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Mesna (Mesna) - Off Label Use - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Off Label Use (15)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Mesna where reactions include off label use. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Mesna side effects in

Reported by a health professional (non-physician/pharmacist) from China on 2012-05-11

Patient:

Reactions: Hypersensitivity, Petechiae, Off Label Use, Neurotoxicity, Hepatotoxicity, Granulocytopenia, Bone Marrow Failure, White Blood Cell Count Decreased, Gastrointestinal Toxicity, Anaemia, Nephropathy Toxic, Urinary Tract Infection, Toxicity To Various Agents, Soft Tissue Infection, Sepsis, Platelet Count Decreased, Infection

Drug(s) suspected as cause:
Mesna
    Indication: Acute Myeloid Leukaemia

Epirubicin
    Indication: non-Hodgkin's Lymphoma

Epirubicin
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: Acute Lymphocytic Leukaemia

Vindesine
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Indication: Acute Lymphocytic Leukaemia

Vindesine
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: non-Hodgkin's Lymphoma

Mesna
    Indication: non-Hodgkin's Lymphoma

Other drugs received by patient: Leucovorin Calcium



Possible Mesna side effects in

Reported by a health professional (non-physician/pharmacist) from China on 2012-05-11

Patient:

Reactions: Neurotoxicity, Off Label Use

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Indication: Acute Lymphocytic Leukaemia

Vindesine
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: non-Hodgkin's Lymphoma

Epirubicin
    Indication: Acute Lymphocytic Leukaemia

Mesna
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Indication: Acute Lymphocytic Leukaemia

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Indication: non-Hodgkin's Lymphoma

Cytarabine
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Indication: non-Hodgkin's Lymphoma

Epirubicin
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: non-Hodgkin's Lymphoma

Mesna
    Indication: Acute Myeloid Leukaemia

Vindesine
    Indication: non-Hodgkin's Lymphoma

Other drugs received by patient: Leucovorin Calcium



Possible Mesna side effects in

Reported by a health professional (non-physician/pharmacist) from China on 2012-05-11

Patient:

Reactions: Off Label Use, Pulmonary Toxicity

Drug(s) suspected as cause:
Vincristine
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Mesna
    Indication: Acute Myeloid Leukaemia

Vincristine
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia

Mesna
    Indication: non-Hodgkin's Lymphoma

Cytarabine
    Indication: non-Hodgkin's Lymphoma

Cytarabine
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Indication: Acute Lymphocytic Leukaemia

Vindesine
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin HCL
    Indication: Acute Lymphocytic Leukaemia

Vindesine
    Indication: non-Hodgkin's Lymphoma

Other drugs received by patient: Leucovorin Calcium



Possible Mesna side effects in

Reported by a health professional (non-physician/pharmacist) from China on 2012-05-11

Patient:

Reactions: Off Label Use, Hepatotoxicity

Drug(s) suspected as cause:
Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: Acute Lymphocytic Leukaemia

Mesna
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Indication: Acute Lymphocytic Leukaemia

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: non-Hodgkin's Lymphoma

Vindesine
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: non-Hodgkin's Lymphoma

Vindesine
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Indication: non-Hodgkin's Lymphoma

Mesna
    Indication: Acute Myeloid Leukaemia

Other drugs received by patient: Leucovorin Calcium



Possible Mesna side effects in

Reported by a health professional (non-physician/pharmacist) from China on 2012-05-11

Patient:

Reactions: Off Label Use, Hepatotoxicity

Drug(s) suspected as cause:
Doxorubicin HCL
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma

Epirubicin
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Dosage: cycle 1
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: cycle 1
    Indication: Acute Lymphocytic Leukaemia

Mesna
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma

Mesna
    Dosage: cycle 1
    Indication: Acute Myeloid Leukaemia

Doxorubicin HCL
    Dosage: cycle 1
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Dosage: cycle 1
    Indication: Acute Lymphocytic Leukaemia

Vindesine
    Dosage: cycle 1
    Indication: Acute Lymphocytic Leukaemia

Epirubicin
    Dosage: cycle 1
    Indication: Acute Lymphocytic Leukaemia

Cyclophosphamide
    Dosage: cycle 1
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma

Vindesine
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Dosage: cycle 1
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Dosage: cycle 1
    Indication: non-Hodgkin's Lymphoma

Other drugs received by patient: Leucovorin Calcium



Possible Mesna side effects in

Reported by a health professional (non-physician/pharmacist) from China on 2012-05-10

Patient:

Reactions: Hypersensitivity, Neurotoxicity, Off Label Use, Hepatotoxicity, Granulocytopenia, Bone Marrow Failure, White Blood Cell Count Decreased, Gastrointestinal Toxicity, Nephropathy Toxic, Urinary Tract Infection, Anaemia, Soft Tissue Infection, Acute Lymphocytic Leukaemia, Sepsis, Platelet Count Decreased, Infection

Adverse event resulted in: death

Drug(s) suspected as cause:
Cytarabine
    Indication: Acute Lymphocytic Leukaemia

Mesna
    Indication: Acute Myeloid Leukaemia

Methotrexate
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Mesna
    Indication: non-Hodgkin's Lymphoma

Vindesine
    Indication: Acute Lymphocytic Leukaemia

Vindesine
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone TAB
    Indication: non-Hodgkin's Lymphoma

Dexamethasone TAB
    Indication: Acute Lymphocytic Leukaemia

Other drugs received by patient: Leucovorin Calcium



Possible Mesna side effects in

Reported by a health professional (non-physician/pharmacist) from China on 2012-05-10

Patient:

Reactions: Off Label Use, Nephropathy Toxic

Drug(s) suspected as cause:
Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Indication: non-Hodgkin's Lymphoma

Cytarabine
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Indication: non-Hodgkin's Lymphoma

Mesna
    Indication: Acute Myeloid Leukaemia

Epirubicin
    Indication: Acute Myeloid Leukaemia

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Mesna
    Indication: non-Hodgkin's Lymphoma

Vindesine
    Indication: non-Hodgkin's Lymphoma

Vindesine
    Indication: Acute Lymphocytic Leukaemia

Epirubicin
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Indication: Acute Lymphocytic Leukaemia

Other drugs received by patient: Leucovorin Calcium



Possible Mesna side effects in

Reported by a health professional (non-physician/pharmacist) from China on 2012-05-10

Patient:

Reactions: Off Label Use, Nephropathy Toxic

Drug(s) suspected as cause:
Doxorubicin HCL
    Indication: Acute Lymphocytic Leukaemia

Epirubicin
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Vindesine
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone TAB
    Indication: Acute Lymphocytic Leukaemia

Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Mesna
    Indication: Acute Myeloid Leukaemia

Vindesine
    Indication: Acute Lymphocytic Leukaemia

Mesna
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone TAB
    Indication: non-Hodgkin's Lymphoma

Epirubicin
    Indication: Acute Lymphocytic Leukaemia



Possible Mesna side effects in 6 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-05-07

Patient: 6 year old female

Reactions: Off Label Use, Gastrointestinal Ischaemia, Pyrexia, Leukopenia, Hodgkin's Disease

Drug(s) suspected as cause:
Vinorelbine
    Indication: Hodgkin's Disease

Vinorelbine
    Indication: Diffuse Large B-Cell Lymphoma

Ifosfamide
    Indication: Hodgkin's Disease

Ifosfamide
    Indication: Diffuse Large B-Cell Lymphoma

Mesna
    Indication: Diffuse Large B-Cell Lymphoma

Mesna
    Indication: Hodgkin's Disease

Filgrastim (Filgrastim) [ Regimen #1
    Indication: Diffuse Large B-Cell Lymphoma

Filgrastim (Filgrastim) [ Regimen #1
    Indication: Hodgkin's Disease



Possible Mesna side effects in

Reported by a physician from Norway on 2012-03-07

Patient:

Reactions: Stomatitis, Haematuria, Haemoglobin Abnormal, Pyrexia, Platelet Disorder, Blood Creatinine Abnormal, Transaminases Abnormal, Off Label Use, White Blood Cell Count Abnormal, Hospitalisation

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL
    Indication: Sarcoma

Mesna

Ifosfamide
    Indication: Sarcoma

Ifosfamide

Mesna
    Indication: Sarcoma

Doxorubicin HCL

Ifosfamide

Radiation Therapy NOS
    Indication: Sarcoma

Doxorubicin HCL

Mesna



Possible Mesna side effects in

Reported by a physician from Norway on 2012-03-02

Patient:

Reactions: Off Label Use, Hospitalisation

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL
    Indication: Sarcoma

Ifosfamide

Mesna

Doxorubicin HCL

Doxorubicin HCL

Ifosfamide

Mesna

Mesna

Doxorubicin HCL

Doxorubicin HCL

Ifosfamide

Ifosfamide
    Indication: Sarcoma

Ifosfamide

Ifosfamide

Mesna
    Indication: Sarcoma

Mesna

Mesna

Doxorubicin HCL

Radiation Therapy NOS
    Indication: Sarcoma



Possible Mesna side effects in

Reported by a physician from Norway on 2012-03-01

Patient:

Reactions: Stomatitis, Haemoglobin Abnormal, Haematuria, Pyrexia, Platelet Disorder, Blood Creatinine Abnormal, Transaminases Abnormal, Off Label Use, Hospitalisation, White Blood Cell Count Abnormal

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL

Ifosfamide

Mesna
    Indication: Sarcoma

Ifosfamide

Radiation Therapy NOS
    Indication: Sarcoma

Ifosfamide
    Indication: Sarcoma

Doxorubicin HCL
    Indication: Sarcoma

Mesna

Doxorubicin HCL

Mesna



Possible Mesna side effects in

Reported by a physician from Norway on 2012-02-29

Patient:

Reactions: Off Label Use, Nephropathy Toxic

Adverse event resulted in: death

Drug(s) suspected as cause:
Doxorubicin HCL

Doxorubicin HCL
    Indication: Sarcoma

Ifosfamide
    Indication: Sarcoma

Ifosfamide

Ifosfamide

Mesna

Doxorubicin HCL

Mesna
    Indication: Sarcoma

Mesna

Radiation Therapy NOS
    Indication: Sarcoma



Possible Mesna side effects in

Reported by a physician from Norway on 2012-02-29

Patient:

Reactions: Off Label Use, Blood Creatinine Abnormal

Adverse event resulted in: death

Drug(s) suspected as cause:
Doxorubicin HCL

Ifosfamide
    Indication: Sarcoma

Radiation Therapy NOS
    Indication: Sarcoma

Doxorubicin HCL

Ifosfamide

Mesna

Mesna
    Indication: Sarcoma

Ifosfamide

Doxorubicin HCL
    Indication: Sarcoma

Mesna



Possible Mesna side effects in 44 year old male

Reported by a health professional (non-physician/pharmacist) on 2011-12-01

Patient: 44 year old male

Reactions: Off Label Use, Neoplasm Recurrence, Burkitt's Lymphoma, Urinary Retention, Cerebral Toxoplasmosis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL
    Dosage: day 1
    Indication: Burkitt's Lymphoma

Cytarabine
    Dosage: 2g/m2 i.v. and 70mg i.t.
    Indication: Burkitt's Lymphoma

Rituximab
    Indication: Burkitt's Lymphoma

Mesna
    Indication: Burkitt's Lymphoma

Ifosfamide
    Indication: Burkitt's Lymphoma

Methotrexate
    Indication: Burkitt's Lymphoma

Cyclophosphamide
    Indication: Burkitt's Lymphoma

Neupogen
    Indication: Burkitt's Lymphoma

Etoposide
    Dosage: days 1-5
    Indication: Burkitt's Lymphoma

Vincristine
    Dosage: days 1, 8 and 15
    Indication: Burkitt's Lymphoma

Other drugs received by patient: Lopinavir; Tenofovir Disoproxil Fumarate; Trimethoprim + Sulfamethoxazole; Leucovorin Calcium; Azithromycin; Emtricitabine

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