Index of reports
> Disability (24)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Neoral (Cyclosporine) disability. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Neoral side effects in 41 year old male
Reported by a physician from France on 2012-08-23
Patient: 41 year old male
Reactions: Optic Neuritis
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Coly-Mycin S Ophthalmic Drops
Indication: Cystic Fibrosis
Start date: 2007-09-25
Creon
Administration route: Oral
Indication: Pancreatic Insufficiency
Start date: 2007-09-25
Keppra
Administration route: Oral
Indication: Epilepsy
Start date: 2007-07-30
Lovenox
Indication: Product Used FOR Unknown Indication
Start date: 2007-09-25
Moviprep
Administration route: Oral
Indication: Constipation
Start date: 2007-09-25
Neoral
Administration route: Oral
Indication: Lung Transplant
End date: 2007-10-02
Nexium
Administration route: Oral
Indication: Prophylaxis Against Gastrointestinal Ulcer
Start date: 2007-09-25
Oxacillin
Administration route: Oral
Indication: Staphylococcal Infection
Start date: 2007-09-19
End date: 2007-11-07
Prednisolone
Administration route: Oral
Indication: Lung Transplant
Start date: 2007-09-24
Valganciclovir
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2007-09-24
End date: 2007-11-05
Other drugs received by patient: Paroxetine HCL; Atarax; Zolpidem
Possible Neoral side effects in male
Reported by a physician from France on 2012-08-17
Patient: male
Reactions: Optic Neuritis
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Coly-Mycin S Ophthalmic Drops
Indication: Cystic Fibrosis
Start date: 2007-09-25
Creon
Administration route: Oral
Indication: Pancreatic Insufficiency
Start date: 2007-09-25
Keppra
Administration route: Oral
Indication: Convulsion
Start date: 2007-07-30
Lovenox
Start date: 2007-09-25
Moviprep
Administration route: Oral
Indication: Constipation
Start date: 2007-09-25
Neoral
Administration route: Oral
Indication: Lung Transplant
Start date: 2007-07-01
End date: 2007-10-02
Nexium
Administration route: Oral
Indication: Prophylaxis Against Gastrointestinal Ulcer
Start date: 2007-09-25
Oxacillin
Administration route: Oral
Indication: Staphylococcal Infection
Start date: 2007-09-19
End date: 2007-11-07
Prednisolone
Administration route: Oral
Indication: Lung Transplant
Start date: 2007-09-24
Valganciclovir
Administration route: Oral
Start date: 2007-09-24
End date: 2007-11-05
Other drugs received by patient: Paroxetine HCL; Atarax; Zolpidem Tartrate
Possible Neoral side effects in male
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-14
Patient: male
Reactions: White Blood Cell Count Decreased, Visual Impairment, Optic Ischaemic Neuropathy, Papilloedema
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Colistin Sulfate
Dosage: 1 df, bid
Indication: Cystic Fibrosis Pancreatic
Start date: 2007-09-25
Creon
Dosage: 1 df, 5qd
Administration route: Oral
Indication: Pancreatic Insufficiency
Start date: 2007-09-25
Keppra
Dosage: 1 df, bid
Administration route: Oral
Indication: Epilepsy
Start date: 2007-07-30
Lovenox
Dosage: 0.2 ml, daily
Start date: 2007-09-25
Moviprep
Dosage: 1 df, tid
Administration route: Oral
Indication: Constipation
Start date: 2007-09-25
Neoral
Dosage: 325 mg in the morning and 310 mg in th evening
Administration route: Oral
Start date: 2007-10-01
End date: 2007-10-02
Neoral
Administration route: Oral
Indication: Lung Transplant
Start date: 2007-07-01
Nexium
Dosage: 40 mg, qd
Administration route: Oral
Indication: Prophylaxis Against Gastrointestinal Ulcer
Start date: 2007-09-25
Oxacillin
Dosage: 1 g, tid
Administration route: Oral
Indication: Staphylococcal Infection
Start date: 2007-09-19
End date: 2007-11-07
Prednisolone
Dosage: 20 mg, qd
Administration route: Oral
Indication: Lung Transplant
Start date: 2007-09-24
Valganciclovir
Dosage: 1 df, bid
Administration route: Oral
Start date: 2007-09-24
End date: 2007-11-05
Other drugs received by patient: Zolpidem Tartrate; Atarax; Paroxetine HCL
Possible Neoral side effects in 41 year old male
Reported by a health professional (non-physician/pharmacist) from France on 2012-08-14
Patient: 41 year old male
Reactions: Optic Ischaemic Neuropathy
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Colimycine
Dosage: 2 units daily
Indication: Cystic Fibrosis
Start date: 2007-09-25
Creon
Dosage: 5 units daily
Administration route: Oral
Indication: Pancreatic Insufficiency
Start date: 2007-09-25
Keppra
Dosage: daily dose: 2 units
Administration route: Oral
Indication: Convulsion
Start date: 2007-07-30
Lovenox
Dosage: daily dose: 0.2 ml
Start date: 2007-09-25
Moviprep
Dosage: 3 units daily, as necessary
Administration route: Oral
Indication: Constipation
Start date: 2007-09-25
Neoral
Dosage: on 01-oct-2007: 352 mg in morning, 310 mg in evening
Administration route: Oral
Indication: Lung Transplant
Start date: 2007-07-01
End date: 2007-10-02
Nexium
Dosage: daily dose: 40 mg
Administration route: Oral
Indication: Prophylaxis Against Gastrointestinal Ulcer
Start date: 2007-09-25
Oxacillin
Dosage: daily dose: 3 grams
Administration route: Oral
Indication: Staphylococcal Infection
Start date: 2007-09-19
End date: 2007-11-07
Prednisolone
Dosage: daily dose: 20 mg
Administration route: Oral
Indication: Lung Transplant
Start date: 2007-09-24
Valganciclovir
Dosage: 2 units daily
Administration route: Oral
Start date: 2007-09-24
End date: 2007-11-05
Other drugs received by patient: Zolpidem Tartrate; Paroxetine HCL; Atarax; Mycophenolate Mofetil
Possible Neoral side effects in 60 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-31
Patient: 60 year old male
Reactions: Neurotoxicity, CSF Protein Increased, Central Nervous System Lesion, Muscular Weakness, Hemiplegia, Hypoaesthesia, Toxicity To Various Agents
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Possible Neoral side effects in 60 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-31
Patient: 60 year old male
Reactions: Neurotoxicity, CSF Protein Increased, Central Nervous System Lesion, Muscular Weakness, Toxicity To Various Agents, Hypoaesthesia, Hemiplegia
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Possible Neoral side effects in female
Reported by a physician from Japan on 2012-07-25
Patient: female
Reactions: Pruritus, Melanodermia, Leukoderma, Rash Macular
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Other drugs received by patient: Locoid; Ascorbic Acid; Toukishakuyakusan; Ramitect; Protopic; Aleroff; Keishibukuryougan; Fulmeta
Possible Neoral side effects in 45 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-25
Patient: 45 year old female
Reactions: Pulmonary Hypertension, Pulmonary Veno-Occlusive Disease, Hypoxia, Pulmonary Oedema, Respiratory Distress
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Indication: Stem Cell Transplant
Neoral
Dosage: 240 mg, daily
Administration route: Oral
Indication: Prophylaxis Against Graft Versus Host Disease
Start date: 2011-06-01
End date: 2011-10-01
Other drugs received by patient: Methotrexate; Cyclophosphamide
Possible Neoral side effects in 45 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-24
Patient: 45 year old female
Reactions: Pulmonary Hypertension, Pulmonary Veno-Occlusive Disease, Hypoxia, Pulmonary Oedema, Respiratory Distress
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Dosage: 240 mg, daily
Administration route: Oral
Indication: Prophylaxis Against Graft Versus Host Disease
Start date: 2011-06-01
End date: 2011-10-01
Neoral
Indication: Stem Cell Transplant
Other drugs received by patient: Methotrexate; Cyclophosphamide
Possible Neoral side effects in male
Reported by a physician from Cyprus on 2012-05-11
Patient: male, weighing 175.0 kg (385.0 pounds)
Reactions: Erectile Dysfunction, Ejaculation Delayed
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Possible Neoral side effects in female
Reported by a physician from Japan on 2012-05-02
Patient: female
Reactions: Osteoarthritis, Arthralgia
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Possible Neoral side effects in 57 year old female
Reported by a physician from Ireland on 2012-04-24
Patient: 57 year old female
Reactions: Dyslipidaemia, Lymphadenopathy, Mouth Ulceration, Dental Plaque, IGA Nephropathy, Headache, Hepatomegaly, Blood Creatinine Increased, Lethargy, Muscle Spasms, Dyspnoea, Pulmonary Sarcoidosis, Toxicity To Various Agents, Nephrotic Syndrome, Tremor, Anxiety, Antinuclear Antibody Positive, Gingival Pain, Joint Swelling, Lymphoma, Asthenia, Normochromic Normocytic Anaemia, Hypertension
Adverse event resulted in: life threatening event, hospitalization, disablity
Drug(s) suspected as cause:
Cyclosporine
Dosage: 125 mg, 2x/day
Neoral
Dosage: unk
Neoral
Dosage: 125mg mane/100mg nocte
Start date: 2011-04-13
Toviaz
Dosage: 4 mg, unk
Administration route: Oral
Indication: Hypertonic Bladder
Other drugs received by patient: Calcichew-D3; Lansoprazole; Bumetanide; Fosamax; Acetylsalicylic Acid; Ramipril; Ramipril; Amlodipine; Furosemide; Prednisolone; Alendronate Sodium; Lansoprazole; Lercanidipine; Atorvastatin; Prednisolone; Bumetanide
Possible Neoral side effects in 58 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-03-27
Patient: 58 year old male
Reactions: Acute Graft Versus Host Disease, Haemorrhagic Infarction, Encephalitis, Pyrexia, Headache, Hemiparesis, Septic Embolus, Neurologic Neglect Syndrome, Subarachnoid Haemorrhage, Bacterial Sepsis, Depressed Level of Consciousness, Hemiplegia, Bacillus Infection, Meningitis, Engraftment Syndrome
Adverse event resulted in: life threatening event, disablity
Drug(s) suspected as cause:
Neoral
Other drugs received by patient: Fludarabine Phosphate; Irradiation; Busulfan; Corticosteroids; Methotrexate; Solu-Medrol
Possible Neoral side effects in 58 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-03-27
Patient: 58 year old male
Reactions: Acute Graft Versus Host Disease, Haemorrhagic Infarction, Encephalitis, Headache, Hemiparesis, Pyrexia, Septic Embolus, Neurologic Neglect Syndrome, Subarachnoid Haemorrhage, Bacterial Sepsis, Depressed Level of Consciousness, Bacillus Infection, Hemiplegia, Meningitis, Engraftment Syndrome
Adverse event resulted in: life threatening event, disablity
Drug(s) suspected as cause:
Neoral
Other drugs received by patient: Corticosteroids; Fludarabine Phosphate; Methotrexate; Solu-Medrol; Irradiation; Busulfan
Possible Neoral side effects in male
Reported by a physician from Japan on 2012-03-23
Patient: male
Reactions: Dyspnoea, Hepatic Function Abnormal, Liver Disorder, Renal Impairment, Renal Failure, Cardiac Failure, Respiratory Failure, Heart Rate Increased, Oedema Peripheral, Pleural Effusion, Immunosuppressant Drug Level Increased, Renal Tubular Necrosis, Hypertension, Oxygen Saturation Decreased
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Neoral
Other drugs received by patient: Allegra; Candesartan Cilexetil; Tigason
Possible Neoral side effects in female
Reported by a physician from France on 2012-01-05
Patient: female, weighing 50.0 kg (110.0 pounds)
Reactions: Obsessive-Compulsive Disorder, Graft Versus Host Disease, Chills, Tremor, Burning Sensation, Anxiety, Diarrhoea, Disturbance in Attention, Memory Impairment, Hypertension, Blood Creatinine Increased
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Dosage: 100 mg, bid
Neoral
Dosage: 100 mg, bid (twice per day)
Indication: Bone Marrow Transplant
Start date: 2011-06-17
Neoral
Dosage: 75 mg, bid
Neoral
Dosage: 50 mg, bid (twice per day)
Start date: 2011-09-01
Other drugs received by patient: Phenoxymethyl Penicillin; Magnesium; Fluconazole; Prednisone TAB; Valacyclovir Hydrochloride; Speciafoldine; Chlormadinone Acetate TAB; Entocort EC; Bactrim
Possible Neoral side effects in female
Reported by a consumer/non-health professional from France on 2011-12-16
Patient: female, weighing 50.0 kg (110.0 pounds)
Reactions: Obsessive-Compulsive Disorder, Graft Versus Host Disease, Chills, Tremor, Burning Sensation, Anxiety, Diarrhoea, Disturbance in Attention, Memory Impairment, Hypertension, Blood Creatinine Increased
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Dosage: 100 mg, bid
Indication: Bone Marrow Transplant
Start date: 2011-06-17
Neoral
Dosage: 50 mg, bid
Start date: 2011-09-01
Neoral
Dosage: 75 mg, bid
Other drugs received by patient: Magnesium; Speciafoldine; Chlormadinone Acetate TAB; Entocort EC; Fluconazole; Phenoxymethyl Penicillin; Valacyclovir Hydrochloride; Bactrim; Prednisone TAB
Possible Neoral side effects in male
Reported by a physician from Japan on 2011-11-11
Patient: male, weighing 68.0 kg (149.6 pounds)
Reactions: Malaise, Central Nervous System Lesion, Vision Blurred, Dizziness, Visual Acuity Reduced, Altered State of Consciousness, Loss of Consciousness, Convulsion
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Dosage: 50 mg, unk
Administration route: Oral
Start date: 2011-08-24
End date: 2011-08-30
Neoral
Dosage: 125 mg, unk
Administration route: Oral
Indication: Glomerulonephritis Membranous
Start date: 2011-08-03
End date: 2011-08-15
Prednisolone
Dosage: 7.5 mg, unk
Administration route: Oral
Start date: 2011-10-11
Prednisolone
Dosage: 35 mg, unk
Administration route: Oral
Start date: 2011-08-17
End date: 2011-08-30
Prednisolone
Dosage: 45 mg, unk
Administration route: Oral
Start date: 2011-08-03
Prednisolone
Dosage: 40 mg, unk
Administration route: Oral
Start date: 2011-08-10
Prednisolone
Dosage: 10 mg, unk
Administration route: Oral
Start date: 2011-09-29
Prednisolone
Dosage: 50 mg, unk
Administration route: Oral
Start date: 2011-07-30
Prednisolone
Dosage: 60 mg, unk
Administration route: Oral
Indication: Glomerulonephritis Membranous
Start date: 2011-07-05
Prednisolone
Dosage: 50 mg, unk
Administration route: Oral
Start date: 2011-07-19
End date: 2011-07-26
Other drugs received by patient: Baktar; Olmesartan Medoxomil; Alendronate Sodium; Famotidine; Carnaculin; Prednisolone; Prednisolone; Solu-Cortef; Prednisolone; Mecobalamin; Lipitor; Aspirin
Possible Neoral side effects in male
Reported by a physician from Japan on 2011-11-02
Patient: male, weighing 68.0 kg (149.6 pounds)
Reactions: Cerebral Small Vessel Ischaemic Disease, Malaise, Vision Blurred, Dizziness, Visual Acuity Reduced, Altered State of Consciousness, Convulsion, Loss of Consciousness
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Neoral
Dosage: 125 mg, unk
Administration route: Oral
Indication: Glomerulonephritis Membranous
Start date: 2011-08-03
End date: 2011-08-15
Neoral
Dosage: 50 mg, unk
Administration route: Oral
Start date: 2011-08-24
End date: 2011-08-30
Prednisolone
Dosage: 40 mg, unk
Administration route: Oral
Start date: 2011-08-10
Prednisolone
Dosage: 7.5 mg, unk
Administration route: Oral
Start date: 2011-10-11
Prednisolone
Dosage: 50 mg, unk
Administration route: Oral
Start date: 2011-07-19
End date: 2011-07-26
Prednisolone
Dosage: 50 mg, unk
Administration route: Oral
Start date: 2011-07-30
Prednisolone
Dosage: 45 mg, unk
Administration route: Oral
Start date: 2011-08-03
Prednisolone
Dosage: 10 mg, unk
Administration route: Oral
Start date: 2011-09-29
Prednisolone
Dosage: 60 mg, unk
Administration route: Oral
Indication: Glomerulonephritis Membranous
Start date: 2011-07-05
Prednisolone
Dosage: 35 mg, unk
Administration route: Oral
Start date: 2011-08-17
End date: 2011-08-30
Other drugs received by patient: Lipitor; Prednisolone; Carnaculin; Olmesartan Medoxomil; Prednisolone; Aspirin; Alendronate Sodium; Sulfamethoxazole; Prednisolone; Famotidine; Mecobalamin; Solu-Cortef
Possible Neoral side effects in male
Reported by a consumer/non-health professional from United States on 2011-10-31
Patient: male, weighing 112.0 kg (246.4 pounds)
Reactions: Weight Increased, Fatigue, Palpitations, Oedema Peripheral, Orthopnoea, Pulmonary Oedema, Blood Creatinine Increased, Cough, Cardiac Failure Congestive, Chest Discomfort, Dyspnoea, Pneumonia, Nausea, Coronary Artery Disease, Ascites, Hypertension, Blood Pressure Decreased
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Neoral
Other drugs received by patient: Amlodipine Besylate; Mycophenolate Mofetil (Cellcept); Mycophenolate Mofetil (Cellcept); Docusate Sodium; Exforge; Hydrocodone Bitartrate; Hydralazine HCL; Bumetanide; Acetaminophen; Omeprazole; Prilosec; Zaroxolyn; Calcium; BL Calcium; Ferrous Sulfate TAB; Humulin R; Aspirin; Isosorbide Mononitrate; Lipitor; Multivitamin; Prednisone; Terazosin HCL; Simvastatin; Calcium; Humulin N; Tylenol-500
Possible Neoral side effects in male
Reported by a physician from Japan on 2011-10-28
Patient: male
Reactions: Blood Bilirubin Increased, Multi-Organ Failure, Renal Impairment, Blood Lactate Dehydrogenase Increased, Viith Nerve Paralysis, Cardiac Failure Congestive, Herpes Zoster
Adverse event resulted in: death, hospitalization, disablity
Drug(s) suspected as cause:
Exjade
Dosage: 500 mg, unk
Administration route: Oral
End date: 2009-08-25
Exjade
Dosage: 500 mg, unk
Administration route: Oral
Indication: Iron Overload
Start date: 2008-12-18
Exjade
Dosage: 500 mg, qd
Administration route: Oral
Indication: Aplastic Anaemia
Start date: 2008-06-18
Neoral
Dosage: 100 mg/day
Administration route: Oral
Start date: 2008-11-19
End date: 2010-05-08
Neoral
Dosage: 150 mg, qd
Administration route: Oral
Indication: Aplastic Anaemia
Start date: 2008-06-18
End date: 2008-11-18
Other drugs received by patient: RED Blood Cells, Concentrated; RED Blood Cells, Concentrated; RED Blood Cells, Concentrated; Mucosta; RED Blood Cells, Concentrated; Platelets; RED Blood Cells, Concentrated; Solu-Cortef; RED Blood Cells, Concentrated; RED Blood Cells, Concentrated; Kalimate; Magnesium Oxide; RED Blood Cells, Concentrated; RED Blood Cells, Concentrated; Gran
Possible Neoral side effects in female
Reported by a physician from Japan on 2011-10-26
Patient: female, weighing 67.0 kg (147.4 pounds)
Reactions: Renal Tubular Disorder, Hydronephrosis, Nephropathy Toxic, Urine Output Decreased, Anuria, Ureteric Stenosis
Adverse event resulted in: hospitalization, disablity
Drug(s) suspected as cause:
Acetaminophen
Dosage: 4 df in total
Administration route: Oral
Start date: 2006-06-26
End date: 2006-06-28
Mycophenolate Mofetil (Cellcept)
Dosage: 1500 mg/ day
Administration route: Oral
Indication: Renal Transplant
Start date: 2006-06-15
Neoral
Dosage: 550 mg/ day, then tapered
Administration route: Oral
Indication: Renal Transplant
Start date: 2006-06-22
End date: 2006-07-10
Prednisolone
Dosage: 50 mg/day, then tapered
Administration route: Oral
Indication: Renal Transplant
Start date: 2006-06-15
Prograf
Dosage: 10 mg / day, then tapered
Administration route: Oral
Indication: Renal Transplant
Start date: 2006-06-16
End date: 2006-06-21
Prograf
Dosage: 4 mg/day
Start date: 2006-07-11
Simulect
Dosage: 20 mg daily
Indication: Renal Transplant
Start date: 2006-06-21
End date: 2006-06-21
Simulect
Dosage: 20 mg daily
Start date: 2006-06-25
End date: 2006-06-25
Other drugs received by patient: Solu-Medrol; Rabeprazole Sodium; Adalat
Possible Neoral side effects in male
Reported by a physician from Japan on 2011-10-24
Patient: male, weighing 60.0 kg (132.0 pounds)
Reactions: Abdominal Pain, Cholecystitis Acute, Oliguria, Pyrexia, Kidney Transplant Rejection
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Mycophenolate Mofetil (Cellcept)
Start date: 2005-01-28
End date: 2005-03-02
Neoral
Administration route: Oral
Indication: Renal Transplant
Start date: 2005-01-30
End date: 2005-03-09
Prednisolone
Administration route: Oral
Indication: Renal Transplant
Start date: 2005-01-28
Simulect
Dosage: 20 mg,
Start date: 2005-01-31
End date: 2005-02-01
Simulect
Dosage: 20 mg,
Indication: Renal Transplant
Start date: 2005-01-28
End date: 2005-01-28
Other drugs received by patient: Rabeprazole Sodium; Sandimmune; Solu-Medrol; Herbessor R; Sigmart
Possible Neoral side effects in male
Reported by a health professional (non-physician/pharmacist) from France on 2011-10-18
Patient: male, weighing 70.0 kg (154.0 pounds)
Reactions: Weight Increased, Lung Disorder, Oedema Peripheral, Cytomegalovirus Infection, Lymphoedema
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Certican
Dosage: 0.75 mg, bid
Indication: Heart Transplant
Start date: 2009-06-01
End date: 2011-01-17
Mycophenolate Mofetil (Cellcept)
Dosage: 750 mg, bid
Administration route: Oral
Indication: Heart Transplant
End date: 2011-01-17
Neoral
Dosage: 30 mg, bid
Indication: Heart Transplant
Other drugs received by patient: Pravastatin; Lasix; Nexium; Hyperium; Calcium Carbonate; Valproic Acid; Irinotecan HCL; Aspirin; Leucovorin Calcium; Prazepam; Fluorouracil
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