertension, Metastases To Bone

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 800 mg, unk
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-08-08
    End date: 2011-09-03

Nexavar
    Dosage: 600 mg, qd
    End date: 2012-07-23

Nexavar
    Dosage: 400 mg, qd
    Start date: 2011-10-05

Nexavar
    Dosage: 800 mg, unk
    Start date: 2011-09-14
    End date: 2011-10-04

Other drugs received by patient: Bisoprolol Fumarate; Amlodipine Besylate; Hydrocortone; Omeprazole; Multi-Vitamin; Bisoprolol Fumarate; Legalon; Fludrocortisone Acetate; Calcium



Possible Nexavar side effects in 64 year old female

Reported by a physician from Japan on 2012-08-02

Patient: 64 year old female, weighing 54.0 kg (118.8 pounds)

Reactions: Malaise, Cerebral Infarction, Palmar-Plantar Erythrodysaesthesia Syndrome, Gait Disturbance, Hypoaesthesia, Feeling Abnormal

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Nexavar
    Dosage: 600 mg, qd
    Administration route: Oral
    Start date: 2011-07-13
    End date: 2011-11-06

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-06-01
    End date: 2011-07-12

Other drugs received by patient: Rezaltas; Doxazosin Mesylate; Famotidine; Miriplatin; Maglax; Inderal; Trichlormethiazide



Possible Nexavar side effects in 76 year old male

Reported by a physician from Japan on 2012-08-02

Patient: 76 year old male, weighing 80.0 kg (176.0 pounds)

Reactions: Death, Cardio-Respiratory Arrest, Tumour Lysis Syndrome, Malaise, Palmar-Plantar Erythrodysaesthesia Syndrome, Blood Pressure Decreased

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-01-16
    End date: 2012-02-14

Nexavar
    Dosage: 200mg and 400mg alternately
    Administration route: Oral
    Start date: 2012-04-06
    End date: 2012-05-24

Other drugs received by patient: Miglitol; Tanatril; Pravastatin; Glyburide; Actos; Amlodipine



Possible Nexavar side effects in 76 year old male

Reported by a physician from Japan on 2012-08-01

Patient: 76 year old male

Reactions: Hepatic Function Abnormal, Palmar-Plantar Erythrodysaesthesia Syndrome

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant

Nexavar
    Dosage: 400 mg, qod
    Administration route: Oral



Possible Nexavar side effects in 71 year old male

Reported by a physician from Japan on 2012-07-30

Patient: 71 year old male, weighing 81.0 kg (178.2 pounds)

Reactions: Stomatitis, Palmar-Plantar Erythrodysaesthesia Syndrome, Generalised Oedema, Glomerulonephritis Membranous, Weight Increased, Hypoalbuminaemia, Blood Creatinine Increased, Acute Myocardial Infarction, Renal Failure Acute

Adverse event resulted in: death, hospitalization, disablity

Drug(s) suspected as cause:
Allopurinol
    Dosage: 100 mg, qd
    Administration route: Oral
    Indication: Hyperuricaemia
    End date: 2012-03-18

Furosemide
    Dosage: 40 mg, qd
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-02-22

Furosemide
    Dosage: unk
    Indication: Renal Failure Acute
    Start date: 2012-02-14
    End date: 2012-02-19

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Renal Cell Carcinoma
    Start date: 2012-01-31
    End date: 2012-02-14

Other drugs received by patient: Sumiferon; Vaseline



Possible Nexavar side effects in 71 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-26

Patient: 71 year old male, weighing 81.0 kg (178.2 pounds)

Reactions: Renal Disorder, Stomatitis, Palmar-Plantar Erythrodysaesthesia Syndrome, Generalised Oedema, Glomerulonephritis Membranous, Weight Increased, Hypoalbuminaemia, Acute Myocardial Infarction, Blood Creatinine Increased

Adverse event resulted in: death, hospitalization, disablity

Drug(s) suspected as cause:
Allopurinol
    Dosage: 100 mg, qd
    Administration route: Oral
    Indication: Hyperuricaemia
    End date: 2012-03-18

Furosemide
    Dosage: unk
    Indication: Renal Failure Acute
    Start date: 2012-02-14
    End date: 2012-02-19

Furosemide
    Dosage: 40 mg, qd
    Administration route: Oral
    Indication: Hypertension
    End date: 2012-02-22

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Renal Cell Carcinoma
    Start date: 2012-01-31
    End date: 2012-02-14

Other drugs received by patient: Sumiferon; Vaseline



Possible Nexavar side effects in male

Reported by a consumer/non-health professional from United States on 2012-07-25

Patient: male, weighing 72.6 kg (159.6 pounds)

Reactions: Pain in Extremity, Visual Field Defect, Pain, Musculoskeletal Pain, Palmar-Plantar Erythrodysaesthesia Syndrome, Fatigue, Dizziness, Lacrimation Increased, Asthenia, Arthritis

Drug(s) suspected as cause:
Nexavar
    Dosage: unk
    Indication: Metastatic Renal Cell Carcinoma
    Start date: 2012-04-24
    End date: 2012-05-21

Sutent
    Dosage: 50 mg, cyclic (50mg for the first 42 day cycle)
    Indication: Metastatic Renal Cell Carcinoma
    Start date: 2012-06-26

Other drugs received by patient: Refresh; Proventil Gentlehaler; Nasonex; Ascorbic Acid; Symbicort; Lotemax; Mucinex; Chondroitin / Glucosamine; Mobic



Possible Nexavar side effects in 61 year old female

Reported by a physician from Russian Federation on 2012-07-25

Patient: 61 year old female, weighing 53.0 kg (116.6 pounds)

Reactions: Hepatic Failure, Palmar-Plantar Erythrodysaesthesia Syndrome, Asthenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 64 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-24

Patient: 64 year old female, weighing 54.0 kg (118.8 pounds)

Reactions: Malaise, Cerebral Infarction, Palmar-Plantar Erythrodysaesthesia Syndrome, Gait Disturbance, Hypoaesthesia, Feeling Abnormal

Adverse event resulted in: hospitalization, disablity

Drug(s) suspected as cause:
Nexavar
    Dosage: 600 mg, qd
    Administration route: Oral
    Start date: 2011-07-13
    End date: 2011-11-06

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-06-01
    End date: 2011-07-12

Other drugs received by patient: Doxazosin Mesylate; Trichlormethiazide; Inderal; Rezaltas; Maglax; Miriplatin; Famotidine



Possible Nexavar side effects in 75 year old male

Reported by a physician from Japan on 2012-07-24

Patient: 75 year old male, weighing 53.2 kg (117.0 pounds)

Reactions: Fatigue, Vomiting, Stomatitis, Ileus, Nausea, Hepatic Neoplasm Malignant, Palmar-Plantar Erythrodysaesthesia Syndrome, Decreased Appetite

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 800 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-08-03
    End date: 2009-08-18

Nexavar
    Dosage: 800 mg (daily dose), , oral
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-07-30
    End date: 2009-07-31

Oxycontin
    Dosage: since before nexavar administration
    Administration route: Oral
    Indication: Pain Management
    End date: 2009-08-17

Oxycontin
    Dosage: 160 mg (daily dose), , unknown
    Start date: 2009-08-18
    End date: 2009-08-23

Other drugs received by patient: Sennoside; Sepamit; Gabapentin; Amitriptyline HCL; Keratinamin; Voltaren; Omeprazole; Maglax; Fentanyl-100; Mucosta; Loxonin; Fentanyl-100; Oxycodone Hydrochloride; Anpec



Possible Nexavar side effects in 70 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-23

Patient: 70 year old female

Reactions: Glossodynia, Hyperkeratosis, Skin Exfoliation, Adverse Drug Reaction, Skin Burning Sensation, Erythema, Oedema Peripheral, DRY Mouth, Blister, Blood Pressure Increased, Pain in Extremity, Pain of Skin, Palmar-Plantar Erythrodysaesthesia Syndrome, Rash, DRY Skin, Rash Macular, Paraesthesia, Hyperaesthesia, Diarrhoea, Oral Pain

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Renal Cancer
    Start date: 2012-01-11
    End date: 2012-02-04

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2012-02-27

Nexavar
    Dosage: 400 mg, qod
    Administration route: Oral
    Start date: 2012-01-13

Other drugs received by patient: Antihypertensives



Possible Nexavar side effects in 76 year old male

Reported by a physician from Japan on 2012-07-23

Patient: 76 year old male, weighing 80.0 kg (176.0 pounds)

Reactions: Death, Cardio-Respiratory Arrest, Tumour Lysis Syndrome, Malaise, Palmar-Plantar Erythrodysaesthesia Syndrome, Blood Pressure Decreased

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-01-16
    End date: 2012-02-14

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2012-02-01
    End date: 2012-02-20

Nexavar
    Dosage: 200mg and 400mg alternatively
    Administration route: Oral
    Start date: 2012-04-20

Other drugs received by patient: Amlodipine; Glyburide; Tanatril; Pravastatin; Actos; Miglitol



Possible Nexavar side effects in 49 year old male

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-07-20

Patient: 49 year old male

Reactions: Portal Vein Thrombosis, Palmar-Plantar Erythrodysaesthesia Syndrome

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 800 mg
    Indication: Hepatic Neoplasm Malignant

Nexavar
    Dosage: daily dose 400 mg

Other drugs received by patient: Antivirals FOR Systemic USE



Possible Nexavar side effects in 77 year old female

Reported by a physician from Japan on 2012-07-20

Patient: 77 year old female

Reactions: Cellulitis, Diarrhoea, Skin Ulcer, Alopecia, Palmar-Plantar Erythrodysaesthesia Syndrome

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-03-30
    End date: 2012-06-01

Nexavar
    Dosage: daily dose: 400mg
    Administration route: Oral
    Start date: 2012-06-14

Other drugs received by patient: Norvasc



Possible Nexavar side effects in male

Reported by a health professional (non-physician/pharmacist) from Belgium on 2012-07-19

Patient: male

Reactions: Pneumonia Bacterial, Palmar-Plantar Erythrodysaesthesia Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 62 year old female

Reported by a physician from Japan on 2012-07-18

Patient: 62 year old female, weighing 50.0 kg (110.0 pounds)

Reactions: Hepatic Function Abnormal, Amylase Increased, Palmar-Plantar Erythrodysaesthesia Syndrome, Nail Ridging, Pyrexia, Hypophosphataemia, Diarrhoea, Lipase Increased, Hypertension

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg/day
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-10-19
    End date: 2012-04-25

Nexavar
    Dosage: 200 mg, qod
    Administration route: Oral
    Start date: 2012-04-26
    End date: 2012-05-09

Other drugs received by patient: Lendormin; Urso 250; Zolpidem; Livact; Aminoleban EN; Aminoleban EN; Eurax; Olmesartan Medoxomil; Primperan TAB; Aminoleban EN; Allegra; Loxonin; Olmesartan Medoxomil; Olmesartan Medoxomil; Urepearl



Possible Nexavar side effects in male

Reported by a consumer/non-health professional from United States on 2012-07-18

Patient: male

Reactions: Hyperkeratosis, Skin Discolouration, Palmar-Plantar Erythrodysaesthesia Syndrome, Blister

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 72 year old male

Reported by a physician from Japan on 2012-07-18

Patient: 72 year old male, weighing 59.1 kg (130.0 pounds)

Reactions: Hepatic Function Abnormal, Conjunctival Haemorrhage, Stomatitis, Palmar-Plantar Erythrodysaesthesia Syndrome, Pyrexia, Periorbital Haematoma

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-07-02
    End date: 2009-07-29

Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-11-09
    End date: 2010-03-03

Nexavar
    Dosage: 800 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-08-04
    End date: 2009-08-19

Other drugs received by patient: Urso 250; Rabeprazole Sodium; Baraclude; Vitamin B12; Gasmotin; Famotidine; Urso 250; Naproxen; Soldactone; Lasix; Naproxen; Soldactone; Lasix; Lasix; Hokunalin; Naproxen; Soldactone; Lasix



Possible Nexavar side effects in 60 year old male

Reported by a physician from Japan on 2012-07-17

Patient: 60 year old male, weighing 57.0 kg (125.4 pounds)

Reactions: Jaundice, Hepatic Function Abnormal, Musculoskeletal Pain, Drug-Induced Liver Injury, Palmar-Plantar Erythrodysaesthesia Syndrome, Tumour Haemorrhage

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2009-11-11
    End date: 2009-12-09

Nexavar
    Dosage: 800 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-07-22
    End date: 2009-10-07

Other drugs received by patient: Cytotec; Lansoprazole; Urepearl; Famotidine



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