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Methotrexate (Methotrexate) - Pancytopenia - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Pancytopenia (115)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Methotrexate where reactions include pancytopenia. The selected reports were submitted to the FDA during the sample period of about a year.

 Reports 1 - 30 of 115   Next >>

Possible Methotrexate side effects in 69 year old male

Reported by a physician from Switzerland on 2012-08-27

Patient: 69 year old male

Reactions: Mucosal Inflammation, Agranulocytosis, Glomerular Filtration Rate Decreased, Skin Lesion, Toxic Epidermal Necrolysis, Pancytopenia, Melaena, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Aspirin
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-07-22

Doxorubicin HCL
    Dosage: total cumulates dose 880mg
    Indication: Product Used FOR Unknown Indication
    End date: 2012-07-05

Mefenamic Acid
    Dosage: as necessary
    Administration route: Oral
    Indication: Pain
    Start date: 2012-07-05
    End date: 2012-07-22

Mefenamic Acid
    Dosage: as necessary
    Administration route: Oral
    Indication: Pyrexia
    Start date: 2012-07-05
    End date: 2012-07-22

Methotrexate
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-07-18

Methotrexate
    Start date: 2012-07-11

Novalgine
    Dosage: as necessary
    Administration route: Oral
    Indication: Pain
    Start date: 2012-07-05
    End date: 2012-07-22

Novalgine
    Dosage: as necessary
    Administration route: Oral
    Indication: Pyrexia
    Start date: 2012-07-05
    End date: 2012-07-22

Targretin
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Hydrocortisone; Acetaminophen; Fenofibrate; Levothyroxine Sodium; Metformin HCL; Carvedilol



Possible Methotrexate side effects in female

Reported by a physician from Japan on 2012-08-13

Patient: female

Reactions: White Blood Cell Count Decreased, Vomiting, Compression Fracture, Platelet Count Decreased, Pancytopenia, Lower Limb Fracture, Decreased Appetite

Drug(s) suspected as cause:
Actemra
    Start date: 2009-03-18
    End date: 2009-04-01

Actemra
    Indication: Rheumatoid Arthritis
    Start date: 2009-02-18
    End date: 2009-02-18

Methotrexate
    Administration route: Oral
    Start date: 2009-04-08
    End date: 2009-04-10

Methotrexate
    Dosage: form reported as peroral agent
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2009-02-04
    End date: 2009-03-12

Other drugs received by patient: Loxonin; Prednisolone; Diovan; Rabeprazole Sodium; Folic Acid; Coniel; Amaryl; Alfarol



Possible Methotrexate side effects in 22 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-10

Patient: 22 year old male, weighing 93.1 kg (204.8 pounds)

Reactions: Abdominal Pain, Vomiting, Nausea, Pain, Hyperglycaemia, Unresponsive To Stimuli, Pancytopenia, Disorientation, Pyrexia, Toxicity To Various Agents, Convulsion, Myalgia, Arthralgia, Chest Pain

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Methotrexate



Possible Methotrexate side effects in 62 year old female

Reported by a consumer/non-health professional from United States on 2012-08-09

Patient: 62 year old female

Reactions: Heart Rate Increased, Rectal Haemorrhage, Injection Site Pain, Pancytopenia, Epistaxis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Enbrel
    Dosage: 50 mg, qwk
    Indication: Rheumatoid Arthritis
    Start date: 2009-11-06

Methotrexate
    Dosage: unk
    Start date: 2008-12-01



Possible Methotrexate side effects in 65 year old male

Reported by a pharmacist from United States on 2012-08-09

Patient: 65 year old male

Reactions: Neoplasm Malignant, Pancytopenia, Toxicity To Various Agents, Acute Myocardial Infarction

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Methotrexate



Possible Methotrexate side effects in 44 year old female

Reported by a consumer/non-health professional from Japan on 2012-08-03

Patient: 44 year old female, weighing 55.0 kg (121.0 pounds)

Reactions: Pancytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2007-01-01
    End date: 2011-04-01

Orencia
    Dosage: therapy dates: 2mar11,16mar11
    Indication: Rheumatoid Arthritis
    Start date: 2011-02-16

Tacrolimus
    Indication: Rheumatoid Arthritis

Other drugs received by patient: Prednisolone; Voltaren



Possible Methotrexate side effects in 62 year old female

Reported by a physician from United States on 2012-07-26

Patient: 62 year old female

Reactions: White Blood Cell Count Decreased, RED Blood Cell Count Decreased, Rectal Haemorrhage, Heart Rate Increased, Injection Site Pain, Pancytopenia, Platelet Count Decreased, Epistaxis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Enbrel
    Dosage: 50 mg, qwk
    Indication: Rheumatoid Arthritis
    Start date: 2009-11-06

Methotrexate
    Dosage: unk
    Start date: 2008-12-01



Possible Methotrexate side effects in 49 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-25

Patient: 49 year old female

Reactions: Pancytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Start date: 2012-01-28

Methotrexate
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-11-15
    End date: 2011-12-30

Purinethol
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-11-15
    End date: 2011-12-30

Purinethol
    Start date: 2012-01-28

Vesanoid
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    Start date: 2011-11-16
    End date: 2011-12-30

Vesanoid
    Start date: 2012-02-07



Possible Methotrexate side effects in 34 year old male

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-07-24

Patient: 34 year old male

Reactions: Mucosal Inflammation, Incorrect Dose Administered, Pancytopenia, Febrile Neutropenia, Drug Dispensing Error

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate

Other drugs received by patient: Doxorubicin Hydrochloride; Vincristine Sulfate; Mercaptopurine



Possible Methotrexate side effects in 52 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-17

Patient: 52 year old female

Reactions: Multi-Organ Failure, Oesophageal Mass, Acute Myeloid Leukaemia, Pancytopenia, Chloroma

Adverse event resulted in: death

Drug(s) suspected as cause:
Idarubicin HCL
    Dosage: 12 mg/m2, unk
    Indication: Acute Promyelocytic Leukaemia

Mercaptopurine
    Dosage: 50 mg, unk
    Indication: Acute Promyelocytic Leukaemia

Methotrexate
    Dosage: 15 mg/m2, unk
    Indication: Acute Promyelocytic Leukaemia

Mitoxantrone
    Dosage: 10 mg/m2, unk
    Indication: Acute Promyelocytic Leukaemia

Tretinoin
    Dosage: 45 mg/m2, unk
    Administration route: Oral
    Indication: Acute Promyelocytic Leukaemia

Other drugs received by patient: Cytarabine



Possible Methotrexate side effects in 90 year old male

Reported by a pharmacist from United States on 2012-07-13

Patient: 90 year old male, weighing 59.8 kg (131.6 pounds)

Reactions: Pancytopenia, Renal Failure Acute

Drug(s) suspected as cause:
Methotrexate



Possible Methotrexate side effects in male

Reported by a physician from Japan on 2012-07-10

Patient: male

Reactions: Pancytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 300mg per day
    Start date: 2012-03-15
    End date: 2012-03-18

Cyclophosphamide
    Dosage: 1200mg per day
    Indication: Plasmablastic Lymphoma
    Start date: 2012-03-14
    End date: 2012-03-14

Doxorubicin Hydrochloride
    Dosage: 60mg per day
    Indication: Plasmablastic Lymphoma
    Start date: 2012-03-14
    End date: 2012-03-14

Epzicom
    Dosage: 1iuax per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2012-05-11

Isentress
    Dosage: 2iuax per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2012-05-11

Maraviroc
    Dosage: 300mg per day
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2012-05-28

Methotrexate
    Dosage: 2170mg per day
    Indication: Plasmablastic Lymphoma
    Start date: 2012-03-23
    End date: 2012-03-23

Oncovin
    Dosage: 1.5mg per day
    Indication: Plasmablastic Lymphoma
    Start date: 2012-03-14
    End date: 2012-03-14

Oncovin
    Dosage: 1.5mg per day
    Start date: 2012-03-21
    End date: 2012-03-21

Other drugs received by patient: Isotonic Sodium Chloride Solution; Vitamedin; Sulfamethoxazole and Trimethoprim; Nizatidine; Cefazolin Sodium; Fluconazole; Prostarmon.f; Zithromax; Foscavir; Urso 250; Electrolytes + Glucose; Ciprofloxacin; Alendronate Sodium; Pantol; Isotonic Sodium Chloride Solution; TPN Electrolytes IN Plastic Container; Hydrocortone; Kaytwo N; Meropenem; Amikacin Sulfate; Neutrogin



Possible Methotrexate side effects in female

Reported by a physician from United States on 2012-07-09

Patient: female, weighing 94.3 kg (207.5 pounds)

Reactions: Pneumonia, Pancytopenia, Bronchitis, Cardiac Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 25
    Indication: Metastatic Malignant Melanoma
    Start date: 2011-07-31
    End date: 2011-09-15

Vemurafenib
    Dosage: date of last dose prior to sae: 20/mar/2012
    Administration route: Oral
    Indication: Metastatic Malignant Melanoma

Other drugs received by patient: Lasix; Nexium; Topamax; Calcium; Fish OIL; Cymbalta; Arava; Losartan Potassium; Verapamil; Amitriptyline HCL; Multi-Vitamin; Norco; Potassium Sodium Hydrogen Citrate; Ativan; Ascorbic Acid; Clonazepam; Amlodipine



Possible Methotrexate side effects in 55 year old female

Reported by a physician from United Kingdom on 2012-07-06

Patient: 55 year old female

Reactions: Pancytopenia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Methotrexate

Other drugs received by patient: Etoposide; Daunorubicin HCL; Cytarabine; Vincristine; Mercaptopurine



Possible Methotrexate side effects in 44 year old female

Reported by a consumer/non-health professional from Japan on 2012-07-06

Patient: 44 year old female, weighing 55.0 kg (121.0 pounds)

Reactions: Pancytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2007-01-01
    End date: 2011-04-01

Orencia
    Dosage: therapy dates: 2mar11,16mar11
    Indication: Rheumatoid Arthritis
    Start date: 2011-02-16

Tacrolimus
    Indication: Rheumatoid Arthritis

Other drugs received by patient: Voltaren; Prednisolone



Possible Methotrexate side effects in 49 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-06

Patient: 49 year old female

Reactions: Neoplasm Malignant, Swelling, Pancytopenia, Rash, Neurological Symptom, Generalised Oedema

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Carboplatin
    Dosage: 1df=auc5 also auc4
    Indication: Peritoneal Carcinoma Metastatic

Cyclophosphamide
    Dosage: cyclophosphamide hydrate day1 also 600mg/m2
    Indication: Peritoneal Carcinoma Metastatic

Cytarabine
    Indication: Peritoneal Carcinoma Metastatic

Docetaxel
    Indication: Peritoneal Carcinoma Metastatic

Doxil
    Indication: Peritoneal Carcinoma Metastatic

Epirubicin Hydrochloride
    Dosage: day1
    Indication: Peritoneal Carcinoma Metastatic

Irinotecan HCL
    Dosage: on day 1, 15
    Indication: Peritoneal Carcinoma Metastatic

Methotrexate
    Indication: Peritoneal Carcinoma Metastatic

Mitomycin
    Dosage: inj
    Indication: Peritoneal Carcinoma Metastatic

Nedaplatin
    Dosage: also 60mg/m2,12mg/m2(days1-15),120mg/m2
    Indication: Peritoneal Carcinoma Metastatic

Paclitaxel
    Indication: Peritoneal Carcinoma Metastatic

Prednisolone
    Indication: Peritoneal Carcinoma Metastatic



Possible Methotrexate side effects in 77 year old male

Reported by a consumer/non-health professional from Japan on 2012-07-06

Patient: 77 year old male, weighing 57.0 kg (125.4 pounds)

Reactions: Sepsis, Circulatory Collapse, Febrile Neutropenia, Pancytopenia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Cytarabine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-05-28
    End date: 2010-08-19

Methotrexate
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-05-28
    End date: 2010-08-19

Oncovin
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-08-23
    End date: 2010-08-30

Pinorubin
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-08-23
    End date: 2010-08-25

Prednisolone
    Dosage: 10mg/day 28may10-19aug10,23aug10-31aug10
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-05-28
    End date: 2010-08-31

Sprycel
    Dosage: 70mg 2/1d 28jun-05jul 50mg 1/1d 06jul-22aug10 reduced 140mg to 50mg
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-06-28
    End date: 2010-08-22

Other drugs received by patient: Lasix; Sodium Bicarbonate; Neutrogin; Diamox; Famotidine; Pursennid



Possible Methotrexate side effects in 10 year old female

Reported by a physician from United States on 2012-07-06

Patient: 10 year old female

Reactions: Small Intestinal Obstruction, Drug Tolerance Decreased, Renal Failure, Sepsis, Pancytopenia, Febrile Neutropenia, Toxicity To Various Agents, Hypertension, Abdominal Compartment Syndrome

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate

Other drugs received by patient: Methotrexate / Hydrocortisone; Rituximab; Prednisolone; Cyclophosphamide; Doxorubicin HCL; Cytarabine / Hydrocortisone); Vincristine; Cytarabine



Possible Methotrexate side effects in female

Reported by a physician from United States on 2012-07-02

Patient: female, weighing 55.3 kg (121.7 pounds)

Reactions: Arrhythmia Supraventricular, Pancytopenia

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Methotrexate
    Indication: Sarcoidosis
    End date: 2012-04-06

Xarelto
    Administration route: Oral
    Indication: Atrial Fibrillation
    End date: 2012-04-05

Xarelto
    Administration route: Oral
    Start date: 2012-03-09

Other drugs received by patient: Simvastatin; Folic Acid; Multivitamin



Possible Methotrexate side effects in 49 year old female

Reported by a consumer/non-health professional from Japan on 2012-06-25

Patient: 49 year old female

Reactions: Neoplasm Malignant, Swelling, Pancytopenia, Rash, Neurological Symptom, Generalised Oedema

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Carboplatin
    Dosage: 1df=auc5 also auc4
    Indication: Peritoneal Carcinoma Metastatic

Cyclophosphamide
    Dosage: cyclophosphamide hydrate day1 also 600mg/m2
    Indication: Peritoneal Carcinoma Metastatic

Cytarabine
    Indication: Peritoneal Carcinoma Metastatic

Docetaxel
    Indication: Peritoneal Carcinoma Metastatic

Doxil
    Indication: Peritoneal Carcinoma Metastatic

Epirubicin Hydrochloride
    Dosage: day1
    Indication: Peritoneal Carcinoma Metastatic

Irinotecan HCL
    Dosage: on day 1, 15
    Indication: Peritoneal Carcinoma Metastatic

Methotrexate
    Indication: Peritoneal Carcinoma Metastatic

Mitomycin
    Dosage: inj
    Indication: Peritoneal Carcinoma Metastatic

Nedaplatin
    Dosage: also 60mg/m2,12mg/m2(days1-15),120mg/m2
    Indication: Peritoneal Carcinoma Metastatic

Paclitaxel
    Indication: Peritoneal Carcinoma Metastatic

Prednisolone
    Indication: Peritoneal Carcinoma Metastatic



Possible Methotrexate side effects in 10 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-06-20

Patient: 10 year old female

Reactions: Small Intestinal Obstruction, Renal Failure, Sepsis, Pancytopenia, Febrile Neutropenia, Hypertension, Abdominal Compartment Syndrome

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 250 mg/m2, bid for 6 doses

Cyclophosphamide
    Dosage: 250 mg/m2, bid for 6 doses

Cyclophosphamide
    Dosage: 300 mg/m2, unk
    Indication: Burkitt's Lymphoma Stage III

Cytarabine
    Dosage: 100 mg/m2, for 5 days
    Indication: Burkitt's Lymphoma Stage III

Cytarabine
    Dosage: unknown

Doxorubicin HCL
    Dosage: 30 mg/m2, unk

Doxorubicin HCL
    Dosage: 60 mg/m2, unk
    Indication: Burkitt's Lymphoma Stage III

Hydrocortisone
    Indication: Burkitt's Lymphoma Stage III

Hydrocortisone
    Dosage: intrathecally twice

Hydrocortisone

Hydrocortisone
    Dosage: intrathecally twice

Hydrocortisone
    Dosage: unknwon

Methotrexate
    Dosage: 1500 mg/m2, unk

Methotrexate
    Indication: Burkitt's Lymphoma Stage III

Methotrexate
    Dosage: intrathecally twice

Methotrexate
    Dosage: intrathecally twice

Methotrexate
    Dosage: 1500 mg/m2, unk

Methotrexate
    Dosage: 30000 mg/m2, unk

Methotrexate

Prednisolone
    Dosage: 60 mg/m2, for 5 days, then taper over 3 days

Prednisolone
    Dosage: 60 mg/m2, for 5 days then taper over 3 days

Prednisolone
    Dosage: 60 mg/m2, per day for 7 days
    Indication: Burkitt's Lymphoma Stage III

Rituximab
    Dosage: every 2-4 weeks for 5 total doses with cumulative dose of 1875 mg/m2
    Indication: Burkitt's Lymphoma Stage III

Rituximab
    Dosage: cumulative dose of 1875 mg/m2

Vincristine
    Dosage: 2 mg/m2, unk

Vincristine
    Dosage: 1 mg/m2, unk
    Indication: Burkitt's Lymphoma Stage III

Vincristine
    Dosage: 1 mg/m2, unk



Possible Methotrexate side effects in 47 year old male

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-06-19

Patient: 47 year old male

Reactions: Mucosal Inflammation, Rash Generalised, Vomiting, Nausea, Pancytopenia, Pyrexia, Toxicity To Various Agents

Drug(s) suspected as cause:
Methotrexate



Possible Methotrexate side effects in 62 year old female

Reported by a physician from Canada on 2012-06-19

Patient: 62 year old female

Reactions: Vomiting, Nausea, Condition Aggravated, Pancytopenia

Drug(s) suspected as cause:
Hydroxychloroquine Sulfate
    Indication: Lupus Nephritis

Methotrexate
    Administration route: Oral
    Indication: Condition Aggravated

Prednisone
    Indication: Lupus Nephritis



Possible Methotrexate side effects in 49 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-06-15

Patient: 49 year old female

Reactions: Dysphagia, Metastases To Liver, Vith Nerve Paralysis, Paralysis, Pancytopenia, Visual Acuity Reduced, Vocal Cord Paralysis, Metastases To Lymph Nodes, Loss of Consciousness, Disease Progression, Dysphonia, Hearing Impaired, Gait Disturbance, Neurological Symptom, Metastases To Central Nervous System

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytarabine
    Dosage: 40 mg, unk
    Indication: Metastases To Meninges

Doxorubicin HCL
    Dosage: 40 mg/m2, unk
    Indication: Metastases To Meninges

Methotrexate
    Dosage: 15 mg, unk
    Indication: Metastases To Meninges

Prednisolone
    Dosage: 20 mg, unk
    Indication: Metastases To Meninges



Possible Methotrexate side effects in female

Reported by a health professional (non-physician/pharmacist) from Belgium on 2012-06-15

Patient: female

Reactions: Off Label Use, Neutropenic Sepsis, Pancytopenia, Endocarditis, Ototoxicity, Septic Embolus, Diabetic Hyperosmolar Coma

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Carboplatin
    Indication: Metastatic Choriocarcinoma

Cisplatin
    Dosage: on day 1
    Indication: Metastatic Choriocarcinoma

Dactinomycin
    Dosage: on day 8
    Indication: Metastatic Choriocarcinoma

Etoposide
    Dosage: on day 1
    Indication: Metastatic Choriocarcinoma

Methotrexate
    Dosage: on day 8
    Indication: Metastatic Choriocarcinoma

Other drugs received by patient: Allopurinol; Neupogen; Leucovorin Calcium



Possible Methotrexate side effects in 55 year old female

Reported by a physician from United Kingdom on 2012-06-15

Patient: 55 year old female

Reactions: Acute Myeloid Leukaemia, Pancytopenia, Myelodysplastic Syndrome

Drug(s) suspected as cause:
Cytarabine
    Indication: Acute Lymphocytic Leukaemia

Daunorubicin HCL
    Indication: Acute Lymphocytic Leukaemia

Etoposide
    Indication: Acute Lymphocytic Leukaemia

Mercaptopurine
    Dosage: 50 mg
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Vincristine Sulfate
    Indication: Acute Lymphocytic Leukaemia



Possible Methotrexate side effects in female

Reported by a physician from United States on 2012-06-14

Patient: female, weighing 94.3 kg (207.5 pounds)

Reactions: Pneumonia, Pancytopenia, Bronchitis, Cardiac Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 25
    Indication: Metastatic Malignant Melanoma
    Start date: 2011-07-31
    End date: 2011-09-15

Vemurafenib
    Dosage: date of last dose prior to sae: 20/mar/2012
    Administration route: Oral
    Indication: Metastatic Malignant Melanoma

Other drugs received by patient: Clonazepam; Lasix; Arava; Verapamil; Norco; Ascorbic Acid; Calcium; Ativan; Amlodipine; Fish OIL; Cymbalta; Losartan Potassium; Amitriptyline HCL; Multi-Vitamin; Potassium Sodium Hydrogen Citrate; Nexium; Topamax



Possible Methotrexate side effects in female

Reported by a individual with unspecified qualification from United States on 2012-06-13

Patient: female, weighing 94.3 kg (207.5 pounds)

Reactions: Pneumonia, Pancytopenia, Bronchitis, Cardiac Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 25
    Indication: Metastatic Malignant Melanoma
    Start date: 2011-07-31
    End date: 2011-09-15

Vemurafenib
    Dosage: date of last dose prior to sae: 20/mar/2012
    Administration route: Oral
    Indication: Metastatic Malignant Melanoma

Other drugs received by patient: Cymbalta; Nexium; Losartan Potassium; Ascorbic Acid; Clonazepam; Norco; Potassium Sodium Hydrogen Citrate; Topamax; Calcium; Verapamil; Ativan; Multi-Vitamin; Amlodipine; Lasix; Arava; Fish OIL; Amitriptyline HCL



Possible Methotrexate side effects in male

Reported by a physician from United States on 2012-06-12

Patient: male, weighing 14.6 kg (32.1 pounds)

Reactions: Large Intestine Perforation, Vomiting, Dehydration, Pancytopenia, Pyrexia, Asthenia, Abdominal Tenderness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytarabine
    Dosage: total dose administered 70 mg

Dexamethasone
    Dosage: total dose administered 80 mg

Methotrexate
    Dosage: total dose administered 12 mg

PEG-L-Asparaginase (Pegaspargase, Oncospar)
    Dosage: total dose administered 1550 unit

Vincristine
    Dosage: total dose administered 2.76 mg



Possible Methotrexate side effects in 55 year old female

Reported by a individual with unspecified qualification from United Kingdom on 2012-06-11

Patient: 55 year old female

Reactions: Acute Myeloid Leukaemia, Pancytopenia, Myelodysplastic Syndrome, Anaemia Megaloblastic

Drug(s) suspected as cause:
Daunorubicin HCL
    Indication: Acute Lymphocytic Leukaemia

Etoposide
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Other drugs received by patient: Mercaptopurine; Cytarabine; Vincristine



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