Index of reports
> Death (680)
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Methotrexate death. The selected reports were submitted to the FDA during the sample period of about a year.
Reports 1 - 30 of 680 Next >>
Possible Methotrexate side effects in
Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-08-27
Patient:
Reactions: Acute Graft Versus Host Disease
Adverse event resulted in: death
Drug(s) suspected as cause:
Cyclosporine
Indication: Prophylaxis
Cyclosporine
Cyclosporine
Dosage: 1.5 mg/kg, every 12 hours
Indication: Stem Cell Transplant
Cyclosporine
Administration route: Oral
Methotrexate
Dosage: 10 mg/m2, on day 3, 6 and 11 after transplant
Methotrexate
Dosage: 15 mg/m2, 1 day
Indication: Prophylaxis Against Graft Versus Host Disease
Possible Methotrexate side effects in male
Reported by a physician from Canada on 2012-08-25
Patient: male
Reactions: Lung Adenocarcinoma Metastatic
Adverse event resulted in: death
Drug(s) suspected as cause:
Abatacept
Dosage: 125 milligram daily;
Start date: 2008-06-17
Methotrexate
Start date: 2010-12-01
End date: 2012-08-05
Other drugs received by patient: Amlodipine; Folic Acid; Metformin HCL; Telmisartan; Acetylsalicylic Acid SRT; Rosuvastatin; Prednisone TAB
Possible Methotrexate side effects in 71 year old female
Reported by a physician from Switzerland on 2012-08-24
Patient: 71 year old female
Reactions: Right Ventricular Failure, Aphthous Stomatitis, Bronchitis Chronic, Pulmonary Oedema, Arteriosclerosis Coronary Artery, Pneumonitis
Adverse event resulted in: death
Drug(s) suspected as cause:
Methotrexate
Other drugs received by patient: Folic Acid; Prednisolone; Dexamethasone; Mefenamic Acid; Prednisolone; Diclofenac Sodium
Possible Methotrexate side effects in male
Reported by a physician from United States on 2012-08-22
Patient: male, weighing 78.0 kg (171.6 pounds)
Reactions: Pain in Extremity, Hypotension, Splenic Infarction, Paraesthesia, Septic Embolus, Fungal Test Positive, Hypoxia, Circulatory Collapse, Asthenia, Cough
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Cytarabine
Dosage: 70 mg, intrathecal
End date: 2012-07-12
Daunorubicin HCL
Dosage: 200 mg
End date: 2012-08-02
Methotrexate
Dosage: 30 m, intrathecal
End date: 2012-08-09
PEG-L-Asparaginase (Pegaspargase, Oncospar)
Dosage: 4900 iu, intravenous
End date: 2012-07-15
Prednisone
Dosage: 3360 mg, oral
Administration route: Oral
End date: 2012-08-08
Possible Methotrexate side effects in male
Reported by a physician from Germany on 2012-08-22
Patient: male
Reactions: Metastatic Bronchial Carcinoma
Adverse event resulted in: death
Drug(s) suspected as cause:
Abatacept
Indication: Polyarthritis
Start date: 2007-12-01
End date: 2008-06-01
Adalimumab
Indication: Polyarthritis
Start date: 2006-08-01
End date: 2007-01-01
Anakinra
Indication: Polyarthritis
Start date: 2008-08-01
End date: 2008-10-01
Certolizumab Pegol
Indication: Polyarthritis
Start date: 2011-09-01
End date: 2011-10-01
Golimumab
Indication: Polyarthritis
Start date: 2011-03-01
End date: 2011-08-01
Methotrexate
Indication: Polyarthritis
Start date: 2003-11-01
End date: 2008-09-01
Methotrexate
Start date: 2009-05-01
Roactemra
Indication: Polyarthritis
Start date: 2009-03-01
End date: 2009-06-01
Sulfasalazine
Indication: Polyarthritis
Start date: 2009-07-01
End date: 2011-03-01
Possible Methotrexate side effects in 63 year old male
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-21
Patient: 63 year old male
Reactions: Lung Adenocarcinoma Metastatic
Adverse event resulted in: death
Drug(s) suspected as cause:
Abatacept
Dosage: last dose on 5oct11;drug discontinued 19-oct-2011
Start date: 2008-06-17
End date: 2011-10-05
Methotrexate
Dosage: last dose:05oct11
Start date: 2010-12-01
Other drugs received by patient: Prednisone TAB; Glucophage; Norvasc; Folic Acid; Aspirin; Telmisartan and Hydrochlorothiazide; Crestor
Possible Methotrexate side effects in 77 year old male
Reported by a health professional (non-physician/pharmacist) from China on 2012-08-21
Patient: 77 year old male
Reactions: Adverse Drug Reaction, Diffuse Large B-Cell Lymphoma
Adverse event resulted in: death
Drug(s) suspected as cause:
Cyclophosphamide
Dosage: on day 1
Indication: Diffuse Large B-Cell Lymphoma
Dexamethasone
Dosage: in cycle 1
Indication: Diffuse Large B-Cell Lymphoma
Doxorubicin Hydrochloride
Dosage: on day 1
Indication: Diffuse Large B-Cell Lymphoma
Methotrexate
Dosage: in cycle 1
Indication: Diffuse Large B-Cell Lymphoma
Prednisone
Dosage: on days 1 to 5
Indication: Diffuse Large B-Cell Lymphoma
Vincristine
Dosage: on day 1
Indication: Diffuse Large B-Cell Lymphoma
Possible Methotrexate side effects in female
Reported by a physician from United Kingdom on 2012-08-21
Patient: female, weighing 95.0 kg (209.0 pounds)
Reactions: Glioblastoma, Hydrocephalus
Adverse event resulted in: death
Drug(s) suspected as cause:
Humira
Dosage: had 6 injections
Indication: Psoriasis
End date: 2012-05-01
Methotrexate
Administration route: Oral
Indication: Psoriasis
Start date: 2005-01-01
End date: 2012-05-01
Possible Methotrexate side effects in female
Reported by a physician from Sweden on 2012-08-20
Patient: female
Reactions: Nausea, Progressive Multifocal Leukoencephalopathy, Hepatic Enzyme Increased
Adverse event resulted in: death
Drug(s) suspected as cause:
Azathioprine
Dosage: 150 mg/day
Administration route: Oral
Indication: Polymyositis
Cyclophosphamide
Dosage: 100 mg/day
Administration route: Oral
Indication: Polymyositis
Methotrexate
Dosage: 20 mg/week
Indication: Polymyositis
Methylprednisolone
Prednisone
Dosage: 40 mg/day
Indication: Polymyositis
Prednisone
Dosage: 10mg daily
Prednisone
Dosage: 17.5 mg/day
Administration route: Oral
Prednisone
Dosage: 60 mg/day
Prednisone
Dosage: 2.5 mg/day
Possible Methotrexate side effects in male
Reported by a physician from Germany on 2012-08-20
Patient: male
Reactions: Metastases To Liver, Metastatic Bronchial Carcinoma, Malignant Neoplasm of Pleura
Adverse event resulted in: death
Drug(s) suspected as cause:
Abatacept
Indication: Polyarthritis
Start date: 2007-12-01
End date: 2008-06-01
Anakinra
Indication: Polyarthritis
Start date: 2008-08-01
End date: 2008-10-01
Certolizumab Pegol
Dosage: cumulative dose: 200 mg
Indication: Polyarthritis
Start date: 2011-09-01
End date: 2011-10-01
Golimumab
Indication: Polyarthritis
Start date: 2011-03-01
End date: 2011-08-01
Humira
Indication: Rheumatoid Arthritis
Start date: 2006-08-01
End date: 2007-01-01
Methotrexate
Indication: Polyarthritis
Start date: 2003-11-01
End date: 2008-09-01
Methotrexate
Start date: 2009-05-01
Sulfasalazine
Indication: Polyarthritis
Start date: 2009-07-01
End date: 2011-03-01
Tocilizumab
Indication: Polyarthritis
Start date: 2009-03-01
End date: 2009-06-01
Other drugs received by patient: Methotrexate; Abatacept; Tocilizumab; Sulfasalazine; Methotrexate; Certolizumab; Golimumab; Anakinra
Possible Methotrexate side effects in female
Reported by a physician from Sweden on 2012-08-20
Patient: female
Reactions: Nausea, Progressive Multifocal Leukoencephalopathy, Hepatic Enzyme Increased
Adverse event resulted in: death
Drug(s) suspected as cause:
Azathioprine
Dosage: 150 mg/day
Administration route: Oral
Indication: Polymyositis
Cyclophosphamide
Dosage: 100 mg/day
Administration route: Oral
Indication: Polymyositis
Methotrexate
Dosage: 20 mg/week
Indication: Polymyositis
Methylprednisolone
Prednisone
Dosage: 40 mg/day
Indication: Polymyositis
Prednisone
Dosage: 2.5 mg/day
Prednisone
Dosage: 10mg daily
Prednisone
Dosage: 60 mg/day
Prednisone
Dosage: 17.5 mg/day
Administration route: Oral
Possible Methotrexate side effects in 79 year old female
Reported by a pharmacist from United Kingdom on 2012-08-20
Patient: 79 year old female, weighing 55.4 kg (121.9 pounds)
Reactions: Pruritus, Pulmonary Embolism, Eczema, Erythema, Rash Pruritic, Oedema Peripheral, Blood Creatinine Increased, Blister, Toxic Epidermal Necrolysis, Skin Tightness, Staphylococcal Scalded Skin Syndrome, Exfoliative Rash, Vasculitis, Rash Maculo-Papular, Hypersensitivity, Skin Exfoliation, Scab, Adverse Drug Reaction, Pain, Petechiae, Skin Swelling, Stevens-Johnson Syndrome, Renal Failure Acute, Fluid Overload, Rash Generalised, Atrial Fibrillation, DRY Skin, Rash, Pulmonary Fibrosis, Skin Irritation, Mucosal Erosion, Haemoglobin Decreased, Diarrhoea, Skin Erosion
Adverse event resulted in: death
Drug(s) suspected as cause:
Amiodarone HCL
Indication: Product Used FOR Unknown Indication
Amoxicillin
Indication: Product Used FOR Unknown Indication
Bumetanide
Indication: Product Used FOR Unknown Indication
Clarithromycin
Administration route: Oral
Indication: Pneumonia
Start date: 2012-05-12
End date: 2012-05-21
Methotrexate
Indication: Product Used FOR Unknown Indication
Simvastatin
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Spironolactone
Indication: Product Used FOR Unknown Indication
Other drugs received by patient: Dalteparin Sodium; Candesartan Cilexetil; Bisoprolol Fumarate; Bisoprolol Fumarate; Clotrimazole; Fortisip; Diclofenac Diethylammonium Salt; Adenosine; Furosemide; Acetaminophen; Tramadol HCL; Acetaminophen and Codeine Phosphate; Teicoplanin; Adcal-D3; Dioralyte; Gentamicin; Amoxicillin and Clavulanate Potassium; Heparin; Folic Acid; Omeprazole; Metoclopramide
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-20
Patient:
Reactions: Multi-Organ Failure, Off Label Use, Sepsis, Cerebral Ischaemia
Adverse event resulted in: death
Drug(s) suspected as cause:
Asparaginase
Dosage: 2500 units/m2/dose as 4 weekly doses
Indication: Acute Lymphocytic Leukaemia
Bortezomib
Dosage: 1.3 mg/sq.m/dose on days 1, 4, 8 and 11 combined with vxld
Indication: Acute Lymphocytic Leukaemia
Cytarabine
Dosage: on day 1 for all patients and on days 8, 15, 22 for cns invlovment
Indication: Acute Lymphocytic Leukaemia
Dexamethasone
Dosage: 10 mg/m2/day divided in to 2 doses for 14 consecutive days
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: on day 1 over 15-30 minutes
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Dosage: on days 8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: 1 dose on day 15 for no cns involvement and on days 8, 15, 22 for cns involvement
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: 1.5 mg/m2/dose, max. 2 mg, by push on days 1, 8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in female
Reported by a physician from Sweden on 2012-08-20
Patient: female
Reactions: Nausea, Progressive Multifocal Leukoencephalopathy, Hepatic Enzyme Increased
Adverse event resulted in: death
Drug(s) suspected as cause:
Azathioprine
Dosage: 150 mg/day
Administration route: Oral
Indication: Polymyositis
Cyclophosphamide
Dosage: 100 mg/day
Administration route: Oral
Indication: Polymyositis
Methotrexate
Dosage: 20 mg/week
Indication: Polymyositis
Methylprednisolone
Prednisone
Dosage: 10mg daily
Prednisone
Dosage: 17.5 mg/day
Administration route: Oral
Prednisone
Dosage: 60 mg/day
Prednisone
Dosage: 2.5 mg/day
Prednisone
Dosage: 40 mg/day
Indication: Polymyositis
Possible Methotrexate side effects in female
Reported by a physician from United States on 2012-08-20
Patient: female, weighing 70.8 kg (155.8 pounds)
Reactions: Abdominal Pain, Hyperpyrexia, Anaphylactic Reaction, Chills, Pain, Hepatic Failure, Transaminases Increased, Splenic Infarction, Loss of Consciousness, Aortic Thrombosis, Off Label Use, Malaise, C-Reactive Protein Increased, Myositis, Dyspnoea, Hypotension, Arrhythmia, Lung Consolidation, Hypophosphataemia, Zygomycosis, Bacteraemia, Ventricular Tachycardia, Hyperammonaemia, Neutropenia, Hepatic Infarction, Shock, Infusion Related Reaction
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Cytarabine
Dosage: day 1,8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Start date: 2007-10-23
Decadron Phosphate
Dosage: day 1
Indication: Acute Lymphocytic Leukaemia
Start date: 2007-10-23
Doxil
Dosage: day 1
Indication: Acute Lymphocytic Leukaemia
Start date: 2007-10-23
End date: 2007-10-23
Methotrexate
Dosage: day 1
Indication: Acute Lymphocytic Leukaemia
Start date: 2005-01-01
End date: 2007-01-01
PEG-Asparaginase
Dosage: day 2, 8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Start date: 2007-10-25
End date: 2007-10-25
Velcade
Dosage: day 1, 4, 8 and 11
Indication: Acute Lymphocytic Leukaemia
Start date: 2007-10-23
End date: 2007-10-23
Vincristine
Dosage: day 1,8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Start date: 2007-10-23
End date: 2007-10-23
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-17
Patient:
Reactions: Off Label Use, Hypoxia, Pleural Effusion, Bacterial Sepsis
Adverse event resulted in: death
Drug(s) suspected as cause:
Asparaginase
Dosage: (pegylated) 2500 units/ m2/ dose as 4 weekly doses
Indication: Acute Lymphocytic Leukaemia
Bortezomib
Dosage: on days 1, 4, 8 and 11
Indication: Acute Lymphocytic Leukaemia
Cytarabine
Dosage: on day 1 and as cns involvement on days 8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Dexamethasone
Dosage: divided into 2 doses for 14 consecutive days
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: over 15-30 minutes on day 1
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Dosage: on days 8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: on day 15 and triple therapy on days 8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: by push day 1, 8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in male
Reported by a physician from Japan on 2012-08-17
Patient: male, weighing 65.0 kg (143.0 pounds)
Reactions: Pneumocystis Jiroveci Pneumonia, Arthralgia, Joint Swelling, Decreased Appetite
Adverse event resulted in: death, life threatening event
Drug(s) suspected as cause:
Adalimumab
Indication: Rheumatoid Arthritis
Start date: 2010-07-13
End date: 2011-01-12
Methotrexate
Administration route: Oral
Indication: Rheumatoid Arthritis
Start date: 2009-07-01
End date: 2011-01-21
Other drugs received by patient: Prednisolone; Amlodipine Besylate; Methotrexate; Diclofenac Sodium
Possible Methotrexate side effects in female
Reported by a physician from Netherlands on 2012-08-16
Patient: female, weighing 7.4 kg (16.3 pounds)
Reactions: Capillary Leak Syndrome, Hepatic Function Abnormal, Respiratory Failure, Disease Progression, Ascites
Adverse event resulted in: death, life threatening event, hospitalization
Drug(s) suspected as cause:
Clofarabine
Dosage: 11 mg (40 mg/m2), qdx5
Indication: Acute Lymphocytic Leukaemia
Start date: 2010-07-23
End date: 2010-07-27
Cyclophosphamide
Dosage: 80 mg, qd
Indication: Acute Lymphocytic Leukaemia
Start date: 2010-07-23
End date: 2010-07-27
Cytarabine
Dosage: 15 mg, od
Indication: Acute Lymphocytic Leukaemia
Start date: 2010-07-28
End date: 2010-07-28
Cytarabine
Indication: Chemotherapy
Etoposide
Dosage: 28 mg, qd
Indication: Acute Lymphocytic Leukaemia
Start date: 2010-07-23
End date: 2010-07-27
Methotrexate
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: 6 mgr, od
Indication: Chemotherapy
Start date: 2010-07-28
End date: 2010-07-28
Prednisolone
Indication: Chemotherapy
Prednisolone
Dosage: 6 mgr, od
Indication: Acute Lymphocytic Leukaemia
Start date: 2010-07-28
End date: 2010-07-28
Other drugs received by patient: Itraconazole; Vancomycin; Dexamethasone; Filgrastim; Teicoplanin; Ciprofloxacin HCL; Ciprofloxacin HCL; Tramadol HCL; Vancomycin; Ceftazidime; Zofran; Vancomycin; Furosemide; Cotrim; Vancomycin; Vitamin K TAB; Cotrim; Itraconazole; Vancomycin; Vancomycin; Omeprazole; Acetaminophen; Ciprofloxacin; Furosemide; Ceftazidime; Furosemide; Omeprazole
Possible Methotrexate side effects in male
Reported by a physician from Germany on 2012-08-16
Patient: male
Reactions: Metastases To Liver, Metastatic Bronchial Carcinoma, Malignant Neoplasm of Pleura
Adverse event resulted in: death
Drug(s) suspected as cause:
Abatacept
Indication: Polyarthritis
Start date: 2007-12-01
End date: 2008-06-01
Anakinra
Indication: Polyarthritis
Start date: 2008-08-01
End date: 2008-10-01
Cimzia
Dosage: cumulative dose: 200 mg
Indication: Polyarthritis
Start date: 2011-09-01
End date: 2011-10-01
Golimumab
Indication: Polyarthritis
Start date: 2011-03-01
End date: 2011-08-01
Humira
Indication: Rheumatoid Arthritis
Start date: 2006-08-01
End date: 2007-01-01
Methotrexate
Indication: Polyarthritis
Start date: 2003-11-01
Sulfasalazine
Indication: Polyarthritis
Start date: 2009-07-01
End date: 2011-03-01
Tocilizumab
Indication: Polyarthritis
Start date: 2009-03-01
End date: 2009-06-01
Other drugs received by patient: Sulfasalazine; Methotrexate; Anakinra; Abatacept; Golimumab; Methotrexate; Tocilizumab; Certolizumab
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-15
Patient:
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytarabine
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Decadron
Dosage: 10 mg/m2, cyclic
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: 60 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Oncaspar
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Velcade
Dosage: 1.3 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: 1.5 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-15
Patient:
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytarabine
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Dexamethasone
Dosage: 10 mg/m2, cyclic
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: 60 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
PEG-Asparaginase
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Velcade
Dosage: 1.3 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: 1.5 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-15
Patient:
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytarabine
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Decadron
Dosage: 10 mg/m2, cyclic
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: 60 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Oncaspar
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Velcade
Dosage: 1.3 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: 1.5 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-15
Patient:
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytarabine
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Decadron
Dosage: 10 mg/m2, cyclic
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: 60 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Oncaspar
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Velcade
Dosage: 1.3 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: 1.5 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-15
Patient:
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytarabine
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Dexamethasone
Dosage: 10 mg/m2, cyclic
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: 60 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
PEG-Asparaginase
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Velcade
Dosage: 1.3 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: 1.5 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-15
Patient:
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytarabine
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Decadron
Dosage: 10 mg/m2, cyclic
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: 60 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Oncaspar
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Velcade
Dosage: 1.3 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: 1.5 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-15
Patient:
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Cytarabine
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Dexamethasone
Dosage: 10 mg/m2, cyclic
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: 60 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
PEG-Asparaginase
Dosage: unk, cyclic
Indication: Acute Lymphocytic Leukaemia
Velcade
Dosage: 1.3 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: 1.5 mg/m2, cyclic
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in
Reported by a physician from United States on 2012-08-14
Patient:
Reactions: Multi-Organ Failure, Sepsis, Cerebral Ischaemia
Adverse event resulted in: death
Drug(s) suspected as cause:
Asparaginase
Dosage: 2500 units/m2/dose as 4 weekly doses
Indication: Acute Lymphocytic Leukaemia
Bortezomib
Dosage: 1.3 mg/sq.m/dose on days 1, 4, 8 and 11 combined with vxld
Indication: Acute Lymphocytic Leukaemia
Cytarabine
Dosage: on day 1 for all patients and on days 8, 15, 22 for cns invlovment
Indication: Acute Lymphocytic Leukaemia
Dexamethasone
Dosage: 10 mg/m2/day divided in to 2 doses for 14 consecutive days
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: on day 1 over 15-30 minutes
Indication: Acute Lymphocytic Leukaemia
Hydrocortisone
Dosage: on days 8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Dosage: 1 dose on day 15 for no cns involvement and on days 8, 15, 22 for cns involvement
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: 1.5 mg/m2/dose, max. 2 mg, by push on days 1, 8, 15 and 22
Indication: Acute Lymphocytic Leukaemia
Possible Methotrexate side effects in 79 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-14
Patient: 79 year old female, weighing 55.5 kg (122.0 pounds)
Reactions: Haemoglobin Decreased, Fluid Overload, Toxic Epidermal Necrolysis, Atrial Fibrillation, Renal Failure Acute, Pulmonary Fibrosis
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Bumetanide
Clarithromycin
Dosage: 500mg, bid
Administration route: Oral
Start date: 2012-05-12
End date: 2012-05-21
Methotrexate
Dosage: stopped on admission. pulmonary fibrosis secondary to methotrexate and fluid overload.
Spironolactone
Zocor
Administration route: Oral
Other drugs received by patient: Clotrimazole; Tramadol HCL; Dalteparin Sodium; Diclofenac Diethylamine; Adcal-D3; Candesartan Cilexetil; Acetaminophen; Fortisip; Adenosine; Folic Acid; Bisoprolol; Dioralyte; Heparin; Amiodarone HCL; Furosemide; Metoclopramide; Acetaminophen and Codeine Phosphate; Warfarin Sodium; Acetaminophen W / Codeine; Omeprazole; Gentamicin; Amoxicillin and Clavulanate Potassium; Teicoplanin
Possible Methotrexate side effects in male
Reported by a physician from Japan on 2012-08-14
Patient: male, weighing 43.0 kg (94.6 pounds)
Reactions: Pneumonia Aspiration, Urine Output Decreased, Pyrexia, Haemothorax, Cardio-Respiratory Arrest, Hypopnoea, Respiratory Failure, Decreased Immune Responsiveness, Pleural Infection, Depressed Level of Consciousness, Hypoxia, Blood Pressure Decreased, Cough, Decreased Appetite
Adverse event resulted in: death
Drug(s) suspected as cause:
Etanercept
Start date: 2011-02-15
Etanercept
Start date: 2011-03-19
End date: 2011-03-19
Etanercept
Start date: 2011-03-26
End date: 2011-03-26
Etanercept
Etanercept
Indication: Rheumatoid Arthritis
Start date: 2009-06-01
End date: 2009-10-01
Etanercept
Start date: 2011-04-02
End date: 2011-04-02
Humira
Indication: Rheumatoid Arthritis
Start date: 2011-04-15
End date: 2011-04-29
Methotrexate
Administration route: Oral
Indication: Rheumatoid Arthritis
Start date: 2011-04-14
End date: 2011-04-21
Prednisolone
Administration route: Oral
Indication: Rheumatoid Arthritis
Start date: 2011-03-24
End date: 2011-05-04
Possible Methotrexate side effects in 43 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-14
Patient: 43 year old female
Reactions: Pneumocystis Jiroveci Pneumonia, Chronic Graft Versus Host Disease
Adverse event resulted in: death
Drug(s) suspected as cause:
Cyclosporine
Administration route: Oral
Indication: Prophylaxis Against Graft Versus Host Disease
Cyclosporine
Indication: Stem Cell Transplant
Methotrexate
Other drugs received by patient: Thiotepa; Acyclovir; Amphotericin B; Sulfamethoxazole and Trimethoprim; Cyclophosphamide; Antibiotics; Immune Globulin NOS
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