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Methotrexate (Methotrexate) - Vomiting - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Vomiting (134)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Methotrexate where reactions include vomiting. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 134   Next >>

Possible Methotrexate side effects in 51 year old female

Reported by a consumer/non-health professional from United States on 2012-08-24

Patient: 51 year old female, weighing 53.0 kg (116.6 pounds)

Reactions: Vomiting, Pneumonia, Pain, Joint Dislocation, Urine Odour Abnormal, RIB Fracture, Thoracic Vertebral Fracture, Inflammation

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Abatacept Subq Injection 125mg / ML
    Dosage: next injection on 13aug2012
    Indication: Rheumatoid Arthritis
    Start date: 2011-12-01

Methotrexate

Prednisone TAB
    Dosage: tapered down to 40 mg, 30 mg, 20 mg and to 10 mg. stayed on 10 mg for a couple of months and 5 mg



Possible Methotrexate side effects in 65 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-08-14

Patient: 65 year old male, weighing 66.0 kg (145.2 pounds)

Reactions: Weight Decreased, Vomiting, Mycobacterium Chelonae Infection, Hyperkalaemia, Hypercreatininaemia, Rectal Haemorrhage, Reticulocyte Count Decreased, Diarrhoea, RED Blood Cell Count Decreased, Megakaryocytes Abnormal, Neutropenia, Thrombocytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clarithromycin
    Dosage: 500 mg, 2x/day
    Start date: 2012-05-31
    End date: 2012-06-26

Ketoprofen
    Dosage: 100-300 mg, daily
    Administration route: Oral
    Indication: Juvenile Arthritis

Methotrexate
    Dosage: 20 mg, weekly
    Administration route: Oral
    Indication: Juvenile Arthritis

Prednisone TAB
    Dosage: 3 mg, daily
    Administration route: Oral
    Indication: Juvenile Arthritis

Zyvox
    Dosage: 7.8 mg/l, unknown
    Start date: 2012-06-28

Zyvox
    Dosage: 600 mg, 2x/day
    Start date: 2012-05-31
    End date: 2012-06-26

Other drugs received by patient: Sertraline; Bisoprolol; Metformin; Tetrazepam; Pantoprazole; Aspegic 1000



Possible Methotrexate side effects in female

Reported by a physician from Japan on 2012-08-13

Patient: female

Reactions: White Blood Cell Count Decreased, Vomiting, Compression Fracture, Platelet Count Decreased, Pancytopenia, Lower Limb Fracture, Decreased Appetite

Drug(s) suspected as cause:
Actemra
    Start date: 2009-03-18
    End date: 2009-04-01

Actemra
    Indication: Rheumatoid Arthritis
    Start date: 2009-02-18
    End date: 2009-02-18

Methotrexate
    Administration route: Oral
    Start date: 2009-04-08
    End date: 2009-04-10

Methotrexate
    Dosage: form reported as peroral agent
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2009-02-04
    End date: 2009-03-12

Other drugs received by patient: Loxonin; Prednisolone; Diovan; Rabeprazole Sodium; Folic Acid; Coniel; Amaryl; Alfarol



Possible Methotrexate side effects in 22 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-10

Patient: 22 year old male, weighing 93.1 kg (204.8 pounds)

Reactions: Abdominal Pain, Vomiting, Nausea, Pain, Hyperglycaemia, Unresponsive To Stimuli, Pancytopenia, Disorientation, Pyrexia, Toxicity To Various Agents, Convulsion, Myalgia, Arthralgia, Chest Pain

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Methotrexate



Possible Methotrexate side effects in 55 year old female

Reported by a consumer/non-health professional from United Kingdom on 2012-08-07

Patient: 55 year old female

Reactions: Malaise, Vomiting, Pain, Thyroid Disorder

Drug(s) suspected as cause:
Methotrexate



Possible Methotrexate side effects in female

Reported by a physician from United States on 2012-08-02

Patient: female, weighing 16.9 kg (37.2 pounds)

Reactions: Paronychia, Vomiting, Stomatitis, Pulmonary Alveolar Haemorrhage, Pyrexia, Loss of Consciousness, Mucosal Inflammation, Respiratory Failure, Hypophagia, Rash Maculo-Papular, Diffuse Alveolar Damage, Oesophageal Ulcer, Staphylococcus Test Positive, Pulseless Electrical Activity

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 1040 mg

Vincristine Sulfate
    Dosage: 5 mg

Other drugs received by patient: Bactrim; Zofran; Ceftazidime; Morphine Sulfate



Possible Methotrexate side effects in female

Reported by a consumer/non-health professional from Brazil on 2012-08-01

Patient: female, weighing 77.0 kg (169.4 pounds)

Reactions: Vomiting, Spinal Pain, Flatulence, Neck Mass, Pyrexia, Upper Extremity Mass, Lower Extremity Mass, Malaise, Diarrhoea, Arthralgia, Swelling, Lymph Node Tuberculosis, Dysuria

Drug(s) suspected as cause:
Humira
    Indication: Rheumatoid Arthritis
    End date: 2011-11-29

Methotrexate
    Dosage: 2 tb am, 2 tb pm, on mondays
    Start date: 2010-09-01

Methotrexate
    Dosage: 4 tablets every monday, once
    Indication: Rheumatoid Arthritis

Other drugs received by patient: Meticorten; Tenoxicam; Meticorten; Losartan Potassium; Hydrochlorothiazide



Possible Methotrexate side effects in female

Reported by a physician from Germany on 2012-07-31

Patient: female, weighing 57.0 kg (125.4 pounds)

Reactions: Abdominal Pain, Malaise, Vomiting, General Physical Health Deterioration, Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Asparaginase

Cytarabine

Methotrexate

Tasigna
    Dosage: 400 mg, bid
    Administration route: Oral
    Start date: 2012-04-16

Tasigna
    Dosage: 400 mg, bid
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-02-14
    End date: 2012-04-14

Other drugs received by patient: Acyclovir; Cotrim



Possible Methotrexate side effects in female

Reported by a individual with unspecified qualification from United States on 2012-07-27

Patient: female, weighing 56.3 kg (123.9 pounds)

Reactions: Blood Bilirubin Increased, Tachycardia, Disseminated Intravascular Coagulation, Pyrexia, Acidosis, Abdominal Tenderness, Labile Blood Pressure, Hypoxia, Unevaluable Event, Blood Creatinine Increased, Epistaxis, Mouth Haemorrhage, Hypotension, Blood Lactate Dehydrogenase Increased, Encephalopathy, Hyperammonaemia, Sinusitis Fungal, Pulseless Electrical Activity, Hepatic Function Abnormal, Skin Exfoliation, Haemorrhage, Mental Status Changes, Serum Ferritin Increased, Oral Herpes, Weight Increased, Dialysis, Tachypnoea, Dizziness, Drug Clearance Decreased, Fluid Overload, Vomiting, Febrile Neutropenia, Hepatic Enzyme Increased, Renal Impairment, Lower Respiratory Tract Infection Fungal, Diarrhoea, Respiratory Failure, Oliguria, Bradycardia, Hypertension, Cardiac Arrest, Klebsiella Test Positive, Nasal Ulcer, Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 15 mg it, : 290mg x2 iv

Vincristine Sulfate
    Dosage: 4 mg iv

Other drugs received by patient: Fluconazole; Amphotericin B; Piperacillin and Tazobactam; Fligrastim; Vancomycin; Valacyclovir Hydrochloride; Dexamethasone; Etoposide



Possible Methotrexate side effects in 53 year old female

Reported by a consumer/non-health professional from Ecuador on 2012-07-20

Patient: 53 year old female

Reactions: Abdominal Pain, Vomiting, Diarrhoea, Dehydration

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Methotrexate
    Indication: Rheumatoid Arthritis

Rituximab
    Dosage: 2 cycles
    Start date: 2011-10-17
    End date: 2011-10-31

Rituximab
    Dosage: 2 cycles
    Indication: Rheumatoid Arthritis
    Start date: 2009-01-01

Other drugs received by patient: Vitamin B Complex CAP; Naproxen; Prednisone; Gemfibrozil



Possible Methotrexate side effects in 68 year old female

Reported by a consumer/non-health professional from Australia on 2012-07-18

Patient: 68 year old female, weighing 84.0 kg (184.8 pounds)

Reactions: Vomiting, Photophobia, Headache, Arthritis, Influenza Like Illness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate

Orencia
    Dosage: last inf:04-jun-2012.
    Indication: Rheumatoid Arthritis
    Start date: 2011-01-24

Prednisolone

Other drugs received by patient: Oxycontin; Amoxicillin; Arava; Nexium; Endep



Possible Methotrexate side effects in

Reported by a physician from United Kingdom on 2012-07-17

Patient:

Reactions: Abdominal Pain, Tachycardia, Skin Toxicity, Pyrexia, Fatigue, Neuropathy Peripheral, Hepatotoxicity, Adverse Event, Dizziness, Oedema, Hallucination, Vomiting, Nausea, Gastrointestinal Toxicity, Neutropenic Sepsis, Nephropathy Toxic, Hypotension, Condition Aggravated, Adult T-Cell Lymphoma / Leukaemia, Mucosal Inflammation, Lung Disorder, Infection, Infusion Related Reaction

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: on day 1 of 21 day cycle, (cycle 1-5)
    Indication: Adult T-Cell Lymphoma / Leukaemia

Cytarabine
    Indication: Adult T-Cell Lymphoma / Leukaemia

Doxorubicin HCL
    Dosage: on day 1 of 21 day, (cycle 1-5)

Doxorubicin HCL
    Dosage: on day 1 of 21 day, (cycle 1-5)
    Indication: Adult T-Cell Lymphoma / Leukaemia

Hydrocortisone
    Indication: Adult T-Cell Lymphoma / Leukaemia

Methotrexate
    Indication: Adult T-Cell Lymphoma / Leukaemia

Prednisolone
    Dosage: on days 1-5 of 21 day cycle, (cycle 1-5)
    Administration route: Oral
    Indication: Adult T-Cell Lymphoma / Leukaemia

Radiotherapy
    Indication: Adult T-Cell Lymphoma / Leukaemia

Vincristine
    Dosage: (maximum 2 mg) on day 1 of 21 day cycle, (cycle 1-5)
    Indication: Adult T-Cell Lymphoma / Leukaemia

Zenapax
    Dosage: on days 7 and 14 on cycle 1 of 21 day cycle
    Indication: Adult T-Cell Lymphoma / Leukaemia

Other drugs received by patient: Acyclovir; Thiabendazole; Cotrim; Itraconazole



Possible Methotrexate side effects in

Reported by a physician from United Kingdom on 2012-07-10

Patient:

Reactions: Abdominal Pain, Skin Toxicity, Tachycardia, Pyrexia, Fatigue, Neuropathy Peripheral, Hepatotoxicity, Adverse Event, Oedema, Dizziness, Hallucination, Vomiting, Gastrointestinal Toxicity, Nausea, Neutropenic Sepsis, Nephropathy Toxic, Hypotension, Adult T-Cell Lymphoma / Leukaemia, Condition Aggravated, Mucosal Inflammation, Lung Disorder, Infection, Infusion Related Reaction

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: on day 1 of 21 day cycle, (cycle 1-5)
    Indication: Adult T-Cell Lymphoma / Leukaemia

Cytarabine
    Indication: Adult T-Cell Lymphoma / Leukaemia

Doxorubicin HCL
    Dosage: on day 1 of 21 day, (cycle 1-5)
    Indication: Adult T-Cell Lymphoma / Leukaemia

Hydrocortisone
    Indication: Adult T-Cell Lymphoma / Leukaemia

Methotrexate
    Indication: Adult T-Cell Lymphoma / Leukaemia

Prednisolone
    Dosage: on days 1-5 of 21 day cycle, (cycle 1-5)
    Administration route: Oral
    Indication: Adult T-Cell Lymphoma / Leukaemia

Radiotherapy
    Indication: Adult T-Cell Lymphoma / Leukaemia

Vincristine
    Dosage: (maximum 2 mg) on day 1 of 21 day cycle, (cycle 1-5)
    Indication: Adult T-Cell Lymphoma / Leukaemia

Zenapax
    Dosage: on days 7 and 14 on cycle 1 of 21 day cycle
    Indication: Adult T-Cell Lymphoma / Leukaemia

Other drugs received by patient: Cotrim; Itraconazole; Thiabendazole; Acyclovir



Possible Methotrexate side effects in female

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-07-06

Patient: female

Reactions: Vomiting, Arachnoiditis, Respiratory Failure, Mental Status Changes, Headache, Progressive Multifocal Leukoencephalopathy

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Methotrexate



Possible Methotrexate side effects in 10 year old female

Reported by a physician from Korea, Democratic People's Republic of on 2012-07-06

Patient: 10 year old female

Reactions: Vomiting, Wernicke's Encephalopathy, Nausea, Malnutrition, Mental Status Changes, Convulsion

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Methotrexate

Other drugs received by patient: Cisplatin; Adriamycin PFS



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-07-05

Patient:

Reactions: Fatigue, Central Nervous System Haemorrhage, Erythema Multiforme, Dyspnoea, Stomatitis, Vomiting, Gastrointestinal Toxicity, Nausea, Condition Aggravated, Rash, Haematotoxicity, Pulmonary Haemorrhage, Tumour Lysis Syndrome, Diarrhoea, Respiratory Failure, Neurological Symptom, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: for 5 days in cycle 1
    Indication: Burkitt's Lymphoma

Cyclophosphamide
    Dosage: days 1-5 during cycle 3,5 and 7

Cyclophosphamide
    Dosage: for 5 days in cycle 1
    Indication: Burkitt's Leukaemia

Cyclophosphamide
    Dosage: days 1-5 during cycle 3,5 and 7

Cytarabine
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Cytarabine
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Lymphoma

Dexamethasone Sodium Phosphate
    Dosage: on days 1-5 of cycle 2,4 and 6

Dexamethasone Sodium Phosphate
    Dosage: on days 1-5 of cycle 2,4 and 6

Dexamethasone Sodium Phosphate
    Dosage: on days 1-5 of cycle 3,5 and 7
    Indication: Burkitt's Leukaemia

Dexamethasone Sodium Phosphate
    Dosage: on days 1-5 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Doxorubicin HCL
    Dosage: on days 4 and 5 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Doxorubicin HCL
    Dosage: on days 4 and 5 of cycle 3,5 and 7
    Indication: Burkitt's Leukaemia

Etoposide
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Lymphoma

Etoposide
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Ifosfamide
    Dosage: on days 1-5 in cycle 2,4 and 6
    Indication: Burkitt's Lymphoma

Ifosfamide
    Dosage: on days 1-5 in cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Methotrexate
    Dosage: on day 1 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Methotrexate
    Dosage: on day 1 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Methotrexate
    Dosage: on day 1 of cycle 3,5 and 7

Methotrexate
    Dosage: on day 1 of cycle 2,4 and 6

Prednisone
    Dosage: for 7 days in cycle 1
    Indication: Burkitt's Lymphoma

Prednisone
    Dosage: for 7 days in cycle 1
    Indication: Burkitt's Leukaemia

Rituximab
    Dosage: on day 8 from cycle 3 to 7

Rituximab
    Dosage: on day 8 from cycle 3 to 7

Rituximab
    Dosage: day 8 on cycle 2; doage increased to 375 mg/m2 on day 10 and 12
    Indication: Burkitt's Leukaemia

Rituximab
    Dosage: day 8 on cycle 2; doage increased to 375 mg/m2 on day 10 and 12
    Indication: Burkitt's Lymphoma

Vincristine
    Dosage: on day 1 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Vincristine
    Dosage: on day 1 of cycle 2,4 and 6

Vincristine
    Dosage: on day 1 of cycle 3,5 and 7

Vincristine
    Dosage: on day 1 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Other drugs received by patient: Filgrastim; Unknown Medication; Leucovorin Calcium



Possible Methotrexate side effects in female

Reported by a individual with unspecified qualification from United States on 2012-07-02

Patient: female, weighing 16.8 kg (37.0 pounds)

Reactions: Pupillary Reflex Impaired, Vomiting, Stomatitis, Retching, Pain, Cardio-Respiratory Arrest, Diarrhoea, Choking

Drug(s) suspected as cause:
Methotrexate

Other drugs received by patient: Zosyn; Dextrose 5% Normal Saline; Zofran



Possible Methotrexate side effects in male

Reported by a individual with unspecified qualification from United States on 2012-06-28

Patient: male, weighing 99.5 kg (218.9 pounds)

Reactions: Vomiting, Fatigue, Nausea, Blood Triglycerides Increased, Asthenia

Drug(s) suspected as cause:
Methotrexate
    Dosage: 570 mg

PEG-L-Asparaginase (K-H)
    Dosage: 5600 unit

Vincristine Sulfate
    Dosage: 4 mg



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-06-28

Patient:

Reactions: Fatigue, Central Nervous System Haemorrhage, Erythema Multiforme, Vomiting, Stomatitis, Dyspnoea, Gastrointestinal Toxicity, Nausea, Condition Aggravated, Rash, Haematotoxicity, Pulmonary Haemorrhage, Tumour Lysis Syndrome, Respiratory Failure, Diarrhoea, Neurological Symptom, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: days 1-5 during cycle 3,5 and 7

Cyclophosphamide
    Dosage: days 1-5 during cycle 3,5 and 7

Cyclophosphamide
    Dosage: for 5 days in cycle 1
    Indication: Burkitt's Leukaemia

Cyclophosphamide
    Dosage: for 5 days in cycle 1
    Indication: Burkitt's Lymphoma

Cytarabine
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Lymphoma

Cytarabine
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Dexamethasone
    Dosage: on days 1-5 of cycle 2,4 and 6

Dexamethasone
    Dosage: on days 1-5 of cycle 2,4 and 6

Dexamethasone
    Dosage: on days 1-5 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Dexamethasone
    Dosage: on days 1-5 of cycle 3,5 and 7
    Indication: Burkitt's Leukaemia

Doxorubicin HCL
    Dosage: on days 4 and 5 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Doxorubicin HCL
    Dosage: on days 4 and 5 of cycle 3,5 and 7
    Indication: Burkitt's Leukaemia

Etoposide
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Etoposide
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Lymphoma

Ifosfamide
    Dosage: on days 1-5 in cycle 2,4 and 6
    Indication: Burkitt's Lymphoma

Ifosfamide
    Dosage: on days 1-5 in cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Methotrexate
    Dosage: on day 1 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Methotrexate
    Dosage: on day 1 of cycle 2,4 and 6

Methotrexate
    Dosage: on day 1 of cycle 3,5 and 7

Methotrexate
    Dosage: on day 1 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Prednisone TAB
    Dosage: for 7 days in cycle 1
    Indication: Burkitt's Leukaemia

Prednisone TAB
    Dosage: for 7 days in cycle 1
    Indication: Burkitt's Lymphoma

Rituximab
    Dosage: on day 8 from cycle 3 to 7

Rituximab
    Dosage: day 8 on cycle 2; doage increased to 375 mg/m2 on day 10 and 12
    Indication: Burkitt's Leukaemia

Rituximab
    Dosage: day 8 on cycle 2; doage increased to 375 mg/m2 on day 10 and 12
    Indication: Burkitt's Lymphoma

Rituximab
    Dosage: on day 8 from cycle 3 to 7

Vincristine
    Dosage: on day 1 of cycle 2,4 and 6

Vincristine
    Dosage: on day 1 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Vincristine
    Dosage: on day 1 of cycle 3,5 and 7

Vincristine
    Dosage: on day 1 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Other drugs received by patient: Unknown Medication; Leucovorin Calcium; Filgrastim



Possible Methotrexate side effects in 14 year old male

Reported by a individual with unspecified qualification from Japan on 2012-06-25

Patient: 14 year old male

Reactions: Dysphagia, Vomiting, Nausea, Hypophagia, Hearing Impaired, Oesophageal Stenosis

Drug(s) suspected as cause:
Cisplatin
    Dosage: 167 mg
    Indication: Bone Sarcoma

Doxorubicin HCL
    Dosage: 42 mg
    Indication: Bone Sarcoma

Etoposide
    Dosage: 84 mg
    Indication: Bone Sarcoma

Ifosfamide
    Dosage: 4200
    Indication: Bone Sarcoma

Methotrexate
    Dosage: 28 mg
    Indication: Bone Sarcoma



Possible Methotrexate side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-25

Patient:

Reactions: Fatigue, Central Nervous System Haemorrhage, Erythema Multiforme, Stomatitis, Vomiting, Dyspnoea, Nausea, Gastrointestinal Toxicity, Condition Aggravated, Rash, Haematotoxicity, Pulmonary Haemorrhage, Tumour Lysis Syndrome, Diarrhoea, Respiratory Failure, Neurological Symptom, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: for 5 days in cycle 1
    Indication: Burkitt's Lymphoma

Cyclophosphamide
    Dosage: days 1-5 during cycle 3,5 and 7

Cyclophosphamide
    Dosage: days 1-5 during cycle 3,5 and 7

Cyclophosphamide
    Dosage: for 5 days in cycle 1
    Indication: Burkitt's Leukaemia

Cytarabine
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Cytarabine
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Lymphoma

Dexamethasone
    Dosage: on days 1-5 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Dexamethasone
    Dosage: on days 1-5 of cycle 2,4 and 6

Dexamethasone
    Dosage: on days 1-5 of cycle 3,5 and 7
    Indication: Burkitt's Leukaemia

Dexamethasone
    Dosage: on days 1-5 of cycle 2,4 and 6

Doxorubicin HCL
    Dosage: on days 4 and 5 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Doxorubicin HCL
    Dosage: on days 4 and 5 of cycle 3,5 and 7
    Indication: Burkitt's Leukaemia

Etoposide
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Lymphoma

Etoposide
    Dosage: on days 4 and 5 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Ifosfamide
    Dosage: on days 1-5 in cycle 2,4 and 6
    Indication: Burkitt's Lymphoma

Ifosfamide
    Dosage: on days 1-5 in cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Methotrexate
    Dosage: on day 1 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Methotrexate
    Dosage: on day 1 of cycle 3,5 and 7

Methotrexate
    Dosage: on day 1 of cycle 2,4 and 6

Methotrexate
    Dosage: on day 1 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Prednisone TAB
    Dosage: for 7 days in cycle 1
    Indication: Burkitt's Lymphoma

Prednisone TAB
    Dosage: for 7 days in cycle 1
    Indication: Burkitt's Leukaemia

Rituximab
    Dosage: on day 8 from cycle 3 to 7

Rituximab
    Dosage: on day 8 from cycle 3 to 7

Rituximab
    Dosage: day 8 on cycle 2; doage increased to 375 mg/m2 on day 10 and 12
    Indication: Burkitt's Leukaemia

Rituximab
    Dosage: day 8 on cycle 2; doage increased to 375 mg/m2 on day 10 and 12
    Indication: Burkitt's Lymphoma

Vincristine
    Dosage: on day 1 of cycle 2,4 and 6
    Indication: Burkitt's Leukaemia

Vincristine
    Dosage: on day 1 of cycle 2,4 and 6

Vincristine
    Dosage: on day 1 of cycle 3,5 and 7

Vincristine
    Dosage: on day 1 of cycle 3,5 and 7
    Indication: Burkitt's Lymphoma

Other drugs received by patient: Unknown Medication; Leucovorin Calcium; Filgrastim



Possible Methotrexate side effects in 14 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-06-22

Patient: 14 year old male

Reactions: Vomiting, Nausea, Hearing Impaired, Oesophageal Stenosis

Drug(s) suspected as cause:
Cisplatin
    Indication: Bone Sarcoma

Doxorubicin HCL
    Indication: Bone Sarcoma

Etoposide
    Dosage: 2,6 courses
    Indication: Bone Sarcoma

Ifosfamide
    Dosage: inj.2,6 courses.
    Indication: Bone Sarcoma

Methotrexate



Possible Methotrexate side effects in 47 year old male

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-06-19

Patient: 47 year old male

Reactions: Mucosal Inflammation, Rash Generalised, Vomiting, Nausea, Pancytopenia, Pyrexia, Toxicity To Various Agents

Drug(s) suspected as cause:
Methotrexate



Possible Methotrexate side effects in 62 year old female

Reported by a physician from Canada on 2012-06-19

Patient: 62 year old female

Reactions: Vomiting, Nausea, Condition Aggravated, Pancytopenia

Drug(s) suspected as cause:
Hydroxychloroquine Sulfate
    Indication: Lupus Nephritis

Methotrexate
    Administration route: Oral
    Indication: Condition Aggravated

Prednisone
    Indication: Lupus Nephritis



Possible Methotrexate side effects in 14 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-06-14

Patient: 14 year old male

Reactions: Vomiting, Nausea, Hearing Impaired, Oesophageal Stenosis

Drug(s) suspected as cause:
Cisplatin
    Dosage: 167mg
    Indication: Bone Sarcoma

Doxorubicin HCL
    Dosage: 42mg
    Indication: Bone Sarcoma

Etoposide
    Dosage: 84mg
    Indication: Bone Sarcoma

Ifosfamide
    Dosage: 4200mg
    Indication: Bone Sarcoma

Methotrexate
    Dosage: 28mg
    Indication: Bone Sarcoma



Possible Methotrexate side effects in 14 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-06-14

Patient: 14 year old male

Reactions: Vomiting, Nausea, Hearing Impaired, Oesophageal Stenosis

Drug(s) suspected as cause:
Cisplatin
    Dosage: 167mg
    Indication: Bone Sarcoma

Doxorubicin HCL
    Dosage: 42mg
    Indication: Bone Sarcoma

Etoposide
    Dosage: 84mg
    Indication: Bone Sarcoma

Ifosfamide
    Dosage: 4200mg
    Indication: Bone Sarcoma

Methotrexate
    Dosage: 28mg
    Indication: Bone Sarcoma



Possible Methotrexate side effects in 14 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-06-14

Patient: 14 year old male

Reactions: Vomiting, Nausea, Hearing Impaired, Oesophageal Stenosis

Drug(s) suspected as cause:
Cisplatin
    Dosage: 167mg
    Indication: Bone Sarcoma

Doxorubicin HCL
    Dosage: 42mg
    Indication: Bone Sarcoma

Etoposide
    Dosage: 84mg
    Indication: Bone Sarcoma

Ifosfamide
    Dosage: 4200mg
    Indication: Bone Sarcoma

Methotrexate
    Dosage: 28mg
    Indication: Bone Sarcoma



Possible Methotrexate side effects in male

Reported by a physician from United States on 2012-06-12

Patient: male, weighing 72.6 kg (159.8 pounds)

Reactions: Abdominal Pain, Vomiting, Stomatitis, Drug Ineffective, Retching, Gastrointestinal Disorder, Unevaluable Event, Muscle Spasms

Drug(s) suspected as cause:
Humira
    Indication: Ankylosing Spondylitis
    Start date: 2008-01-01
    End date: 2008-01-01

Humira
    Start date: 2011-07-01

Humira
    Start date: 2008-01-01
    End date: 2011-07-01

Humira
    Dosage: 40mg qow then 40 mg qweekly
    Start date: 2011-11-08
    End date: 2012-05-08

Methotrexate
    Start date: 2011-07-01

Methotrexate
    Start date: 2007-01-01
    End date: 2007-01-01

Methotrexate
    Indication: Ankylosing Spondylitis
    Start date: 2000-01-01
    End date: 2000-01-01

Other drugs received by patient: Niacin; Wellbutrin; Flexeril; Remeron; Lisinopril; Meloxicam; Simvastatin; Folic Acid; Lisinopril; Prednisone; Aspirin



Possible Methotrexate side effects in male

Reported by a physician from United States on 2012-06-12

Patient: male, weighing 14.6 kg (32.1 pounds)

Reactions: Large Intestine Perforation, Vomiting, Dehydration, Pancytopenia, Pyrexia, Asthenia, Abdominal Tenderness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytarabine
    Dosage: total dose administered 70 mg

Dexamethasone
    Dosage: total dose administered 80 mg

Methotrexate
    Dosage: total dose administered 12 mg

PEG-L-Asparaginase (Pegaspargase, Oncospar)
    Dosage: total dose administered 1550 unit

Vincristine
    Dosage: total dose administered 2.76 mg



Possible Methotrexate side effects in 14 year old male

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-06-11

Patient: 14 year old male

Reactions: Dysphagia, Vomiting, Nausea, Oesophageal Stenosis

Drug(s) suspected as cause:
Cisplatin
    Dosage: 167 mg, unk
    Indication: Bone Sarcoma

Doxorubicin HCL
    Dosage: 42 mg, unk
    Indication: Bone Sarcoma

Etoposide
    Dosage: 84 mg, unk
    Indication: Bone Sarcoma

Ifosfamide
    Dosage: 4200 mg, unk
    Indication: Bone Sarcoma

Methotrexate
    Dosage: 28 mg, unk
    Indication: Bone Sarcoma



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