This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Morphine and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (911)
Death (415)
Life Threatening Events (48)
Disability (6)
Reports by Reaction Type
Completed Suicide (135),
Toxicity To Various Agents (118),
Death (83),
Cardio-Respiratory Arrest (83),
Cardiac Arrest (78),
Respiratory Arrest (77),
Drug Abuse (68),
Drug Ineffective (41),
Vomiting (41),
Somnolence (38),
Overdose (37),
Drug Hypersensitivity (36)
Below are a few examples of reports where side effects / adverse reactions may be related to Morphine. For a complete list or a specific selection of reports, please use the links above.
Possible Morphine side effects in 79 year old female
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: 79 year old female
Reactions: Hallucination, Visual, Hallucination, Auditory, Drug Interaction, Toxicity To Various Agents, Somnolence, Crying
Drug(s) suspected as cause:
Lexapro
Indication: Depression
Start date: 2007-01-01
Lunesta
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Morphine
Indication: Pain
Start date: 2011-11-01
End date: 2012-02-01
Oxycontin
Indication: Pain
Oxycontin
Other drugs received by patient: Vicodin
Possible Morphine side effects in 33 year old male
Reported by a physician from Turkey on 2012-08-27
Patient: 33 year old male
Reactions: Hypersensitivity, Disease Recurrence, Kounis Syndrome, Rash Erythematous, Condition Aggravated
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Amoxicillin and Clavulanate Potassium
Administration route: Oral
Indication: Upper Respiratory Tract Infection
Cefazolin
Indication: Upper Respiratory Tract Infection
Morphine
Dosage: single dose
Indication: Kounis Syndrome
Other drugs received by patient: Methimazole
Possible Morphine side effects in
Reported by a physician from United Kingdom on 2012-08-27
Patient:
Reactions: Anaphylactic Reaction, Oxygen Saturation Abnormal, Cardiac Arrest, Pulseless Electrical Activity
Adverse event resulted in: life threatening event
Drug(s) suspected as cause:
Morphine
Dosage: 10 mg, unk
Indication: Perioperative Analgesia
Start date: 2012-05-09
End date: 2012-05-09
Rocuronium Bromide
Dosage: 50 mg, unk
Indication: Hypotonia
Start date: 2012-05-09
End date: 2012-05-09
Possible Morphine side effects in 76 year old male
Reported by a physician from Switzerland on 2012-08-27
Patient: 76 year old male, weighing 88.0 kg (193.6 pounds)
Reactions: Myoclonus, Drug Level Increased, Drug Interaction, Renal Failure Acute
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Cefepim
Dosage: 6 gram daily;
Start date: 2012-04-07
End date: 2012-04-21
Citalopram Hydrobromide
Administration route: Oral
Start date: 2012-04-03
Duragesic-100
Start date: 2012-04-11
End date: 2012-04-19
Lasilacton
Dosage: 50 milligram daily;
Administration route: Oral
Start date: 2012-04-07
Lasix
Dosage: 40 milligram daily;
Administration route: Oral
Start date: 2012-03-13
End date: 2012-04-07
Lasix
Dosage: 20 milligram daily;
Administration route: Oral
Start date: 2012-04-09
End date: 2012-04-16
Morphine
Dosage: 2%
Start date: 2012-03-13
Tramadol Hydrochloride
Start date: 2012-03-13
End date: 2012-03-14
Other drugs received by patient possibly interacting with the suspect drug:
Torsemide
Dosage: 10 milligram daily;
Administration route: Oral
Start date: 2012-04-17
Vancocin Hydrochloride
Dosage: 2 gram daily;
Start date: 2012-04-07
End date: 2012-04-21
Other drugs received by patient: Lyrica; Konakion; Droperidol; Motilium; Levothyroxine Sodium; Allopurinol; Konakion; Folvite; Navoban; Fragmin; Nitroderm; Perenterol; Novalgin; Dipiperon; Marcumar; Acetaminophen; Fragmin; Metoprolol Tartrate; Imodium; Pantoprazole; Moviprep; Cozaar; Ondansetron
Possible Morphine side effects in 33 year old male
Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-08-27
Patient: 33 year old male
Reactions: Hypersensitivity, Kounis Syndrome, Acute Coronary Syndrome
Drug(s) suspected as cause:
Amoxicillin and Clavulanate Potassium
Dosage: unk
Administration route: Oral
Indication: Upper Respiratory Tract Infection
Cefazolin
Dosage: unk
Indication: Upper Respiratory Tract Infection
Morphine
Dosage: 2 mg, single
Indication: Pain
Possible Morphine side effects in 50 year old female
Reported by a physician from United States on 2012-08-27
Patient: 50 year old female
Reactions: Memory Impairment, Ankle Fracture, Feeling Abnormal, Loss of Consciousness
Drug(s) suspected as cause:
Avinza
Dosage: 60 mg, 1x/day
Flexeril
Dosage: unk
Morphine
Dosage: 15 mg, every 4 hrs
MS Contin
Dosage: 30 mg, 2x/day
Skelaxin
Dosage: unk
Tramadol HCL
Dosage: 50 mg, every 4 hrs
Possible Morphine side effects in 76 year old female
Reported by a consumer/non-health professional from United States on 2012-08-24
Patient: 76 year old female
Reactions: Pain in Extremity, Hemiparesis, Headache, Cerebrovascular Accident, Periarthritis, Hypokinesia, Hallucination, Visual, Hypertension
Drug(s) suspected as cause:
Drug Therapy NOS
Dosage: unk, unk
Morphine
Dosage: unk, unk
Phenylephrine HCL
Dosage: unk, everynight as needed
Indication: Nasal Congestion
Start date: 1992-01-01
Possible Morphine side effects in 66 year old male
Reported by a pharmacist from United States on 2012-08-24
Patient: 66 year old male, weighing 163.6 kg (359.9 pounds)
Reactions: Sedation
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Morphine
Possible Morphine side effects in 55 year old female
Reported by a physician from United States on 2012-08-24
Patient: 55 year old female
Reactions: Mental Status Changes, Delirium, Renal Failure Chronic
Drug(s) suspected as cause:
Fentanyl
Dosage: 75 microg/h
Fentanyl
Dosage: 50 microg/h
Indication: Cancer Pain
Methadone Hydrochloride
Administration route: Oral
Indication: Cancer Pain
Morphine
Indication: Breakthrough Pain
Morphine
Dosage: 40mg total dose on day 2
Morphine
Dosage: 40mg total dose on day 2
Morphine
Indication: Cancer Pain
Percocet
Dosage: 10/325mg; up to 6 tablets/day
Indication: Breakthrough Pain
Tacrolimus
Indication: Immunosuppressant Drug Therapy
Other drugs received by patient: Duloxetine Hydrochloride; Ropivacaine Hydrochloride; Ketamine HCL; Ropivacaine Hydrochloride
Possible Morphine side effects in 55 year old female
Reported by a physician from United States on 2012-08-24
Patient: 55 year old female
Reactions: Mental Status Changes, Renal Failure Chronic, Delirium
Drug(s) suspected as cause:
Fentanyl
Dosage: 50 microg/h
Indication: Cancer Pain
Fentanyl
Dosage: 75 microg/h
Methadone Hydrochloride
Administration route: Oral
Indication: Cancer Pain
Morphine
Indication: Cancer Pain
Morphine
Dosage: 40mg total dose on day 2
Morphine
Indication: Breakthrough Pain
Morphine
Dosage: 40mg total dose on day 2
Percocet
Dosage: 10/325mg; up to 6 tablets/day
Indication: Breakthrough Pain
Tacrolimus
Indication: Immunosuppressant Drug Therapy
Other drugs received by patient: Ketamine HCL; Ropivacaine Hydrochloride; Ropivacaine Hydrochloride; Duloxetine Hydrochloride
Possible Morphine side effects in 55 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-24
Patient: 55 year old female
Reactions: Mental Status Changes, Delirium
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Fentanyl
Dosage: 50 a?g/hour
Indication: Breakthrough Pain
Fentanyl
Dosage: 75 a?g/hour
Hydrocodone Bitartrate and Acetaminophen
Dosage: 6 tablets,daily
Indication: Breakthrough Pain
Ketamine HCL
Indication: Product Used FOR Unknown Indication
Methadone Hydrochloride
Dosage: 10 mg, bid
Administration route: Oral
Indication: Breakthrough Pain
Morphine
Dosage: 40 mg
Morphine
Dosage: unk
Indication: Breakthrough Pain
Other drugs received by patient: Duloxetine Hydrochloride; Ropivacaine Hydrochloride
Possible Morphine side effects in 55 year old female
Reported by a physician from United States on 2012-08-23
Patient: 55 year old female
Reactions: Diabetes Mellitus, Mental Status Changes, Renal Failure Chronic, Stupor, Delirium
Drug(s) suspected as cause:
Fentanyl
Dosage: 75 microg/h
Fentanyl
Dosage: 50 microg/h
Indication: Cancer Pain
Hydrocodone Bitartrate + Acetaminophen
Dosage: 10/325mg; up to 6 tablets/day
Indication: Breakthrough Pain
Methadone Hydrochloride
Administration route: Oral
Indication: Cancer Pain
Morphine
Indication: Cancer Pain
Morphine
Dosage: 40mg total dose on day 2
Indication: Breakthrough Pain
Tacrolimus
Indication: Immunosuppressant Drug Therapy
Other drugs received by patient: Ropivacaine Hydrochloride; Ropivacaine Hydrochloride; Ketamine HCL; Duloxetine Hydrochloride
Possible Morphine side effects in 50 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-23
Patient: 50 year old female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Codeine Sulfate
Dosage: unk
Morphine
Dosage: unk
Possible Morphine side effects in 37 year old male
Reported by a health professional (non-physician/pharmacist) from Australia on 2012-08-23
Patient: 37 year old male
Reactions: Dependence, Suicidal Ideation
Drug(s) suspected as cause:
Morphine
Indication: Product Used FOR Unknown Indication
Oxycontin
Indication: Product Used FOR Unknown Indication
Valium
Indication: Product Used FOR Unknown Indication
Possible Morphine side effects in
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-22
Patient:
Reactions: Drug Dose Omission, Overdose, Incorrect Dose Administered
Drug(s) suspected as cause:
Fentanyl
Indication: Product Used FOR Unknown Indication
Hydromorphone HCL
Indication: Product Used FOR Unknown Indication
Meperidine HCL
Indication: Product Used FOR Unknown Indication
Morphine
Indication: Product Used FOR Unknown Indication
Oxycodone HCL
Indication: Product Used FOR Unknown Indication
Possible Morphine side effects in female
Reported by a consumer/non-health professional from Canada on 2012-08-22
Patient: female, weighing 54.0 kg (118.9 pounds)
Reactions: Weight Decreased, Osteoporosis, Pain, Corneal Disorder, Fall, Spinal Compression Fracture, Skin Discolouration, Joint Range of Motion Decreased, Poor Peripheral Circulation, Feeling Hot, Oedema Peripheral, Sinusitis, Vomiting, Cataract, Pain in Extremity, Musculoskeletal Pain, Drug Hypersensitivity, Laceration, Cystitis, Arthralgia, Hypophagia, Visual Impairment, Inflammation
Drug(s) suspected as cause:
Humira
Start date: 2012-08-10
Humira
Indication: Rheumatoid Arthritis
Start date: 2004-02-23
End date: 2012-01-01
Morphine
Indication: Product Used FOR Unknown Indication
Other drugs received by patient: Methotrexate; Folic Acid; Calcium Caltrate; Vitamin B-12; Oxycet; Celebrex; Centrum Advantage
Possible Morphine side effects in 69 year old male
Reported by a physician from United States on 2012-08-22
Patient: 69 year old male
Reactions: Agitation, Abnormal Behaviour, Delirium, Amnesia, Gastritis, Aggression, Delusion, Haemoglobin Decreased, Oesophagitis, Hallucination, Crying
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Morphine
Tylenol W / Codeine NO. 3
Indication: Headache
Viibryd
Dosage: 10 mg
Administration route: Oral
Indication: Depression
Start date: 2012-04-13
End date: 2012-04-01
Viibryd
Dosage: 20 mg
Administration route: Oral
Start date: 2012-04-01
End date: 2012-01-01
Viibryd
Dosage: 40 mg
Administration route: Oral
Start date: 2012-01-01
End date: 2012-06-12
Other drugs received by patient: Tramadol HCL; Fluticasone Propionate / Salmeterol
Possible Morphine side effects in 57 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-21
Patient: 57 year old female
Reactions: Drug Hypersensitivity
Drug(s) suspected as cause:
Morphine
Possible Morphine side effects in 51 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-21
Patient: 51 year old female
Reactions: NO Adverse Event
Drug(s) suspected as cause:
Codeine
Dosage: unk
Morphine
Dosage: unk
Possible Morphine side effects in 75 year old male
Reported by a health professional (non-physician/pharmacist) from Switzerland on 2012-08-20
Patient: 75 year old male, weighing 88.0 kg (193.6 pounds)
Reactions: Myoclonus, Drug Level Increased, Renal Failure Acute
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Cefepime
Indication: Intervertebral Discitis
Start date: 2012-04-07
End date: 2012-04-21
Citalopram Hydrobromide
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-03
Duragesic-100
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-11
End date: 2012-04-19
Lasilactone
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-07
Lasix
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-09
End date: 2012-04-16
Lasix
Administration route: Oral
Start date: 2012-03-13
End date: 2012-04-07
Morphine
Indication: Product Used FOR Unknown Indication
Start date: 2012-03-13
Torsemide
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2012-04-17
Tramadol Hydrochloride
Indication: Product Used FOR Unknown Indication
Start date: 2012-03-13
End date: 2012-03-14
Vancocin Hydrochloride
Indication: Intervertebral Discitis
Start date: 2012-04-07
End date: 2012-04-21
Other drugs received by patient: Metoprolol Tartrate; Moviprep; Dalteparin Sodium; Dalteparin Sodium; Novalgin; Folvite; Marcumar; Acetaminophen; Lyrica; Navoban; Cozaar; Imodium; Perenterol; Ondansetron; Dipiperon; Nitroderm; Motilium; Levothyroxine Sodium; Allopurinol; Konakion; Droperidol; Pantoprazole
Possible Morphine side effects in male
Reported by a physician from United States on 2012-08-17
Patient: male
Reactions: Microcytosis, Iron Deficiency Anaemia, Hypercapnia, Pulmonary Oedema, Mental Status Changes, Anaemia Folate Deficiency, Hypoxia, Chronic Obstructive Pulmonary Disease
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Humalog
Indication: Diabetes Mellitus
Start date: 2011-09-23
Lantus
Indication: Diabetes Mellitus
Morphine
Indication: Pain
Placebo
Indication: Diabetes Mellitus
Start date: 2010-07-06
Saxagliptin
Indication: Diabetes Mellitus
Start date: 2012-07-06
Valium
Indication: Pain
Other drugs received by patient: Aspirin; Prednisone TAB; Azithromycin; Ezetimibe; Ferrous Sulfate TAB; Folic Acid
Possible Morphine side effects in 51 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-16
Patient: 51 year old female
Reactions: NO Adverse Event
Drug(s) suspected as cause:
Codeine Sulfate
Dosage: unk
Morphine
Dosage: unk
Possible Morphine side effects in
Reported by a physician from Australia on 2012-08-14
Patient:
Reactions: Overdose, Cognitive Disorder
Drug(s) suspected as cause:
Alprazolam
Indication: Product Used FOR Unknown Indication
Clonazepam
Indication: Product Used FOR Unknown Indication
Codeine Sulfate
Indication: Product Used FOR Unknown Indication
Diazepam
Indication: Product Used FOR Unknown Indication
Lorazepam
Indication: Product Used FOR Unknown Indication
Methadone Hydrochloride
Indication: Product Used FOR Unknown Indication
Morphine
Indication: Product Used FOR Unknown Indication
Olanzapine
Indication: Product Used FOR Unknown Indication
Oxycodone HCL
Indication: Product Used FOR Unknown Indication
Propoxyphene Hydrochloride
Indication: Product Used FOR Unknown Indication
Quetiapine Fumarate
Indication: Product Used FOR Unknown Indication
Risperidone
Indication: Product Used FOR Unknown Indication
Temazepam
Indication: Product Used FOR Unknown Indication
Tramadol HCL
Indication: Product Used FOR Unknown Indication
Possible Morphine side effects in 79 year old female
Reported by a consumer/non-health professional from United States on 2012-08-14
Patient: 79 year old female
Reactions: Hallucination, Auditory, Hallucination, Visual, Drug Interaction, Toxicity To Various Agents, Somnolence, Crying
Drug(s) suspected as cause:
Lexapro
Dosage: 20 mg
Administration route: Oral
Indication: Depression
Start date: 2007-01-01
Lunesta
Dosage: 3 mg
Morphine
Indication: Pain
Start date: 2011-11-01
End date: 2012-02-01
Oxycontin
Indication: Pain
Oxycontin
Dosage: 40 mg every 8 hours as needed
Other drugs received by patient: Vicodin
Possible Morphine side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-13
Patient: female
Reactions: Drug Hypersensitivity
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dianeal
Indication: Peritoneal Dialysis
Morphine
Possible Morphine side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-13
Patient: male, weighing 61.2 kg (134.7 pounds)
Reactions: Abdominal Pain, Drug Level Below Therapeutic, Depression, Suicidal Ideation
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Morphine
Administration route: Oral
Indication: Pain
Start date: 2008-01-01
Morphine
Dosage: 1-2 tablets every 6 hours as needed
Administration route: Oral
Start date: 2008-01-01
Pancreaze
Dosage: 42000 units capsule/21000 unit 2 tablet 4 times daily
Administration route: Oral
Start date: 2010-04-01
End date: 2012-01-01
Pancreaze
Dosage: 42000 unit capsule/21000/2 tablet 5 times daily
Administration route: Oral
Indication: Dyspepsia
Start date: 2012-01-01
Other drugs received by patient: Docusate Sodium; Famotidine; Valium; Valium
Possible Morphine side effects in 90 year old female
Reported by a consumer/non-health professional from United Kingdom on 2012-08-09
Patient: 90 year old female
Reactions: Excoriation, Skin Exfoliation, Blister, Stevens-Johnson Syndrome
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Clonazepam
Dosage: 125ug once a day, oral
Administration route: Oral
Indication: Analgesic Therapy
Start date: 2012-06-30
End date: 2012-07-09
Metoclopramide
Dosage: 10mg four time day oral
Administration route: Oral
Indication: Nausea
Start date: 2012-06-28
End date: 2012-07-10
Morphine
Dosage: 5mg two hourly oral
Administration route: Oral
Start date: 2012-06-28
End date: 2012-06-28
Morphine
Dosage: 5mg two hourly oral
Administration route: Oral
Start date: 2012-06-19
End date: 2012-06-20
Ondansetron
Dosage: 4mg bd oral
Administration route: Oral
Indication: Nausea
Start date: 2012-06-28
Oxycodone HCL
Dosage: oral
Administration route: Oral
Indication: Analgesic Therapy
Start date: 2012-06-28
End date: 2012-07-05
Possible Morphine side effects in 46 year old male
Reported by a physician from Korea, Republic of on 2012-08-09
Patient: 46 year old male
Reactions: Dysarthria, Drug Effect Decreased, Pneumonia Aspiration, Sedation, Respiratory Depression
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Morphine
Dosage: 4.0 ml, on-demand bolus
Morphine
Dosage: 1.0 ml/hour basal rate
Morphine
Dosage: 0.5 ml/hour basal rate
Indication: Pain
Morphine Sulfate
Dosage: 0.3 mg, single
Indication: Pain
Tramadol HCL
Dosage: 50 mg, unk
Indication: Pain
Possible Morphine side effects in 90 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-09
Patient: 90 year old female
Reactions: NO Adverse Event
Drug(s) suspected as cause:
Morphine
Possible Morphine side effects in 90 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-08
Patient: 90 year old female
Reactions: NO Adverse Event
Drug(s) suspected as cause:
Morphine
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