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Index of reports
> Cases with Hepatic Function Abnormal (124)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Nexavar (Sorafenib) where reactions include hepatic function abnormal. The selected reports were submitted to the FDA during the sample period of about a year. Reports 1 - 30 of 124 Next >>
Possible Nexavar side effects in 35 year old male
Reported by a physician from Japan on 2012-08-27
Patient: 35 year old male, weighing 68.3 kg (150.3 pounds)
Reactions: Hepatic Function Abnormal
Adverse event resulted in: death
Drug(s) suspected as cause:
Nexavar
Dosage: 200 mg (daily dose), , oral
Administration route: Oral
Start date: 2010-06-18
End date: 2010-06-19
Nexavar
Dosage: 400 mg (daily dose), , oral
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2010-06-11
End date: 2010-06-17
Other drugs received by patient: Fentanyl-100; Oxycontin; Restamin; Primperan TAB; Omeprazole; Magmitt; Enteronon R; Cefazolin Sodium; Ketoprofen; Celecoxib; Pursennid; Zometa; Baraclude; Prochlorperazine; Acetaminophen; Wystal; Enteronon R; Oxycodone Hydrochloride; Primperan TAB; Primperan TAB
Possible Nexavar side effects in male
Reported by a physician from Japan on 2012-08-21
Patient: male
Reactions: Hepatic Function Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Possible Nexavar side effects in 66 year old male
Reported by a physician from Japan on 2012-08-17
Patient: 66 year old male, weighing 86.0 kg (189.2 pounds)
Reactions: Hepatic Function Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: 200 unk, unk
Start date: 2012-06-13
End date: 2012-07-13
Nexavar
Dosage: daily dose 200 mg
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2012-05-25
End date: 2012-05-29
Nexavar
Dosage: 200 mg, qod
Start date: 2012-05-29
End date: 2012-06-13
Other drugs received by patient: Livact; Glakay; Carvedilol; Omeprazole; Pydoxal; Lactulose
Possible Nexavar side effects in 77 year old female
Reported by a physician from Japan on 2012-08-17
Patient: 77 year old female
Reactions: Hepatic Function Abnormal, Platelet Count Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Possible Nexavar side effects in 77 year old male
Reported by a physician from Japan on 2012-08-15
Patient: 77 year old male
Reactions: Hepatic Function Abnormal
Drug(s) suspected as cause:
Nexavar
Possible Nexavar side effects in female
Reported by a physician from Austria on 2012-08-14
Patient: female
Reactions: Hepatic Function Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Possible Nexavar side effects in 54 year old male
Reported by a physician from Japan on 2012-08-13
Patient: 54 year old male, weighing 40.5 kg (89.1 pounds)
Reactions: Blood Bilirubin Increased, Blood Alkaline Phosphatase Increased, Pneumonia, Hepatic Function Abnormal, Anaemia, Constipation, Ascites, Diarrhoea, Platelet Count Decreased, Metastases To Bone, Liver Carcinoma Ruptured, Bilirubin Conjugated Increased, Decreased Appetite
Adverse event resulted in: death, life threatening event, hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: 400 mg, bid
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2009-08-10
End date: 2009-09-10
Nexavar
Dosage: 600 mg, qd
Administration route: Oral
Start date: 2009-09-12
End date: 2009-09-25
Other drugs received by patient: Fentanyl-100; TPN; Zolpidem; Bismuth Subnitrate; Voltaren; Lansoprazole; Albumin Tannate; Oxycodone Hydrochloride; Elemenmic
Possible Nexavar side effects in 77 year old female
Reported by a physician from Japan on 2012-08-10
Patient: 77 year old female
Reactions: Hepatic Function Abnormal, Platelet Count Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Possible Nexavar side effects in 61 year old male
Reported by a physician from Japan on 2012-08-10
Patient: 61 year old male
Reactions: Hepatic Function Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Other drugs received by patient: Allopurinol; Celecoxib; Famotidine; Flomox; Norvasc
Possible Nexavar side effects in 48 year old male
Reported by a physician from Taiwan, Province of China on 2012-08-08
Patient: 48 year old male, weighing 67.7 kg (148.9 pounds)
Reactions: Hepatic Function Abnormal, Sepsis, Hepatic Failure, Constipation, Acute Respiratory Failure, Oesophageal Varices Haemorrhage
Adverse event resulted in: death, life threatening event, hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: 400 mg, bid
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2011-10-05
End date: 2011-10-25
Nexavar
Dosage: 400 mg, qd
Administration route: Oral
Start date: 2011-11-15
End date: 2011-11-15
Nexavar
Dosage: 400 mg, bid
Administration route: Oral
Start date: 2011-10-26
End date: 2011-11-14
Other drugs received by patient: Entecavir; Lactulose; Metoclopramide; Ultracet; Oxybutynin Chloride; Tamsulosin HCL; Esomeprazole
Possible Nexavar side effects in 72 year old female
Reported by a physician from Japan on 2012-08-07
Patient: 72 year old female, weighing 46.0 kg (101.2 pounds)
Reactions: Blood Bilirubin Increased, Hepatic Function Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: 200 mg, bid
Administration route: Oral
Start date: 2012-01-30
End date: 2012-05-22
Nexavar
Dosage: 400 mg, qd
Administration route: Oral
Start date: 2012-06-27
End date: 2012-07-11
Other drugs received by patient: Denosumab
Possible Nexavar side effects in 81 year old male
Reported by a physician from Japan on 2012-08-06
Patient: 81 year old male, weighing 45.8 kg (100.8 pounds)
Reactions: Neutrophil Count Increased, Hepatic Function Abnormal, Amylase Increased, Hepatic Neoplasm Malignant, Disseminated Intravascular Coagulation, Anaemia, Hyponatraemia, Pyrexia, Cardiac Failure Acute, Ascites, Platelet Count Decreased, Ammonia Increased, Lipase Increased
Adverse event resulted in: death, life threatening event, hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: 400 mg, qd
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2010-06-10
End date: 2010-06-22
Nexavar
Dosage: 400 mg, qod
Administration route: Oral
Start date: 2010-06-24
End date: 2010-06-25
Other drugs received by patient: Magmitt; Antianaemic Preparations; Pantosin; Metilon; Aminoleban; Urso 250; Losartan Potassium; Metilon; Urepearl; Metilon; Metilon; Ferrous Sulfate TAB; Hirudoid; Metilon; Metilon
Possible Nexavar side effects in 68 year old female
Reported by a physician from Japan on 2012-08-03
Patient: 68 year old female, weighing 45.8 kg (100.8 pounds)
Reactions: Hepatic Function Abnormal, Hepatorenal Syndrome
Adverse event resulted in: death
Drug(s) suspected as cause:
Nexavar
Other drugs received by patient: Keratinamin; Cisplatin
Possible Nexavar side effects in 76 year old male
Reported by a physician from Japan on 2012-08-01
Patient: 76 year old male
Reactions: Hepatic Function Abnormal, Palmar-Plantar Erythrodysaesthesia Syndrome
Drug(s) suspected as cause:
Nexavar
Dosage: 400 mg, qd
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Nexavar
Dosage: 400 mg, qod
Administration route: Oral
Possible Nexavar side effects in 71 year old male
Reported by a physician from Japan on 2012-07-30
Patient: 71 year old male, weighing 61.0 kg (134.2 pounds)
Reactions: Blood Creatine Phosphokinase Increased, Hepatic Function Abnormal, Dysphonia, Blood Sodium Decreased
Drug(s) suspected as cause:
Lipidil
Dosage: daily dose 100 mg
Administration route: Oral
Indication: Hyperlipidaemia
Nexavar
Dosage: daily dose 400 mg
Administration route: Oral
Start date: 2012-07-13
Nexavar
Dosage: daily dose 400 mg
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2012-05-23
End date: 2012-06-04
Other drugs received by patient: Cilnidipine; Olmesartan Medoxomil; Mitiglinide; Mecobalamin; Alinamin F [fursultiamine]; Atenolol; Bezatol; Kallidinogenase
Possible Nexavar side effects in 62 year old female
Reported by a physician from Japan on 2012-07-20
Patient: 62 year old female, weighing 58.0 kg (127.6 pounds)
Reactions: Hepatic Function Abnormal, Hepatic Neoplasm Malignant, Nausea, Diarrhoea
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: 200 mg, bid
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2012-01-18
End date: 2012-01-25
Nexavar
Dosage: daily dose 600 mg
Administration route: Oral
Start date: 2012-01-25
End date: 2012-01-29
Possible Nexavar side effects in 62 year old female
Reported by a physician from Japan on 2012-07-18
Patient: 62 year old female, weighing 50.0 kg (110.0 pounds)
Reactions: Hepatic Function Abnormal, Amylase Increased, Palmar-Plantar Erythrodysaesthesia Syndrome, Nail Ridging, Pyrexia, Hypophosphataemia, Diarrhoea, Lipase Increased, Hypertension
Drug(s) suspected as cause:
Nexavar
Dosage: 200 mg/day
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2011-10-19
End date: 2012-04-25
Nexavar
Dosage: 200 mg, qod
Administration route: Oral
Start date: 2012-04-26
End date: 2012-05-09
Other drugs received by patient: Lendormin; Urso 250; Zolpidem; Livact; Aminoleban EN; Aminoleban EN; Eurax; Olmesartan Medoxomil; Primperan TAB; Aminoleban EN; Allegra; Loxonin; Olmesartan Medoxomil; Olmesartan Medoxomil; Urepearl
Possible Nexavar side effects in 72 year old male
Reported by a physician from Japan on 2012-07-18
Patient: 72 year old male, weighing 59.1 kg (130.0 pounds)
Reactions: Hepatic Function Abnormal, Conjunctival Haemorrhage, Stomatitis, Palmar-Plantar Erythrodysaesthesia Syndrome, Pyrexia, Periorbital Haematoma
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2009-07-02
End date: 2009-07-29
Nexavar
Dosage: 400 mg (daily dose), , oral
Administration route: Oral
Start date: 2009-11-09
End date: 2010-03-03
Nexavar
Dosage: 800 mg (daily dose), , oral
Administration route: Oral
Start date: 2009-08-04
End date: 2009-08-19
Other drugs received by patient: Urso 250; Rabeprazole Sodium; Baraclude; Vitamin B12; Gasmotin; Famotidine; Urso 250; Naproxen; Soldactone; Lasix; Naproxen; Soldactone; Lasix; Lasix; Hokunalin; Naproxen; Soldactone; Lasix
Possible Nexavar side effects in 69 year old male
Reported by a physician from Japan on 2012-07-17
Patient: 69 year old male
Reactions: Hepatic Function Abnormal, Haematuria, Hypothyroidism, Hypertension
Drug(s) suspected as cause:
Nexavar
Administration route: Oral
Indication: Renal Cell Carcinoma
Start date: 2009-01-13
End date: 2009-03-13
Nexavar
Dosage: 400 mg, bid
Administration route: Oral
Start date: 2009-09-16
End date: 2012-06-01
Nexavar
Dosage: 400 mg (daily dose), , oral
Administration route: Oral
Start date: 2009-04-06
End date: 2009-04-12
Nexavar
Dosage: 800 mg (daily dose), , oral
Administration route: Oral
Start date: 2009-04-13
End date: 2009-08-18
Nexavar
Dosage: 400 mg (daily dose), , oral
Administration route: Oral
Start date: 2009-08-19
End date: 2009-09-15
Other drugs received by patient: Ferric Hydroxide Polymaltose Complex; Lamisil; Adona; Transamine CAP; Almarl; Levothyroxine Sodium; Levothyroxine Sodium; Felodipine
Possible Nexavar side effects in 65 year old male
Reported by a physician from Japan on 2012-07-17
Patient: 65 year old male, weighing 53.4 kg (117.5 pounds)
Reactions: Hepatic Function Abnormal, Hepatic Neoplasm Malignant, Hepatic Failure, Neoplasm Progression, Rash, Oesophageal Varices Haemorrhage, Haematemesis, Renal Failure, Interstitial Lung Disease, Diarrhoea
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: 600 mg (daily dose), , oral
Administration route: Oral
Start date: 2009-07-22
End date: 2009-07-30
Nexavar
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2009-06-29
End date: 2009-07-21
Other drugs received by patient: Proheparum; Monilac; Rabeprazole Sodium; Glycyron [glycyrrhizic Acid]; FOY; Rhythmy; Aldactone; Etodolac; Flomax; Urso 250; Loxonin
Possible Nexavar side effects in 60 year old male
Reported by a physician from Japan on 2012-07-17
Patient: 60 year old male, weighing 57.0 kg (125.4 pounds)
Reactions: Jaundice, Hepatic Function Abnormal, Musculoskeletal Pain, Drug-Induced Liver Injury, Palmar-Plantar Erythrodysaesthesia Syndrome, Tumour Haemorrhage
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: 400 mg, qd
Administration route: Oral
Start date: 2009-11-11
End date: 2009-12-09
Nexavar
Dosage: 800 mg, qd
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2009-07-22
End date: 2009-10-07
Other drugs received by patient: Cytotec; Lansoprazole; Urepearl; Famotidine
Possible Nexavar side effects in 69 year old male
Reported by a physician from Japan on 2012-07-09
Patient: 69 year old male
Reactions: Hepatic Function Abnormal, Haematuria, Hypothyroidism, Hypertension
Drug(s) suspected as cause:
Nexavar
Dosage: 400 mg (daily dose), , oral
Administration route: Oral
Start date: 2009-08-19
End date: 2009-09-15
Nexavar
Administration route: Oral
Indication: Renal Cell Carcinoma
Start date: 2009-01-13
End date: 2009-03-13
Nexavar
Dosage: 400 mg (daily dose), , oral
Administration route: Oral
Start date: 2009-04-06
End date: 2009-04-12
Nexavar
Dosage: 400 mg, bid
Administration route: Oral
Start date: 2009-09-16
End date: 2012-06-01
Nexavar
Dosage: 800 mg (daily dose), , oral
Administration route: Oral
Start date: 2009-04-13
End date: 2009-08-18
Other drugs received by patient: Ferric Hydroxide Polymaltose Complex; Transamine CAP; Lamisil; Levothyroxine Sodium; Adona; Felodipine; Almarl; Levothyroxine Sodium
Possible Nexavar side effects in 62 year old female
Reported by a physician from Japan on 2012-07-05
Patient: 62 year old female, weighing 58.0 kg (127.6 pounds)
Reactions: Hepatic Function Abnormal, Nausea, Hepatic Neoplasm Malignant, Diarrhoea
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: daily dose 600 mg
Administration route: Oral
Start date: 2012-01-25
End date: 2012-01-29
Nexavar
Dosage: 200 mg, bid
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2012-01-18
End date: 2012-01-25
Possible Nexavar side effects in 78 year old male
Reported by a physician from Japan on 2012-07-02
Patient: 78 year old male, weighing 53.0 kg (116.6 pounds)
Reactions: Hepatic Function Abnormal, Hepatic Neoplasm Malignant, Platelet Count Decreased
Adverse event resulted in: death
Drug(s) suspected as cause:
Nexavar
Dosage: 400 mg daily
Administration route: Oral
Start date: 2011-03-25
End date: 2011-04-21
Nexavar
Dosage: 400 mg, qod
Start date: 2011-04-21
End date: 2011-07-29
Other drugs received by patient: Urso 250; Livact; Lansoprazole
Possible Nexavar side effects in 43 year old female
Reported by a physician from Japan on 2012-06-25
Patient: 43 year old female
Reactions: Hepatic Function Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: daily dose 800 mg
Administration route: Oral
Indication: Renal Cell Carcinoma
Start date: 2012-03-27
End date: 2012-05-22
Nexavar
Dosage: daily dose 800 mg
Administration route: Oral
Start date: 2012-06-01
End date: 2012-06-05
Nexavar
Dosage: daily dose 400 mg
Administration route: Oral
Start date: 2012-05-23
End date: 2012-05-31
Other drugs received by patient: IPE Roxo+#12288;(supplement)
Possible Nexavar side effects in 42 year old female
Reported by a physician from Japan on 2012-06-22
Patient: 42 year old female, weighing 40.8 kg (89.8 pounds)
Reactions: Hepatic Function Abnormal, Cholecystitis Acute, Diarrhoea, Palmar-Plantar Erythrodysaesthesia Syndrome, Platelet Count Decreased, Eosinophilia
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Nexavar
Dosage: 800 mg (daily dose), , oral
Administration route: Oral
Indication: Hepatic Neoplasm Malignant
Start date: 2009-09-14
Nexavar
Dosage: 800 mg, qd
Nexavar
Dosage: 200 mg, qod
Administration route: Oral
Start date: 2009-11-17
Nexavar
Dosage: 400 mg (daily dose), , oral
Administration route: Oral
End date: 2009-10-10
Possible Nexavar side effects in 64 year old female
Reported by a physician from Japan on 2012-06-14
Patient: 64 year old female
Reactions: Hepatic Function Abnormal, Oedema, Ascites
Drug(s) suspected as cause:
Nexavar
Possible Nexavar side effects in 77 year old male
Reported by a physician from Japan on 2012-06-12
Patient: 77 year old male, weighing 42.0 kg (92.4 pounds)
Reactions: Hepatic Function Abnormal
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Nexavar
Possible Nexavar side effects in 69 year old female
Reported by a health professional (non-physician/pharmacist) from Italy on 2012-06-12
Patient: 69 year old female
Reactions: Muscle Atrophy, Hepatic Function Abnormal, Oedema Peripheral, Ascites
Drug(s) suspected as cause:
Nexavar
Other drugs received by patient: Luvion
Possible Nexavar side effects in 43 year old female
Reported by a physician from Japan on 2012-06-11
Patient: 43 year old female
Reactions: Hepatic Function Abnormal
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Nexavar
Other drugs received by patient: IPE Roxo+#12288;(supplement)
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