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Methotrexate (Methotrexate) - Sepsis - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Sepsis (153)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Methotrexate where reactions include sepsis. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 153   Next >>

Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-20

Patient:

Reactions: Multi-Organ Failure, Off Label Use, Sepsis, Cerebral Ischaemia

Adverse event resulted in: death

Drug(s) suspected as cause:
Asparaginase
    Dosage: 2500 units/m2/dose as 4 weekly doses
    Indication: Acute Lymphocytic Leukaemia

Bortezomib
    Dosage: 1.3 mg/sq.m/dose on days 1, 4, 8 and 11 combined with vxld
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: on day 1 for all patients and on days 8, 15, 22 for cns invlovment
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 10 mg/m2/day divided in to 2 doses for 14 consecutive days
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: on day 1 over 15-30 minutes
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Dosage: on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 1 dose on day 15 for no cns involvement and on days 8, 15, 22 for cns involvement
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2/dose, max. 2 mg, by push on days 1, 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in 69 year old female

Reported by a consumer/non-health professional from United States on 2012-08-20

Patient: 69 year old female, weighing 80.7 kg (177.6 pounds)

Reactions: Pneumonia, Hypotension, Anaemia, Encephalopathy, Hyponatraemia, Rheumatoid Arthritis, Sepsis, Dehydration, Altered State of Consciousness, Type 1 Diabetes Mellitus, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cimzia
    Dosage: 400 mug, unk
    Indication: Rheumatoid Arthritis
    Start date: 2012-02-01

Methotrexate
    Dosage: 7.5 mg, unk
    Administration route: Oral
    Indication: Rheumatoid Arthritis

Prednisone TAB
    Dosage: 8 mg, qd
    Administration route: Oral
    Indication: Rheumatoid Arthritis

Prolia
    Dosage: 60 mg, q6mo
    Indication: Osteoporosis Postmenopausal
    Start date: 2010-01-01
    End date: 2012-07-05

Other drugs received by patient: Diovan HCT; Nexium



Possible Methotrexate side effects in

Reported by a physician from United States on 2012-08-14

Patient:

Reactions: Multi-Organ Failure, Sepsis, Cerebral Ischaemia

Adverse event resulted in: death

Drug(s) suspected as cause:
Asparaginase
    Dosage: 2500 units/m2/dose as 4 weekly doses
    Indication: Acute Lymphocytic Leukaemia

Bortezomib
    Dosage: 1.3 mg/sq.m/dose on days 1, 4, 8 and 11 combined with vxld
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: on day 1 for all patients and on days 8, 15, 22 for cns invlovment
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 10 mg/m2/day divided in to 2 doses for 14 consecutive days
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin Hydrochloride
    Dosage: on day 1 over 15-30 minutes
    Indication: Acute Lymphocytic Leukaemia

Hydrocortisone
    Dosage: on days 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 1 dose on day 15 for no cns involvement and on days 8, 15, 22 for cns involvement
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.5 mg/m2/dose, max. 2 mg, by push on days 1, 8, 15 and 22
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in male

Reported by a consumer/non-health professional from United States on 2012-08-02

Patient: male, weighing 119.8 kg (263.5 pounds)

Reactions: Diabetes Mellitus, Abasia, Perineal Cyst, Decreased Immune Responsiveness, Intervertebral Disc Degeneration, Abnormal Loss of Weight, Oxygen Saturation Decreased, Intervertebral Disc Protrusion, Fistula, Gout, Convulsion, Cholelithiasis, Diarrhoea, Sepsis, Heart Rate Increased, Arthritis, Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Colchicine
    Administration route: Oral
    Indication: Gout
    Start date: 2012-05-01

Levemir
    Dosage: 52 units/ at night/subcutaneous
    Indication: Diabetes Mellitus

Methotrexate
    Administration route: Oral
    Indication: Intervertebral Disc Protrusion
    Start date: 2011-01-01
    End date: 2011-01-01

Novolog
    Dosage: 40 units/solution before meals
    Indication: Diabetes Mellitus
    Start date: 2011-01-01
    End date: 2011-01-01

Remicade
    Indication: Crohn's Disease
    Start date: 2004-09-09
    End date: 2010-01-01

Remicade
    Start date: 2010-01-01

Other drugs received by patient: Flomax; Dilaudid; Ambien; Valium; Hydrochlorothiazide; Cymbalta; Lyrica; Lisinopril; Simvastatin; Nexium; Humalog; Onglyza



Possible Methotrexate side effects in 24 year old female

Reported by a consumer/non-health professional from United States on 2012-07-30

Patient: 24 year old female, weighing 51.0 kg (112.2 pounds)

Reactions: Abdominal Pain, Hyperkalaemia, Disseminated Intravascular Coagulation, Gastrointestinal Necrosis, Acidosis, Nephrolithiasis, Skin Discolouration, Ecchymosis, Clostridial Infection, Emphysema, White Blood Cell Count Decreased, Hypotension, Anaemia, Condition Aggravated, Soft Tissue Infection, Sepsis, Flank Pain, Colitis, Cardiac Arrest, Sinus Tachycardia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: last dose on 16jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Cytarabine
    Dosage: last dose:17jun12 route:intra ommya
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Dexamethasone
    Dosage: last dose:16jun12
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Doxorubicin HCL
    Dosage: last dose:17jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Filgrastim
    Dosage: last dose:18jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17
    End date: 2012-01-01

Leucovorin Calcium
    Dosage: last dose :21may12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Mesna
    Dosage: last dose:17jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Methotrexate
    Dosage: last dose:13jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Methylprednisolone
    Dosage: last dose:21may12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Sprycel
    Dosage: last dose on 26jun12
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Vincristine Sulfate
    Dosage: last dose:17jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17



Possible Methotrexate side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-27

Patient: female

Reactions: Iatrogenic Injury, Ischaemic Stroke, Candida Sepsis, Coma, Status Epilepticus, Aplasia, Convulsion, Subarachnoid Haemorrhage, Sepsis, Posterior Reversible Encephalopathy Syndrome, Oedema, Bone Marrow Failure, Candidiasis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytarabine
    Dosage: 40 mg, unk
    Start date: 2012-05-24

Cytarabine
    Dosage: 40 mg, unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-07
    End date: 2012-05-24

Cytarabine
    Dosage: 40 mg, unk
    Start date: 2012-05-17

Imatinib Mesylate
    Dosage: 400 mg, daily
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-10
    End date: 2012-05-26

Methotrexate
    Dosage: 15 mg, unk
    Start date: 2012-05-24

Methotrexate
    Dosage: 15 mg, unk
    Start date: 2012-05-17

Methotrexate
    Dosage: 15 mg, unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-07

Other drugs received by patient: Aspegic 1000; Flagyl; Clonazepam; Fluconazole; Zyvox; Trandate; Amphotericin B; Depakene; Keppra; Idarubicin HCL; Olmesartan Medoxomil and Hydrochlorothizide; Metformin Hydrochloride; Fenofibrate; Vincristine; Vincristine; Vancomycin; Aspegic 1000; Bactrim DS; Mesna; Colimycine; Vibramycin D; Fluconazole; Cyclophosphamide; Cyclophosphamide; Tazobactam; Pyostacine; Idarubicin HCL; Methylprednisolone; Ciprofloxacin Hydrochloride; Heparin Sodium; Idarubicin HCL; Ventolin; Valacyclovir Hydrochloride; Mesna; Amikacin; Imipenem and Cilastatin Sodium; Vfend; Idarubicin HCL; Vincristine; Gentamicin; Rocephin; Fosphenytoin Sodium



Possible Methotrexate side effects in 81 year old female

Reported by a physician from Japan on 2012-07-20

Patient: 81 year old female

Reactions: Death, Bronchopulmonary Aspergillosis, Interstitial Lung Disease, Cerebral Infarction, Sepsis, Oral Disorder, Disseminated Intravascular Coagulation, Bone Marrow Failure, Melaena

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Methotrexate
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-10-01

Remicade
    Indication: Rheumatoid Arthritis



Possible Methotrexate side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-13

Patient: female

Reactions: Ischaemic Stroke, Coma, Status Epilepticus, Aplasia, Convulsion, Subarachnoid Haemorrhage, Posterior Reversible Encephalopathy Syndrome, Sepsis, Oedema, Candidiasis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Depocyt
    Dosage: 40 mg, unk
    Start date: 2012-05-24

Depocyt
    Dosage: 40 mg, unk
    Start date: 2012-05-17

Depocyt
    Dosage: 40 mg, unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-07

Imatinib Mesylate
    Dosage: 400 mg, daily
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-10
    End date: 2012-05-26

Methotrexate
    Dosage: 15 mg, unk
    Start date: 2012-05-17

Methotrexate
    Dosage: 15 mg, unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-07

Methotrexate
    Dosage: 15 mg, unk
    Start date: 2012-05-24

Other drugs received by patient: Aspegic 1000; Bactrim DS; Tazobactam; Imipenem and Cilastatin Sodium; Fluconazole; Amikacin; Vincristine; Vibramycin D; Aspegic 1000; Fosphenytoin Sodium; Keppra; Vincristine; Gentamicin; Cyclophosphamide; Mesna; Colimycine; Pyostacine; Depakene; Iradubicin; Iradubicin; Fluconazole; Vincristine; Methylprednisolone; Ciprofloxacin Hydrochloride; Vancomycin; Mesna; Vfend; Iradubicin; Rocephin; Heparin Sodium; Flagyl; Amphotericin B; Zyvox; Clonazepam; Iradubicin; Valacyclovir Hydrochloride; Cyclophosphamide



Possible Methotrexate side effects in 59 year old male

Reported by a health professional (non-physician/pharmacist) from Croatia (Local Name: Hrvatska) on 2012-07-11

Patient: 59 year old male, weighing 69.0 kg (151.8 pounds)

Reactions: Pneumonia, Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Methotrexate
    Indication: Psoriatic Arthropathy
    Start date: 2003-01-01

Remicade
    Dosage: second dose
    Start date: 2010-07-22

Remicade
    Dosage: seventh dose
    Indication: Psoriatic Arthropathy
    End date: 2011-05-04

Remicade
    Dosage: fourth dose
    Start date: 2010-10-20

Remicade
    Dosage: fifth dose
    Start date: 2010-12-21

Remicade
    Dosage: first dose
    Start date: 2010-07-08

Remicade
    Dosage: third dose
    Start date: 2010-08-23

Remicade
    Dosage: sixth dose
    Start date: 2011-02-16

Other drugs received by patient: Arava; Lubor; Sulfasalazine; Prednisone TAB; Pantoprazole; Folic Acid



Possible Methotrexate side effects in 10 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-10

Patient: 10 year old female

Reactions: Small Intestinal Obstruction, Renal Failure, Sepsis, Febrile Neutropenia, Hypertension, Abdominal Compartment Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 300 mg/m2

Cyclophosphamide
    Dosage: 250 mg/m2, bid for six doses
    Indication: non-Hodgkin's Lymphoma

Cytarabine
    Dosage: 100 mg/m2, daily x 5 days
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Dosage: 30 mg/m2, single
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Dosage: 60 mg/m2, single

Hydrocortisone Acetate
    Dosage: given with methotrexate
    Indication: non-Hodgkin's Lymphoma

Hydrocortisone Acetate
    Dosage: given with cytarabine

Methotrexate
    Dosage: 3000 mg/m2, single

Methotrexate
    Dosage: given with hydrocortisone twice x 2
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Dosage: 1500 mg/m2, single

Prednisolone
    Dosage: 60 mg/m2, daily for 5 days then tapered over 3 days
    Indication: non-Hodgkin's Lymphoma

Prednisolone
    Dosage: 60 mg/m2, daily for 7 days

Rituximab
    Dosage: 1875 mg/m2, every 2-4 weeks for 5 total doses
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Dosage: 2 mg/m2, single

Vincristine
    Dosage: 1 mg/m2, single
    Indication: non-Hodgkin's Lymphoma



Possible Methotrexate side effects in 59 year old male

Reported by a health professional (non-physician/pharmacist) from Croatia (Local Name: Hrvatska) on 2012-07-09

Patient: 59 year old male, weighing 69.0 kg (151.8 pounds)

Reactions: Pneumonia, Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Methotrexate
    Indication: Psoriatic Arthropathy
    Start date: 2003-01-01

Remicade
    Dosage: first dose
    Start date: 2010-07-08

Remicade
    Dosage: fifth dose
    Start date: 2010-12-21

Remicade
    Dosage: fourth dose
    Start date: 2010-10-20

Remicade
    Dosage: third dose
    Start date: 2010-08-23

Remicade
    Dosage: second dose
    Start date: 2010-07-22

Remicade
    Dosage: seventh dose
    Indication: Psoriatic Arthropathy
    End date: 2011-05-04

Remicade
    Dosage: sixth dose
    Start date: 2011-02-16

Other drugs received by patient: Lubor; Folic Acid; Prednisone TAB; Arava; Sulfasalazine; Pantoprazole



Possible Methotrexate side effects in 77 year old male

Reported by a consumer/non-health professional from Japan on 2012-07-06

Patient: 77 year old male, weighing 57.0 kg (125.4 pounds)

Reactions: Sepsis, Circulatory Collapse, Febrile Neutropenia, Pancytopenia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cytarabine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-05-28
    End date: 2010-08-19

Methotrexate
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-05-28
    End date: 2010-08-19

Oncovin
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-08-23
    End date: 2010-08-30

Pinorubin
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-08-23
    End date: 2010-08-25

Prednisolone
    Dosage: 10mg/day 28may10-19aug10,23aug10-31aug10
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-05-28
    End date: 2010-08-31

Sprycel
    Dosage: 70mg 2/1d 28jun-05jul 50mg 1/1d 06jul-22aug10 reduced 140mg to 50mg
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-06-28
    End date: 2010-08-22

Other drugs received by patient: Lasix; Sodium Bicarbonate; Neutrogin; Diamox; Famotidine; Pursennid



Possible Methotrexate side effects in 18 month old male

Reported by a physician from United States on 2012-07-06

Patient: 18 month old male, weighing 11.4 kg (25.1 pounds)

Reactions: Sepsis, Febrile Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Asparaginase
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-04-18

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-04-18

Dexamethasone Sodium Phosphate
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-04-18

Dexamethasone Sodium Phosphate

Etoposide
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-04-18

Hydrocortisone
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-04-18

Lestaurtinib
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-04-18

Lestaurtinib

Mercaptopurine

Mercaptopurine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-04-18

Methotrexate
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-04-18

Methotrexate

Vincristine

Vincristine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2011-04-18



Possible Methotrexate side effects in 10 year old female

Reported by a physician from United States on 2012-07-06

Patient: 10 year old female

Reactions: Small Intestinal Obstruction, Drug Tolerance Decreased, Renal Failure, Sepsis, Pancytopenia, Febrile Neutropenia, Toxicity To Various Agents, Hypertension, Abdominal Compartment Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate

Other drugs received by patient: Methotrexate / Hydrocortisone; Rituximab; Prednisolone; Cyclophosphamide; Doxorubicin HCL; Cytarabine / Hydrocortisone); Vincristine; Cytarabine



Possible Methotrexate side effects in female

Reported by a physician from India on 2012-07-02

Patient: female, weighing 61.5 kg (135.3 pounds)

Reactions: Multi-Organ Failure, Overdose, Sepsis, Bone Marrow Failure, Septic Shock

Adverse event resulted in: death

Drug(s) suspected as cause:
Blinded Gp2013
    Dosage: code not broken
    Start date: 2011-12-20

Blinded Mabthera
    Dosage: code not broken
    Start date: 2011-12-20

Blinded NO Treatment Received
    Dosage: code not broken
    Start date: 2011-12-20

Methotrexate
    Dosage: 20 mg, qw
    Indication: Rheumatoid Arthritis
    Start date: 2010-09-13

Other drugs received by patient: Folic Acid; Prednisolone; Glimepiride W / Metformin; Sulfasalazine; Isoniazid; Iron Pentacarbonyl; Calcium Carbonate; Pyridoxine HCL; Acetaminophen; Rabeprazole Sodium; Telmisartan and Hydrochlorothiazide; Hydroxychloroquine Sulfate; Aceclofenac



Possible Methotrexate side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-29

Patient: female

Reactions: Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: (100 mg/m2 on days 1-14 oral)
    Administration route: Oral
    Indication: Breast Cancer

Fluorouracil
    Dosage: (600 mg/m2 ondays 1 and 8 intravenous (not otherwise specified))
    Indication: Breast Cancer

Methotrexate
    Dosage: (40 mg/m2 on days 1 and 8 intravenous (not otherwise specified))
    Indication: Breast Cancer



Possible Methotrexate side effects in male

Reported by a health professional (non-physician/pharmacist) from Denmark on 2012-06-29

Patient: male

Reactions: Pneumonia, Staphylococcal Infection, Cardiac Failure, Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Actemra
    Dosage: 560 mg hver 4. uge
    Indication: Rheumatoid Arthritis
    Start date: 2010-08-01
    End date: 2012-02-23

Methotrexate
    Indication: Rheumatoid Arthritis
    Start date: 2002-04-04

Prednisolone
    Indication: Rheumatoid Arthritis
    Start date: 2002-04-04



Possible Methotrexate side effects in 14 year old female

Reported by a physician from United States on 2012-06-28

Patient: 14 year old female, weighing 60.4 kg (132.9 pounds)

Reactions: Stomatitis, Hypotension, Encephalopathy, Acidosis, Hypercalcaemia, Respiratory Failure, Sepsis, Posterior Reversible Encephalopathy Syndrome, Hypocalcaemia, Enterocolitis, Cardiac Arrest

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Ambisome
    Dosage: unk
    Indication: Candida Test Positive
    Start date: 2012-05-20

Calcium Gluconate

Cefepime
    Dosage: unk
    Indication: Klebsiella Infection
    Start date: 2012-05-10

Dexamethasone Sodium Phosphate
    Dosage: 10 mg/m2, bid or iv on days 1-5 and 15-19
    Administration route: Oral
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2012-04-30

Methotrexate
    Dosage: 8-15 mg (age based dosing) it on days 1 (or up to 72 hours prior to day 1) and 8
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2012-04-30

Mitoxantrone Hydrochloride
    Dosage: 10 mg/m2, over 30 minutes on days 1 and 2
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2012-04-30

Pegaspargase
    Dosage: 2500 iu/m2 over 1 hr on days 3 and 17
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2012-04-30

Temsirolimus
    Dosage: 7.5 mg/m2, over 30 minutes on days i, 8 and 15 (max dose: 15 mg)
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2012-04-30

Vincristine
    Dosage: 1.5 mg/m2 cyclic (max 2 mg) over i-5 minutes or infusion via mini bag on days 1, 8, i5 and 22
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2012-04-30



Possible Methotrexate side effects in male

Reported by a physician from Denmark on 2012-06-25

Patient: male

Reactions: Pneumonia, Staphylococcal Infection, Cardiac Failure, Sepsis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Actemra
    Dosage: dosis: 560 mg hver 4. uge
    Indication: Rheumatoid Arthritis
    Start date: 2010-08-01
    End date: 2012-02-23

Methotrexate
    Dosage: behandling stoppet pga. mors, drug reported as emthexate
    Indication: Rheumatoid Arthritis
    Start date: 2002-04-04

Prednisolone
    Dosage: behandling stoppet pga. mors
    Indication: Rheumatoid Arthritis
    Start date: 2002-04-04



Possible Methotrexate side effects in 10 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-21

Patient: 10 year old female

Reactions: Small Intestinal Obstruction, Renal Failure, Sepsis, Febrile Neutropenia, Hypertension, Abdominal Compartment Syndrome

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: six doses as part of copadm1 and six doses as part of dose-reduced copadm2

Cyclophosphamide
    Dosage: 300 mg/m2 as part of cop
    Indication: Burkitt's Lymphoma Stage III

Cytarabine
    Dosage: continuous infusion of 100 mg/m2 daily for 5 days
    Indication: Burkitt's Lymphoma Stage III

Cytarabine
    Dosage: administered once with hydrocortisone as part of cym1

Doxorubicin HCL
    Dosage: as part of copadm1
    Indication: Burkitt's Lymphoma Stage III

Doxorubicin HCL
    Dosage: as part of copadm2

Hydrocortisone
    Dosage: administered with methotrexate
    Indication: Burkitt's Lymphoma Stage III

Hydrocortisone
    Dosage: administered once with cytarabine as part of cym1

Methotrexate
    Dosage: 3000 mg/m2; administered with hydrocortisone
    Indication: Burkitt's Lymphoma Stage III

Methotrexate
    Dosage: as part of copadm1

Methotrexate
    Dosage: as part of copadm2 and cym1

Prednisolone
    Dosage: 60 mg/m2/day for 5 days, then tapered over 3 days as part of copadm1 and copadm2

Prednisolone
    Dosage: 60 mg/m2/day for 7 days as part of cop
    Indication: Burkitt's Lymphoma Stage III

Rituximab
    Dosage: five total doses; cumulative dose of 1875 mg/m2
    Indication: Burkitt's Lymphoma Stage III

Vincristine
    Dosage: as part of copadm1

Vincristine
    Dosage: as part of copadm2

Vincristine
    Dosage: as part of cop
    Indication: Burkitt's Lymphoma Stage III



Possible Methotrexate side effects in 10 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-21

Patient: 10 year old female

Reactions: Small Intestinal Obstruction, Renal Failure, Sepsis, Febrile Neutropenia, Hypertension, Abdominal Compartment Syndrome

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 300 mg/m2 as part of cop
    Indication: Burkitt's Lymphoma Stage III

Cyclophosphamide
    Dosage: six doses as part of copadm1 and six doses as part of dose-reduced copadm2

Cytarabine
    Dosage: continuous infusion of 100 mg/m2 daily for 5 days
    Indication: Burkitt's Lymphoma Stage III

Cytarabine
    Dosage: administered once with hydrocortisone as part of cym1

Doxorubicin HCL
    Dosage: as part of copadm1
    Indication: Burkitt's Lymphoma Stage III

Doxorubicin HCL
    Dosage: as part of copadm2

Hydrocortisone
    Dosage: administered once with cytarabine as part of cym1

Hydrocortisone
    Dosage: administered with methotrexate
    Indication: Burkitt's Lymphoma Stage III

Methotrexate
    Dosage: as part of copadm1

Methotrexate
    Dosage: as part of copadm2 and cym1

Methotrexate
    Dosage: administered with hydrocortisone
    Indication: Burkitt's Lymphoma Stage III

Prednisolone
    Dosage: 60 mg/m2/day for 5 days, then tapered over 3 days as part of copadm1 and copadm2

Prednisolone
    Dosage: 60 mg/m2/day for 7 days as part of cop
    Indication: Burkitt's Lymphoma Stage III

Rituximab
    Dosage: five total doses; cumulative dose of 1875 mg/m2
    Indication: Burkitt's Lymphoma Stage III

Vincristine
    Dosage: as part of copadm2

Vincristine
    Dosage: as part of cop
    Indication: Burkitt's Lymphoma Stage III

Vincristine
    Dosage: as part of copadm1



Possible Methotrexate side effects in 10 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-21

Patient: 10 year old female

Reactions: Small Intestinal Obstruction, Renal Failure, Sepsis, Febrile Neutropenia, Hypertension, Abdominal Compartment Syndrome

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: six doses as part of copadm1 and six doses as part of dose-reduced copadm2

Cyclophosphamide
    Dosage: 300 mg/m2 as part of cop
    Indication: Burkitt's Lymphoma Stage III

Cytarabine
    Dosage: continuous infusion of 100 mg/m2 daily for 5 days
    Indication: Burkitt's Lymphoma Stage III

Cytarabine
    Dosage: administered once with hydrocortisone as part of cym1

Doxorubicin HCL
    Dosage: as part of copadm1
    Indication: Burkitt's Lymphoma Stage III

Doxorubicin HCL
    Dosage: as part of copadm2

Hydrocortisone
    Dosage: administered once with cytarabine as part of cym1

Hydrocortisone
    Dosage: administered with methotrexate
    Indication: Burkitt's Lymphoma Stage III

Methotrexate
    Dosage: as part of copadm2 and cym1

Methotrexate
    Dosage: administered with hydrocortisone
    Indication: Burkitt's Lymphoma Stage III

Methotrexate
    Dosage: as part of copadm1

Prednisolone
    Dosage: 60 mg/m2/day for 7 days as part of cop
    Indication: Burkitt's Lymphoma Stage III

Prednisolone
    Dosage: 60 mg/m2/day for 5 days, then tapered over 3 days as part of copadm1 and copadm2

Rituximab
    Dosage: five total doses; cumulative dose of 1875 mg/m2
    Indication: Burkitt's Lymphoma Stage III

Vincristine
    Dosage: as part of copadm2

Vincristine
    Dosage: as part of copadm1

Vincristine
    Dosage: as part of cop
    Indication: Burkitt's Lymphoma Stage III



Possible Methotrexate side effects in 10 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-20

Patient: 10 year old female

Reactions: Small Intestinal Obstruction, Renal Failure, Sepsis, Pancytopenia, Febrile Neutropenia, Hypertension, Abdominal Compartment Syndrome

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 250 mg/m2, bid for 6 doses

Cyclophosphamide
    Dosage: 250 mg/m2, bid for 6 doses

Cyclophosphamide
    Dosage: 300 mg/m2, unk
    Indication: Burkitt's Lymphoma Stage III

Cytarabine
    Dosage: 100 mg/m2, for 5 days
    Indication: Burkitt's Lymphoma Stage III

Cytarabine
    Dosage: unknown

Doxorubicin HCL
    Dosage: 30 mg/m2, unk

Doxorubicin HCL
    Dosage: 60 mg/m2, unk
    Indication: Burkitt's Lymphoma Stage III

Hydrocortisone
    Indication: Burkitt's Lymphoma Stage III

Hydrocortisone
    Dosage: intrathecally twice

Hydrocortisone

Hydrocortisone
    Dosage: intrathecally twice

Hydrocortisone
    Dosage: unknwon

Methotrexate
    Dosage: 1500 mg/m2, unk

Methotrexate
    Indication: Burkitt's Lymphoma Stage III

Methotrexate
    Dosage: intrathecally twice

Methotrexate
    Dosage: intrathecally twice

Methotrexate
    Dosage: 1500 mg/m2, unk

Methotrexate
    Dosage: 30000 mg/m2, unk

Methotrexate

Prednisolone
    Dosage: 60 mg/m2, for 5 days, then taper over 3 days

Prednisolone
    Dosage: 60 mg/m2, for 5 days then taper over 3 days

Prednisolone
    Dosage: 60 mg/m2, per day for 7 days
    Indication: Burkitt's Lymphoma Stage III

Rituximab
    Dosage: every 2-4 weeks for 5 total doses with cumulative dose of 1875 mg/m2
    Indication: Burkitt's Lymphoma Stage III

Rituximab
    Dosage: cumulative dose of 1875 mg/m2

Vincristine
    Dosage: 2 mg/m2, unk

Vincristine
    Dosage: 1 mg/m2, unk
    Indication: Burkitt's Lymphoma Stage III

Vincristine
    Dosage: 1 mg/m2, unk



Possible Methotrexate side effects in male

Reported by a individual with unspecified qualification from Italy on 2012-06-18

Patient: male

Reactions: Epstein-Barr Virus Infection, Diarrhoea, Anaemia, Sepsis, Cytomegalovirus Infection, Neutropenia, Thrombocytopenia, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Cisplatin
    Indication: Burkitt's Lymphoma

Cyclophosphamide
    Indication: Burkitt's Lymphoma

Cytarabine
    Indication: Burkitt's Lymphoma

Doxorubicin Hydrochloride
    Indication: Burkitt's Lymphoma

Etoposide
    Indication: Burkitt's Lymphoma

Mabthera
    Indication: Burkitt's Lymphoma

Methotrexate
    Indication: Burkitt's Lymphoma

Methylprednisolone
    Indication: Burkitt's Lymphoma

Vincristine Sulfate
    Indication: Burkitt's Lymphoma



Possible Methotrexate side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-14

Patient: female

Reactions: Metastases To Liver, Sepsis, Metastases To Skin, Endocarditis, Metastases To Kidney, Metastases To Central Nervous System, Metastases To Lung

Adverse event resulted in: death

Drug(s) suspected as cause:
Cisplatin
    Dosage: on day 1, intravenous (not otherwise specifed)
    Indication: Gestational Trophoblastic Tumour

Cisplatin
    Dosage: on day 1, intravenous (not otherwise specifed)
    Indication: Choriocarcinoma

Dactinomycin
    Dosage: 0.5 mg milligram(s), on day 8, intravenous (not otherwise specified)
    Indication: Choriocarcinoma

Dactinomycin
    Dosage: 0.5 mg milligram(s), on day 8, intravenous (not otherwise specified)
    Indication: Gestational Trophoblastic Tumour

Methotrexate
    Dosage: on day 8
    Indication: Gestational Trophoblastic Tumour

Methotrexate
    Dosage: on day 8
    Indication: Choriocarcinoma



Possible Methotrexate side effects in male

Reported by a physician from Italy on 2012-06-14

Patient: male

Reactions: Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: Burkitt's Lymphoma

Doxorubicin HCL
    Indication: Burkitt's Lymphoma

Etoposide
    Indication: Burkitt's Lymphoma

Methotrexate
    Indication: Burkitt's Lymphoma

Methylprednisolone
    Indication: Burkitt's Lymphoma

Rituximab
    Indication: Burkitt's Lymphoma

Vincristine
    Indication: Burkitt's Lymphoma

Other drugs received by patient: Unknown Medication



Possible Methotrexate side effects in female

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-06-08

Patient: female, weighing 51.7 kg (113.7 pounds)

Reactions: Pneumonia Aspiration, Sepsis, Atrial Fibrillation, Clostridial Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Letrozole
    Dosage: 2.5 mg, qd
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2007-05-24

Methotrexate
    Dosage: 25 ml, qw (q weekly)
    Indication: Rheumatoid Arthritis

Other drugs received by patient: Avapro; Metoprolol; Metoprolol; Norvasc



Possible Methotrexate side effects in female

Reported by a pharmacist from Philippines on 2012-06-06

Patient: female, weighing 48.0 kg (105.6 pounds)

Reactions: Pneumonia, Sepsis

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Golimumab
    Indication: Rheumatoid Arthritis
    Start date: 2008-07-25

Golimumab
    Start date: 2008-05-21

Golimumab
    Start date: 2009-02-25

Golimumab
    Start date: 2008-11-19

Golimumab
    Start date: 2008-10-10

Golimumab
    Start date: 2008-08-13

Golimumab
    Start date: 2008-09-10

Golimumab
    Start date: 2011-07-06

Golimumab
    Start date: 2008-06-21

Methotrexate
    Administration route: Oral
    Start date: 2007-04-05
    End date: 2007-08-30

Methotrexate
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2007-09-06
    End date: 2008-02-25

Methotrexate
    Administration route: Oral
    Start date: 2007-03-29
    End date: 2007-03-29

Methotrexate
    Administration route: Oral
    Start date: 2007-03-22
    End date: 2007-05-22

Methotrexate
    Administration route: Oral
    Start date: 2007-02-22
    End date: 2007-03-01

Methotrexate
    Administration route: Oral
    Start date: 2007-03-08
    End date: 2007-03-15

Other drugs received by patient: Prednisone; Prednisone; Mobic; Folic Acid; Methotrexate; Neurobion; Caltrate Plus



Possible Methotrexate side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-04

Patient:

Reactions: Sepsis, Toxicity To Various Agents

Adverse event resulted in: death

Drug(s) suspected as cause:
Elspar
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: intrathecal
    Indication: Acute Lymphocytic Leukaemia

Prednisolone
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-04

Patient:

Reactions: Sepsis, Toxicity To Various Agents

Adverse event resulted in: death

Drug(s) suspected as cause:
Elspar
    Indication: Lymphocytic Leukaemia

Methotrexate
    Dosage: intrathecal
    Indication: Acute Lymphocytic Leukaemia

Prednisolone
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Indication: Acute Lymphocytic Leukaemia



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