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Nexavar (Sorafenib) - Diarrhoea - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Diarrhoea (345)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Nexavar (Sorafenib) where reactions include diarrhoea. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 345   Next >>

Possible Nexavar side effects in 62 year old male

Reported by a physician from Japan on 2012-08-27

Patient: 62 year old male

Reactions: Diarrhoea, Cerebral Infarction, Palmar-Plantar Erythrodysaesthesia Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2010-06-21
    End date: 2010-10-11

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2010-10-12
    End date: 2010-11-19



Possible Nexavar side effects in 59 year old female

Reported by a physician from United States on 2012-08-27

Patient: 59 year old female, weighing 59.0 kg (129.7 pounds)

Reactions: Weight Decreased, Peripheral Coldness, Vomiting, Glossodynia, Nausea, Pain, Rash, Hyperhidrosis, Constipation, Erythema, Fatigue, Diarrhoea, Dehydration, Feeling Hot, Dizziness, Cold Sweat, Blister

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, daily
    Administration route: Oral
    Start date: 2012-07-14

Nexavar
    Dosage: 400 mg, qd
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-05-09

Nexavar
    Dosage: 400 mg, bid
    Start date: 2012-05-19

Nexavar
    Dosage: 400 mg am and 200 mg pm
    End date: 2012-07-11



Possible Nexavar side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-27

Patient: 54 year old male

Reactions: Blood Pressure Increased, Weight Decreased, Nausea, Pain in Extremity, Hypotension, Rash, Skin Irritation, Frequent Bowel Movements, Fatigue, Diarrhoea, Gait Disturbance, Decreased Appetite

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 67 year old male

Reported by a physician from Korea, Republic of on 2012-08-24

Patient: 67 year old male, weighing 63.0 kg (138.6 pounds)

Reactions: Diarrhoea, Febrile Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 800 mg
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-03-09
    End date: 2011-04-13

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2011-04-14
    End date: 2011-08-26



Possible Nexavar side effects in 65 year old male

Reported by a physician from Japan on 2012-08-24

Patient: 65 year old male, weighing 63.0 kg (138.6 pounds)

Reactions: C-Reactive Protein Increased, Diarrhoea, Aspartate Aminotransferase Increased, Pyrexia, Rash

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-05-15
    End date: 2012-07-27

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2012-08-03

Other drugs received by patient: Loxonin; Lendormin; Livact; Allopurinol; Amlodipine; Micardis; Pravastatin Sodium; Urso 250; Lansoprazole; Pursennid; Doxazosin Mesylate; Enalapril Maleate



Possible Nexavar side effects in 63 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-21

Patient: 63 year old female, weighing 48.1 kg (105.8 pounds)

Reactions: Blood Creatine Phosphokinase Increased, Angina Unstable, Palmar-Plantar Erythrodysaesthesia Syndrome, Wound Infection, Blood Creatine Phosphokinase MB Increased, Malaise, C-Reactive Protein Increased, Diarrhoea, Impaired Healing, Hepatectomy, Chest Pain, Platelet Count Decreased, Skin Necrosis, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-01-07
    End date: 2011-01-28

Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Indication: Metastases To Lung
    Start date: 2011-03-05
    End date: 2011-03-24

Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Start date: 2011-03-17

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2011-04-22
    End date: 2011-08-22

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2011-10-25
    End date: 2011-10-30

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2011-08-31
    End date: 2011-10-23

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2011-11-03

Other drugs received by patient: Urepearl; Epirubicin Hydrochloride; Famotidine; Amlodipine; Miriplatin



Possible Nexavar side effects in 67 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-20

Patient: 67 year old female

Reactions: Adverse Drug Reaction, Oropharyngeal Pain, Constipation, Pharyngeal Oedema, Hair Texture Abnormal, Oedema Peripheral, DRY Mouth, Blister, LIP DRY, Pain in Extremity, Palmar-Plantar Erythrodysaesthesia Syndrome, Ear Infection, Antibiotic Therapy, Arthralgia, Diarrhoea, Limb Injury, Joint Swelling, Alopecia, Hair Disorder

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Indication: Thyroid Cancer
    Start date: 2009-07-09

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar
    Dosage: 200 mg, qd
    Administration route: Oral

Nexavar



Possible Nexavar side effects in 73 year old male

Reported by a physician from Japan on 2012-08-20

Patient: 73 year old male, weighing 52.0 kg (114.4 pounds)

Reactions: Malaise, Hepatic Neoplasm Malignant, Diarrhoea, Pyrexia, Altered State of Consciousness

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 63 year old male

Reported by a health professional (non-physician/pharmacist) from Brazil on 2012-08-17

Patient: 63 year old male, weighing 67.0 kg (147.4 pounds)

Reactions: Weight Decreased, Blood Pressure Increased, Abdominal Pain, Back Pain, Urinary Tract Infection, Diplopia, Diarrhoea, Metastases To Bone, Eye Disorder, Decreased Appetite

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Preparations Increasing Uric Acid Excretion; Omeprazole; Captopril; Hydrochlorothiazide; Preparations Increasing Uric Acid Excretion; Preparations Increasing Uric Acid Excretion; Preparations Increasing Uric Acid Excretion; Hydrochlorothiazide



Possible Nexavar side effects in 65 year old male

Reported by a consumer/non-health professional from United States on 2012-08-17

Patient: 65 year old male

Reactions: Tumour Necrosis, Vomiting, Nausea, Musculoskeletal Pain, Pain, Neoplasm Progression, Pyrexia, Weight Increased, Diarrhoea, Nail Disorder

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16

Patient: 54 year old male

Reactions: Frequent Bowel Movements, Diarrhoea, Pain in Extremity, Rash, Gait Disturbance, Skin Irritation

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 60 year old male

Reported by a physician from United States on 2012-08-15

Patient: 60 year old male

Reactions: Weight Decreased, Cellulitis, Retching, Pain in Extremity, Pyrexia, Fall, Erythema, Diarrhoea, Oedema Peripheral, Asthenia, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Analgesics



Possible Nexavar side effects in 79 year old female

Reported by a physician from Japan on 2012-08-14

Patient: 79 year old female, weighing 54.4 kg (119.7 pounds)

Reactions: Abdominal Pain, Vomiting, Nausea, Diarrhoea, Abdominal Distension, Subileus

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Urso 250; Rabeprazole Sodium; Alcadol; Lorazepam; Dogmatyl; Livact; Alendronate Sodium; Trichlormethiazide



Possible Nexavar side effects in 54 year old male

Reported by a physician from Japan on 2012-08-13

Patient: 54 year old male, weighing 40.5 kg (89.1 pounds)

Reactions: Blood Bilirubin Increased, Blood Alkaline Phosphatase Increased, Pneumonia, Hepatic Function Abnormal, Anaemia, Constipation, Ascites, Diarrhoea, Platelet Count Decreased, Metastases To Bone, Liver Carcinoma Ruptured, Bilirubin Conjugated Increased, Decreased Appetite

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-08-10
    End date: 2009-09-10

Nexavar
    Dosage: 600 mg, qd
    Administration route: Oral
    Start date: 2009-09-12
    End date: 2009-09-25

Other drugs received by patient: Fentanyl-100; TPN; Zolpidem; Bismuth Subnitrate; Voltaren; Lansoprazole; Albumin Tannate; Oxycodone Hydrochloride; Elemenmic



Possible Nexavar side effects in 59 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-10

Patient: 59 year old female

Reactions: Weight Decreased, Peripheral Coldness, Glossodynia, Pain, Constipation, Erythema, Hyperhidrosis, Fatigue, Feeling Hot, Dizziness, Cold Sweat, Blister, Vomiting, Nausea, Rash, Diarrhoea, Dehydration

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Start date: 2012-05-19

Nexavar
    Dosage: 400 mg am and 200 mg pm
    End date: 2012-07-11

Nexavar
    Dosage: 400 mg, daily
    Administration route: Oral
    Start date: 2012-07-14

Nexavar
    Dosage: 400 mg, qd
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-05-09



Possible Nexavar side effects in 79 year old female

Reported by a physician from Japan on 2012-08-09

Patient: 79 year old female

Reactions: Diarrhoea, Abdominal Distension

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 64 year old male

Reported by a pharmacist from Japan on 2012-08-09

Patient: 64 year old male, weighing 62.0 kg (136.4 pounds)

Reactions: Diarrhoea, Hepatic Neoplasm Malignant, Hyperammonaemia, Eczema, Decreased Appetite, Ascites

Adverse event resulted in: death

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg/day
    Administration route: Oral
    Start date: 2009-09-09
    End date: 2009-10-01

Nexavar
    Dosage: 400 mg/day
    Administration route: Oral
    Start date: 2009-10-28
    End date: 2009-10-30

Nexavar
    Dosage: 600 mg/day
    Administration route: Oral
    Start date: 2009-10-02
    End date: 2009-10-27

Nexavar
    Dosage: 800 mg/day
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-08-06
    End date: 2009-09-08

Other drugs received by patient: Lamivudine; Mucosta; Aldactone; Lasix; Oxycontin; Rabeprazole Sodium; Loxoprofen; Fentanyl-100; Pastaron; Ensure [minerals Nos,vitamins Nos]; Hepsera; Hypoca; Morphine; Aldactone



Possible Nexavar side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-08

Patient: 54 year old male

Reactions: Frequent Bowel Movements, Diarrhoea, Pain in Extremity, Gait Disturbance, Rash, Skin Irritation

Drug(s) suspected as cause:
Nexavar



Possible Nexavar side effects in 62 year old male

Reported by a physician from Japan on 2012-08-08

Patient: 62 year old male, weighing 57.0 kg (125.4 pounds)

Reactions: Fatigue, Dyspnoea, Diarrhoea, Bone Marrow Failure, Acute Respiratory Distress Syndrome, Decreased Appetite

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 800 mg
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-03-10
    End date: 2012-03-20

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2012-04-01
    End date: 2012-05-01

Nexavar
    Dosage: 400 mg, qod
    Start date: 2012-04-28
    End date: 2012-04-30

Nexavar
    Dosage: 200 mg, bid
    Start date: 2012-03-29
    End date: 2012-04-27

Other drugs received by patient: Silece; Risperidone; Zometa; Fentanyl Citrate; Lyrica; Loxonin; Lamivudine; Hepsera



Possible Nexavar side effects in 63 year old female

Reported by a physician from Japan on 2012-08-06

Patient: 63 year old female, weighing 48.1 kg (105.8 pounds)

Reactions: Blood Creatine Phosphokinase Increased, Angina Unstable, Palmar-Plantar Erythrodysaesthesia Syndrome, Wound Infection, Blood Creatine Phosphokinase MB Increased, Malaise, C-Reactive Protein Increased, Diarrhoea, Impaired Healing, Hepatectomy, Chest Pain, Platelet Count Decreased, Skin Necrosis, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 200-400 mg
    Administration route: Oral
    Start date: 2011-08-01

Nexavar
    Dosage: daily dose 600 mg
    Administration route: Oral
    Indication: Metastases To Lung
    Start date: 2011-03-05
    End date: 2011-03-24

Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Start date: 2011-03-17

Nexavar
    Dosage: 200 mg, tid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-01-07
    End date: 2011-01-28

Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral
    Start date: 2011-04-22

Other drugs received by patient: Amlodipine; Miriplatin; Epirubicin Hydrochloride; Famotidine; Urepearl



Possible Nexavar side effects in 80 year old male

Reported by a physician from Japan on 2012-08-06

Patient: 80 year old male

Reactions: Malaise, Dysphonia, Diarrhoea, Haematuria, Pollakiuria, Bladder Cancer

Drug(s) suspected as cause:
Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    End date: 2012-02-15

Nexavar
    Dosage: daily dose 600 mg
    Administration route: Oral
    Start date: 2012-02-16

Nexavar
    Dosage: 400 mg, qod
    Administration route: Oral
    Start date: 2012-04-01
    End date: 2012-06-14

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-08-01
    End date: 2011-08-10



Possible Nexavar side effects in 72 year old female

Reported by a consumer/non-health professional from France on 2012-08-01

Patient: 72 year old female

Reactions: Vomiting, Diarrhoea, Urinary Tract Infection, Pancytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: unk
    Start date: 2010-11-01
    End date: 2012-05-25

Ofloxacin
    Dosage: 200 mg, bid
    Administration route: Oral
    Indication: Urinary Tract Infection
    Start date: 2012-05-23
    End date: 2012-06-02

Other drugs received by patient: Levothyroxine Sodium; Vialebex; Lasix; Propranolol; Lantus; Folic Acid; Novorapid; Potassium Chloride



Possible Nexavar side effects in 85 year old male

Reported by a physician from Japan on 2012-07-31

Patient: 85 year old male

Reactions: Upper Limb Fracture, Diarrhoea, Fall, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, qd
    Administration route: Oral

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2011-06-07
    End date: 2011-08-30



Possible Nexavar side effects in 66 year old female

Reported by a consumer/non-health professional from United States on 2012-07-31

Patient: 66 year old female

Reactions: Blood Pressure Increased, Diarrhoea, Asthenia, Rash Pruritic

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    End date: 2012-07-15

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-07-13

Other drugs received by patient: Ramipril



Possible Nexavar side effects in 54 year old male

Reported by a consumer/non-health professional from United States on 2012-07-31

Patient: 54 year old male

Reactions: Pain in Extremity, DRY Skin, Hyperhidrosis, Abdominal Pain Upper, Dysphonia, Oropharyngitis Fungal, Diarrhoea, Gait Disturbance, Aphonia

Drug(s) suspected as cause:
Nexavar

Other drugs received by patient: Prednisone TAB; Laxatives; Stool Softener; Morphine Sulfate; Lactulose



Possible Nexavar side effects in 67 year old female

Reported by a consumer/non-health professional from United States on 2012-07-30

Patient: 67 year old female

Reactions: Chills, Adverse Drug Reaction, Pyrexia, Oropharyngeal Spasm, Faeces Discoloured, Herpes Zoster, Dyspepsia, Cranial Nerve Disorder, Alpha 1 Foetoprotein Increased, Dizziness, Vulvovaginal Rash, Nausea, Pain of Skin, Musculoskeletal Discomfort, Skin Disorder, Rash, Hepatic Enzyme Increased, Diarrhoea, Thyroid Disorder, Hypertension

Drug(s) suspected as cause:
Nexavar
    Dosage: 200 mg, daily
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant non-Resectable
    Start date: 2012-04-03

Nexavar

Nexavar
    Dosage: 200 mg, bid
    Start date: 2012-04-30
    End date: 2012-05-15

Nexavar
    Dosage: 400 mg, bid
    End date: 2012-05-15

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2012-05-21
    End date: 2012-05-22

Other drugs received by patient: Antihypertensives; Cardiac Therapy



Possible Nexavar side effects in 75 year old male

Reported by a physician from United States on 2012-07-30

Patient: 75 year old male

Reactions: Chest Discomfort, Dysphagia, Nausea, Pyrexia, Disorientation, Hypoaesthesia, Eructation, Fatigue, Malaise, Diarrhoea, Abdominal Distension, Gastrooesophageal Reflux Disease

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: unk
    Start date: 2012-06-11
    End date: 2012-07-19

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2012-07-06
    End date: 2012-07-09

Nexavar
    Dosage: daily dose 600 mg (200 in am 400 in pm)
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-06-11
    End date: 2012-06-22

Nexavar
    Dosage: unk
    Start date: 2012-07-21

Nexavar
    Dosage: 200 mg, bid
    Administration route: Oral
    Start date: 2012-07-02
    End date: 2012-07-05

Other drugs received by patient: Glucophage



Possible Nexavar side effects in 74 year old male

Reported by a physician from Japan on 2012-07-30

Patient: 74 year old male

Reactions: Dyspnoea, Anaemia, Malaise, Cardiac Failure, Diarrhoea, Interstitial Lung Disease, Pneumonia Bacterial, Alopecia, Platelet Count Decreased

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: unk
    Administration route: Oral
    Indication: Renal Cell Carcinoma
    Start date: 2011-12-05
    End date: 2011-12-18

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2011-12-19
    End date: 2012-05-09

Nexavar
    Dosage: daily dose 400 mg
    Administration route: Oral
    Start date: 2012-05-30
    End date: 2012-07-11

Other drugs received by patient: Sumiferon; Zoledronic Acid; Sumiferon; Sumiferon; Sumiferon



Possible Nexavar side effects in 59 year old female

Reported by a consumer/non-health professional from United States on 2012-07-25

Patient: 59 year old female

Reactions: Peripheral Coldness, Weight Decreased, Glossodynia, Vomiting, Nausea, Pain, Rash, Hyperhidrosis, Constipation, Erythema, Fatigue, Diarrhoea, Feeling Hot, Dehydration, Dizziness, Cold Sweat

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Start date: 2012-05-19

Nexavar
    Dosage: 400 mg, qd
    Indication: Hepatic Neoplasm Malignant
    Start date: 2012-05-09

Nexavar
    Dosage: 400 mg am and 200 mg pm
    End date: 2012-07-11



Possible Nexavar side effects in 76 year old male

Reported by a physician from Colombia on 2012-07-24

Patient: 76 year old male, weighing 64.0 kg (140.8 pounds)

Reactions: Hyperkalaemia, Impetigo, Hepatic Failure, Renal Failure Chronic, Lividity, Hepatic Encephalopathy, Diarrhoea, Oedema Peripheral, Epistaxis

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Nexavar
    Dosage: 400 mg, bid
    Start date: 2010-01-30
    End date: 2010-12-25

Nexavar
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Hepatic Neoplasm Malignant
    Start date: 2009-12-16
    End date: 2010-01-27

Nexavar
    Dosage: daily dose 800 mg
    Start date: 2011-01-04
    End date: 2011-01-11

Other drugs received by patient: Lactulosa; Furosemide; Enoxaparin; Insulin; Spironolactone; Ondansetron HCL; Midazolam; Dextrose 5%; Lactulosa; Propranolol; Midazolam; Furosemide; Dextrose 5%; Insulin; Haldol; Omeprazole; Spironolactone; Lactulosa; Haldol; Saline Solutions; NPH Insulin; Furosemide; Ampicillin and Sulbactam; Heparin; Acetylsalicylic Acid SRT; Diphenhydramine HCL



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