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Nexavar (Sorafenib) - Hepatic Function Abnormal - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Hepatic Function Abnormal (124)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Nexavar (Sorafenib) where reactions include hepatic function abnormal. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 124   Next >>

Possible Nexavar side effects in 35 year old male

Reported by a physician from Japan on 2012-08-27

Patient: 35 year old male, weighing 68.3 kg (150.3 pounds)

Reactions: Hepatic Function Abnormal

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2010-06-18
    End date: 2010-06-19

Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-06-11
    End date: 2010-06-17

Other drugs received by patient: Fentanyl-100; Oxycontin; Restamin; Primperan TAB; Omeprazole; Magmitt; Enteronon R; Cefazolin Sodium; Ketoprofen; Celecoxib; Pursennid; Zometa; Baraclude; Prochlorperazine; Acetaminophen; Wystal; Enteronon R; Oxycodone Hydrochloride; Primperan TAB; Primperan TAB



Possible Nexavar side effects in male

Reported by a physician from Japan on 2012-08-21

Patient: male

Reactions: Hepatic Function Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 77 year old female

Reported by a physician from Japan on 2012-08-17

Patient: 77 year old female

Reactions: Hepatic Function Abnormal, Platelet Count Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 66 year old male

Reported by a physician from Japan on 2012-08-17

Patient: 66 year old male, weighing 86.0 kg (189.2 pounds)

Reactions: Hepatic Function Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 unk, unk
    Start date: 2012-06-13
    End date: 2012-07-13

Nexavar
    Dosage: daily dose 200 mg
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-05-25
    End date: 2012-05-29

Nexavar
    Dosage: 200 mg, qod
    Start date: 2012-05-29
    End date: 2012-06-13

Other drugs received by patient: Livact; Glakay; Carvedilol; Omeprazole; Pydoxal; Lactulose



Possible Nexavar side effects in 77 year old male

Reported by a physician from Japan on 2012-08-15

Patient: 77 year old male

Reactions: Hepatic Function Abnormal

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in female

Reported by a physician from Austria on 2012-08-14

Patient: female

Reactions: Hepatic Function Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 54 year old male

Reported by a physician from Japan on 2012-08-13

Patient: 54 year old male, weighing 40.5 kg (89.1 pounds)

Reactions: Blood Bilirubin Increased, Blood Alkaline Phosphatase Increased, Pneumonia, Hepatic Function Abnormal, Anaemia, Constipation, Ascites, Diarrhoea, Platelet Count Decreased, Metastases To Bone, Liver Carcinoma Ruptured, Bilirubin Conjugated Increased, Decreased Appetite

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-08-10
    End date: 2009-09-10

Nexavar
    Dosage: 600 mg, qd
    Administration route: Oral
    Start date: 2009-09-12
    End date: 2009-09-25

Other drugs received by patient: Fentanyl-100; TPN; Zolpidem; Bismuth Subnitrate; Voltaren; Lansoprazole; Albumin Tannate; Oxycodone Hydrochloride; Elemenmic



Possible Nexavar side effects in 77 year old female

Reported by a physician from Japan on 2012-08-10

Patient: 77 year old female

Reactions: Hepatic Function Abnormal, Platelet Count Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 61 year old male

Reported by a physician from Japan on 2012-08-10

Patient: 61 year old male

Reactions: Hepatic Function Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Allopurinol; Celecoxib; Famotidine; Flomox; Norvasc



Possible Nexavar side effects in 48 year old male

Reported by a physician from Taiwan, Province of China on 2012-08-08

Patient: 48 year old male, weighing 67.7 kg (148.9 pounds)

Reactions: Hepatic Function Abnormal, Sepsis, Hepatic Failure, Constipation, Acute Respiratory Failure, Oesophageal Varices Haemorrhage

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-10-05
    End date: 2011-10-25

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2011-11-15
    End date: 2011-11-15

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2011-10-26
    End date: 2011-11-14

Other drugs received by patient: Entecavir; Lactulose; Metoclopramide; Ultracet; Oxybutynin Chloride; Tamsulosin HCL; Esomeprazole



Possible Nexavar side effects in 72 year old female

Reported by a physician from Japan on 2012-08-07

Patient: 72 year old female, weighing 46.0 kg (101.2 pounds)

Reactions: Blood Bilirubin Increased, Hepatic Function Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2012-01-30
    End date: 2012-05-22

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2012-06-27
    End date: 2012-07-11

Other drugs received by patient: Denosumab



Possible Nexavar side effects in 81 year old male

Reported by a physician from Japan on 2012-08-06

Patient: 81 year old male, weighing 45.8 kg (100.8 pounds)

Reactions: Neutrophil Count Increased, Hepatic Function Abnormal, Amylase Increased, Hepatic Neoplasm Malignant, Disseminated Intravascular Coagulation, Anaemia, Hyponatraemia, Pyrexia, Cardiac Failure Acute, Ascites, Platelet Count Decreased, Ammonia Increased, Lipase Increased

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-06-10
    End date: 2010-06-22

Nexavar
    Dosage: 400 mg, qod
    Administration route: Oral
    Start date: 2010-06-24
    End date: 2010-06-25

Other drugs received by patient: Magmitt; Antianaemic Preparations; Pantosin; Metilon; Aminoleban; Urso 250; Losartan Potassium; Metilon; Urepearl; Metilon; Metilon; Ferrous Sulfate TAB; Hirudoid; Metilon; Metilon



Possible Nexavar side effects in 68 year old female

Reported by a physician from Japan on 2012-08-03

Patient: 68 year old female, weighing 45.8 kg (100.8 pounds)

Reactions: Hepatic Function Abnormal, Hepatorenal Syndrome

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Keratinamin; Cisplatin



Possible Nexavar side effects in 76 year old male

Reported by a physician from Japan on 2012-08-01

Patient: 76 year old male

Reactions: Hepatic Function Abnormal, Palmar-Plantar Erythrodysaesthesia Syndrome

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant

Nexavar
    Dosage: 400 mg, qod
    Administration route: Oral



Possible Nexavar side effects in 71 year old male

Reported by a physician from Japan on 2012-07-30

Patient: 71 year old male, weighing 61.0 kg (134.2 pounds)

Reactions: Blood Creatine Phosphokinase Increased, Hepatic Function Abnormal, Dysphonia, Blood Sodium Decreased

Drug(s) suspected as cause:
Lipidil
    Dosage: daily dose 100 mg
    Administration route: Oral
    Indication: Hyperlipidaemia

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2012-07-13

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-05-23
    End date: 2012-06-04

Other drugs received by patient: Cilnidipine; Olmesartan Medoxomil; Mitiglinide; Mecobalamin; Alinamin F [fursultiamine]; Atenolol; Bezatol; Kallidinogenase



Possible Nexavar side effects in 62 year old female

Reported by a physician from Japan on 2012-07-20

Patient: 62 year old female, weighing 58.0 kg (127.6 pounds)

Reactions: Hepatic Function Abnormal, Hepatic Neoplasm Malignant, Nausea, Diarrhoea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-01-18
    End date: 2012-01-25

Nexavar
    Dosage: daily dose 600 mg
    Administration route: Oral
    Start date: 2012-01-25
    End date: 2012-01-29



Possible Nexavar side effects in 62 year old female

Reported by a physician from Japan on 2012-07-18

Patient: 62 year old female, weighing 50.0 kg (110.0 pounds)

Reactions: Hepatic Function Abnormal, Amylase Increased, Palmar-Plantar Erythrodysaesthesia Syndrome, Nail Ridging, Pyrexia, Hypophosphataemia, Diarrhoea, Lipase Increased, Hypertension

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg/day
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-10-19
    End date: 2012-04-25

Nexavar
    Dosage: 200 mg, qod
    Administration route: Oral
    Start date: 2012-04-26
    End date: 2012-05-09

Other drugs received by patient: Lendormin; Urso 250; Zolpidem; Livact; Aminoleban EN; Aminoleban EN; Eurax; Olmesartan Medoxomil; Primperan TAB; Aminoleban EN; Allegra; Loxonin; Olmesartan Medoxomil; Olmesartan Medoxomil; Urepearl



Possible Nexavar side effects in 72 year old male

Reported by a physician from Japan on 2012-07-18

Patient: 72 year old male, weighing 59.1 kg (130.0 pounds)

Reactions: Hepatic Function Abnormal, Conjunctival Haemorrhage, Stomatitis, Palmar-Plantar Erythrodysaesthesia Syndrome, Pyrexia, Periorbital Haematoma

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-07-02
    End date: 2009-07-29

Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-11-09
    End date: 2010-03-03

Nexavar
    Dosage: 800 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-08-04
    End date: 2009-08-19

Other drugs received by patient: Urso 250; Rabeprazole Sodium; Baraclude; Vitamin B12; Gasmotin; Famotidine; Urso 250; Naproxen; Soldactone; Lasix; Naproxen; Soldactone; Lasix; Lasix; Hokunalin; Naproxen; Soldactone; Lasix



Possible Nexavar side effects in 60 year old male

Reported by a physician from Japan on 2012-07-17

Patient: 60 year old male, weighing 57.0 kg (125.4 pounds)

Reactions: Jaundice, Hepatic Function Abnormal, Musculoskeletal Pain, Drug-Induced Liver Injury, Palmar-Plantar Erythrodysaesthesia Syndrome, Tumour Haemorrhage

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2009-11-11
    End date: 2009-12-09

Nexavar
    Dosage: 800 mg, qd
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-07-22
    End date: 2009-10-07

Other drugs received by patient: Cytotec; Lansoprazole; Urepearl; Famotidine



Possible Nexavar side effects in 69 year old male

Reported by a physician from Japan on 2012-07-17

Patient: 69 year old male

Reactions: Hepatic Function Abnormal, Haematuria, Hypothyroidism, Hypertension

Drug(s) suspected as cause:
Nexavar
    Administration route: Oral
    Indication: Renal Cell Carcinoma
    Start date: 2009-01-13
    End date: 2009-03-13

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2009-09-16
    End date: 2012-06-01

Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-04-06
    End date: 2009-04-12

Nexavar
    Dosage: 800 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-04-13
    End date: 2009-08-18

Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-08-19
    End date: 2009-09-15

Other drugs received by patient: Ferric Hydroxide Polymaltose Complex; Lamisil; Adona; Transamine CAP; Almarl; Levothyroxine Sodium; Levothyroxine Sodium; Felodipine



Possible Nexavar side effects in 65 year old male

Reported by a physician from Japan on 2012-07-17

Patient: 65 year old male, weighing 53.4 kg (117.5 pounds)

Reactions: Hepatic Function Abnormal, Hepatic Neoplasm Malignant, Hepatic Failure, Neoplasm Progression, Rash, Oesophageal Varices Haemorrhage, Haematemesis, Renal Failure, Interstitial Lung Disease, Diarrhoea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 600 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-07-22
    End date: 2009-07-30

Nexavar
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-06-29
    End date: 2009-07-21

Other drugs received by patient: Proheparum; Monilac; Rabeprazole Sodium; Glycyron [glycyrrhizic Acid]; FOY; Rhythmy; Aldactone; Etodolac; Flomax; Urso 250; Loxonin



Possible Nexavar side effects in 69 year old male

Reported by a physician from Japan on 2012-07-09

Patient: 69 year old male

Reactions: Hepatic Function Abnormal, Haematuria, Hypothyroidism, Hypertension

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-08-19
    End date: 2009-09-15

Nexavar
    Administration route: Oral
    Indication: Renal Cell Carcinoma
    Start date: 2009-01-13
    End date: 2009-03-13

Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-04-06
    End date: 2009-04-12

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2009-09-16
    End date: 2012-06-01

Nexavar
    Dosage: 800 mg (daily dose), , oral
    Administration route: Oral
    Start date: 2009-04-13
    End date: 2009-08-18

Other drugs received by patient: Ferric Hydroxide Polymaltose Complex; Transamine CAP; Lamisil; Levothyroxine Sodium; Adona; Felodipine; Almarl; Levothyroxine Sodium



Possible Nexavar side effects in 62 year old female

Reported by a physician from Japan on 2012-07-05

Patient: 62 year old female, weighing 58.0 kg (127.6 pounds)

Reactions: Hepatic Function Abnormal, Nausea, Hepatic Neoplasm Malignant, Diarrhoea

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 600 mg
    Administration route: Oral
    Start date: 2012-01-25
    End date: 2012-01-29

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-01-18
    End date: 2012-01-25



Possible Nexavar side effects in 78 year old male

Reported by a physician from Japan on 2012-07-02

Patient: 78 year old male, weighing 53.0 kg (116.6 pounds)

Reactions: Hepatic Function Abnormal, Hepatic Neoplasm Malignant, Platelet Count Decreased

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg daily
    Administration route: Oral
    Start date: 2011-03-25
    End date: 2011-04-21

Nexavar
    Dosage: 400 mg, qod
    Start date: 2011-04-21
    End date: 2011-07-29

Other drugs received by patient: Urso 250; Livact; Lansoprazole



Possible Nexavar side effects in 43 year old female

Reported by a physician from Japan on 2012-06-25

Patient: 43 year old female

Reactions: Hepatic Function Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 800 mg
    Administration route: Oral
    Indication: Renal Cell Carcinoma
    Start date: 2012-03-27
    End date: 2012-05-22

Nexavar
    Dosage: daily dose 800 mg
    Administration route: Oral
    Start date: 2012-06-01
    End date: 2012-06-05

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2012-05-23
    End date: 2012-05-31

Other drugs received by patient: IPE Roxo+#12288;(supplement)



Possible Nexavar side effects in 42 year old female

Reported by a physician from Japan on 2012-06-22

Patient: 42 year old female, weighing 40.8 kg (89.8 pounds)

Reactions: Hepatic Function Abnormal, Cholecystitis Acute, Diarrhoea, Palmar-Plantar Erythrodysaesthesia Syndrome, Platelet Count Decreased, Eosinophilia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 800 mg (daily dose), , oral
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-09-14

Nexavar
    Dosage: 800 mg, qd

Nexavar
    Dosage: 200 mg, qod
    Administration route: Oral
    Start date: 2009-11-17

Nexavar
    Dosage: 400 mg (daily dose), , oral
    Administration route: Oral
    End date: 2009-10-10



Possible Nexavar side effects in 64 year old female

Reported by a physician from Japan on 2012-06-14

Patient: 64 year old female

Reactions: Hepatic Function Abnormal, Oedema, Ascites

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 77 year old male

Reported by a physician from Japan on 2012-06-12

Patient: 77 year old male, weighing 42.0 kg (92.4 pounds)

Reactions: Hepatic Function Abnormal

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 69 year old female

Reported by a health professional (non-physician/pharmacist) from Italy on 2012-06-12

Patient: 69 year old female

Reactions: Muscle Atrophy, Hepatic Function Abnormal, Oedema Peripheral, Ascites

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Luvion



Possible Nexavar side effects in 71 year old male

Reported by a physician from Japan on 2012-06-11

Patient: 71 year old male

Reactions: Hepatic Function Abnormal, Blood Creatine Phosphokinase Increased, Dysphonia

Drug(s) suspected as cause:
Nexavar



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