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Mercaptopurine (Mercaptopurine) - Rash - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Rash (16)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Mercaptopurine where reactions include rash. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Mercaptopurine side effects in 66 year old female

Reported by a consumer/non-health professional from United States on 2012-08-21

Patient: 66 year old female, weighing 83.0 kg (182.6 pounds)

Reactions: Diplopia, Diarrhoea, Rash

Drug(s) suspected as cause:
Mercaptopurine
    Administration route: Oral
    Indication: Crohn's Disease
    Start date: 2010-08-01
    End date: 2010-03-01

Metoprolol Succinate
    Administration route: Oral
    Indication: Blood Pressure Increased
    Start date: 2006-01-01
    End date: 2011-06-01

Mercaptopurine
    Administration route: Oral
    Start date: 2011-03-01
    End date: 2011-06-01

Mercaptopurine
    Administration route: Oral
    Start date: 2011-06-01

Other drugs received by patient: Omeprazole; Simvastatin; Amitriptyline HCL; Lisinopril



Possible Mercaptopurine side effects in female

Reported by a individual with unspecified qualification from United States on 2012-05-25

Patient: female, weighing 14.9 kg (32.8 pounds)

Reactions: Anaemia, Hyponatraemia, Rash, Pyrexia, Ascites, Abdominal Pain Upper, Abdominal Compartment Syndrome, Respiratory Failure, Pneumonia Herpes Viral, Bone Marrow Failure, Neutropenia, Thrombocytopenia, Cardiac Arrest, Septic Shock, Infection in AN Immunocompromised Host

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vincristine
    Dosage: .99 mg

Methotrexate
    Dosage: 24.5 mg

Dexamethasone
    Dosage: 17.5 ml

Mercaptopurine
    Dosage: 460 mg



Possible Mercaptopurine side effects in female

Reported by a individual with unspecified qualification from United States on 2012-05-25

Patient: female, weighing 14.9 kg (32.8 pounds)

Reactions: Coagulopathy, Hepatic Failure, Pyrexia, Abdominal Pain Upper, Laboratory Test Abnormal, Malaise, Bone Marrow Failure, Thrombocytopenia, Anaemia, Condition Aggravated, Hyponatraemia, Rash, Varicella, Abdominal Compartment Syndrome, Ascites, Respiratory Failure, Pneumonia Herpes Viral, Neutropenia, Immune System Disorder, Cardiac Arrest, Septic Shock

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 460 mg

Dexamethasone
    Dosage: 17.5 mg

Vincristine Sulfate
    Dosage: .99 mg

Methotrexate
    Dosage: 24.5 mg



Possible Mercaptopurine side effects in 17 year old female

Reported by a consumer/non-health professional from Japan on 2012-04-24

Patient: 17 year old female

Reactions: Renal Impairment, Subileus, Rash, Leukoencephalopathy

Drug(s) suspected as cause:
Etoposide
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: Acute Lymphocytic Leukaemia

Itraconazole
    Indication: Acute Lymphocytic Leukaemia

Mercaptopurine
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 2nd dose stopped on day 15
    Indication: Acute Lymphocytic Leukaemia

Leucovorin Calcium
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 2nd dose stopped on 15 day
    Indication: Acute Lymphocytic Leukaemia



Possible Mercaptopurine side effects in 17 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-17

Patient: 17 year old female

Reactions: Drug Level Increased, Inappropriate Antidiuretic Hormone Secretion, Drug Interaction, Rash, Subileus, Leukoencephalopathy

Drug(s) suspected as cause:
Tacrolimus
    Dosage: unk
    Indication: Lung Transplant

Vincristine
    Dosage: 1.3 mg/day, 1 time
    Indication: Chemotherapy

Asparaginase
    Dosage: 3000 iu/mm/day on day 9, 11, 13, 16, 18, 20
    Indication: Chemotherapy

Etoposide
    Dosage: 100 mg/m2, 3 times
    Indication: Chemotherapy

Mercaptopurine
    Dosage: 25 mg/m2, 21 times
    Indication: Chemotherapy

Dexamethasone

Methotrexate
    Dosage: unk
    Indication: Chemotherapy

Itraconazole
    Dosage: unk
    Indication: Prophylaxis

Leukovorin
    Indication: Chemotherapy

Prednisolone
    Dosage: 60 mg/mm/day on day 1-7
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 40 mg/body 2 times
    Indication: Chemotherapy

Cytarabine
    Dosage: 2 g, unk 2 times
    Indication: Chemotherapy

Methotrexate
    Dosage: 500 mg/m2, unk



Possible Mercaptopurine side effects in 17 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-09

Patient: 17 year old female

Reactions: Renal Disorder, Drug Level Increased, Hyperglycaemia, Leukoencephalopathy, Subileus, Rash, Liver Disorder

Drug(s) suspected as cause:
Dexamethasone
    Dosage: 40 mg/kg/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 500 mg/m2/day

Asparaginase
    Dosage: 3000 iu/m2/day
    Indication: Acute Lymphocytic Leukaemia

Etoposide
    Dosage: 100 mg/m2/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Leucovorin Calcium
    Indication: Acute Lymphocytic Leukaemia

Mercaptopurine
    Dosage: 25 mg/m2/day on days 1-21
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone

Other drugs received by patient possibly interacting with the suspect drug:
Itraconazole
    Indication: Prophylaxis

Tacrolimus
    Indication: Immunosuppression

Other drugs received by patient: Cytarabine; Cytarabine; Vincristine; Vincristine; Prednisolone; Daunorubicin HCL



Possible Mercaptopurine side effects in 17 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-08

Patient: 17 year old female

Reactions: Renal Impairment, Rash, Leukoencephalopathy, Subileus

Drug(s) suspected as cause:
Methotrexate
    Dosage: 2nd dose stopped on day 15
    Indication: Acute Lymphocytic Leukaemia

Leucovorin Calcium
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Indication: Acute Lymphocytic Leukaemia

Etoposide
    Indication: Acute Lymphocytic Leukaemia

Itraconazole
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 2nd dose stopped on 15 day
    Indication: Acute Lymphocytic Leukaemia

Mercaptopurine
    Indication: Acute Lymphocytic Leukaemia



Possible Mercaptopurine side effects in 17 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-03

Patient: 17 year old female

Reactions: Hepatic Function Abnormal, Hyperglycaemia, Drug Interaction, Rash, Toxicity To Various Agents, Subileus, Renal Impairment, Inappropriate Antidiuretic Hormone Secretion, Leukoencephalopathy, Immunosuppressant Drug Level Increased

Drug(s) suspected as cause:
Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 500 mg/m2/day

Etoposide
    Dosage: 100 mg/m2/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 40 mg/kg/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: 2 g/m2/day
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone

Vincristine
    Dosage: 1.3 mg/m2/day
    Indication: Acute Lymphocytic Leukaemia

Leucovorin Calcium
    Indication: Acute Lymphocytic Leukaemia

Mercaptopurine
    Dosage: 25 mg/m2/day on days 1-21
    Indication: Acute Lymphocytic Leukaemia

Other drugs received by patient: Prednisolone; Daunorubicin HCL; Cytarabine; Vincristine



Possible Mercaptopurine side effects in 17 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-03

Patient: 17 year old female

Reactions: Subileus, Leukoencephalopathy, Rash

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 25 mg/m2/day on days 1-21
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Leucovorin Calcium
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: 2 g/m2/day
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone

Vincristine
    Dosage: 1.3 mg/m2/day
    Indication: Acute Lymphocytic Leukaemia

Etoposide
    Dosage: 100 mg/m2/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 500 mg/m2/day

Dexamethasone
    Dosage: 40 mg/kg/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Other drugs received by patient: Vincristine; Cytarabine; Daunorubicin HCL; Prednisolone



Possible Mercaptopurine side effects in 17 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-03

Patient: 17 year old female

Reactions: Subileus, Rash, Leukoencephalopathy

Drug(s) suspected as cause:
Methotrexate
    Dosage: 500 mg/m2/day

Dexamethasone
    Dosage: 40 mg/kg/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone

Vincristine
    Dosage: 1.3 mg/m2/day
    Indication: Acute Lymphocytic Leukaemia

Etoposide
    Dosage: 100 mg/m2/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Leucovorin Calcium
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: 2 g/m2/day
    Indication: Acute Lymphocytic Leukaemia

Mercaptopurine
    Dosage: 25 mg/m2/day on days 1-21
    Indication: Acute Lymphocytic Leukaemia

Other drugs received by patient: Cytarabine; Daunorubicin HCL; Prednisolone; Vincristine



Possible Mercaptopurine side effects in 17 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-03

Patient: 17 year old female

Reactions: Subileus, Rash, Leukoencephalopathy

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 25 mg/m2/day on days 1-21
    Indication: Acute Lymphocytic Leukaemia

Vincristine
    Dosage: 1.3 mg/m2/day
    Indication: Acute Lymphocytic Leukaemia

Etoposide
    Dosage: 100 mg/m2/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone
    Dosage: 40 mg/kg/day on days 1-3
    Indication: Acute Lymphocytic Leukaemia

Leucovorin Calcium
    Indication: Acute Lymphocytic Leukaemia

Cytarabine
    Dosage: 2 g/m2/day
    Indication: Acute Lymphocytic Leukaemia

Dexamethasone

Methotrexate
    Dosage: 500 mg/m2/day

Other drugs received by patient: Daunorubicin HCL; Prednisolone; Vincristine; Cytarabine



Possible Mercaptopurine side effects in 17 year old female

Reported by a health professional (non-physician/pharmacist) from Japan on 2012-04-02

Patient: 17 year old female

Reactions: Dyskinesia, Leukoencephalopathy, Rash, Subileus

Drug(s) suspected as cause:
Cytarabine
    Dosage: 2 g/m2/day on days 1-3

Dexamethasone
    Dosage: 40 mg/body/day on days 1-3

Methotrexate

Etoposide
    Dosage: 100 mg/m2/day on days 1-3

Vincristine
    Dosage: 1.3 mg/m2/day

Leucovorin Calcium

Mercaptopurine
    Dosage: 25 mg/m2/day on day 1-21

Other drugs received by patient: Tacrolimus; Prednisolone; Itraconazole



Possible Mercaptopurine side effects in 29 year old female

Reported by a physician from United States on 2012-02-27

Patient: 29 year old female

Reactions: Anal Fistula, Crohn's Disease, Rash, Intestinal Obstruction, Intestinal Stenosis

Drug(s) suspected as cause:
Humira
    Indication: Crohn's Disease
    Start date: 2010-03-01

Mercaptopurine
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Colazol; Adderall 5



Possible Mercaptopurine side effects in female

Reported by a consumer/non-health professional from United States on 2012-01-30

Patient: female, weighing 124.8 kg (274.7 pounds)

Reactions: Weight Decreased, Renal Disorder, Fistula, Nausea, Drug Ineffective, Rash, Weight Increased, Hospitalisation, Malaise, Diarrhoea, Blood Potassium Decreased, Hypophagia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Humira
    Indication: Crohn's Disease
    Start date: 2010-09-01
    End date: 2011-02-01

Mercaptopurine
    Indication: Crohn's Disease
    Start date: 2011-03-01
    End date: 2011-08-01

Humira
    Start date: 2011-10-01

Other drugs received by patient: Methotrexate; Lantus; Ativan; Vicodin; Amaryl; Vitamin D; Folic Acid; Vitamin B-12



Possible Mercaptopurine side effects in 9 year old female

Reported by a physician from United States on 2012-01-30

Patient: 9 year old female, weighing 39.4 kg (86.7 pounds)

Reactions: Tachycardia, Pulmonary Embolism, Pyrexia, Constipation, Somnolence, Hypokalaemia, Partial Seizures, Sinusitis, Blepharospasm, Atrial Thrombosis, Hypotension, Cerebral Atrophy, Rash, Varicella Virus Test Positive, Tremor, Haemoglobin Decreased, Fungal Infection, Bacteraemia, Lacunar Infarction, Hypoalbuminaemia, Platelet Count Decreased, Neutropenia, Seizure Like Phenomena

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytarabine
    Dosage: 100 mg, 3x/day, subuctaneous; 100 mg once, subcutaneous
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-06-07
    End date: 2011-06-10

Cytarabine
    Dosage: 100 mg, 3x/day, subuctaneous; 100 mg once, subcutaneous
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-06-13
    End date: 2011-06-16

Vincristine Sulfate
    Dosage: 2 mg, weekly, intravenous; 1.9 mg, single, intravenous
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-04-08
    End date: 2011-04-29

Vincristine Sulfate
    Dosage: 2 mg, weekly, intravenous; 1.9 mg, single, intravenous
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-06-20
    End date: 2011-06-20

*peg-Asparaginase (Asparaginase) Unknown
    Dosage: 3150 iu, single, intramuscular
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-06-20
    End date: 2011-06-20

Methotrexate
    Dosage: see image
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-06-06
    End date: 2011-06-06

Methotrexate
    Dosage: see image
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-06-13
    End date: 2011-06-13

Methotrexate
    Dosage: see image
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-05-06
    End date: 2011-05-06

Methotrexate
    Dosage: see image
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-06-20
    End date: 2011-06-20

Methotrexate
    Dosage: see image
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-04-15
    End date: 2011-04-15

Dalteparin Sodium
    Dosage: 5395 iu, 2x/day, subcutaneous; 5395 iu, 2x/day, subcutaneous
    Indication: Pulmonary Embolism
    Start date: 2011-05-13
    End date: 2011-06-26

Dalteparin Sodium
    Dosage: 5395 iu, 2x/day, subcutaneous; 5395 iu, 2x/day, subcutaneous
    Indication: Atrial Thrombosis
    Start date: 2011-05-13
    End date: 2011-06-26

Dalteparin Sodium
    Dosage: 5395 iu, 2x/day, subcutaneous; 5395 iu, 2x/day, subcutaneous
    Indication: Pulmonary Embolism
    Start date: 2011-06-27

Dalteparin Sodium
    Dosage: 5395 iu, 2x/day, subcutaneous; 5395 iu, 2x/day, subcutaneous
    Indication: Atrial Thrombosis
    Start date: 2011-06-27

Cyclophosphamide
    Dosage: 1300 mg single, intravenous; 100mg once, subcutaneous
    Start date: 2011-06-06
    End date: 2011-06-06

Mercaptopurine
    Dosage: 75 mg, once daily six days per week, oral; 100 mg, once per day on seventh day of week, oral
    Administration route: Oral
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-06-06
    End date: 2011-06-19

Mercaptopurine
    Dosage: 75 mg, once daily six days per week, oral; 100 mg, once per day on seventh day of week, oral
    Administration route: Oral
    Indication: B Precursor Type Acute Leukaemia
    Start date: 2011-06-06
    End date: 2011-06-19

Other drugs received by patient: Zofran; Bactrim; Sodium Chloride 0.9%; Heparin; Ranitidine Hydrochloride; Emla; Acetaminophen



Possible Mercaptopurine side effects in 57 year old male

Reported by a consumer/non-health professional from United States on 2011-12-02

Patient: 57 year old male, weighing 68.0 kg (149.7 pounds)

Reactions: Abdominal Pain, Respiratory Disorder, Pruritus, Ocular Hyperaemia, Heart Rate Irregular, Rash, Headache, Abdominal Pain Upper

Drug(s) suspected as cause:
Mercaptopurine

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