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Mesna (Mesna) - Hypotension - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Hypotension (17)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Mesna where reactions include hypotension. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Mesna side effects in 24 year old female

Reported by a consumer/non-health professional from United States on 2012-07-30

Patient: 24 year old female, weighing 51.0 kg (112.2 pounds)

Reactions: Abdominal Pain, Hyperkalaemia, Disseminated Intravascular Coagulation, Gastrointestinal Necrosis, Acidosis, Nephrolithiasis, Skin Discolouration, Ecchymosis, Clostridial Infection, Emphysema, White Blood Cell Count Decreased, Hypotension, Anaemia, Condition Aggravated, Soft Tissue Infection, Sepsis, Flank Pain, Colitis, Cardiac Arrest, Sinus Tachycardia

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Sprycel
    Dosage: last dose on 26jun12
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Cytarabine
    Dosage: last dose:17jun12 route:intra ommya
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Vincristine Sulfate
    Dosage: last dose:17jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Filgrastim
    Dosage: last dose:18jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17
    End date: 2012-01-01

Leucovorin Calcium
    Dosage: last dose :21may12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Methotrexate
    Dosage: last dose:13jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Dexamethasone
    Dosage: last dose:16jun12
    Administration route: Oral
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Doxorubicin HCL
    Dosage: last dose:17jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Mesna
    Dosage: last dose:17jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Cyclophosphamide
    Dosage: last dose on 16jun12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17

Methylprednisolone
    Dosage: last dose:21may12
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2012-05-17



Possible Mesna side effects in male

Reported by a pharmacist from United States on 2012-06-29

Patient: male, weighing 21.3 kg (46.9 pounds)

Reactions: B-Cell Lymphoma, Hypotension, Alanine Aminotransferase Increased, Pancytopenia, Roseolovirus Test Positive, Aspartate Aminotransferase Increased, Venoocclusive Liver Disease, Acute Respiratory Distress Syndrome, Renal Failure Acute

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Fludarabine Phosphate
    Indication: Product Used FOR Unknown Indication

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: B-Cell Lymphoma
    Start date: 2011-12-27
    End date: 2012-01-16

Mesna
    Indication: Product Used FOR Unknown Indication

Cyclophosphamide
    Indication: Product Used FOR Unknown Indication



Possible Mesna side effects in male

Reported by a consumer/non-health professional from United States on 2012-05-25

Patient: male, weighing 21.3 kg (46.9 pounds)

Reactions: B-Cell Lymphoma, Hypotension, Alanine Aminotransferase Increased, Pancytopenia, Roseolovirus Test Positive, Aspartate Aminotransferase Increased, Venoocclusive Liver Disease, Acute Respiratory Distress Syndrome, Renal Failure Acute

Adverse event resulted in: death, life threatening event, hospitalization

Drug(s) suspected as cause:
Mesna
    Indication: Product Used FOR Unknown Indication

Fludarabine Phosphate
    Indication: Product Used FOR Unknown Indication

Velcade
    Dosage: 1.3 mg/m2, cyclic
    Indication: B-Cell Lymphoma
    Start date: 2011-12-27
    End date: 2012-01-06

Cytoxan
    Indication: Product Used FOR Unknown Indication



Possible Mesna side effects in female

Reported by a individual with unspecified qualification from United States on 2012-05-22

Patient: female, weighing 12.4 kg (27.3 pounds)

Reactions: Dyspnoea, Vomiting, Hypotension, Unresponsive To Stimuli, Hypercapnia, Neoplasm Progression, Mental Status Changes, Acute Respiratory Distress Syndrome, Pleural Effusion, Radiation Pneumonitis, Apnoea, Metastases To Lung, Oxygen Saturation Decreased, Cough, Shock

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin Hydrochloride
    Dosage: 27 mg

Cytoxan
    Dosage: 36 mg

Mesna
    Dosage: 145 mg

Vincristine Sulfate
    Dosage: .9 mg



Possible Mesna side effects in 31 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-02-02

Patient: 31 year old male

Reactions: Pneumonia, Syncope, Fatigue, Anaemia, Hypotension, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 420 mg, unk
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Dosage: 2 mg, unk
    Indication: non-Hodgkin's Lymphoma

Rituxan
    Dosage: 788 mg, unk
    Indication: non-Hodgkin's Lymphoma
    Start date: 2011-09-07

Doxorubicin HCL
    Dosage: 103 mg, unk
    Indication: non-Hodgkin's Lymphoma

Neulasta
    Dosage: 6 mg, unk
    Indication: Product Used FOR Unknown Indication

Cytarabine
    Dosage: 6.3 g, unk
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Dosage: 618 mg, unk
    Indication: non-Hodgkin's Lymphoma

Leucovorin Sodium
    Dosage: 50 mg, unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Mesna
    Dosage: 1236 mg, unk
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Dosage: 40 mg, unk
    Indication: non-Hodgkin's Lymphoma

Other drugs received by patient: Ciprofloxacin; Valtrex; Medrol; Fluconazole; Voriconazole; Protonix



Possible Mesna side effects in male

Reported by a physician from United States on 2012-01-30

Patient: male

Reactions: Pneumonia, Fatigue, Syncope, Anaemia, Hypotension, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Rituximab
    Indication: non-Hodgkin's Lymphoma
    Start date: 2011-09-07

Neulasta
    Indication: Product Used FOR Unknown Indication

Leucovorin Calcium
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Mesna
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Administration route: Oral
    Indication: non-Hodgkin's Lymphoma

Cytarabine
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Administration route: Oral
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Other drugs received by patient: Ciprofloxacin; Voriconazole; Fluconazole; Protonix; Valtrex; Medrol



Possible Mesna side effects in 31 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-24

Patient: 31 year old male

Reactions: Fatigue, Syncope, Pneumonia, Hypotension, Anaemia, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mesna
    Indication: non-Hodgkin's Lymphoma

Rituximab
    Indication: non-Hodgkin's Lymphoma
    Start date: 2011-09-07

Methotrexate
    Administration route: Oral
    Indication: non-Hodgkin's Lymphoma

Leucovorin Calcium
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Vincristine Sulfate
    Indication: non-Hodgkin's Lymphoma

Pegfilgrastim
    Indication: Product Used FOR Unknown Indication

Cytarabine
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Administration route: Oral
    Indication: non-Hodgkin's Lymphoma

Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Other drugs received by patient: Fluconazole; Voriconazole; Ciprofloxacin; Medrol; Pantoprazole; Valtrex



Possible Mesna side effects in female

Reported by a physician from United States on 2012-01-23

Patient: female, weighing 16.0 kg (35.2 pounds)

Reactions: Respiratory Disorder, Hyperkalaemia, Coagulopathy, Tachycardia, Pyrexia, Pericardial Effusion, Liver Disorder, Cardiac Disorder, Stem Cell Transplant, Multi-Organ Failure, Electrolyte Imbalance, Fluid Retention, Lethargy, Anuria, Vomiting, Renal Disorder, Metabolic Acidosis, Hyperphosphataemia, Nausea, Hypotension, General Physical Health Deterioration, Skin Oedema, Hypercalcaemia, Ascites, Lung Disorder, Pseudomonas Test Positive

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mesna
    Dosage: 670 mg

Cisplatin
    Dosage: 153 mg

Vincristine Sulfate
    Dosage: 1.53 mg

Topotecan
    Dosage: 6 mg

Carboplatin
    Dosage: 880 mg

Etoposide
    Dosage: 1172 mg

Cyclophosphamide
    Dosage: 4760 mg

Doxorubicin HCL
    Dosage: 60 mg

Melphalan Hydrochloride
    Dosage: 111 mg



Possible Mesna side effects in 1 year old female

Reported by a consumer/non-health professional from France on 2012-01-10

Patient: 1 year old female, weighing 9.0 kg (19.8 pounds)

Reactions: Haemoglobin Decreased, Angioedema, Tachycardia, Hypotension, White Blood Cell Count Increased

Drug(s) suspected as cause:
Mesna
    Indication: Prophylaxis
    Start date: 2011-10-21

Etoposide
    Dosage: powder for solution for injection,infused twice for 2 hrs with 28mg(1st inf:21oct11,2nd inf 22oct11
    Indication: Aesthesioneuroblastoma
    Start date: 2011-10-21
    End date: 2011-10-22

Ifosfamide
    Dosage: infused for 3 hours on 21-0ct-2011
    Indication: Aesthesioneuroblastoma
    Start date: 2011-10-21

Other drugs received by patient: Zofran; Chlorpromazine HCL



Possible Mesna side effects in female

Reported by a individual with unspecified qualification from United States on 2012-01-09

Patient: female, weighing 58.4 kg (128.5 pounds)

Reactions: Hepatic Function Abnormal, Hypotension, Acute Myeloid Leukaemia, Urine Output Decreased, Mental Status Changes, Caecitis, Respiratory Failure, Pulmonary Oedema, Blood Creatinine Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ifosfamide
    Dosage: 10800 mg

Doxorubicin HCL
    Dosage: 88 mg

Mesna
    Dosage: 2160 mg

Neulasta
    Dosage: 6 mg



Possible Mesna side effects in 18 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-05

Patient: 18 year old male

Reactions: Lung Infection, Hypotension, Febrile Neutropenia, Hypokalaemia

Drug(s) suspected as cause:
Methotrexate

Etoposide

Ifosfamide

Cisplatin

Mesna

Doxorubicin HCL



Possible Mesna side effects in male

Reported by a individual with unspecified qualification from United States on 2011-12-19

Patient: male

Reactions: Fatigue, Syncope, Pneumonia, Hypotension, Anaemia, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Neulasta
    Dosage: 6 mg, unk
    Indication: Product Used FOR Unknown Indication

Dexamethasone
    Administration route: Oral
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Indication: non-Hodgkin's Lymphoma

Leucovorin Calcium
    Dosage: 50 mg, unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Cyclophosphamide
    Indication: non-Hodgkin's Lymphoma

Mabthera

Cytarabine
    Dosage: 6.3 g, x4
    Indication: non-Hodgkin's Lymphoma

Leucovorin Calcium
    Dosage: 15 mg, q6h
    Administration route: Oral

Doxorubicin HCL
    Indication: non-Hodgkin's Lymphoma

Mesna
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Dosage: 1680 mg, unk

Mabthera
    Dosage: 788 mg, unknown
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Dosage: 420 mg, unk
    Indication: non-Hodgkin's Lymphoma

Other drugs received by patient: Medrol; Fluconazole; Protonix; Ciprofloxacin; Valtrex



Possible Mesna side effects in 31 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-19

Patient: 31 year old male

Reactions: Pneumonia, Fatigue, Syncope, Anaemia, Hypotension, Neutropenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL
    Dosage: 103 mg, unk
    Indication: non-Hodgkin's Lymphoma

Dexamethasone
    Dosage: 40 mg, unk
    Indication: non-Hodgkin's Lymphoma

Cyclophosphamide
    Dosage: 618 mg, unk
    Indication: non-Hodgkin's Lymphoma

Methotrexate
    Dosage: 420 mg, unk
    Indication: non-Hodgkin's Lymphoma

Leucovorin Sodium
    Dosage: 50 mg, unk
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Mesna
    Dosage: 1236 mg, unk
    Indication: non-Hodgkin's Lymphoma

Vincristine
    Dosage: 2 mg, unk
    Indication: non-Hodgkin's Lymphoma

Rituximab
    Dosage: 788 mg, unk
    Indication: non-Hodgkin's Lymphoma
    Start date: 2011-09-07

Pegfilgrastim
    Dosage: 6 mg, unk
    Indication: Product Used FOR Unknown Indication

Cytarabine
    Dosage: 6.3 g, unk
    Indication: non-Hodgkin's Lymphoma

Other drugs received by patient: Protonix; Medrol; Voriconazole; Valtrex; Ciprofloxacin; Fluconazole



Possible Mesna side effects in 36 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2011-12-09

Patient: 36 year old male

Reactions: Cardiac Tamponade, Hypotension, Tachycardia, Diastolic Dysfunction, Myopericarditis, Systolic Dysfunction, Sepsis, Cardiac Arrest, Anuria

Adverse event resulted in: death, life threatening event

Drug(s) suspected as cause:
Metoclopramide
    Dosage: 3 unit
    Start date: 2011-03-05
    End date: 2011-03-06

Gentamicin Sulfate
    Dosage: 300 mg, unk
    Administration route: Oral
    Start date: 2011-03-02
    End date: 2011-03-06

Cyclophosphamide
    Dosage: 3200 mg, unk
    Start date: 2011-03-01
    End date: 2011-03-04

Fondaparinux Sodium

Carboplatin
    Dosage: 899 mg, unk
    Start date: 2011-03-01
    End date: 2011-03-04

Morphine
    Dosage: unk
    Start date: 2011-03-05
    End date: 2011-03-06

Amifostine
    Dosage: 2 unit
    Start date: 2011-03-01
    End date: 2011-03-04

Mesna
    Dosage: 800 mg, unk
    Start date: 2011-03-01
    End date: 2011-03-04

Etoposide
    Dosage: 900 mg, unk
    Start date: 2011-03-01
    End date: 2011-03-04

Acyclovir
    Dosage: 750 mg, unk
    Start date: 2011-03-05
    End date: 2011-03-06

Amikacin
    Dosage: 1300 mg, unk
    Start date: 2011-03-04
    End date: 2011-03-05

Piperacillin and Tazobactam
    Dosage: 12 g, unk
    Start date: 2011-03-04
    End date: 2011-03-06

Other drugs received by patient: Prednisolone; Levetiracetam; Clonazepam; Esomeprazole; Pregabalin



Possible Mesna side effects in 19 year old male

Reported by a physician from United States on 2011-11-09

Patient: 19 year old male, weighing 65.8 kg (144.8 pounds)

Reactions: Hypotension, Lung Infection, Febrile Neutropenia, Hypokalaemia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Doxorubicin HCL
    Start date: 2011-10-13

Ifosfamide
    Indication: Bone Sarcoma
    Start date: 2011-10-13
    End date: 2011-10-17

Methotrexate
    Start date: 2011-10-13

Mesna
    Start date: 2011-10-13
    End date: 2011-10-17

Doxorubicin HCL
    Indication: Bone Sarcoma
    Start date: 2011-06-03

Etoposide
    Start date: 2011-06-03

Ifosfamide
    Start date: 2011-06-03

Cisplatin
    Indication: Bone Sarcoma
    Start date: 2011-06-03

Mesna
    Indication: Bone Sarcoma
    Start date: 2011-06-03

Methotrexate
    Indication: Bone Sarcoma
    Start date: 2011-06-03

Etoposide
    Indication: Bone Sarcoma
    Start date: 2011-10-13
    End date: 2011-10-17

Cisplatin
    Start date: 2011-10-13



Possible Mesna side effects in male

Reported by a physician from United States on 2011-10-26

Patient: male, weighing 65.8 kg (144.8 pounds)

Reactions: White Blood Cell Count Decreased, Pneumonia, Vomiting, Nausea, Hypotension, Pyrexia, Headache, Hypokalaemia, Fatigue

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ifosfamide
    Dosage: 24.775 g

Mesna
    Dosage: 24.75 g

Etoposide
    Dosage: 875 mg



Possible Mesna side effects in 11 year old male

Reported by a individual with unspecified qualification from United States on 2011-10-26

Patient: 11 year old male

Reactions: Hypersensitivity, Angioedema, Hypotension, Disseminated Intravascular Coagulation, Pyrexia, Drug Rash With Eosinophilia and Systemic Symptoms, Eosinophilia, Respiratory Failure, Oliguria, Hypoxia, Leukocytosis, Rash Maculo-Papular, Septic Shock, Leukopenia, Renal Failure Acute

Drug(s) suspected as cause:
Mesna
    Dosage: 500 mg/m2, intravenous (not otherwise specified) 1500 mg/m2, intravenous (not otherwise specified)
    Indication: Primitive Neuroectodermal Tumour

Amifostine
    Dosage: 600 mg/m2
    Indication: Primitive Neuroectodermal Tumour

Other drugs received by patient: Cisplatin; Cyclophosphamide; Vincristine

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