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Mercaptopurine (Mercaptopurine) - Headache - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Headache (15)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Mercaptopurine where reactions include headache. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Mercaptopurine side effects in 30 year old male

Reported by a consumer/non-health professional from United States on 2012-07-11

Patient: 30 year old male

Reactions: White Blood Cell Count Decreased, Headache

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mercaptopurine

Other drugs received by patient: Asacol



Possible Mercaptopurine side effects in male

Reported by a physician from Japan on 2012-06-26

Patient: male, weighing 80.0 kg (176.0 pounds)

Reactions: Amylase Increased, Herpes Ophthalmic, Lacunar Infarction, Headache, Hemiparesis, Transient Ischaemic Attack, Dyslalia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Humira
    Indication: Crohn's Disease
    Start date: 2011-04-22
    End date: 2011-04-22

Humira
    Start date: 2011-07-02

Humira
    Start date: 2011-06-23
    End date: 2011-06-23

Mercaptopurine
    Start date: 2011-09-03

Mercaptopurine
    Administration route: Oral
    Indication: Crohn's Disease
    Start date: 2006-09-01
    End date: 2011-09-03

Other drugs received by patient: Sodium Ferrous Citrate; Mesalamine; Lansoprazole; Metronidazole; Diflucortolone Valerate / Lidocaine; Mesalamine; Mesalamine; Mesalamine; Sulfasalazine; Mesalamine; Sodium Ferrous Citrate; Mercaptopurine



Possible Mercaptopurine side effects in male

Reported by a physician from United States on 2012-05-30

Patient: male, weighing 29.4 kg (64.7 pounds)

Reactions: Respiratory Rate Increased, White Blood Cell Count Decreased, Body Temperature Increased, Muscular Weakness, Headache, Hepatic Enzyme Increased, Haemoglobin Decreased, Activated Partial Thromboplastin Time Prolonged, Heart Rate Increased, Deep Vein Thrombosis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cyclophosphamide
    Dosage: 1050 mg
    End date: 2012-05-07

Methotrexate
    Dosage: 12 mg
    End date: 2012-05-21

PEG-L-Asparaginase (K-H)
    Dosage: 2625 iu
    End date: 2012-05-21

Cytarabine
    Dosage: 78.8 mg
    End date: 2012-05-17

Vincristine Sulfate
    Dosage: 1.58 mg
    End date: 2012-05-21

Mercaptopurine
    Dosage: 450 mg
    End date: 2012-05-20



Possible Mercaptopurine side effects in male

Reported by a physician from United States on 2012-05-24

Patient: male, weighing 103.3 kg (227.3 pounds)

Reactions: Rectal Haemorrhage, Anaemia, Blood Blister, Petechiae, Headache, Haemolysis, Dysgeusia, Ecchymosis, Thrombocytopenia, Papule

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 3900 mg

Cytarabine
    Dosage: 2890 mg

Cyclophosphamide
    Dosage: 4600 mg

Methotrexate
    Dosage: 60 mg

PEG-L-Asparaginase (K-H)
    Dosage: 5700 unit

Vincristine Sulfate
    Dosage: 4 mg



Possible Mercaptopurine side effects in male

Reported by a individual with unspecified qualification from United States on 2012-05-14

Patient: male, weighing 103.3 kg (227.3 pounds)

Reactions: Oral Mucosal Blistering, Anaemia, Rash Papular, Blood Blister, Headache, Haemolysis, Dysgeusia, Haemoglobin Decreased, Ecchymosis, Platelet Count Decreased, Thrombocytopenia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Cytoxan
    Dosage: 4600 mg

Cytarabine
    Dosage: 2890 mg

Vincristine Sulfate
    Dosage: 4 mg

PEG-L -Asparaginase (K-H)
    Dosage: 5700 unit

Methotrexate
    Dosage: 60 mg

Mercaptopurine
    Dosage: 3900 mg



Possible Mercaptopurine side effects in male

Reported by a individual with unspecified qualification from United States on 2012-05-07

Patient: male, weighing 77.0 kg (169.4 pounds)

Reactions: Pneumonia Fungal, Fatigue, Full Blood Count Abnormal, Pancytopenia, Headache, Decreased Appetite

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vincristine Sulfate
    Dosage: 2 mg

Methotrexate
    Dosage: 15 mg

Mercaptopurine
    Dosage: 650 mg

Dexamethasone
    Dosage: 60 mg



Possible Mercaptopurine side effects in 76 year old male

Reported by a consumer/non-health professional from United States on 2012-04-16

Patient: 76 year old male, weighing 79.4 kg (174.6 pounds)

Reactions: Renal Failure, Activities of Daily Living Impaired, Pyrexia, Headache, Asthenia

Adverse event resulted in: life threatening event, disablity

Drug(s) suspected as cause:
Mercaptopurine



Possible Mercaptopurine side effects in male

Reported by a physician from Japan on 2012-03-28

Patient: male, weighing 80.0 kg (176.0 pounds)

Reactions: Amylase Increased, Herpes Ophthalmic, Lacunar Infarction, Hemiparesis, Headache, Transient Ischaemic Attack, Dyslalia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Administration route: Oral
    Indication: Crohn's Disease
    Start date: 2006-09-01
    End date: 2011-09-03

Humira
    Start date: 2011-07-02

Humira
    Indication: Crohn's Disease
    Start date: 2011-04-22
    End date: 2011-04-22

Humira
    Start date: 2011-06-23
    End date: 2011-06-23

Mercaptopurine
    Start date: 2011-09-03

Other drugs received by patient: Sodium Ferrous Citrate; Lansoprazole; Sulfasalazine; Mesalamine; Mesalamine; Diflucortolone Valerate / Lidocaine; Metronidazole; Sodium Ferrous Citrate



Possible Mercaptopurine side effects in 63 year old male

Reported by a pharmacist from United States on 2012-02-17

Patient: 63 year old male

Reactions: Myalgia, Night Sweats, Headache, Pyrexia

Drug(s) suspected as cause:
Mercaptopurine



Possible Mercaptopurine side effects in 57 year old male

Reported by a consumer/non-health professional from United States on 2011-12-02

Patient: 57 year old male, weighing 68.0 kg (149.7 pounds)

Reactions: Abdominal Pain, Respiratory Disorder, Pruritus, Ocular Hyperaemia, Heart Rate Irregular, Rash, Headache, Abdominal Pain Upper

Drug(s) suspected as cause:
Mercaptopurine



Possible Mercaptopurine side effects in 22 year old female

Reported by a physician from United States on 2011-11-10

Patient: 22 year old female

Reactions: White Blood Cell Count Decreased, Headache, Hypertension, Neutrophil Count Decreased, Fluid Retention, Enterocolitis Infectious

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Hydrocortisone
    Dosage: 30 mg, unk
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Cytarabine
    Dosage: 60 mg, unk
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Daunorubicin Hydrochloride
    Indication: Lymphocytic Leukaemia

Pegaspargase
    Indication: Lymphocytic Leukaemia

Vincristine Sulfate
    Dosage: 4 mg, unk
    Indication: Lymphocytic Leukaemia
    Start date: 2011-06-17

Cyclophosphamide
    Dosage: 480 mg (total dose: 2400 mg: 300 mg/m2/dose)
    Start date: 2011-09-11

Etoposide
    Dosage: 160 mg (total dose 800 mg: 100 mg/m2/dose) on days 29-33
    Start date: 2011-09-11

Prednisone
    Dosage: 600 mg, unk
    Administration route: Oral
    Indication: Lymphocytic Leukaemia
    Start date: 2011-06-17

Prednisone
    Dosage: 30 mg 2x/day (20 mg/m2/dose) on days 1-5 and on days 29-33 of maintenance cycle 3
    Administration route: Oral
    Start date: 2011-09-11

Dasatinib
    Dosage: 1400 mg, unk
    Administration route: Oral
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Cytarabine
    Dosage: 30 mg (total dose: 60 mg) given it
    Start date: 2011-09-07

Mercaptopurine
    Dosage: 125 mg x 5 days each week and 100 x 2 days each week, repeated for 3 weeks total (days 8-28)
    Start date: 2011-09-06

Methotrexate Sodium
    Dosage: 8127.5 mg, unk
    Administration route: Oral
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Flagyl
    Dosage: unk
    Indication: Clostridium Difficile Colitis
    Start date: 2011-06-18
    End date: 2011-06-22

Dasatinib
    Dosage: unk
    Start date: 2011-06-17

Methotrexate Sodium
    Dosage: unk
    Start date: 2011-06-17

Dexamethasone Sodium Phosphate
    Dosage: unk
    Administration route: Oral
    Indication: Lymphocytic Leukaemia

Dasatinib
    Dosage: 100 mg, 1x/day (total dose: 1400 mg) qd x 14 days (60 mg/m2/dose) on maintenance cycle 3
    Administration route: Oral
    Start date: 2011-09-20

Etoposide
    Dosage: 800 mg, unk
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Hydrocortisone
    Dosage: 15 mg (total dose: 30 mg)
    Start date: 2011-09-07

Methotrexate Sodium
    Dosage: 8000 mg (5000 mg/m2/dose) given as 24 hour infusion on day 1 and 15 mg it on days 1 and 29
    Start date: 2011-08-12

Dexamethasone Sodium Phosphate
    Dosage: 2 mg, on days 1 and 29 of maintenance cycle 3
    Start date: 2011-09-07

Cyclophosphamide
    Dosage: 2400 mg, unk
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Elspar
    Indication: Lymphocytic Leukaemia

Mercaptopurine
    Dosage: 2475 mg, unk
    Administration route: Oral
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Ifosfamide
    Indication: Lymphocytic Leukaemia



Possible Mercaptopurine side effects in 22 year old female

Reported by a physician from United States on 2011-11-10

Patient: 22 year old female

Reactions: White Blood Cell Count Decreased, Headache, Neutrophil Count Decreased, Hypertension, Enterocolitis Infectious, Fluid Retention

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 2475 mg total dose
    Administration route: Oral
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Daunorubicin Hydrochloride
    Indication: Lymphocytic Leukaemia

Asparaginase
    Indication: Lymphocytic Leukaemia

Methotrexate
    Dosage: 8127.5 mg total
    Administration route: Oral
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Cyclophosphamide
    Dosage: 2400 mg total
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Cytarabine
    Indication: Lymphocytic Leukaemia

Dexamethasone
    Administration route: Oral
    Indication: Lymphocytic Leukaemia

Prednisone TAB
    Dosage: 600 mg
    Administration route: Oral
    Indication: Lymphocytic Leukaemia

Ifosfamide
    Indication: Lymphocytic Leukaemia

Etoposide
    Dosage: 800 mg total
    Indication: Lymphocytic Leukaemia
    Start date: 2011-05-28

Hydrocortisone
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28

Metronidazole
    Indication: Lymphocytic Leukaemia

Vincristine
    Indication: Lymphocytic Leukaemia

Pegaspargase
    Indication: Lymphocytic Leukaemia

Dasatinib
    Dosage: 1400 mg
    Administration route: Oral
    Indication: Lymphocytic Leukaemia
    Start date: 2010-05-28



Possible Mercaptopurine side effects in 16 year old female

Reported by a physician from United States on 2011-10-06

Patient: 16 year old female

Reactions: Abdominal Pain, Electrocardiogram QT Prolonged, Unresponsive To Stimuli, Headache, Hypokalaemia, Malaise, Hypomagnesaemia, Blood Creatinine Increased, Chest Discomfort, Nausea, Urine Output Decreased, Chromaturia, Anxiety, Torsade DE Pointes, Renal Impairment, Ventricular Tachycardia, Feeling Jittery, Pulse Absent, Renal Tubular Necrosis, Ventricular Fibrillation, Cardiac Arrest

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Ondansetron HCL
    Administration route: Oral

Tobramycin
    Indication: Ecthyma

Furosemide
    Indication: Blood Creatinine Increased

Mercaptopurine

Vancomycin
    Indication: Ecthyma

Clarithromycin

Vincristine

Ondansetron HCL

Asparaginase

Cytarabine

Other drugs received by patient: Cefepime; Pantoprazole; Amoxicillin; Diphenhydramine HCL; Cefepime; Cefepime; Amoxicillin; Cefepime; Pantoprazole; Metronidazole; Lorazepam; Sulfamethoxazole and Trimethoprim; Hydroxyzine



Possible Mercaptopurine side effects in male

Reported by a physician from Japan on 2011-10-04

Patient: male, weighing 80.0 kg (176.0 pounds)

Reactions: Herpes Zoster Ophthalmic, Lacunar Infarction, Hemiparesis, Headache, Dyslalia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Humira
    Start date: 2011-06-23
    End date: 2011-06-23

Humira
    Indication: Crohn's Disease
    Start date: 2011-04-22
    End date: 2011-04-22

Mercaptopurine
    Administration route: Oral
    Indication: Crohn's Disease
    Start date: 2006-09-01

Other drugs received by patient: Sulfasalazine; Mesalamine; Ferrous Citrate; Metronidazole



Possible Mercaptopurine side effects in female

Reported by a individual with unspecified qualification from United States on 2011-10-04

Patient: female, weighing 82.0 kg (180.4 pounds)

Reactions: Vomiting, Hypotension, Tachycardia, Pyrexia, Headache, Fatigue, Diarrhoea, Dizziness, Neutropenia, Klebsiella Test Positive, Septic Shock

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Prednisone
    Dosage: 400 mg
    End date: 2011-09-26

Mercaptopurine
    Dosage: 300 mg
    End date: 2011-09-19

Methotrexate
    Dosage: 30 mg
    End date: 2011-09-22

Vincristine Sulfate
    Dosage: 4 mg
    End date: 2011-09-22

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