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Mercaptopurine (Mercaptopurine) - Diarrhoea - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Diarrhoea (17)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Mercaptopurine where reactions include diarrhoea. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Mercaptopurine side effects in 66 year old female

Reported by a consumer/non-health professional from United States on 2012-08-21

Patient: 66 year old female, weighing 83.0 kg (182.6 pounds)

Reactions: Diplopia, Diarrhoea, Rash

Drug(s) suspected as cause:
Mercaptopurine
    Administration route: Oral
    Indication: Crohn's Disease
    Start date: 2010-08-01
    End date: 2010-03-01

Metoprolol Succinate
    Administration route: Oral
    Indication: Blood Pressure Increased
    Start date: 2006-01-01
    End date: 2011-06-01

Mercaptopurine
    Administration route: Oral
    Start date: 2011-03-01
    End date: 2011-06-01

Mercaptopurine
    Administration route: Oral
    Start date: 2011-06-01

Other drugs received by patient: Omeprazole; Simvastatin; Amitriptyline HCL; Lisinopril



Possible Mercaptopurine side effects in 17 year old female

Reported by a physician from United States on 2012-07-25

Patient: 17 year old female, weighing 47.6 kg (104.7 pounds)

Reactions: Blood Bilirubin Increased, Dysphagia, Muscular Weakness, Vocal Cord Paralysis, Cerebrovascular Accident, Caecitis, Eating Disorder, Diarrhoea, Depressed Level of Consciousness, Acute Respiratory Distress Syndrome, Sinus Tachycardia, Spinal Cord Oedema, Peripheral Motor Neuropathy, Epistaxis, Neuralgia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Nelarabine
    Dosage: 650mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-04-13

PEG-Asparaginase
    Indication: T-Cell Type Acute Leukaemia

Mercaptopurine
    Dosage: 60mgm2 cyclic
    Administration route: Oral
    Indication: T-Cell Type Acute Leukaemia

Dalteparin Sodium
    Indication: Product Used FOR Unknown Indication

Methotrexate
    Indication: T-Cell Type Acute Leukaemia

Cyclophosphamide
    Dosage: 1000mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Cytarabine
    Dosage: 75mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Vincristine
    Dosage: 1.5mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Other drugs received by patient: Insulin Aspart; Lansoprazole; Vancomycin; Nystatin; Piperacillin and Tazobactam; Voriconazole



Possible Mercaptopurine side effects in 17 year old female

Reported by a physician from United States on 2012-07-13

Patient: 17 year old female, weighing 47.6 kg (104.7 pounds)

Reactions: Blood Bilirubin Increased, Dysphagia, Muscular Weakness, Vocal Cord Paralysis, Cerebrovascular Accident, Caecitis, Eating Disorder, Diarrhoea, Depressed Level of Consciousness, Acute Respiratory Distress Syndrome, Spinal Cord Oedema, Peripheral Motor Neuropathy, Sinus Tachycardia, Neuralgia, Epistaxis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
PEG-Asparaginase
    Indication: T-Cell Type Acute Leukaemia

Cyclophosphamide
    Dosage: 1000mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Cytarabine
    Dosage: 75mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Nelarabine
    Dosage: 650mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-04-13

Methotrexate
    Indication: T-Cell Type Acute Leukaemia

Dalteparin Sodium
    Indication: Product Used FOR Unknown Indication

Vincristine
    Dosage: 1.5mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Mercaptopurine
    Dosage: 60mgm2 cyclic
    Administration route: Oral
    Indication: T-Cell Type Acute Leukaemia

Other drugs received by patient: Insulin Aspart; Nystatin; Voriconazole; Vancomycin; Piperacillin and Tazobactam; Lansoprazole



Possible Mercaptopurine side effects in 17 year old female

Reported by a physician from United States on 2012-07-09

Patient: 17 year old female, weighing 47.6 kg (104.7 pounds)

Reactions: Blood Bilirubin Increased, Dysphagia, Cerebrovascular Accident, Caecitis, Eating Disorder, Dysphonia, Diarrhoea, Acute Respiratory Distress Syndrome, Depressed Level of Consciousness, Peripheral Motor Neuropathy, Sinus Tachycardia, Epistaxis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Methotrexate
    Indication: T-Cell Type Acute Leukaemia

Vincristine
    Dosage: 1.5mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Mercaptopurine
    Dosage: 60mgm2 cyclic
    Administration route: Oral
    Indication: T-Cell Type Acute Leukaemia

Nelarabine
    Dosage: 650mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-04-13

Cyclophosphamide
    Dosage: 1000mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Dalteparin Sodium
    Indication: Product Used FOR Unknown Indication

Cytarabine
    Dosage: 75mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

PEG-Asparaginase
    Indication: T-Cell Type Acute Leukaemia

Other drugs received by patient: Lansoprazole; Piperacillin and Tazobactam; Vancomycin; Voriconazole; Insulin Aspart; Nystatin



Possible Mercaptopurine side effects in 17 year old female

Reported by a physician from United States on 2012-06-08

Patient: 17 year old female, weighing 47.6 kg (104.7 pounds)

Reactions: Blood Bilirubin Increased, Pyrexia, Caecitis, Loss of Consciousness, Oedema Peripheral, Pulmonary Oedema, Hypocalcaemia, Acute Respiratory Distress Syndrome, Melaena, Hypertriglyceridaemia, Epistaxis, Dysphagia, Anaemia, Hyperglycaemia, General Physical Health Deterioration, Eating Disorder, Tremor, Cerebral Infarction, Depressed Level of Consciousness, Neutropenia, Confusional State, Dyskinesia, Somnolence, Splenic Infarction, Hypokalaemia, Pleural Effusion, White Blood Cell Count Decreased, Cerebrovascular Accident, Ascites, Diarrhoea, Hypophagia, Hypoalbuminaemia, Sinus Tachycardia, Hypertension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 60mgm2 cyclic
    Administration route: Oral
    Indication: T-Cell Type Acute Leukaemia

Vincristine
    Dosage: 1.5mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Cyclophosphamide
    Dosage: 1000mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Methotrexate
    Indication: T-Cell Type Acute Leukaemia

Oncaspar
    Indication: T-Cell Type Acute Leukaemia

Nelarabine
    Dosage: 650mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-04-13

Cytarabine
    Dosage: 75mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Dalteparin Sodium
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Nystatin; Lansoprazole; Insulin Aspart; Piperacillin and Tazobactam; Vancomycin; Voriconazole



Possible Mercaptopurine side effects in 17 year old female

Reported by a physician from United States on 2012-05-31

Patient: 17 year old female, weighing 47.6 kg (104.7 pounds)

Reactions: Blood Bilirubin Increased, Cerebrovascular Accident, Eating Disorder, Diarrhoea, Depressed Level of Consciousness, Acute Respiratory Distress Syndrome, Sinus Tachycardia, Epistaxis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Vincristine
    Dosage: 1.5mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Mercaptopurine
    Dosage: 60mgm2 cyclic
    Administration route: Oral
    Indication: T-Cell Type Acute Leukaemia

Cyclophosphamide
    Dosage: 1000mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Cytarabine
    Dosage: 75mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia

Dalteparin Sodium
    Indication: Product Used FOR Unknown Indication

Methotrexate
    Indication: T-Cell Type Acute Leukaemia

Nelarabine
    Dosage: 650mgm2 cyclic
    Indication: T-Cell Type Acute Leukaemia
    Start date: 2012-04-13

PEG-Asparaginase
    Indication: T-Cell Type Acute Leukaemia

Other drugs received by patient: Voriconazole; Insulin Aspart; Nystatin; Vancomycin; Lansoprazole; Piperacillin and Tazobactam



Possible Mercaptopurine side effects in male

Reported by a individual with unspecified qualification from United States on 2012-05-24

Patient: male, weighing 8.8 kg (19.4 pounds)

Reactions: Parainfluenzae Virus Infection, Vomiting, Pneumocystis Jiroveci Infection, Drug Intolerance, Cytomegalovirus Viraemia, Lower Respiratory Tract Infection, Cytomegalovirus Colitis, Pneumonia Cytomegaloviral, Diarrhoea, Diarrhoea Haemorrhagic

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Methotrexate
    Dosage: 80 mg
    End date: 2012-04-17

Mercaptopurine
    Dosage: 1890 mg
    End date: 2012-04-23

Vincristine Sulfate
    Dosage: 1.2 mg
    End date: 2012-03-27



Possible Mercaptopurine side effects in 1 year old male

Reported by a physician from United States on 2012-05-14

Patient: 1 year old male, weighing 8.8 kg (19.4 pounds)

Reactions: Food Intolerance, Parainfluenzae Virus Infection, Vomiting, Lung Infection, Cytomegalovirus Viraemia, Cytomegalovirus Colitis, Pneumonia Cytomegaloviral, Respiratory Syncytial Virus Infection, Pneumocystis Jiroveci Pneumonia, Lower Respiratory Tract Infection Viral, Diarrhoea

Adverse event resulted in: death

Drug(s) suspected as cause:
Methotrexate
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-09-30

Dexamethasone
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-09-30

Mercaptopurine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-09-30

Lestaurtinib

Vincristine
    Indication: Acute Lymphocytic Leukaemia
    Start date: 2010-09-30



Possible Mercaptopurine side effects in female

Reported by a health professional (non-physician/pharmacist) from France on 2012-05-08

Patient: female

Reactions: Weight Decreased, Hyperbilirubinaemia, Gamma-Glutamyltransferase Increased, Diarrhoea, Transaminases Increased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 100 mg
    Administration route: Oral
    Start date: 2009-05-12
    End date: 2009-10-28

Telmisartan
    Dosage: 0.5 anz
    Administration route: Oral
    Start date: 2009-08-15
    End date: 2009-10-28

Other drugs received by patient: Vincristine Sulfate; Methotrexate; Azithromycin; Dexamethasone



Possible Mercaptopurine side effects in female

Reported by a physician from United States on 2012-04-26

Patient: female

Reactions: Gastrointestinal Bacterial Infection, Back Pain, Pain in Extremity, Pain of Skin, Injection Site Pain, Pyrexia, Hypoaesthesia, Paraesthesia, Diarrhoea, Bacterial Infection, Abdominal Distension, Pancreatitis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Mercaptopurine
    Indication: Product Used FOR Unknown Indication

Humira
    Indication: Crohn's Disease



Possible Mercaptopurine side effects in female

Reported by a consumer/non-health professional from United States on 2012-04-24

Patient: female, weighing 90.8 kg (199.8 pounds)

Reactions: Gastrointestinal Bacterial Infection, Back Pain, Pancreas Infection, Pain in Extremity, Injection Site Pain, Hypoaesthesia, Pyrexia, Paraesthesia, Diarrhoea, Sensory Disturbance, Pancreatitis, Abdominal Distension, Tenderness, Hypertension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Humira
    Start date: 2010-03-01

Humira
    Indication: Crohn's Disease
    Start date: 2009-01-01
    End date: 2010-01-01

Mercaptopurine
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Slow FE; Levothyroxine Sodium; Zyrtec; Multi-Vitamin; Prilosec



Possible Mercaptopurine side effects in 3 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-04-11

Patient: 3 year old male

Reactions: Weight Decreased, Lymphopenia, Malnutrition, Haematemesis, Apathy, Diarrhoea, Cholangitis, Cryptosporidiosis Infection, Decreased Appetite

Drug(s) suspected as cause:
Mercaptopurine
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 20 mg/m2, 1 in 1 wk
    Indication: Acute Lymphocytic Leukaemia



Possible Mercaptopurine side effects in male

Reported by a consumer/non-health professional from United States on 2012-04-10

Patient: male

Reactions: Abdominal Pain, Gastrointestinal Motility Disorder, Crohn's Disease, Rectal Haemorrhage, Drug Ineffective FOR Unapproved Indication, Diarrhoea, Fistula Discharge, Muscle Spasms

Drug(s) suspected as cause:
Mercaptopurine

Other drugs received by patient: M.v.i.



Possible Mercaptopurine side effects in 3 year old male

Reported by a physician from France on 2012-04-03

Patient: 3 year old male

Reactions: Diarrhoea, Cholangitis, Lymphopenia, Cryptosporidiosis Infection

Drug(s) suspected as cause:
Mercaptopurine
    Dosage: 50 mg/m2;
    Indication: Acute Lymphocytic Leukaemia

Methotrexate
    Dosage: 20 mg/m2/weeks
    Indication: Acute Lymphocytic Leukaemia



Possible Mercaptopurine side effects in male

Reported by a consumer/non-health professional from United States on 2012-03-05

Patient: male

Reactions: Abdominal Pain, Gastrointestinal Motility Disorder, Diarrhoea, Drug Ineffective FOR Unapproved Indication, Rectal Haemorrhage, Fistula Discharge, Muscle Spasms

Drug(s) suspected as cause:
Mercaptopurine

Other drugs received by patient: M.v.i.



Possible Mercaptopurine side effects in female

Reported by a consumer/non-health professional from United States on 2012-01-30

Patient: female, weighing 124.8 kg (274.7 pounds)

Reactions: Weight Decreased, Renal Disorder, Fistula, Nausea, Drug Ineffective, Rash, Weight Increased, Hospitalisation, Malaise, Diarrhoea, Blood Potassium Decreased, Hypophagia

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Humira
    Indication: Crohn's Disease
    Start date: 2010-09-01
    End date: 2011-02-01

Mercaptopurine
    Indication: Crohn's Disease
    Start date: 2011-03-01
    End date: 2011-08-01

Humira
    Start date: 2011-10-01

Other drugs received by patient: Methotrexate; Lantus; Ativan; Vicodin; Amaryl; Vitamin D; Folic Acid; Vitamin B-12



Possible Mercaptopurine side effects in female

Reported by a individual with unspecified qualification from United States on 2011-10-04

Patient: female, weighing 82.0 kg (180.4 pounds)

Reactions: Vomiting, Hypotension, Tachycardia, Pyrexia, Headache, Fatigue, Diarrhoea, Dizziness, Neutropenia, Klebsiella Test Positive, Septic Shock

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Prednisone
    Dosage: 400 mg
    End date: 2011-09-26

Mercaptopurine
    Dosage: 300 mg
    End date: 2011-09-19

Methotrexate
    Dosage: 30 mg
    End date: 2011-09-22

Vincristine Sulfate
    Dosage: 4 mg
    End date: 2011-09-22

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