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Metolazone (Metolazone) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Metolazone and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (111)
Death (30)
Life Threatening Events (1)
Disability (1)

Reports by Reaction Type

Renal Failure Acute (38)Toxicity To Various Agents (30)Dehydration (25)Confusional State (24)Somnolence (18)Hypokalaemia (12)Blood Creatinine Increased (11)Dyspnoea (11)Disease Progression (10)Torsade DE Pointes (9)Electrocardiogram QT Prolonged (8)Azotaemia (8)

Below are a few examples of reports where side effects / adverse reactions may be related to Metolazone. For a complete list or a specific selection of reports, please use the links above.

Possible Metolazone side effects in 60 year old female

Reported by a pharmacist from United States on 2012-08-24

Patient: 60 year old female, weighing 81.0 kg (178.2 pounds)

Reactions: Unresponsive To Stimuli, Cardiac Arrest

Adverse event resulted in: death

Drug(s) suspected as cause:
Furosemide
    Dosage: 40 mg daily po
    Administration route: Oral

Metolazone
    Dosage: 5 mg twice weekly po
    Administration route: Oral



Possible Metolazone side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-20

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Diclofenac Sodium
    Dosage: 50 mg, tid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Metolazone
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Morphine Sulfate
    Dosage: 5 mg, bid
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Losartan Potassium
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Albuterol Sulate

Other drugs received by patient: Citalopram; Pregabalin; Acetaminophen; Omeprazole



Possible Metolazone side effects in female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-20

Patient: female

Reactions: Agitation, Weight Decreased, Confusional State, Mental Status Changes, Disorientation, Constipation, Haematocrit Decreased, Fatigue, Decreased Appetite, Protein Total Decreased, Delirium, Haemoglobin Decreased, Hallucination, Visual, Dehydration, Insomnia, Visual Impairment, Pseudodementia, Memory Impairment

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Haloperidol
    Dosage: 2 mg, at bed time
    Administration route: Oral

Hydrocodone Bitartrate + Acetaminophen
    Dosage: 1 df, (every 4-6 hours as needed)
    Administration route: Oral
    Indication: Pain

Diphenoxylate HCL + Atropine Sulfate
    Dosage: 2.5 mg, q3h
    Administration route: Oral
    Indication: Diarrhoea

Lorazepam
    Dosage: 0.5 mg, qd
    Administration route: Oral
    Indication: Sleep Disorder

Ezetimibe
    Dosage: 10 mg, unk
    Administration route: Oral

Saccharomyces Boulardii
    Dosage: 250 mg, bid
    Administration route: Oral
    Start date: 2009-01-01

Haloperidol
    Dosage: 1 mg, at bed time
    Administration route: Oral

Metoprolol Tartrate
    Dosage: 100 mg, qd
    Start date: 2009-01-01

Prednisone
    Dosage: 5 mg, every other day
    Administration route: Oral

Acetaminophen
    Dosage: 650 mg, q4h (as nedded)
    Indication: Pain
    Start date: 2009-01-01

Vitamin D
    Dosage: 50000 iu (every 7 days)
    Administration route: Oral
    Start date: 2009-01-01

Amlodipine
    Dosage: 10 mg, unk
    Administration route: Oral

Aspirin
    Dosage: 325 mg/day
    Administration route: Oral
    Start date: 2009-05-01

Digoxin
    Dosage: 125 ug/day
    Administration route: Oral

Haloperidol
    Dosage: 0.5 mg, at bed time
    Administration route: Oral

Memantine Hydrochloride
    Dosage: 5 mg, bid
    Start date: 2009-01-01

Multivitamin
    Dosage: 1 df/day
    Administration route: Oral

Sertraline Hydrochloride
    Dosage: 50 mg/day
    Administration route: Oral

Teriparatide
    Dosage: 20 ug/day
    Start date: 2009-01-01

Calcium with Vitamin D
    Dosage: 1 df, unk
    Administration route: Oral

Esomeprazole Sodium
    Dosage: 80 mg/day
    Administration route: Oral

Esomeprazole Sodium
    Dosage: 20 mg, at breakfast
    Start date: 2009-05-01

Potassium Chloride
    Dosage: 20 meq, bid
    Administration route: Oral
    Start date: 2009-07-01

Psyllium
    Dosage: 5.85 g, unk
    Administration route: Oral
    Start date: 2009-01-01

Fentanyl
    Dosage: 50 ug, unk
    Start date: 2009-01-01

Levothyroxine Sodium
    Dosage: 50 ug, unk
    Start date: 2009-01-01

Metoprolol Succinate
    Dosage: 200 mg, qd
    Administration route: Oral

Levalbuterol HCL
    Dosage: 0.63 mg, q6h
    Start date: 2009-01-01

Carisoprodol
    Dosage: 1 df, q6h

Dicyclomine
    Dosage: 10 mg, qid
    Administration route: Oral
    Start date: 2009-05-01

Furosemide

Potassium Chloride
    Dosage: 20 df, bid
    Administration route: Oral
    Start date: 2009-09-01

Metaxalone
    Dosage: 400 mg, qid as needed
    Administration route: Oral

Sertraline Hydrochloride
    Dosage: 25 mg/day
    Administration route: Oral

Sucralfate
    Dosage: 1 g, qid
    Administration route: Oral

Teriparatide
    Dosage: 20 ug (every other day)
    Start date: 2009-01-01

Phenoxybenzamine Hydrochloride
    Dosage: 10 mg, unk
    Start date: 2009-01-01

Vitamin D
    Dosage: 1000 iu/day
    Administration route: Oral
    Start date: 2009-01-01

Digoxin
    Dosage: 125 ug (every other day)
    Administration route: Oral

Fentanyl
    Dosage: 75 ug, unk

Salmeterol / Fluticasone
    Dosage: 1 ot, bid (puff)

Metolazone
    Dosage: 0.5 df, as needed
    Administration route: Oral
    Start date: 2009-01-01

Rosuvastatin
    Dosage: 10 mg/day

Acetaminophen
    Indication: Pyrexia

Other drugs received by patient: Omeprazole; Acetaminophen



Possible Metolazone side effects in 56 year old male

Reported by a pharmacist from United States on 2012-08-14

Patient: 56 year old male, weighing 147.2 kg (323.8 pounds)

Reactions: Inappropriate Schedule of Drug Administration, Blood Urea Increased, Chest Discomfort, Urine Output Decreased, Chronic Obstructive Pulmonary Disease, Dizziness, Blood Creatinine Increased, Oxygen Saturation Decreased, Lethargy, Cardiac Failure Congestive

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Furosemide
    Dosage: 80 mg tid po
    Administration route: Oral
    Indication: Renal Failure Acute
    Start date: 2009-10-01

Metolazone
    Dosage: 2.5 mg every day po
    Administration route: Oral
    Indication: Renal Failure Acute
    Start date: 2011-09-16
    End date: 2011-10-04



Possible Metolazone side effects in 64 year old male

Reported by a pharmacist from United States on 2012-07-30

Patient: 64 year old male, weighing 118.6 kg (260.9 pounds)

Reactions: Hyponatraemia, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Bumetanide
    Dosage: 2 mg bid po
    Administration route: Oral
    Indication: Polyuria
    Start date: 2010-10-31
    End date: 2012-07-24

Metolazone
    Dosage: 5 mg other po
    Administration route: Oral
    Indication: Polyuria
    Start date: 2012-07-05
    End date: 2012-07-24



Possible Metolazone side effects in 65 year old female

Reported by a pharmacist from United Kingdom on 2012-07-26

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Diclofenac
    Dosage: 50 mg, 3x/day
    Administration route: Oral
    End date: 2012-03-08

Morphine Sulfate
    Dosage: 5 mg, 2x/day
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Losartan Potassium
    Dosage: unk
    Administration route: Oral
    End date: 2012-03-08

Metolazone
    Dosage: unk
    Administration route: Oral
    End date: 2012-03-08

Other drugs received by patient: Omeprazole; Pregabalin; Salbutamol; Citalopram; Paracetamol



Possible Metolazone side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-19

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Metolazone
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Losartan Potassium
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Diclofenac
    Dosage: 50 mg, tid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Morphine Sulfate (Kadian)
    Dosage: 5 mg, bid
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Albuterol Sulate

Other drugs received by patient: Citalopram Hydrobromide; Acetaminophen; Pregabalin; Omeprazole



Possible Metolazone side effects in 90 year old female

Reported by a physician from United States on 2012-07-19

Patient: 90 year old female

Reactions: Medication Error, Bradycardia, Accidental Overdose, Shock

Adverse event resulted in: death

Drug(s) suspected as cause:
Lisinopril
    Dosage: 20 mg, single
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Potassium Chloride
    Dosage: 80 mg, single
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Metolazone
    Dosage: 20 mg, single
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Tenormin
    Dosage: 200 mg, single
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Furosemide
    Dosage: 160 mg, single
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Warfarin Sodium
    Dosage: 8 mg, single
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Glyburide
    Dosage: 20 mg, single
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Diltiazem HCL
    Dosage: 960 mg, single
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Hydralazine HCL
    Dosage: 100 mg, single
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication



Possible Metolazone side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-19

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Morphine Sulfate (Kadian)
    Dosage: 5 mg, bid
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Metolazone
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Diclofenac
    Dosage: 50 mg, tid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Losartan Potassium
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Other drugs received by patient: Pregabalin; Citalopram Hydrobromide; Acetaminophen; Albuterol Sulate; Omeprazole



Possible Metolazone side effects in 66 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-13

Patient: 66 year old male, weighing 175.6 kg (386.3 pounds)

Reactions: Hypotension, Polyuria, Orthostatic Hypotension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Bumetanide
    Indication: Cardiac Failure Congestive
    Start date: 2011-10-25
    End date: 2012-04-21

Metolazone
    Start date: 2009-10-01
    End date: 2012-04-21



Possible Metolazone side effects in

Reported by a individual with unspecified qualification from United States on 2012-07-09

Patient:

Reactions: Medication Error, Wrong Drug Administered, Drug Dispensing Error

Drug(s) suspected as cause:
Methotrexate

Metolazone



Possible Metolazone side effects in male

Reported by a physician from United States on 2012-07-02

Patient: male, weighing 111.4 kg (245.1 pounds)

Reactions: Hyponatraemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lisinopril
    Indication: Hypertension

Aliskiren
    Dosage: 300 mg, qd
    Administration route: Oral
    Indication: Cardiac Failure Acute
    Start date: 2011-09-28
    End date: 2012-06-05

Lisinopril
    Dosage: 20 mg, qd
    Administration route: Oral
    Indication: Cardiac Failure

Metolazone
    Dosage: unk
    Administration route: Oral
    Indication: Oedema Peripheral
    End date: 2012-06-20

Other drugs received by patient: Formoterol Fumarate; Carvedilol; Albuterol; Budesonide; Furosemide; Carvedilol



Possible Metolazone side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-27

Patient: male, weighing 111.4 kg (245.1 pounds)

Reactions: Hyponatraemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Aliskiren
    Dosage: 300 mg, unk
    Administration route: Oral
    Indication: Cardiac Failure Acute
    Start date: 2011-09-28
    End date: 2012-06-05

Lisinopril

Metolazone

Other drugs received by patient: Carvedilol; Albuterol; Furosemide; Budesonide



Possible Metolazone side effects in

Reported by a individual with unspecified qualification from United States on 2012-06-12

Patient:

Reactions: Medication Error, Intercepted Drug Dispensing Error

Drug(s) suspected as cause:
Methadone HCL
    Dosage: tablet oral 5 mg
    Administration route: Oral

Metolazone
    Dosage: tablet oral 5 mg
    Administration route: Oral



Possible Metolazone side effects in male

Reported by a health professional (non-physician/pharmacist) from Denmark on 2012-06-08

Patient: male, weighing 114.6 kg (252.1 pounds)

Reactions: Blood Creatinine Increased, Disease Progression

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Furosemide
    Dosage: 120 mg, tid
    Administration route: Oral
    Start date: 2011-12-26
    End date: 2012-03-29

Blinded Aliskiren
    Dosage: code not broken
    Administration route: Oral
    Start date: 2011-12-21

Bumetanide
    Dosage: 8 mg, unk
    Start date: 2011-12-03
    End date: 2011-12-13

Enalapril Maleate
    Dosage: code not broken
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-07-08
    End date: 2011-11-30

Enalapril Maleate
    Dosage: code not broken
    Administration route: Oral
    Start date: 2011-12-21

Furosemide
    Dosage: unk
    Start date: 2011-12-13

Metolazone
    Dosage: 2.5 mg, unk
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-12-05
    End date: 2011-12-08

Blinded NO Treatment Received
    Dosage: code not broken
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-07-08
    End date: 2011-11-30

Bumetanide
    Dosage: 2 mg x 4
    Start date: 2011-12-03
    End date: 2011-12-13

Furosemide
    Dosage: 120 + 80 + 120 mg
    Start date: 2011-12-14
    End date: 2011-12-20

Blinded Aliskiren
    Dosage: code not broken
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-07-08
    End date: 2011-11-30

Blinded NO Treatment Received
    Dosage: code not broken
    Administration route: Oral
    Start date: 2011-12-21

Other drugs received by patient: Spironolactone; Metoprolol; Hydrochlorothiazde TAB; Warfarin Sodium; Spironolactone; Spironolactone; Digoxin; Digoxin; Simvastatin



Possible Metolazone side effects in 63 year old male

Reported by a physician from United States on 2012-06-07

Patient: 63 year old male

Reactions: Nausea, Atrial Fibrillation, Cardiomyopathy, Hepatic Enzyme Increased, Renal Failure, Fatigue, Insomnia, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Roflumilast
    Dosage: 500 microgram;
    Administration route: Oral
    Indication: Chronic Obstructive Pulmonary Disease
    Start date: 2012-04-01
    End date: 2012-05-16

Metolazone
    Start date: 2012-04-01

Other drugs received by patient: Levothyroxine Sodium; Furosemide; Tiotropium Bromide; Allopurinol; Metformin HCL



Possible Metolazone side effects in 47 year old male

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-05-29

Patient: 47 year old male

Reactions: Mucosal Inflammation, Vomiting, Nausea, Pancytopenia, Rash, Pyrexia, Drug Dispensing Error

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 2.5 mg, four times weekly

Metolazone
    Dosage: 2.5 mg, four times a week



Possible Metolazone side effects in 63 year old male

Reported by a physician from United States on 2012-05-23

Patient: 63 year old male

Reactions: Renal Failure, Fatigue, Nausea, Liver Function Test Abnormal, Insomnia, Atrial Fibrillation, Cardiomyopathy, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Daliresp
    Dosage: 500 mcg
    Administration route: Oral
    Indication: Chronic Obstructive Pulmonary Disease
    Start date: 2012-04-01
    End date: 2012-05-16

Metolazone
    Start date: 2012-04-01

Other drugs received by patient: Synthroid; Metoformin; Spiriva; Lasix; Allopurinol



Possible Metolazone side effects in 64 year old male

Reported by a physician from Canada on 2012-05-11

Patient: 64 year old male

Reactions: Back Pain, Dyspnoea, Hepatic Function Abnormal, Pneumonia, Cardiogenic Shock, Renal Failure Acute, Acute Prerenal Failure, Cardiac Failure Congestive

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Blinded Therapy
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-11-03
    End date: 2012-03-03

Lasix
    End date: 2011-10-20

Metolazone
    End date: 2011-10-20

Metformin HCL
    Indication: Type 2 Diabetes Mellitus
    End date: 2011-02-01

Novorapid
    Indication: Type 2 Diabetes Mellitus

NPH Insulin
    Indication: Type 2 Diabetes Mellitus

Placebo
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-11-03

Metformin HCL
    Start date: 2011-02-01

Other drugs received by patient: Aspirin; Tylenol (Caplet)



Possible Metolazone side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-09

Patient: 65 year old female

Reactions: Dehydration, Drug Interaction, Toxicity To Various Agents, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Metolazone
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Morphine Sulfate
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Losartan Potassium
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Diclofenac
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Other drugs received by patient: Albuterol; Pregabalin; Acetaminophen; Citalopram Hydrobromide; Omeprazole



Possible Metolazone side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from Denmark on 2012-05-08

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Diclofenac Sodium
    Dosage: 50 mg;tid;po
    Administration route: Oral
    End date: 2012-03-08

Metolazone
    Dosage: po
    Administration route: Oral
    End date: 2012-03-08

Losartan Potassium
    Dosage: po
    Administration route: Oral
    End date: 2012-03-08

Kadian
    Dosage: 5 mg;bid;po
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Other drugs received by patient: Prilosec; Pregabalin; Albuterol; Citalopram Hydrobromide; Acetaminophen



Possible Metolazone side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-02

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Losartan Potassium
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Metolazone
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Diclofenac Sodium
    Dosage: 50 mg, tid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Morphine
    Dosage: 5 mg, bid
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Other drugs received by patient: Citalopram; Acetaminophen; Pregabalin; Albuterol; Omeprazole



Possible Metolazone side effects in 65 year old female

Reported by a pharmacist from United Kingdom on 2012-05-01

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Diclofenac
    Dosage: 50 mg, 3x/day
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Morphine Sulfate
    Dosage: 5 mg, 2x/day
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Losartan Potassium
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Metolazone
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Other drugs received by patient: Citalopram; Salbutamol; Paracetamol; Pregabalin; Omeprazole



Possible Metolazone side effects in 65 year old female

Reported by a pharmacist from United Kingdom on 2012-04-26

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Metolazone
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Losartan Potassium
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Diclofenac
    Dosage: 50 mg, 3x/day
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Morphine Sulfate
    Dosage: 5 mg, 2x/day
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Other drugs received by patient: Citalopram; Paracetamol; Pregabalin; Omeprazole; Salbutamol



Possible Metolazone side effects in 64 year old male

Reported by a physician from Canada on 2012-04-26

Patient: 64 year old male

Reactions: Back Pain, Dyspnoea, Hepatic Function Abnormal, Pneumonia, Cardiogenic Shock, Renal Failure Acute, Acute Prerenal Failure, Cardiac Failure Congestive

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Lasix
    End date: 2011-10-20

Novorapid
    Indication: Type 2 Diabetes Mellitus

Placebo
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-11-03

Metolazone
    End date: 2011-10-20

NPH Insulin
    Indication: Type 2 Diabetes Mellitus

Metformin HCL
    Indication: Type 2 Diabetes Mellitus
    End date: 2011-02-01

Blinded Therapy
    Indication: Type 2 Diabetes Mellitus
    Start date: 2010-11-03
    End date: 2012-03-03

Metformin HCL
    Start date: 2011-02-01

Other drugs received by patient: Aspirin; Tylenol (Caplet)



Possible Metolazone side effects in male

Reported by a health professional (non-physician/pharmacist) from Denmark on 2012-04-24

Patient: male, weighing 114.6 kg (252.1 pounds)

Reactions: Blood Creatinine Increased, Disease Progression

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Blinded Aliskiren
    Dosage: code not broken
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-07-08
    End date: 2011-11-30

Blinded NO Treatment Received
    Dosage: code not broken
    Administration route: Oral
    Start date: 2011-12-21

Metolazone
    Dosage: 2.5 mg, unk
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-12-05
    End date: 2011-12-08

Blinded Aliskiren
    Dosage: code not broken
    Administration route: Oral
    Start date: 2011-12-21

Furosemide
    Dosage: 120 mg, tid
    Administration route: Oral
    Start date: 2011-12-26
    End date: 2012-03-29

Bumetanide
    Dosage: 8 mg, unk
    Start date: 2011-12-03
    End date: 2011-12-13

Furosemide
    Dosage: unk
    Start date: 2011-12-13

Enalapril Maleate
    Dosage: code not broken
    Administration route: Oral
    Start date: 2011-12-21

Furosemide
    Dosage: 120 + 80 + 120 mg
    Start date: 2011-12-14
    End date: 2011-12-20

Enalapril Maleate
    Dosage: code not broken
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-07-08
    End date: 2011-11-30

Blinded NO Treatment Received
    Dosage: code not broken
    Administration route: Oral
    Indication: Cardiac Failure
    Start date: 2011-07-08
    End date: 2011-11-30

Other drugs received by patient: Hydrochlorothiazide; Spironolactone; Digoxin; Digoxin; Simvastatin; Warfarin Sodium; Metoprolol Tartrate



Possible Metolazone side effects in 65 year old female

Reported by a pharmacist from United Kingdom on 2012-04-23

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Morphine
    Dosage: 5 mg, 2x/day
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Diclofenac Potassium
    Dosage: 50 mg, 3x/day
    Administration route: Oral
    End date: 2012-03-08

Losartan Potassium
    Dosage: unk
    Administration route: Oral
    End date: 2012-03-08

Metolazone
    Dosage: unk
    Administration route: Oral
    End date: 2012-03-08

Other drugs received by patient: Paracetamol; Pregabalin; Omeprazole; Citalopram; Salbutamol



Possible Metolazone side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-04-20

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Morphine Sulfate
    Dosage: 5 mg, bid
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Diclofenac Sodium
    Dosage: 50 mg, tid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Metolazone
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Albuterol

Losartan Potassium
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Other drugs received by patient: Citalopram Hydrobromide; Acetaminophen; Pregabalin; Omeprazole



Possible Metolazone side effects in 65 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-04-19

Patient: 65 year old female

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Diclofenac
    Administration route: Oral
    End date: 2012-03-08

Metolazone
    Administration route: Oral
    End date: 2012-03-08

Morphine Sulfate
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Cozaar
    Administration route: Oral
    End date: 2012-03-08

Other drugs received by patient: Acetaminophen; Citalopram; Omeprazole; Pregabalin; Albuterol



Possible Metolazone side effects in 65 year old

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-04-19

Patient: 65 year old

Reactions: Confusional State, Dehydration, Toxicity To Various Agents, Somnolence, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Morphine Sulfate
    Dosage: 5 mg, bid
    Administration route: Oral
    Indication: Pain
    Start date: 2012-03-04
    End date: 2012-03-08

Metolazone
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Diclofenac Sodium
    Dosage: 50 mg, tid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Losartan Potassium
    Dosage: unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-03-08

Other drugs received by patient: Acetaminophen; Pregabalin; Albuterol; Omeprazole; Citalopram

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