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Methotrexate (Methotrexate) - Side Effect Reports to FDA

 
 



This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Methotrexate and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.

Reports by Event Outcome

All Cases (4019)
Death (680)
Life Threatening Events (354)
Disability (141)

Reports by Reaction Type

Pyrexia (208)Pneumonia (195)Nausea (162)Sepsis (153)Diarrhoea (136)Vomiting (134)Anaemia (115)Pancytopenia (115)Neutropenia (111)Dyspnoea (109)Drug Ineffective (103)Infection (101)

Below are a few examples of reports where side effects / adverse reactions may be related to Methotrexate. For a complete list or a specific selection of reports, please use the links above.

Possible Methotrexate side effects in female

Reported by a physician from Canada on 2012-08-27

Patient: female, weighing 56.6 kg (124.5 pounds)

Reactions: Diverticulitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ustekinumab
    Indication: Psoriasis
    Start date: 2012-03-26

Methotrexate
    Indication: Product Used FOR Unknown Indication



Possible Methotrexate side effects in 10 year old male

Reported by a physician from United States on 2012-08-27

Patient: 10 year old male, weighing 76.1 kg (167.4 pounds)

Reactions: Hypersensitivity, Hyperglycaemia, Peripheral Motor Neuropathy

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nelarabine
    Dosage: 650mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-05-22

Cytarabine
    Dosage: 75mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Mercaptopurine
    Dosage: 60mgm2 cyclic
    Administration route: Oral
    Indication: T-Cell Type Acute Leukaemia

PEG-Asparaginase
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-06-13

Methotrexate
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-06-06

Vincristine
    Dosage: 1.5mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-06-13

Cyclophosphamide
    Dosage: 1000mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Other drugs received by patient: Radiation



Possible Methotrexate side effects in 59 year old

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-27

Patient: 59 year old

Reactions: Drug Hypersensitivity

Drug(s) suspected as cause:
Methotrexate
    Dosage: unk

Septra
    Dosage: unk

Phenylephrine Hydrochloride
    Dosage: unk

Chlorpheniramine Maleate
    Dosage: unk

Albuterol Sulfate
    Dosage: unk

Bactrim
    Dosage: unk

Tetracycline Hydrochloride
    Dosage: unk

Chlorpheniramine Maleate
    Dosage: unk

Triprolidine Hydrochloride
    Dosage: unk

Leflunomide
    Dosage: unk

Ceclor
    Dosage: unk

Amlodipine Besylate
    Dosage: unk

Celebrex
    Dosage: unk

Meclizine HCL
    Dosage: unk

Phenylpropanolamine HCL
    Dosage: unk

Naprosyn
    Dosage: unk

Gemifloxacin Mesylate
    Dosage: unk

Sulfanilamide
    Dosage: unk

Astemizole
    Dosage: unk

Lodine
    Dosage: unk

Morphine Sulfate
    Dosage: unk

Fosinopril Sodium
    Dosage: unk

Fluticasone Propionate
    Dosage: unk

Cefadroxil
    Dosage: unk

Cefuroxime
    Dosage: unk

Dexchlorpheniramine Maleate
    Dosage: unk

Moxifloxacin Hydrochloride
    Dosage: unk

Codeine Sulfate
    Dosage: unk

Theophylline
    Dosage: unk

Pseudoephedrine Hydrochloride
    Dosage: unk

Pseudoephedrine Sulfate
    Dosage: unk

Codeine Phosphate
    Dosage: unk

Demerol
    Dosage: unk

Acetaminophen
    Dosage: unk

Oxymetazoline HCL
    Dosage: unk

Methscopolamine Bromide
    Dosage: unk

Phenyltoloxamine
    Dosage: unk

Cromolyn Sodium
    Dosage: unk

Caffeine Citrate
    Dosage: unk

Aspirin
    Dosage: unk



Possible Methotrexate side effects in 69 year old male

Reported by a physician from Switzerland on 2012-08-27

Patient: 69 year old male

Reactions: Mucosal Inflammation, Agranulocytosis, Glomerular Filtration Rate Decreased, Skin Lesion, Toxic Epidermal Necrolysis, Pancytopenia, Melaena, Renal Failure Acute

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mefenamic Acid
    Dosage: as necessary
    Administration route: Oral
    Indication: Pain
    Start date: 2012-07-05
    End date: 2012-07-22

Methotrexate
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-07-18

Doxorubicin HCL
    Dosage: total cumulates dose 880mg
    Indication: Product Used FOR Unknown Indication
    End date: 2012-07-05

Mefenamic Acid
    Dosage: as necessary
    Administration route: Oral
    Indication: Pyrexia
    Start date: 2012-07-05
    End date: 2012-07-22

Targretin
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Aspirin
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication
    End date: 2012-07-22

Novalgine
    Dosage: as necessary
    Administration route: Oral
    Indication: Pain
    Start date: 2012-07-05
    End date: 2012-07-22

Methotrexate
    Start date: 2012-07-11

Novalgine
    Dosage: as necessary
    Administration route: Oral
    Indication: Pyrexia
    Start date: 2012-07-05
    End date: 2012-07-22

Other drugs received by patient: Hydrocortisone; Acetaminophen; Fenofibrate; Levothyroxine Sodium; Metformin HCL; Carvedilol



Possible Methotrexate side effects in female

Reported by a physician from United States on 2012-08-27

Patient: female, weighing 84.9 kg (186.8 pounds)

Reactions: Breast Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-06-15
    End date: 2012-08-01

Avastin
    Dosage: last dose prior to event - 27/jul/2012
    Indication: Breast Cancer
    Start date: 2012-06-15

Cyclophosphamide
    Administration route: Oral
    Indication: Breast Cancer
    Start date: 2012-06-15
    End date: 2012-08-01



Possible Methotrexate side effects in male

Reported by a physician from United States on 2012-08-27

Patient: male, weighing 26.7 kg (58.7 pounds)

Reactions: Crohn's Disease

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Remicade
    Indication: Crohn's Disease

Remicade
    Start date: 2011-12-06

Methotrexate
    Indication: Crohn's Disease
    Start date: 2011-12-04
    End date: 2012-01-20

Remicade

Other drugs received by patient: Multivitamin; Ferrous Sulfate TAB; Cholecalciferol; Cefdinir; Folic Acid; Oxycodone / Acetaminophen; Hydrocortisone; Metronidazole; Calcium Carbonate; Acetaminophen



Possible Methotrexate side effects in 54 year old female

Reported by a physician from Japan on 2012-08-27

Patient: 54 year old female

Reactions: Pneumocystis Jiroveci Pneumonia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Remicade
    Indication: Rheumatoid Arthritis

Methotrexate
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication



Possible Methotrexate side effects in female

Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-27

Patient: female, weighing 51.2 kg (112.6 pounds)

Reactions: Weight Decreased, Nasopharyngitis, Mouth Ulceration, Pain, Psoriasis, Pallor, Dysphonia, Fungal Infection, Asthenia

Drug(s) suspected as cause:
Remicade
    Dosage: has had 20 inflixiamb infusions
    Start date: 2012-08-16

Methotrexate

Remicade
    Dosage: has had 20 inflixiamb infusions
    Indication: Psoriatic Arthropathy
    Start date: 2009-06-17

Methotrexate
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-08-15

Other drugs received by patient: Folic Acid; Pantoprazole Sodium



Possible Methotrexate side effects in 39 year old female

Reported by a consumer/non-health professional from United States on 2012-08-27

Patient: 39 year old female

Reactions: Incorrect Route of Drug Administration, Wrong Technique in Drug Usage Process, Injection Site Haematoma, Adverse Drug Reaction, False Positive Investigation Result, Joint Stiffness, Rheumatoid Arthritis, Malaise, Premature Rupture of Membranes, Umbilical Cord Around Neck, Amniotic Fluid Volume Decreased, Injection Site Induration, Breech Presentation, Drug Effect Decreased, Injection Site Pain, Hormone Level Abnormal, Lung Disorder, Arthralgia, Infertility

Drug(s) suspected as cause:
Methotrexate
    Indication: Product Used FOR Unknown Indication

Humira
    Start date: 2007-08-01
    End date: 2008-12-01

Methotrexate
    End date: 2012-08-10

Humira
    Start date: 2009-08-01

Humira
    Indication: Rheumatoid Arthritis
    Start date: 2006-01-01
    End date: 2007-01-01

Other drugs received by patient: Methotrexate; Hormone Injections; Zyrtec; Prednisone TAB; BCP; Nasonex; Generic FOR Prilosec; Albuterol; Semar



Possible Methotrexate side effects in 45 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-27

Patient: 45 year old female

Reactions: Drug Ineffective, Systemic Lupus Erythematosus, Alopecia, Leukopenia

Drug(s) suspected as cause:
Methotrexate
    Indication: Rheumatoid Arthritis

Infliximab, Recombinant
    Dosage: 0 (initial dose of 3 mg/kg), 2, and 6 weeks and then every 8 weeks
    Indication: Rheumatoid Arthritis



Possible Methotrexate side effects in 13 year old female

Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-08-27

Patient: 13 year old female

Reactions: Intra-Abdominal Haemorrhage, Pruritus, Febrile Neutropenia, Hyperaemia, Thoracic Haemorrhage, Mucosal Inflammation, Haemoglobin Decreased, Tumour Lysis Syndrome, Fungal Oesophagitis, Abdominal Distension, Pulmonary Oedema, Tachypnoea, Platelet Count Decreased, Renal Failure Acute, Blister

Adverse event resulted in: life threatening event

Drug(s) suspected as cause:
Methotrexate

Other drugs received by patient: Etoposide; Cytarabine; Leucovorin Calcium



Possible Methotrexate side effects in

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-08-27

Patient:

Reactions: Acute Graft Versus Host Disease

Adverse event resulted in: death

Drug(s) suspected as cause:
Cyclosporine
    Indication: Prophylaxis

Cyclosporine

Cyclosporine
    Dosage: 1.5 mg/kg, every 12 hours
    Indication: Stem Cell Transplant

Methotrexate
    Dosage: 10 mg/m2, on day 3, 6 and 11 after transplant

Cyclosporine
    Administration route: Oral

Methotrexate
    Dosage: 15 mg/m2, 1 day
    Indication: Prophylaxis Against Graft Versus Host Disease



Possible Methotrexate side effects in male

Reported by a physician from Canada on 2012-08-25

Patient: male

Reactions: Lung Adenocarcinoma Metastatic

Adverse event resulted in: death

Drug(s) suspected as cause:
Abatacept
    Dosage: 125 milligram daily;
    Start date: 2008-06-17

Methotrexate
    Start date: 2010-12-01
    End date: 2012-08-05

Other drugs received by patient: Amlodipine; Folic Acid; Metformin HCL; Telmisartan; Acetylsalicylic Acid SRT; Rosuvastatin; Prednisone TAB



Possible Methotrexate side effects in female

Reported by a physician from United States on 2012-08-24

Patient: female, weighing 91.6 kg (201.6 pounds)

Reactions: Vitamin D Deficiency, Blood Thyroid Stimulating Hormone, Breast Cancer, Bunion, Bladder Prolapse, Lymphadenopathy, Cystitis, Constipation, Therapeutic Response Decreased, Sialoadenitis, Hypertonic Bladder, Hypertension, Thyroid Neoplasm, Haematoma

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Remicade
    Start date: 2003-09-30

Methotrexate
    Indication: Rheumatoid Arthritis
    Start date: 1998-01-01
    End date: 2005-01-01

Remicade
    Indication: Rheumatoid Arthritis
    Start date: 2011-01-01

Remicade
    Start date: 2007-01-01
    End date: 2011-01-01

Remicade
    End date: 2007-01-01

Remicade
    Dosage: approx. no. of infusion 53
    Start date: 2012-05-16

Other drugs received by patient: Calcium; Ascorbic Acid; Docusate; Hydrochlorothiazide; Darvocet-N 50; Enalapril Maleate; Nexium; M.v.i.; Folic Acid; Tylenol; Vesicare; Meloxicam; Lorazepam; Meclizine; Mobic



Possible Methotrexate side effects in female

Reported by a physician from United States on 2012-08-24

Patient: female, weighing 61.7 kg (135.8 pounds)

Reactions: Night Sweats, Malaise, Pyrexia, Chronic Myeloid Leukaemia

Drug(s) suspected as cause:
Humira
    Indication: Rheumatoid Arthritis

Humira
    Indication: Psoriatic Arthropathy
    Start date: 2010-04-01

Methotrexate
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Prednisone TAB; Tasigna; Lyrica; Trazodone HCL; Prednisone TAB; Flonase; Premarin; Cymbalta; Flexeril; Ativan



Possible Methotrexate side effects in 71 year old female

Reported by a physician from Switzerland on 2012-08-24

Patient: 71 year old female

Reactions: Right Ventricular Failure, Aphthous Stomatitis, Bronchitis Chronic, Pulmonary Oedema, Arteriosclerosis Coronary Artery, Pneumonitis

Adverse event resulted in: death

Drug(s) suspected as cause:
Methotrexate

Other drugs received by patient: Folic Acid; Prednisolone; Dexamethasone; Mefenamic Acid; Prednisolone; Diclofenac Sodium



Possible Methotrexate side effects in female

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-08-24

Patient: female

Reactions: Escherichia Urinary Tract Infection, Pyrexia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Simponi
    Indication: Rheumatoid Arthritis
    Start date: 2010-10-01

Methotrexate
    Indication: Rheumatoid Arthritis

Other drugs received by patient: Amitriptyline HCL; Atacand; Dipyrone TAB; Torsemide



Possible Methotrexate side effects in 82 year old female

Reported by a consumer/non-health professional from Sweden on 2012-08-24

Patient: 82 year old female

Reactions: Large Intestinal Ulcer Haemorrhage, Diverticulitis

Drug(s) suspected as cause:
Orencia

Methotrexate



Possible Methotrexate side effects in 66 year old female

Reported by a physician from Czech Republic on 2012-08-24

Patient: 66 year old female, weighing 88.0 kg (193.6 pounds)

Reactions: Asthenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2012-02-16
    End date: 2012-02-23

Methotrexate
    Start date: 2012-03-23

Humira
    Indication: Rheumatoid Arthritis
    Start date: 2012-02-15

Other drugs received by patient: Diclofenac Sodium; Aspirin; Atorvastatin; Gabapentin; Omeprazole; Perindopril Erbumine; Carvedilol; Metoprolol Tartrate; Lansoprazole; Folic Acid



Possible Methotrexate side effects in female

Reported by a physician from Japan on 2012-08-24

Patient: female, weighing 47.0 kg (103.4 pounds)

Reactions: Urinary Tract Infection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Golimumab
    Start date: 2012-06-12

Methotrexate
    Administration route: Oral
    Indication: Rheumatoid Arthritis
    Start date: 2012-03-01
    End date: 2012-03-01

Methotrexate
    Administration route: Oral
    Start date: 2012-04-11
    End date: 2012-04-19

Methotrexate
    Administration route: Oral
    Start date: 2012-05-07

Methotrexate
    Administration route: Oral
    Start date: 2012-03-08
    End date: 2012-03-08

Golimumab
    Start date: 2012-04-17

Golimumab
    Indication: Rheumatoid Arthritis
    Start date: 2011-12-06

Methotrexate
    Administration route: Oral
    Start date: 2012-03-21
    End date: 2012-03-21

Other drugs received by patient: Diclofenac Sodium; Aspara-CA; Edirol; Rebamipide; Sulfasalazine; Mizoribine; Prednisolone; Flurbiprofen; Cetraxate Hydrochloride; Alfacalcidol; Candesartan Cilexetil / Hydrochlorothiazide



Possible Methotrexate side effects in 51 year old female

Reported by a consumer/non-health professional from United States on 2012-08-24

Patient: 51 year old female, weighing 53.0 kg (116.6 pounds)

Reactions: Vomiting, Pneumonia, Pain, Joint Dislocation, Urine Odour Abnormal, RIB Fracture, Thoracic Vertebral Fracture, Inflammation

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Abatacept Subq Injection 125mg / ML
    Dosage: next injection on 13aug2012
    Indication: Rheumatoid Arthritis
    Start date: 2011-12-01

Methotrexate

Prednisone TAB
    Dosage: tapered down to 40 mg, 30 mg, 20 mg and to 10 mg. stayed on 10 mg for a couple of months and 5 mg



Possible Methotrexate side effects in 43 year old female

Reported by a consumer/non-health professional from Argentina on 2012-08-23

Patient: 43 year old female

Reactions: Bronchopneumonia, Immune System Disorder, Application Site Pain, White Blood Cell Count Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Enbrel
    Dosage: 50 mg, every 15 days
    Indication: Rheumatoid Arthritis
    Start date: 2007-03-03
    End date: 2012-05-01

Methotrexate
    Dosage: unk



Possible Methotrexate side effects in 53 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-08-23

Patient: 53 year old male

Reactions: Weight Increased, Oedema Peripheral, Nephrotic Syndrome, Glomerulonephritis Membranous, Small Cell Lung Cancer Stage Unspecified

Drug(s) suspected as cause:
Prednisolone
    Indication: Rheumatoid Arthritis

Methotrexate
    Indication: Rheumatoid Arthritis

Tofacitinib Citrate
    Indication: Rheumatoid Arthritis



Possible Methotrexate side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-08-23

Patient: 54 year old male, weighing 80.0 kg (176.0 pounds)

Reactions: Chronic Myeloid Leukaemia

Drug(s) suspected as cause:
Enbrel
    Dosage: daily dose: 50 mg millgram(s) every weeks
    Indication: Polyarthritis
    Start date: 2001-03-05

Methotrexate
    Dosage: daily dose: 15 mg millgram(s) every weeks
    Indication: Product Used FOR Unknown Indication
    Start date: 1998-01-01

Other drugs received by patient: Diclofenac Sodium; Prednisone TAB



Possible Methotrexate side effects in 62 year old female

Reported by a consumer/non-health professional from United States on 2012-08-23

Patient: 62 year old female

Reactions: Thyroid Cancer Recurrent

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Start date: 2008-01-01
    End date: 2008-03-01

Mabthera
    Indication: Rheumatoid Arthritis
    Start date: 2009-09-01
    End date: 2010-03-01

Abatacept
    Indication: Rheumatoid Arthritis
    Start date: 2009-09-01
    End date: 2010-03-01

Methotrexate
    Indication: Rheumatoid Arthritis
    Start date: 2008-04-01
    End date: 2009-11-01

Tocilizumab
    Indication: Rheumatoid Arthritis
    Start date: 2010-04-01
    End date: 2010-11-01

Golimumab
    Indication: Rheumatoid Arthritis
    Start date: 2010-11-01
    End date: 2011-02-01

Other drugs received by patient: Leflunomide; Etanercept; Etanercept; Levothyroxine Sodium; Metformin



Possible Methotrexate side effects in 54 year old male

Reported by a health professional (non-physician/pharmacist) from Germany on 2012-08-23

Patient: 54 year old male, weighing 80.0 kg (176.0 pounds)

Reactions: Chronic Myeloid Leukaemia

Drug(s) suspected as cause:
Enbrel
    Dosage: daily dose: 50 mg millgram(s) every weeks
    Indication: Polyarthritis
    Start date: 2001-03-05

Methotrexate
    Dosage: daily dose: 15 mg millgram(s) every weeks
    Indication: Product Used FOR Unknown Indication
    Start date: 1998-01-01

Other drugs received by patient: Diclofenac Sodium; Prednisone TAB



Possible Methotrexate side effects in male

Reported by a physician from Netherlands on 2012-08-22

Patient: male, weighing 65.0 kg (143.0 pounds)

Reactions: Confusional State, Hepatic Enzyme Abnormal, Disorientation

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Etoposide
    Dosage: 212 mg, unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-07-28

Prednisolone
    Dosage: 55 mg, bid
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-06

Cytarabine
    Dosage: 360 mg, unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-07-28

Methotrexate
    Dosage: 900 mg, unk
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-07-31

Methotrexate
    Dosage: 15 mg, unk
    Start date: 2012-08-06

Clofarabine
    Dosage: 57 mg, qd
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-06-06

Other drugs received by patient: Esomeprazole Sodium; Oxazepam; Fluconazole



Possible Methotrexate side effects in male

Reported by a physician from United States on 2012-08-22

Patient: male, weighing 78.0 kg (171.6 pounds)

Reactions: Pain in Extremity, Hypotension, Splenic Infarction, Paraesthesia, Septic Embolus, Fungal Test Positive, Hypoxia, Circulatory Collapse, Asthenia, Cough

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 30 m, intrathecal
    End date: 2012-08-09

Prednisone
    Dosage: 3360 mg, oral
    Administration route: Oral
    End date: 2012-08-08

PEG-L-Asparaginase (Pegaspargase, Oncospar)
    Dosage: 4900 iu, intravenous
    End date: 2012-07-15

Cytarabine
    Dosage: 70 mg, intrathecal
    End date: 2012-07-12

Daunorubicin HCL
    Dosage: 200 mg
    End date: 2012-08-02



Possible Methotrexate side effects in male

Reported by a physician from Germany on 2012-08-22

Patient: male

Reactions: Metastatic Bronchial Carcinoma

Adverse event resulted in: death

Drug(s) suspected as cause:
Golimumab
    Indication: Polyarthritis
    Start date: 2011-03-01
    End date: 2011-08-01

Sulfasalazine
    Indication: Polyarthritis
    Start date: 2009-07-01
    End date: 2011-03-01

Abatacept
    Indication: Polyarthritis
    Start date: 2007-12-01
    End date: 2008-06-01

Anakinra
    Indication: Polyarthritis
    Start date: 2008-08-01
    End date: 2008-10-01

Roactemra
    Indication: Polyarthritis
    Start date: 2009-03-01
    End date: 2009-06-01

Methotrexate
    Indication: Polyarthritis
    Start date: 2003-11-01
    End date: 2008-09-01

Methotrexate
    Start date: 2009-05-01

Certolizumab Pegol
    Indication: Polyarthritis
    Start date: 2011-09-01
    End date: 2011-10-01

Adalimumab
    Indication: Polyarthritis
    Start date: 2006-08-01
    End date: 2007-01-01



Possible Methotrexate side effects in female

Reported by a consumer/non-health professional from Brazil on 2012-08-22

Patient: female

Reactions: Autoimmune Disorder, Skin Discolouration, Blood Thyroid Stimulating Hormone Increased, Injection Site Nodule

Drug(s) suspected as cause:
Rebif
    Indication: Product Used FOR Unknown Indication
    Start date: 2012-04-01

Amlodipine
    Indication: Autoimmune Disorder

Prednisone TAB
    Indication: Autoimmune Disorder

Methotrexate
    Indication: Autoimmune Disorder

Hydroxychloroquine Sulfate
    Indication: Autoimmune Disorder

Spironolactone
    Indication: Autoimmune Disorder

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