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Nexavar (Sorafenib) - Hepatic Neoplasm Malignant - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Hepatic Neoplasm Malignant (164)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Nexavar (Sorafenib) where reactions include hepatic neoplasm malignant. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 164   Next >>

Possible Nexavar side effects in 59 year old male

Reported by a physician from France on 2012-08-23

Patient: 59 year old male, weighing 120.0 kg (264.0 pounds)

Reactions: Fatigue, Hepatic Neoplasm Malignant, Hepatic Failure, Encephalopathy, Hepatic Cirrhosis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Propranolol; Glucophage; Lorazepam



Possible Nexavar side effects in 69 year old female

Reported by a physician from Denmark on 2012-08-22

Patient: 69 year old female

Reactions: Hepatic Neoplasm Malignant, JAW Fracture, Loose Tooth, Dental Leakage

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 73 year old male

Reported by a physician from Japan on 2012-08-20

Patient: 73 year old male, weighing 52.0 kg (114.4 pounds)

Reactions: Malaise, Hepatic Neoplasm Malignant, Diarrhoea, Pyrexia, Altered State of Consciousness

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 61 year old male

Reported by a consumer/non-health professional from United States on 2012-08-14

Patient: 61 year old male

Reactions: Vomiting, Hepatic Neoplasm Malignant

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-01-01

Nexavar
    Dosage: 400 mg, bid

Nexavar
    Dosage: 400 mg, bid

Nexavar
    Dosage: 400 mg, bid

Nexavar
    Dosage: 400 mg, bid

Nexavar
    Dosage: unk
    End date: 2012-03-23

Nexavar
    Dosage: 400 mg, bid

Nexavar
    Dosage: 400 mg, bid

Nexavar
    Dosage: 400 mg, bid



Possible Nexavar side effects in 68 year old female

Reported by a physician from Japan on 2012-08-09

Patient: 68 year old female, weighing 49.0 kg (107.8 pounds)

Reactions: Hepatic Neoplasm Malignant, Disseminated Intravascular Coagulation, Sepsis, Duodenal Ulcer, Melaena, Haemorrhagic Ascites

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Diclofenac Sodium
    Dosage: 25 mg, unk
    Indication: Product Used FOR Unknown Indication
    Start date: 2009-06-22

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-06-16
    End date: 2009-06-23

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2009-06-24
    End date: 2009-06-28

Other drugs received by patient: Aldactone; Lasix; Fentanyl-100



Possible Nexavar side effects in 64 year old male

Reported by a pharmacist from Japan on 2012-08-09

Patient: 64 year old male, weighing 62.0 kg (136.4 pounds)

Reactions: Diarrhoea, Hepatic Neoplasm Malignant, Hyperammonaemia, Eczema, Decreased Appetite, Ascites

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg/day
    Administration route: Oral
    Start date: 2009-09-09
    End date: 2009-10-01

Nexavar
    Dosage: 400 mg/day
    Administration route: Oral
    Start date: 2009-10-28
    End date: 2009-10-30

Nexavar
    Dosage: 600 mg/day
    Administration route: Oral
    Start date: 2009-10-02
    End date: 2009-10-27

Nexavar
    Dosage: 800 mg/day
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-08-06
    End date: 2009-09-08

Other drugs received by patient: Lamivudine; Mucosta; Aldactone; Lasix; Oxycontin; Rabeprazole Sodium; Loxoprofen; Fentanyl-100; Pastaron; Ensure [minerals Nos,vitamins Nos]; Hepsera; Hypoca; Morphine; Aldactone



Possible Nexavar side effects in 59 year old male

Reported by a physician from United States on 2012-08-06

Patient: 59 year old male

Reactions: Death, Hepatic Neoplasm Malignant

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 81 year old male

Reported by a physician from Japan on 2012-08-06

Patient: 81 year old male, weighing 45.8 kg (100.8 pounds)

Reactions: Neutrophil Count Increased, Hepatic Function Abnormal, Amylase Increased, Hepatic Neoplasm Malignant, Disseminated Intravascular Coagulation, Anaemia, Hyponatraemia, Pyrexia, Cardiac Failure Acute, Ascites, Platelet Count Decreased, Ammonia Increased, Lipase Increased

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-06-10
    End date: 2010-06-22

Nexavar
    Dosage: 400 mg, qod
    Administration route: Oral
    Start date: 2010-06-24
    End date: 2010-06-25

Other drugs received by patient: Magmitt; Antianaemic Preparations; Pantosin; Metilon; Aminoleban; Urso 250; Losartan Potassium; Metilon; Urepearl; Metilon; Metilon; Ferrous Sulfate TAB; Hirudoid; Metilon; Metilon



Possible Nexavar side effects in 73 year old female

Reported by a physician from Japan on 2012-08-02

Patient: 73 year old female

Reactions: Hepatic Neoplasm Malignant, Palmar-Plantar Erythrodysaesthesia Syndrome, Jaundice Cholestatic, Duodenal Stenosis, Liver Disorder

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg - dose reduced
    Start date: 2012-01-01
    End date: 2012-01-01

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-09-09

Other drugs received by patient: Warfarin Potassium



Possible Nexavar side effects in 72 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-30

Patient: 72 year old female

Reactions: Hepatic Neoplasm Malignant

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Oxycodone HCL; Zolpidem; Glimepiride; Spironolactone; Ranitidine; Omeprazole; Cetirizine HCL; Singulair; Torsemide; Calcium D; Qvar 40; Metaxalone; Acebutolol; Januvia; Amlodipine; Prochlorperaz



Possible Nexavar side effects in 86 year old male

Reported by a physician from Japan on 2012-07-26

Patient: 86 year old male, weighing 42.0 kg (92.4 pounds)

Reactions: Hepatic Neoplasm Malignant, Neoplasm Progression, Liver Disorder

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Lasix; Taurine; Famotidine; Urso 250; Aldactone



Possible Nexavar side effects in 67 year old female

Reported by a physician from United States on 2012-07-24

Patient: 67 year old female, weighing 64.5 kg (141.9 pounds)

Reactions: Renal Failure, Vomiting, Hepatic Neoplasm Malignant, Nausea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 54 year old female

Reported by a consumer/non-health professional from China on 2012-07-24

Patient: 54 year old female

Reactions: Hepatic Neoplasm Malignant, Tumour Haemorrhage, Haematemesis, Abdominal Pain Upper

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 65 year old female

Reported by a consumer/non-health professional from United States on 2012-07-24

Patient: 65 year old female, weighing 70.2 kg (154.4 pounds)

Reactions: Hepatic Neoplasm Malignant, Pulmonary Oedema

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Indication: Metastatic Neoplasm
    Start date: 2012-04-03

Nexavar
    Indication: Metastases To Liver

Other drugs received by patient: Oxycontin; Compazine; Dulcolax [docusate Sodium]; Oxycodone HCL; Senna-Mint WAF; Amlodipine Besylate and Benazepril HCL; Vicodin



Possible Nexavar side effects in 75 year old male

Reported by a physician from Japan on 2012-07-24

Patient: 75 year old male, weighing 53.2 kg (117.0 pounds)

Reactions: Fatigue, Vomiting, Stomatitis, Ileus, Nausea, Hepatic Neoplasm Malignant, Palmar-Plantar Erythrodysaesthesia Syndrome, Decreased Appetite

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 800 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-08-03
    End date: 2009-08-18

Nexavar
    Dosage: 800 mg (daily dose), , oral
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-07-30
    End date: 2009-07-31

Oxycontin
    Dosage: since before nexavar administration
    Administration route: Oral
    Indication: Pain Management
    End date: 2009-08-17

Oxycontin
    Dosage: 160 mg (daily dose), , unknown
    Start date: 2009-08-18
    End date: 2009-08-23

Other drugs received by patient: Sennoside; Sepamit; Gabapentin; Amitriptyline HCL; Keratinamin; Voltaren; Omeprazole; Maglax; Fentanyl-100; Mucosta; Loxonin; Fentanyl-100; Oxycodone Hydrochloride; Anpec



Possible Nexavar side effects in 62 year old female

Reported by a physician from Japan on 2012-07-20

Patient: 62 year old female, weighing 58.0 kg (127.6 pounds)

Reactions: Hepatic Function Abnormal, Hepatic Neoplasm Malignant, Nausea, Diarrhoea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-01-18
    End date: 2012-01-25

Nexavar
    Dosage: daily dose 600 mg
    Administration route: Oral
    Start date: 2012-01-25
    End date: 2012-01-29



Possible Nexavar side effects in 58 year old male

Reported by a physician from Japan on 2012-07-20

Patient: 58 year old male, weighing 60.0 kg (132.0 pounds)

Reactions: Hepatic Neoplasm Malignant, Duodenal Ulcer Haemorrhage, Faeces Discoloured

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400mg daily
    Administration route: Oral
    Start date: 2011-06-06
    End date: 2011-06-30

Nexavar
    Dosage: 200 mg daily
    Administration route: Oral
    Start date: 2011-05-25
    End date: 2011-06-05

Nexavar
    Dosage: 800 mg daily
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-03-28
    End date: 2011-05-20

Other drugs received by patient: Diovan; Tamsulosin HCL; Carvedilol; Baraclude; Omeprazole; Urso 250; Daikentyuto; Rabeprazole Sodium



Possible Nexavar side effects in 74 year old female

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-07-19

Patient: 74 year old female

Reactions: Abdominal Pain, Weight Decreased, Hepatic Neoplasm Malignant, Portal Vein Thrombosis, Musculoskeletal Pain, Pyrexia, Headache, Ascites, Hepatic Enzyme Increased, Diarrhoea, Asthenia, Decreased Appetite

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 67 year old female

Reported by a physician from Japan on 2012-07-18

Patient: 67 year old female

Reactions: White Blood Cell Count Decreased, Pneumonia, Hepatic Neoplasm Malignant, Platelet Count Decreased

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 800 mg
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-04-27
    End date: 2012-05-23

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    End date: 2012-05-24



Possible Nexavar side effects in 66 year old male

Reported by a physician from Japan on 2012-07-17

Patient: 66 year old male, weighing 70.0 kg (154.0 pounds)

Reactions: Hepatic Encephalopathy, Hepatic Neoplasm Malignant, Bradykinesia, Depressed Level of Consciousness, Asthenia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Adalat; Glimicron



Possible Nexavar side effects in 65 year old male

Reported by a physician from Japan on 2012-07-17

Patient: 65 year old male, weighing 53.4 kg (117.5 pounds)

Reactions: Hepatic Function Abnormal, Hepatic Neoplasm Malignant, Hepatic Failure, Neoplasm Progression, Rash, Oesophageal Varices Haemorrhage, Haematemesis, Renal Failure, Interstitial Lung Disease, Diarrhoea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 600 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-07-22
    End date: 2009-07-30

Nexavar
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-06-29
    End date: 2009-07-21

Other drugs received by patient: Proheparum; Monilac; Rabeprazole Sodium; Glycyron [glycyrrhizic Acid]; FOY; Rhythmy; Aldactone; Etodolac; Flomax; Urso 250; Loxonin



Possible Nexavar side effects in 59 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-10

Patient: 59 year old male, weighing 115.0 kg (253.0 pounds)

Reactions: Hepatic Neoplasm Malignant, Cerebral Ischaemia, Convulsion

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Lidocaine; Hydralazine Hydrochloride; Norvasc; Aspirin; Omeprazole; Norvasc; Rapamune; Morphine; Percocet; Percocet; Acyclovir; Acetaminophen; Rapamune; Polyethylene Glycol; Sulfamethoxazole and Trimethoprim; Rapamune; Aspirin; Hydralazine Hydrochloride; Oxycontin; Lidocaine; Magnesium Oxide



Possible Nexavar side effects in 74 year old male

Reported by a physician from Japan on 2012-07-06

Patient: 74 year old male, weighing 62.0 kg (136.4 pounds)

Reactions: Hepatic Neoplasm Malignant, Hyperkalaemia, Disseminated Intravascular Coagulation, International Normalised Ratio Increased, Pyrexia, Hypernatraemia, Diarrhoea, Sepsis, Metastases To Central Nervous System, Decreased Appetite

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Digoxin; Lasix; Oxycontin; Magnesium Oxide; Motilium; Warfarin Sodium; Alosenn; Aldactone; Oxycodone Hydrochloride; Oxycodone Hydrochloride; Polaramine; Prochlorperazine; Lansoprazole



Possible Nexavar side effects in 65 year old male

Reported by a physician from Japan on 2012-07-05

Patient: 65 year old male

Reactions: Nausea, Hepatic Neoplasm Malignant, Hepatic Artery Occlusion

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 600 mg
    Administration route: Oral

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2011-02-15
    End date: 2011-05-09

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-12-02

Nexavar
    Dosage: daily dose 800 mg
    Administration route: Oral
    Start date: 2011-01-01

Other drugs received by patient: Chemotherapeutics NOS; Combinations OF Antineoplastic Agents; Fluorouracil; Cisplatin



Possible Nexavar side effects in 68 year old female

Reported by a physician from Japan on 2012-07-05

Patient: 68 year old female, weighing 49.0 kg (107.8 pounds)

Reactions: Hepatic Neoplasm Malignant, Disseminated Intravascular Coagulation, Sepsis, Palmar-Plantar Erythrodysaesthesia Syndrome, Duodenal Ulcer, Haemorrhagic Ascites, Melaena

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Diclofenac Sodium
    Dosage: 25 mg, unk
    Indication: Product Used FOR Unknown Indication
    Start date: 2009-06-22

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2009-06-24
    End date: 2009-06-28

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-06-16
    End date: 2009-06-23

Other drugs received by patient: Lasix; Aldactone; Fentanyl-100



Possible Nexavar side effects in 62 year old female

Reported by a physician from Japan on 2012-07-05

Patient: 62 year old female, weighing 58.0 kg (127.6 pounds)

Reactions: Hepatic Function Abnormal, Nausea, Hepatic Neoplasm Malignant, Diarrhoea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 600 mg
    Administration route: Oral
    Start date: 2012-01-25
    End date: 2012-01-29

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-01-18
    End date: 2012-01-25



Possible Nexavar side effects in 78 year old male

Reported by a physician from Japan on 2012-07-02

Patient: 78 year old male, weighing 53.0 kg (116.6 pounds)

Reactions: Hepatic Function Abnormal, Hepatic Neoplasm Malignant, Platelet Count Decreased

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg daily
    Administration route: Oral
    Start date: 2011-03-25
    End date: 2011-04-21

Nexavar
    Dosage: 400 mg, qod
    Start date: 2011-04-21
    End date: 2011-07-29

Other drugs received by patient: Urso 250; Livact; Lansoprazole



Possible Nexavar side effects in 64 year old male

Reported by a pharmacist from Japan on 2012-07-02

Patient: 64 year old male, weighing 62.0 kg (136.4 pounds)

Reactions: Hepatic Neoplasm Malignant, Diarrhoea, Hyperammonaemia, Palmar-Plantar Erythrodysaesthesia Syndrome, Eczema, Decreased Appetite, Ascites

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 800 mg/day
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-08-06
    End date: 2009-09-08

Nexavar
    Dosage: 400 mg/day
    Administration route: Oral
    Start date: 2009-10-28
    End date: 2009-10-30

Nexavar
    Dosage: 600 mg/day
    Administration route: Oral
    Start date: 2009-10-02
    End date: 2009-10-27

Nexavar
    Dosage: 400 mg/day
    Administration route: Oral
    Start date: 2009-09-09
    End date: 2009-10-01

Other drugs received by patient: Pastaron; Morphine; Fentanyl-100; Aldactone; Rabeprazole Sodium; Mucosta; Ensure [minerals Nos,vitamins Nos]; Hypoca; Aldactone; Lamivudine; Oxycontin; Hepsera; Loxoprofen; Lasix



Possible Nexavar side effects in 60 year old female

Reported by a consumer/non-health professional from United States on 2012-06-29

Patient: 60 year old female

Reactions: Hepatic Neoplasm Malignant

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Ondansetron; Lorazepam; Nexium; Rapamune; Lamictal



Possible Nexavar side effects in 73 year old male

Reported by a physician from United States on 2012-06-29

Patient: 73 year old male

Reactions: Hospitalisation, Hepatic Neoplasm Malignant, Hepatic Failure, Pyrexia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar



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