Metolazone and Serious Reactions - Suspected Cause

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Index of reports > Serious Reactions (22)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Metolazone serious reactions. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Metolazone side effects in 63 year old male

Reported by a physician from United States on 2012-06-07

Patient: 63 year old male

Reactions: Nausea, Atrial Fibrillation, Cardiomyopathy, Hepatic Enzyme Increased, Renal Failure, Fatigue, Insomnia, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Roflumilast
    Dosage: 500 microgram;
    Administration route: Oral
    Indication: Chronic Obstructive Pulmonary Disease
    Start date: 2012-04-01
    End date: 2012-05-16

Metolazone
Start date: 2012-04-01

Other drugs received by patient: Levothyroxine Sodium; Furosemide; Tiotropium Bromide; Allopurinol; Metformin HCL

Possible Metolazone side effects in 64 year old male

Reported by a physician from Canada on 2012-05-11

Patient: 64 year old male

Reactions: Back Pain, Dyspnoea, Hepatic Function Abnormal, Pneumonia, Cardiogenic Shock, Renal Failure Acute, Acute Prerenal Failure, Cardiac Failure Congestive

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Blinded Therapy
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-11-03
    End date: 2012-03-03

Lasix
End date: 2011-10-20

Metolazone
End date: 2011-10-20

Metformin HCL
Indication: Type 2 Diabetes Mellitus
End date: 2011-02-01

Novorapid
Indication: Type 2 Diabetes Mellitus

NPH Insulin
Indication: Type 2 Diabetes Mellitus

Placebo
Indication: Type 2 Diabetes Mellitus
Start date: 2010-11-03

Metformin HCL
Start date: 2011-02-01

Other drugs received by patient: Aspirin; Tylenol (Caplet)

Possible Metolazone side effects in 64 year old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-04-17

Patient: 64 year old female

Reactions: Electrocardiogram QT Prolonged, Torsade DE Pointes, Electrolyte Imbalance

Drug(s) suspected as cause:
Domperidone
Dosage: unknown
Indication: Product Used FOR Unknown Indication

Venlafaxine HCL
Dosage: unknown
Indication: Product Used FOR Unknown Indication

Amiodarone HCL
Dosage: unknown
Indication: Ventricular Arrhythmia

Furosemide
Dosage: unknown
Indication: Product Used FOR Unknown Indication

Metolazone
Indication: Product Used FOR Unknown Indication

Possible Metolazone side effects in 64 year old female

Reported by a physician from Canada on 2012-04-12

Patient: 64 year old female

Reactions: Torsade DE Pointes, Blood Potassium Decreased, Ventricular Arrhythmia

Drug(s) suspected as cause:
Amiodarone HCL
Indication: Ventricular Arrhythmia

Furosemide
Indication: Product Used FOR Unknown Indication

Domperidone (Domperidone)
Indication: Product Used FOR Unknown Indication

Venlafaxine
Indication: Product Used FOR Unknown Indication

Metolazone
Indication: Product Used FOR Unknown Indication

Possible Metolazone side effects in 64 year old female

Reported by a physician from Canada on 2012-04-10

Patient: 64 year old female

Reactions: Torsade DE Pointes, Electrocardiogram QT Prolonged, Hypomagnesaemia, Electrolyte Imbalance, Hypokalaemia

Drug(s) suspected as cause:
Amiodarone Hydrochloride
Indication: Ventricular Arrhythmia

Venlafaxine

Furosemide

Domperidone

Metolazone

Possible Metolazone side effects in 64 year old female

Reported by a physician from Canada on 2012-04-10

Patient: 64 year old female

Reactions: Torsade DE Pointes, Electrocardiogram QT Prolonged

Drug(s) suspected as cause:
Venlafaxine Hydrochloride
Dosage: unk
Indication: Product Used FOR Unknown Indication

Metolazone
Dosage: unk
Indication: Product Used FOR Unknown Indication

Omeprazole
Dosage: unk
Indication: Product Used FOR Unknown Indication

Furosemide
Dosage: unk
Indication: Product Used FOR Unknown Indication

Possible Metolazone side effects in 64 year old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-03-23

Patient: 64 year old female

Reactions: Torsade DE Pointes, Electrocardiogram QT Prolonged, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Amiodarone Hydrochloride
Dosage: 150mg bolus

Amiodarone Hydrochloride

Furosemide
Dosage: 40mg od

Venlafaxine
Dosage: 112.5mg od

Domperidone
Dosage: 10mg tid

Metolazone
Dosage: 2.5mg od

Other drugs received by patient: Glyburide; Omeprazole; Levothyroxine Sodium; Irbesartan; Digoxin; Metformin HCL; Lipitor

Possible Metolazone side effects in 64 year old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-03-23

Patient: 64 year old female

Reactions: Torsade DE Pointes, Electrocardiogram QT Prolonged, Road Traffic Accident, Hypomagnesaemia, Atrial Fibrillation, Loss of Consciousness, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Furosemide
Dosage: 40mg od

Domperidone
Dosage: 10mg tid

Amiodarone Hydrochloride
Dosage: 150mg bolus

Metolazone
Dosage: 2.5mg od

Venlafaxine
Dosage: 112.5mg od

Amiodarone Hydrochloride

Other drugs received by patient: Irbesartan; Digoxin; Lipitor; Metformin HCL; Levothyroxine Sodium; Omeprazole; Glyburide

Possible Metolazone side effects in 64 year old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-03-23

Patient: 64 year old female

Reactions: Electrocardiogram QT Prolonged, Torsade DE Pointes, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Domperidone
Dosage: 10mg tid

Metolazone
Dosage: 2.5mg od

Venlafaxine
Dosage: 112.5mg od

Amiodarone Hydrochloride
Dosage: 150mg bolus

Amiodarone Hydrochloride

Furosemide
Dosage: 40mg od

Other drugs received by patient: Omeprazole; Metformin HCL; Glyburide; Lipitor; Levothyroxine Sodium; Digoxin; Irbesartan

Possible Metolazone side effects in 64 year old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-03-23

Patient: 64 year old female

Reactions: Torsade DE Pointes, Electrocardiogram QT Prolonged, Road Traffic Accident, Hypomagnesaemia, Atrial Fibrillation, Loss of Consciousness, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Venlafaxine
Dosage: 112.5mg od

Amiodarone Hydrochloride

Domperidone
Dosage: 10mg tid

Amiodarone Hydrochloride
Dosage: 150mg bolus

Furosemide
Dosage: 40mg od

Metolazone
Dosage: 2.5mg od

Other drugs received by patient: Omeprazole; Metformin HCL; Lipitor; Irbesartan; Levothyroxine Sodium; Digoxin; Glyburide

Possible Metolazone side effects in male

Reported by a consumer/non-health professional from United States on 2012-02-22

Patient: male, weighing 59.0 kg (129.7 pounds)

Reactions: Nausea, Muscular Weakness, Hypoaesthesia, Syncope, Fatigue, DRY Throat, DRY Mouth, Dizziness, Decreased Appetite

Drug(s) suspected as cause:
Metolazone

Possible Metolazone side effects in 51 year old male

Reported by a consumer/non-health professional from United States on 2012-01-17

Patient: 51 year old male, weighing 148.8 kg (327.3 pounds)

Reactions: Pancreatitis

Drug(s) suspected as cause:
Metolazone

Possible Metolazone side effects in female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-12-29

Patient: female

Reactions: Agitation, Weight Decreased, Confusional State, Mental Status Changes, Disorientation, Constipation, Haematocrit Decreased, Fatigue, Decreased Appetite, Protein Total Decreased, Delirium, Haemoglobin Decreased, Hallucination, Visual, Insomnia, Dehydration, Visual Impairment, Pseudodementia, Memory Impairment

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Calcium with Vitamin D
Dosage: 1 df, unk
Administration route: Oral

Dicyclomine HCL
    Dosage: 10 mg, qid
    Administration route: Oral
    Start date: 2009-05-01

Esomeprazole Sodium
Dosage: 20 mg, at breakfast
Start date: 2009-05-01

Salmeterol Xinafoate
Start date: 2009-05-13

Psyllium
    Dosage: 5.85 g, unk
    Administration route: Oral
    Start date: 2009-01-01

Metoprolol Succinate
Dosage: 200 mg, qd
Administration route: Oral

Phenoxybenzamine
Dosage: 10 mg, unk
Start date: 2009-01-01

Rosuvastatin
Dosage: 10 mg/day

Hydrocodone Bitartrate + Acetaminophen
    Dosage: 1 df, (every 4-6 hours as needed)
    Administration route: Oral
    Indication: Pain

Levalbuterol HCL
Dosage: 0.63 mg, q6h
Start date: 2009-01-01

Lorazepam
    Dosage: 0.5 mg, qd
    Administration route: Oral
    Indication: Sleep Disorder

Memantine Hydrochloride
Dosage: 5 mg, bid
Start date: 2009-01-01

Metolazone
    Dosage: 0.5 df, as needed
    Administration route: Oral
    Start date: 2009-01-01

Sertraline Hydrochloride
Dosage: 50 mg/day
Administration route: Oral

Acetaminophen
Indication: Pyrexia

Furosemide

Fentanyl
Dosage: 75 ug, unk

Haloperidol
Dosage: 1 mg, at bed time
Administration route: Oral

Potassium Chloride
    Dosage: 20 meq, bid
    Administration route: Oral
    Start date: 2009-07-01

Multivitamine
Dosage: 1 df/day
Administration route: Oral

Acetylsalicylic Acid SRT
    Dosage: 325 mg/day
    Administration route: Oral
    Start date: 2009-05-01

Carisoprodol
Dosage: 1 df, q6h

Fentanyl
Dosage: 50 ug, unk
Start date: 2009-01-01

Prednisone TAB
Dosage: 5 mg, every other day
Administration route: Oral

Digoxin
Dosage: 125 ug/day
Administration route: Oral

Esomeprazole Sodium
Dosage: 80 mg/day
Administration route: Oral

Saccharomyces Boulardii
    Dosage: 250 mg, bid
    Administration route: Oral
    Start date: 2009-01-01

Potassium Chloride
    Dosage: 20 df, bid
    Administration route: Oral
    Start date: 2009-09-01

Diphenoxylate HCL + Atropine Sulfate
    Dosage: 2.5 mg, q3h
    Administration route: Oral
    Indication: Diarrhoea

Metoprolol Tartrate
Dosage: 100 mg, qd
Start date: 2009-01-01

Vitamin D
    Dosage: 50000 iu (every 7 days)
    Administration route: Oral
    Start date: 2009-01-01

Amlodipine
Dosage: 10 mg, unk
Administration route: Oral

Digoxin
Dosage: 125 ug (every other day)
Administration route: Oral

Salmeterol / Fluticasone
Dosage: 1 ot, bid (puff)

Metaxalone
Dosage: 400 mg, qid as needed
Administration route: Oral

Teriparatide
Dosage: 20 ug/day
Start date: 2009-01-01

Haloperidol
Dosage: 2 mg, at bed time
Administration route: Oral

Levothyroxine Sodium
Dosage: 50 ug, unk
Start date: 2009-01-01

Teriparatide
Dosage: 20 ug (every other day)
Start date: 2009-01-01

Acetaminophen
    Dosage: 650 mg, q4h (as nedded)
    Indication: Pain
    Start date: 2009-01-01

Ezetimibe
Dosage: 10 mg, unk
Administration route: Oral

Haloperidol
Dosage: 0.5 mg, at bed time
Administration route: Oral

Sertraline Hydrochloride
Dosage: 25 mg/day
Administration route: Oral

Sucralfate
Dosage: 1 g, qid
Administration route: Oral

Vitamin D
    Dosage: 1000 iu/day
    Administration route: Oral
    Start date: 2009-01-01

Other drugs received by patient: Acetaminophen; Omeprazole

Possible Metolazone side effects in female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2011-12-29

Patient: female

Reactions: Agitation, Confusional State, Weight Decreased, Mental Status Changes, Disorientation, Constipation, Fatigue, Haematocrit Decreased, Decreased Appetite, Protein Total Decreased, Delirium, Haemoglobin Decreased, Hallucination, Visual, Dehydration, Insomnia, Visual Impairment, Pseudodementia, Memory Impairment

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Furosemide