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Methotrexate (Methotrexate) - Death - Suspected Cause - Side Effect Reports

 
 



Index of reports > Death (680)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Methotrexate death. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 680   Next >>

Possible Methotrexate side effects in

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-08-27

Patient:

Reactions: Acute Graft Versus Host Disease

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclosporine
    Indication: Prophylaxis

Cyclosporine

Cyclosporine
    Dosage: 1.5 mg/kg, every 12 hours
    Indication: Stem Cell Transplant

Cyclosporine
    Administration route: Oral

Methotrexate
    Dosage: 10 mg/m2, on day 3, 6 and 11 after transplant

Methotrexate
    Dosage: 15 mg/m2, 1 day
    Indication: Prophylaxis Against Graft Versus Host Disease



Possible Methotrexate side effects in male

Reported by a physician from Canada on 2012-08-25

Patient: male

Reactions: Lung Adenocarcinoma Metastatic

Adverse event resulted in: death

Drug(s) suspected as cause:
Abatacept
    Dosage: 125 milligram daily;
    Start date: 2008-06-17

Methotrexate
    Start date: 2010-12-01
    End date: 2012-08-05

Other drugs received by patient: Amlodipine; Folic Acid; Metformin HCL; Telmisartan; Acetylsalicylic Acid SRT; Rosuvastatin; Prednisone TAB



Possible Methotrexate side effects in 71 year old female

Reported by a physician from Switzerland on 2012-08-24

Patient: 71 year old female

Reactions: Right Ventricular Failure, Aphthous Stomatitis, Bronchitis Chronic, Pulmonary Oedema, Arteriosclerosis Coronary Artery, Pneumonitis

Adverse event resulted in: death

Drug(s) suspected as cause:
Methotrexate

Other drugs received by patient: Folic Acid; Prednisolone; Dexamethasone; Mefenamic Acid; Prednisolone; Diclofenac Sodium



Possible Methotrexate side effects in male

Reported by a physician from Germany on 2012-08-22

Patient: male

Reactions: Metastatic Bronchial Carcinoma

Adverse event resulted in: death

Drug(s) suspected as cause:
Abatacept
    Indication: Polyarthritis
    Start date: 2007-12-01
    End date: 2008-06-01

Adalimumab
    Indication: Polyarthritis
    Start date: 2006-08-01
    End date: 2007-01-01

Anakinra
    Indication: Polyarthritis
    Start date: 2008-08-01
    End date: 2008-10-01

Certolizumab Pegol
    Indication: Polyarthritis
    Start date: 2011-09-01
    End date: 2011-10-01

Golimumab
    Indication: Polyarthritis
    Start date: 2011-03-01
    End date: 2011-08-01

Methotrexate
    Indication: Polyarthritis
    Start date: 2003-11-01
    End date: 2008-09-01

Methotrexate
    Start date: 2009-05-01

Roactemra
    Indication: Polyarthritis
    Start date: 2009-03-01
    End date: 2009-06-01

Sulfasalazine
    Indication: Polyarthritis
    Start date: 2009-07-01
    End date: 2011-03-01



Possible Methotrexate side effects in male

Reported by a physician from United States on 2012-08-22

Patient: male, weighing 78.0 kg (171.6 pounds)

Reactions: Pain in Extremity, Hypotension, Splenic Infarction, Paraesthesia, Septic Embolus, Fungal Test Positive, Hypoxia, Circulatory Collapse, Asthenia, Cough

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cytarabine
    Dosage: 70 mg, intrathecal
    End date: 2012-07-12

Daunorubicin HCL
    Dosage: 200 mg
    End date: 2012-08-02

Methotrexate
    Dosage: 30 m, intrathecal
    End date: 2012-08-09

PEG-L-Asparaginase (Pegaspargase, Oncospar)
    Dosage: 4900 iu, intravenous
    End date: 2012-07-15

Prednisone
    Dosage: 3360 mg, oral
    Administration route: Oral
    End date: 2012-08-08



Possible Methotrexate side effects in 77 year old male

Reported by a health professional (non-physician/pharmacist) from China on 2012-08-21

Patient: 77 year old male

Reactions: Adverse Drug Reaction, Diffuse Large B-Cell Lymphoma

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: on day 1
    Indication: Diffuse Large B-Cell Lymphoma

Dexamethasone
    Dosage: in cycle 1
    Indication: Diffuse Large B-Cell Lymphoma

Doxorubicin Hydrochloride
    Dosage: on day 1
    Indication: Diffuse Large B-Cell Lymphoma

Methotrexate
    Dosage: in cycle 1
    Indication: Diffuse Large B-Cell Lymphoma

Prednisone
    Dosage: on days 1 to 5
    Indication: Diffuse Large B-Cell Lymphoma

Vincristine
    Dosage: on day 1
    Indication: Diffuse Large B-Cell Lymphoma



Possible Methotrexate side effects in female

Reported by a physician from United Kingdom on 2012-08-21

Patient: female, weighing 95.0 kg (209.0 pounds)

Reactions: Glioblastoma, Hydrocephalus

Adverse event resulted in: death

Drug(s) suspected as cause:
Humira
    Dosage: had 6 injections
    Indication: Psoriasis
    End date: 2012-05-01

Methotrexate
    Administration route: Oral
    Indication: Psoriasis
    Start date: 2005-01-01
    End date: 2012-05-01



Possible Methotrexate side effects in 63 year old male

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-21

Patient: 63 year old male

Reactions: Lung Adenocarcinoma Metastatic

Adverse event resulted in: death

Drug(s) suspected as cause:
Abatacept
    Dosage: last dose on 5oct11;drug discontinued 19-oct-2011
    Start date: 2008-06-17
    End date: 2011-10-05

Methotrexate
    Dosage: last dose:05oct11
    Start date: 2010-12-01

Other drugs received by patient: Prednisone TAB; Glucophage; Norvasc; Folic Acid; Aspirin; Telmisartan and Hydrochlorothiazide; Crestor



Possible Methotrexate side effects in female

Reported by a physician from Sweden on 2012-08-20

Patient: female

Reactions: Nausea, Progressive Multifocal Leukoencephalopathy, Hepatic Enzyme Increased

Adverse event resulted in: death

Drug(s) suspected as cause:
Azathioprine
    Dosage: 150 mg/day
    Administration route: Oral
    Indication: Polymyositis

Cyclophosphamide
    Dosage: 100 mg/day
    Administration route: Oral
    Indication: Polymyositis

Methotrexate
    Dosage: 20 mg/week
    Indication: Polymyositis

Methylprednisolone

Prednisone
    Dosage: 40 mg/day
    Indication: Polymyositis

Prednisone
    Dosage: 2.5 mg/day

Prednisone
    Dosage: 10mg daily

Prednisone
    Dosage: 60 mg/day

Prednisone
    Dosage: 17.5 mg/day
    Administration route: Oral



Possible Methotrexate side effects in 79 year old female

Reported by a pharmacist from United Kingdom on 2012-08-20

Patient: 79 year old female, weighing 55.4 kg (121.9 pounds)

Reactions: Pruritus, Pulmonary Embolism, Eczema, Erythema, Rash Pruritic, Oedema Peripheral, Blood Creatinine Increased, Blister, Toxic Epidermal Necrolysis, Skin Tightness, Staphylococcal Scalded Skin Syndrome, Exfoliative Rash, Vasculitis, Rash Maculo-Papular, Hypersensitivity, Skin Exfoliation, Scab, Adverse Drug Reaction, Pain, Petechiae, Skin Swelling, Stevens-Johnson Syndrome, Renal Failure Acute, Fluid Overload, Rash Generalised, Atrial Fibrillation, DRY Skin, Rash, Pulmonary Fibrosis, Skin Irritation, Mucosal Erosion, Haemoglobin Decreased, Diarrhoea, Skin Erosion

Adverse event resulted in: death

Drug(s) suspected as cause:
Amiodarone HCL
    Indication: Product Used FOR Unknown Indication

Amoxicillin
    Indication: Product Used FOR Unknown Indication

Bumetanide
    Indication: Product Used FOR Unknown Indication

Clarithromycin
    Administration route: Oral
    Indication: Pneumonia
    Start date: 2012-05-12
    End date: 2012-05-21

Methotrexate
    Indication: Product Used FOR Unknown Indication

Simvastatin
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Spironolactone
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Dalteparin Sodium; Candesartan Cilexetil; Bisoprolol Fumarate; Bisoprolol Fumarate; Clotrimazole; Fortisip; Diclofenac Diethylammonium Salt; Adenosine; Furosemide; Acetaminophen; Tramadol HCL; Acetaminophen and Codeine Phosphate; Teicoplanin; Adcal-D3; Dioralyte; Gentamicin; Amoxicillin and Clavulanate Potassium; Heparin; Folic Acid; Omeprazole; Metoclopramide



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-20

Patient:

Reactions: Multi-Organ Failure, Off Label Use, Sepsis, Cerebral Ischaemia

Adverse event resulted in: death

Drug(s) suspected as cause:
Asparaginase
    Dosage: 2500 units/m2/dose as 4 weekly doses
    Indication: Acute Lymphocytic Leukaemia

Bortezomib
    Dosage: 1.3 mg/sq.m/dose on days 1, 4, 8 and 11 combined with vxld
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: on day 1 for all patients and on days 8, 15, 22 for cns invlovment
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 10 mg/m2/day divided in to 2 doses for 14 consecutive days
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: on day 1 over 15-30 minutes
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Dosage: on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 1 dose on day 15 for no cns involvement and on days 8, 15, 22 for cns involvement
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2/dose, max. 2 mg, by push on days 1, 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in female

Reported by a physician from Sweden on 2012-08-20

Patient: female

Reactions: Nausea, Progressive Multifocal Leukoencephalopathy, Hepatic Enzyme Increased

Adverse event resulted in: death

Drug(s) suspected as cause:
Azathioprine
    Dosage: 150 mg/day
    Administration route: Oral
    Indication: Polymyositis

Cyclophosphamide
    Dosage: 100 mg/day
    Administration route: Oral
    Indication: Polymyositis

Methotrexate
    Dosage: 20 mg/week
    Indication: Polymyositis

Methylprednisolone

Prednisone
    Dosage: 10mg daily

Prednisone
    Dosage: 17.5 mg/day
    Administration route: Oral

Prednisone
    Dosage: 60 mg/day

Prednisone
    Dosage: 2.5 mg/day

Prednisone
    Dosage: 40 mg/day
    Indication: Polymyositis



Possible Methotrexate side effects in female

Reported by a physician from United States on 2012-08-20

Patient: female, weighing 70.8 kg (155.8 pounds)

Reactions: Abdominal Pain, Hyperpyrexia, Anaphylactic Reaction, Chills, Pain, Hepatic Failure, Transaminases Increased, Splenic Infarction, Loss of Consciousness, Aortic Thrombosis, Off Label Use, Malaise, C-Reactive Protein Increased, Myositis, Dyspnoea, Hypotension, Arrhythmia, Lung Consolidation, Hypophosphataemia, Zygomycosis, Bacteraemia, Ventricular Tachycardia, Hyperammonaemia, Neutropenia, Hepatic Infarction, Shock, Infusion Related Reaction

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Cytarabine
    Dosage: day 1,8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-10-23

Decadron Phosphate
    Dosage: day 1
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-10-23

Doxil
    Dosage: day 1
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-10-23
    End date: 2007-10-23

Methotrexate
    Dosage: day 1
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2005-01-01
    End date: 2007-01-01

PEG-Asparaginase
    Dosage: day 2, 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-10-25
    End date: 2007-10-25

Velcade
    Dosage: day 1, 4, 8 and 11
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-10-23
    End date: 2007-10-23

Vincristine
    Dosage: day 1,8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2007-10-23
    End date: 2007-10-23



Possible Methotrexate side effects in female

Reported by a physician from Sweden on 2012-08-20

Patient: female

Reactions: Nausea, Progressive Multifocal Leukoencephalopathy, Hepatic Enzyme Increased

Adverse event resulted in: death

Drug(s) suspected as cause:
Azathioprine
    Dosage: 150 mg/day
    Administration route: Oral
    Indication: Polymyositis

Cyclophosphamide
    Dosage: 100 mg/day
    Administration route: Oral
    Indication: Polymyositis

Methotrexate
    Dosage: 20 mg/week
    Indication: Polymyositis

Methylprednisolone

Prednisone
    Dosage: 40 mg/day
    Indication: Polymyositis

Prednisone
    Dosage: 10mg daily

Prednisone
    Dosage: 17.5 mg/day
    Administration route: Oral

Prednisone
    Dosage: 60 mg/day

Prednisone
    Dosage: 2.5 mg/day



Possible Methotrexate side effects in male

Reported by a physician from Germany on 2012-08-20

Patient: male

Reactions: Metastases To Liver, Metastatic Bronchial Carcinoma, Malignant Neoplasm of Pleura

Adverse event resulted in: death

Drug(s) suspected as cause:
Abatacept
    Indication: Polyarthritis
    Start date: 2007-12-01
    End date: 2008-06-01

Anakinra
    Indication: Polyarthritis
    Start date: 2008-08-01
    End date: 2008-10-01

Certolizumab Pegol
    Dosage: cumulative dose: 200 mg
    Indication: Polyarthritis
    Start date: 2011-09-01
    End date: 2011-10-01

Golimumab
    Indication: Polyarthritis
    Start date: 2011-03-01
    End date: 2011-08-01

Humira
    Indication: Rheumatoid Arthritis
    Start date: 2006-08-01
    End date: 2007-01-01

Methotrexate
    Indication: Polyarthritis
    Start date: 2003-11-01
    End date: 2008-09-01

Methotrexate
    Start date: 2009-05-01

Sulfasalazine
    Indication: Polyarthritis
    Start date: 2009-07-01
    End date: 2011-03-01

Tocilizumab
    Indication: Polyarthritis
    Start date: 2009-03-01
    End date: 2009-06-01

Other drugs received by patient: Methotrexate; Abatacept; Tocilizumab; Sulfasalazine; Methotrexate; Certolizumab; Golimumab; Anakinra



Possible Methotrexate side effects in male

Reported by a physician from Japan on 2012-08-17

Patient: male, weighing 65.0 kg (143.0 pounds)

Reactions: Pneumocystis Jiroveci Pneumonia, Arthralgia, Joint Swelling, Decreased Appetite

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Adalimumab
    Indication: Rheumatoid Arthritis
    Start date: 2010-07-13
    End date: 2011-01-12

Methotrexate
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2009-07-01
    End date: 2011-01-21

Other drugs received by patient: Prednisolone; Amlodipine Besylate; Methotrexate; Diclofenac Sodium



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-17

Patient:

Reactions: Off Label Use, Hypoxia, Pleural Effusion, Bacterial Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Asparaginase
    Dosage: (pegylated) 2500 units/ m2/ dose as 4 weekly doses
    Indication: Acute Lymphocytic Leukaemia

Bortezomib
    Dosage: on days 1, 4, 8 and 11
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: on day 1 and as cns involvement on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: divided into 2 doses for 14 consecutive days
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: over 15-30 minutes on day 1
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Dosage: on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: on day 15 and triple therapy on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: by push day 1, 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in female

Reported by a physician from Netherlands on 2012-08-16

Patient: female, weighing 7.4 kg (16.3 pounds)

Reactions: Capillary Leak Syndrome, Hepatic Function Abnormal, Respiratory Failure, Disease Progression, Ascites

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Clofarabine
    Dosage: 11 mg (40 mg/m2), qdx5
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-07-23
    End date: 2010-07-27

Cyclophosphamide
    Dosage: 80 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-07-23
    End date: 2010-07-27

Cytarabine
    Dosage: 15 mg, od
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-07-28
    End date: 2010-07-28

Cytarabine
    Indication: Chemotherapy

Etoposide
    Dosage: 28 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-07-23
    End date: 2010-07-27

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 6 mgr, od
    Indication: Chemotherapy
    Start date: 2010-07-28
    End date: 2010-07-28

Prednisolone
    Indication: Chemotherapy

Prednisolone
    Dosage: 6 mgr, od
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-07-28
    End date: 2010-07-28

Other drugs received by patient: Itraconazole; Vancomycin; Dexamethasone; Filgrastim; Teicoplanin; Ciprofloxacin HCL; Ciprofloxacin HCL; Tramadol HCL; Vancomycin; Ceftazidime; Zofran; Vancomycin; Furosemide; Cotrim; Vancomycin; Vitamin K TAB; Cotrim; Itraconazole; Vancomycin; Vancomycin; Omeprazole; Acetaminophen; Ciprofloxacin; Furosemide; Ceftazidime; Furosemide; Omeprazole



Possible Methotrexate side effects in male

Reported by a physician from Germany on 2012-08-16

Patient: male

Reactions: Metastases To Liver, Metastatic Bronchial Carcinoma, Malignant Neoplasm of Pleura

Adverse event resulted in: death

Drug(s) suspected as cause:
Abatacept
    Indication: Polyarthritis
    Start date: 2007-12-01
    End date: 2008-06-01

Anakinra
    Indication: Polyarthritis
    Start date: 2008-08-01
    End date: 2008-10-01

Cimzia
    Dosage: cumulative dose: 200 mg
    Indication: Polyarthritis
    Start date: 2011-09-01
    End date: 2011-10-01

Golimumab
    Indication: Polyarthritis
    Start date: 2011-03-01
    End date: 2011-08-01

Humira
    Indication: Rheumatoid Arthritis
    Start date: 2006-08-01
    End date: 2007-01-01

Methotrexate
    Indication: Polyarthritis
    Start date: 2003-11-01

Sulfasalazine
    Indication: Polyarthritis
    Start date: 2009-07-01
    End date: 2011-03-01

Tocilizumab
    Indication: Polyarthritis
    Start date: 2009-03-01
    End date: 2009-06-01

Other drugs received by patient: Sulfasalazine; Methotrexate; Anakinra; Abatacept; Golimumab; Methotrexate; Tocilizumab; Certolizumab



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-15

Patient:

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytarabine
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia

Decadron
    Dosage: 10 mg/m2, cyclic
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: 60 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Oncaspar
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-15

Patient:

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytarabine
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 10 mg/m2, cyclic
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: 60 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

PEG-Asparaginase
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-15

Patient:

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytarabine
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia

Decadron
    Dosage: 10 mg/m2, cyclic
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: 60 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Oncaspar
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-15

Patient:

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytarabine
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 10 mg/m2, cyclic
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: 60 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

PEG-Asparaginase
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-15

Patient:

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytarabine
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia

Decadron
    Dosage: 10 mg/m2, cyclic
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: 60 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Oncaspar
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-15

Patient:

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytarabine
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 10 mg/m2, cyclic
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: 60 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

PEG-Asparaginase
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-15

Patient:

Reactions: Death

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytarabine
    Dosage: unk
    Indication: Acute Lymphocytic Leukaemia

Decadron
    Dosage: 10 mg/m2, cyclic
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: 60 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Oncaspar
    Dosage: unk, cyclic
    Indication: Acute Lymphocytic Leukaemia

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2, cyclic
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in 43 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-14

Patient: 43 year old female

Reactions: Pneumocystis Jiroveci Pneumonia, Chronic Graft Versus Host Disease

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclosporine
    Administration route: Oral
    Indication: Prophylaxis Against Graft Versus Host Disease

Cyclosporine
    Indication: Stem Cell Transplant

Methotrexate

Other drugs received by patient: Thiotepa; Acyclovir; Amphotericin B; Sulfamethoxazole and Trimethoprim; Cyclophosphamide; Antibiotics; Immune Globulin NOS



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-14

Patient:

Reactions: Off Label Use, Bacterial Sepsis, Pleural Effusion, Hypoxia

Adverse event resulted in: death

Drug(s) suspected as cause:
Asparaginase
    Dosage: (pegylated) 2500 units/ m2/ dose as 4 weekly doses
    Indication: Acute Lymphocytic Leukaemia

Bortezomib
    Dosage: on days 1, 4, 8 and 11
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: on day 1 and as cns involvement on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: divided into 2 doses for 14 consecutive days
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: over 15-30 minutes on day 1
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Dosage: on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: on day 15 and triple therapy on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: by push day 1, 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-14

Patient:

Reactions: Multi-Organ Failure, Sepsis, Cerebral Ischaemia

Adverse event resulted in: death

Drug(s) suspected as cause:
Asparaginase
    Dosage: 2500 units/m2/dose as 4 weekly doses
    Indication: Acute Lymphocytic Leukaemia

Bortezomib
    Dosage: 1.3 mg/sq.m/dose on days 1, 4, 8 and 11 combined with vxld
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: on day 1 for all patients and on days 8, 15, 22 for cns invlovment
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 10 mg/m2/day divided in to 2 doses for 14 consecutive days
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: on day 1 over 15-30 minutes
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Dosage: on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 1 dose on day 15 for no cns involvement and on days 8, 15, 22 for cns involvement
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2/dose, max. 2 mg, by push on days 1, 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in 79 year old female

Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-14

Patient: 79 year old female, weighing 55.5 kg (122.0 pounds)

Reactions: Haemoglobin Decreased, Fluid Overload, Toxic Epidermal Necrolysis, Atrial Fibrillation, Renal Failure Acute, Pulmonary Fibrosis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Bumetanide

Clarithromycin
    Dosage: 500mg, bid
    Administration route: Oral
    Start date: 2012-05-12
    End date: 2012-05-21

Methotrexate
    Dosage: stopped on admission. pulmonary fibrosis secondary to methotrexate and fluid overload.

Spironolactone

Zocor
    Administration route: Oral

Other drugs received by patient: Clotrimazole; Tramadol HCL; Dalteparin Sodium; Diclofenac Diethylamine; Adcal-D3; Candesartan Cilexetil; Acetaminophen; Fortisip; Adenosine; Folic Acid; Bisoprolol; Dioralyte; Heparin; Amiodarone HCL; Furosemide; Metoclopramide; Acetaminophen and Codeine Phosphate; Warfarin Sodium; Acetaminophen W / Codeine; Omeprazole; Gentamicin; Amoxicillin and Clavulanate Potassium; Teicoplanin



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