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Mercaptopurine (Mercaptopurine) - Hepatosplenic T-Cell Lymphoma - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Hepatosplenic T-Cell Lymphoma (15)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Mercaptopurine where reactions include hepatosplenic t-cell lymphoma. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Mercaptopurine side effects in male

Reported by a physician from United States on 2012-08-21

Patient: male

Reactions: Multi-Organ Failure, Hepatosplenic T-Cell Lymphoma, Staphylococcal Abscess

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Remicade
    Dosage: date also reported as 5-may-2005
    Start date: 2005-04-01

Remicade
    Dosage: second dose
    Indication: Crohn's Disease
    Start date: 2005-03-21

Mercaptopurine
    Indication: Crohn's Disease

Remicade
    Start date: 2000-01-01

Other drugs received by patient: Prednisone TAB; Mesalamine



Possible Mercaptopurine side effects in male

Reported by a physician from United Kingdom on 2012-08-21

Patient: male

Reactions: Pelvic Pain, Pyrexia, Anal Fistula, C-Reactive Protein Increased, Splenomegaly, Rectal Abscess, Lethargy, Hepatosplenic T-Cell Lymphoma, Crohn's Disease, Sepsis, Platelet Count Decreased, Diabetic Ketoacidosis, Neutropenia, Rectal Discharge, Leukopenia, Influenza Like Illness

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Indication: Crohn's Disease

Azathioprine Sodium
    Dosage: 2.5 mg/kg
    Indication: Crohn's Disease

Azathioprine Sodium
    Start date: 2002-01-01
    End date: 2006-09-01

Prednisolone
    Indication: Product Used FOR Unknown Indication

Remicade
    Indication: Crohn's Disease
    End date: 2005-09-29

Azathioprine Sodium
    Start date: 2001-06-01

Remicade
    Dosage: stopped in february - march (3rd infusion)
    End date: 2006-02-01

Other drugs received by patient: Metronidazole; Vitamin B-12



Possible Mercaptopurine side effects in male

Reported by a physician from United States on 2012-08-21

Patient: male, weighing 81.2 kg (178.6 pounds)

Reactions: Mechanical Ventilation, Renal Failure, Hepatosplenic T-Cell Lymphoma, Sinus Disorder, Pneumothorax

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Administration route: Oral

Remicade
    Dosage: started in oct or nov-2005
    Indication: Crohn's Disease
    Start date: 2005-10-01

Remicade
    Dosage: once every 6 to 7 weeks
    End date: 2007-11-20

Mercaptopurine
    Administration route: Oral
    Indication: Crohn's Disease

Mercaptopurine
    Administration route: Oral
    Start date: 2005-02-01

Other drugs received by patient: Steroids NOS; Allopurinol; Ambien; Wellbutrin; Doxycycline HCL; Protonix; Bentyl; Claritin; Mesalamine; Zoloft



Possible Mercaptopurine side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-21

Patient: male, weighing 63.5 kg (139.7 pounds)

Reactions: Night Sweats, Cellulitis, Hepatosplenic T-Cell Lymphoma, Pyrexia, Thirst, Laryngitis, Leukocytoclastic Vasculitis, Epstein-Barr Virus Infection, Fatigue, Sinus Headache, Bacterial Infection, Vision Blurred, Pharyngitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Remicade
    Start date: 2000-06-16

Remicade
    Start date: 2000-02-03

Remicade
    Start date: 2003-01-06

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Indication: Crohn's Disease
    Start date: 1999-11-01
    End date: 2001-02-01

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Start date: 1998-05-01

Remicade
    Start date: 2002-11-15

Remicade
    Start date: 2002-09-27

Remicade
    Start date: 1999-12-03

Remicade
    Start date: 1999-09-01

Remicade
    Start date: 2002-06-21

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Start date: 1997-12-01

Remicade
    Indication: Crohn's Disease
    Start date: 2000-08-17

Remicade
    Start date: 2000-11-05

Remicade
    Start date: 2002-08-09

Remicade
    Start date: 2002-02-22

Remicade
    Start date: 2002-02-11

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Start date: 1997-07-01

Other drugs received by patient: Prilosec; Azathioprine Sodium; Imuran; Prednisone TAB; Corticosteroids; Fosamax



Possible Mercaptopurine side effects in female

Reported by a physician from United States on 2012-08-21

Patient: female, weighing 53.0 kg (116.6 pounds)

Reactions: Hepatosplenic T-Cell Lymphoma, Neutropenic Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Mesalamine
    Indication: Crohn's Disease

Remicade
    Dosage: summer 2003
    Indication: Crohn's Disease
    Start date: 2001-01-15
    End date: 2003-08-15

Mercaptopurine

Mercaptopurine
    Indication: Crohn's Disease

Other drugs received by patient: Metronidazole; Hydrocortisone; Prednisone TAB



Possible Mercaptopurine side effects in male

Reported by a pharmacist from United States on 2012-08-21

Patient: male, weighing 81.7 kg (179.6 pounds)

Reactions: Neuropathy Peripheral, Lung Neoplasm, Hepatosplenic T-Cell Lymphoma, Nervous System Disorder, Muscle Rupture, Postoperative Abscess

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Remicade
    Dosage: in 2006, the patient received 3 doses; 24 total doses over total treatment period
    Indication: Crohn's Disease
    Start date: 2002-10-01
    End date: 2006-08-01

Mercaptopurine
    Start date: 2002-01-01

Mercaptopurine
    Indication: Crohn's Disease
    Start date: 2002-10-01

Mercaptopurine
    Dosage: decreased to 50 mg/day after 6-tg levels were found to be elevated
    Start date: 2004-01-01
    End date: 2006-08-01

Prednisone TAB
    Indication: Crohn's Disease
    Start date: 2003-08-01

Other drugs received by patient: Nexium; Folic Acid; Singulair; Asacol; Calcium; Nystatin; Balsalazide Disodium



Possible Mercaptopurine side effects in male

Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-20

Patient: male, weighing 63.5 kg (139.7 pounds)

Reactions: Night Sweats, Cellulitis, Hepatosplenic T-Cell Lymphoma, Pyrexia, Thirst, Laryngitis, Leukocytoclastic Vasculitis, Epstein-Barr Virus Infection, Fatigue, Sinus Headache, Bacterial Infection, Vision Blurred, Pharyngitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Remicade
    Indication: Crohn's Disease
    Start date: 2000-08-17

Remicade
    Start date: 2000-11-05

Remicade
    Start date: 2000-02-03

Remicade
    Start date: 2002-06-21

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Indication: Crohn's Disease
    Start date: 1999-11-01
    End date: 2001-02-01

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Start date: 1997-07-01

Remicade
    Start date: 2003-01-06

Remicade
    Start date: 1999-12-03

Remicade
    Start date: 2000-06-16

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Start date: 1997-12-01

Remicade
    Start date: 2002-09-27

Remicade
    Start date: 2002-11-15

Remicade
    Start date: 2002-02-11

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Start date: 1998-05-01

Remicade
    Start date: 1999-09-01

Remicade
    Start date: 2002-02-22

Remicade
    Start date: 2002-08-09

Other drugs received by patient: Prednisone; Imuran; Prilosec; Azathioprine; Fosamax; Corticosteroids



Possible Mercaptopurine side effects in 21 year old male

Reported by a physician from Canada on 2011-11-16

Patient: 21 year old male

Reactions: Klebsiella Infection, Multi-Organ Failure, Proctitis, Histiocytosis Haematophagic, Epstein-Barr Virus Antigen Positive, Hepatosplenic T-Cell Lymphoma, Septic Shock, Escherichia Sepsis, Infection

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 25 mg;qd
    Indication: Crohn's Disease

Infliximab (Infliximab)
    Dosage: 350 mg
    Indication: Crohn's Disease



Possible Mercaptopurine side effects in male

Reported by a physician from United Kingdom on 2011-10-14

Patient: male

Reactions: Pyrexia, Pelvic Pain, Anal Fistula, C-Reactive Protein Increased, Splenomegaly, Rectal Abscess, Lethargy, Crohn's Disease, Hepatosplenic T-Cell Lymphoma, Sepsis, Platelet Count Decreased, Neutropenia, Diabetic Ketoacidosis, Rectal Discharge, Leukopenia, Influenza Like Illness

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Azathioprine
    Start date: 2002-01-01
    End date: 2006-09-01

Remicade
    Indication: Crohn's Disease
    End date: 2005-09-29

Prednisolone
    Indication: Ill-Defined Disorder

Mercaptopurine
    Indication: Crohn's Disease

Azathioprine
    Dosage: 2.5 mg/kg
    Indication: Crohn's Disease

Remicade
    Dosage: stopped in february - march (3rd infusion)
    End date: 2006-02-01

Azathioprine
    Start date: 2001-06-01

Other drugs received by patient: Metronidazole; VIT B12



Possible Mercaptopurine side effects in male

Reported by a consumer/non-health professional from United Kingdom on 2011-10-14

Patient: male, weighing 81.7 kg (179.6 pounds)

Reactions: Neuropathy Peripheral, Hepatosplenic T-Cell Lymphoma, Lung Neoplasm, Nervous System Disorder, Postoperative Abscess, Muscle Rupture

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: decreased to 50 mg/day after 6-tg levels were found to be elevated
    Start date: 2004-01-01
    End date: 2006-08-01

Mercaptopurine
    Indication: Crohn's Disease
    Start date: 2002-10-01

Remicade
    Dosage: in 2006, the patient received 3 doses; 24 total doses over total treatment period
    Indication: Crohn's Disease
    Start date: 2002-10-01
    End date: 2006-08-01

Mercaptopurine
    Start date: 2002-01-01

Prednisone
    Indication: Crohn's Disease
    Start date: 2003-08-01

Other drugs received by patient: Asacol; Folic Acid; Singulair; Nexium; Balsalazide Disodium; Calcium Carbonate; Nystatin



Possible Mercaptopurine side effects in male

Reported by a pharmacist from United States on 2011-10-14

Patient: male

Reactions: Multi-Organ Failure, Hepatosplenic T-Cell Lymphoma, Staphylococcal Abscess

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Remicade
    Start date: 2000-01-01

Remicade
    Dosage: second dose
    Indication: Crohn's Disease
    Start date: 2005-03-21

Remicade
    Dosage: date also reported as 5-may-2005
    Start date: 2005-04-01

Mercaptopurine
    Indication: Crohn's Disease

Other drugs received by patient: Mesalamine; Prednisone



Possible Mercaptopurine side effects in male

Reported by a physician from United States on 2011-10-14

Patient: male, weighing 81.2 kg (178.6 pounds)

Reactions: Mechanical Ventilation, Renal Failure, Sinus Disorder, Hepatosplenic T-Cell Lymphoma, Pneumothorax

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Administration route: Oral

Mercaptopurine
    Administration route: Oral
    Start date: 2005-02-01

Remicade
    Dosage: started in oct or nov-2005
    Indication: Crohn's Disease
    Start date: 2005-10-01

Remicade
    Dosage: once every 6 to 7 weeks
    End date: 2007-11-20

Mercaptopurine
    Administration route: Oral
    Indication: Crohn's Disease

Other drugs received by patient: Allopurinol; Wellbutrin; Mesalamine; Doxycycline; Claritin; Protonix; Bentyl; Ambien; Steroids NOS; Zoloft



Possible Mercaptopurine side effects in female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-14

Patient: female, weighing 53.0 kg (116.6 pounds)

Reactions: Hepatosplenic T-Cell Lymphoma, Neutropenic Sepsis

Adverse event resulted in: death

Drug(s) suspected as cause:
Remicade
    Dosage: summer 2003
    Indication: Crohn's Disease
    Start date: 2001-01-15
    End date: 2003-08-15

Mesalamine
    Indication: Crohn's Disease

Mercaptopurine
    Indication: Crohn's Disease

Mercaptopurine

Other drugs received by patient: Hydrocortisone; Metronidazole; Prednisone



Possible Mercaptopurine side effects in male

Reported by a physician from United States on 2011-10-14

Patient: male, weighing 63.5 kg (139.7 pounds)

Reactions: Night Sweats, Cellulitis, Hepatosplenic T-Cell Lymphoma, Thirst, Pyrexia, Laryngitis, Epstein-Barr Virus Infection, Leukocytoclastic Vasculitis, Fatigue, Sinus Headache, Vision Blurred, Bacterial Infection, Pharyngitis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Remicade
    Start date: 2002-11-15

Remicade
    Start date: 2003-01-06

Remicade
    Start date: 2000-02-03

Remicade
    Start date: 2000-06-16

Remicade
    Start date: 1999-09-01

Remicade
    Start date: 1999-12-03

Remicade
    Start date: 2002-02-11

Remicade
    Start date: 2002-08-09

Remicade
    Start date: 2002-02-22

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Start date: 1998-05-01

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Start date: 1997-12-01

Remicade
    Indication: Crohn's Disease
    Start date: 2000-08-17

Remicade
    Start date: 2002-09-27

Remicade
    Start date: 2002-06-21

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Indication: Crohn's Disease
    Start date: 1999-11-01
    End date: 2001-02-01

Remicade
    Start date: 2000-11-05

Mercaptopurine
    Dosage: 25mg am, 25mg pm
    Start date: 1997-07-01

Other drugs received by patient: Fosamax; Prilosec; Prednisone; Steroids; Imuran; Azathioprine



Possible Mercaptopurine side effects in male

Reported by a physician from United States on 2011-10-10

Patient: male

Reactions: Anxiety, Emotional Distress, Hepatosplenic T-Cell Lymphoma, Anaemia, Fear, Pain, Irritable Bowel Syndrome, Injury

Adverse event resulted in: death

Drug(s) suspected as cause:
Mercaptopurine
    Indication: Inflammatory Bowel Disease

Adalimumab
    Dosage: 1 every 2 weeks for 15 doses
    Indication: Irritable Bowel Syndrome
    Start date: 2006-11-01
    End date: 2007-06-01

Adalimumab
    Indication: Inflammatory Bowel Disease

Adalimumab
    Indication: Colitis
    Start date: 2006-11-01

Infliximab
    Indication: Inflammatory Bowel Disease

Adalimumab
    Indication: Colitis Ulcerative

Mercaptopurine
    Indication: Colitis Ulcerative
    Start date: 1999-10-01
    End date: 2007-04-01

Infliximab
    Dosage: 19 injections over 42 months
    Indication: Colitis Ulcerative
    Start date: 2002-07-01
    End date: 2006-03-07

Other drugs received by patient: Asacol; Asacol; Prednisone; Prednisone

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