This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Mercaptopurine and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (419)
Death (80)
Life Threatening Events (15)
Disability (12)
Reports by Reaction Type
Osteonecrosis (35),
Pyrexia (32),
Acute Myeloid Leukaemia (26),
Off Label Use (24),
Infection (21),
Diarrhoea (17),
Rash (16),
Headache (15),
Maternal Exposure During Pregnancy (15),
Hepatosplenic T-Cell Lymphoma (15),
Abdominal Pain (14),
Multi-Organ Failure (14)
Below are a few examples of reports where side effects / adverse reactions may be related to Mercaptopurine. For a complete list or a specific selection of reports, please use the links above.
Possible Mercaptopurine side effects in 10 year old male
Reported by a physician from United States on 2012-08-27
Patient: 10 year old male, weighing 76.1 kg (167.4 pounds)
Reactions: Hypersensitivity, Hyperglycaemia, Peripheral Motor Neuropathy
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cyclophosphamide
Dosage: 1000mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Cytarabine
Dosage: 75mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Mercaptopurine
Dosage: 60mgm2 cyclic
Administration route: Oral
Indication: T-Cell Type Acute Leukaemia
Methotrexate
Indication: T-Cell Type Acute Leukaemia
Start date: 2012-06-06
Nelarabine
Dosage: 650mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Start date: 2012-05-22
PEG-Asparaginase
Indication: T-Cell Type Acute Leukaemia
Start date: 2012-06-13
Vincristine
Dosage: 1.5mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Start date: 2012-06-13
Other drugs received by patient: Radiation
Possible Mercaptopurine side effects in male
Reported by a physician from Germany on 2012-08-24
Patient: male, weighing 48.0 kg (105.6 pounds)
Reactions: Memory Impairment
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Amphotericin B
Dosage: 6x60 mg/d
Administration route: Oral
Start date: 2012-06-24
Cytarabine
Dosage: 110 mg, per day
Start date: 2012-08-08
End date: 2012-08-11
Cytarabine
Dosage: 110 mg, per day
Start date: 2012-08-16
Furosemide
Dosage: 2x10mg/d
Start date: 2012-08-09
End date: 2012-08-11
Granisetron
Dosage: 3 mg, per day
Start date: 2012-08-08
End date: 2012-08-11
Granisetron
Dosage: 3 mg, per day
Start date: 2012-08-16
Imatinib Mesylate
Dosage: 450 mg, per day
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Start date: 2012-07-13
Mercaptopurine
Dosage: 1x87.5mg/d average
Administration route: Oral
Start date: 2012-08-06
Pantoprazole
Dosage: 40 mg, per day
Administration route: Oral
Start date: 2012-06-24
End date: 2012-08-15
Sulfamethoxazole and Trimethoprim
Dosage: 2x120mg every sat, sun and mon
Administration route: Oral
Possible Mercaptopurine side effects in
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-23
Patient:
Reactions: Neoplasm Malignant
Drug(s) suspected as cause:
Entocort EC
Administration route: Oral
Indication: Crohn's Disease
Infliximab, Recombinant
Indication: Crohn's Disease
Mercaptopurine
Indication: Crohn's Disease
Possible Mercaptopurine side effects in female
Reported by a physician from United States on 2012-08-23
Patient: female
Reactions: Febrile Neutropenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cyclophosphamide
Indication: Acute Lymphocytic Leukaemia
Start date: 2012-07-21
Cytarabine
Indication: Acute Lymphocytic Leukaemia
Start date: 2012-07-17
End date: 2012-07-20
Dasatinib
Dosage: 40 milligram daily;
Administration route: Oral
Indication: Acute Lymphocytic Leukaemia
Start date: 2012-05-29
Mercaptopurine
Indication: Acute Lymphocytic Leukaemia
Start date: 2012-07-13
End date: 2012-07-21
Other drugs received by patient: Zofran; Miralax
Possible Mercaptopurine side effects in male
Reported by a physician from United States on 2012-08-22
Patient: male, weighing 55.2 kg (121.4 pounds)
Reactions: Unresponsive To Stimuli, Moaning, Neutropenia, Septic Shock, Cardiac Arrest
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Mercaptopurine
Start date: 2009-08-21
Methotrexate Sodium
Prednisone
Vincristine
End date: 2012-08-10
Possible Mercaptopurine side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-22
Patient: female, weighing 37.2 kg (81.9 pounds)
Reactions: Tooth Loss, Respiratory Rate Increased, Pain, Off Label Use, Thinking Abnormal, Malaise, Euphoric Mood, Palpitations, Heart Rate Increased, Pancreatitis, Dizziness
Drug(s) suspected as cause:
Actiq
Indication: Pain
Actiq
Indication: Crohn's Disease
Mercaptopurine
Other drugs received by patient: Ciprofloxacin HCL; Morphine; Flagyl; Pentasa
Possible Mercaptopurine side effects in male
Reported by a physician from United States on 2012-08-21
Patient: male, weighing 81.2 kg (178.6 pounds)
Reactions: Mechanical Ventilation, Renal Failure, Hepatosplenic T-Cell Lymphoma, Sinus Disorder, Pneumothorax
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Mercaptopurine
Administration route: Oral
Mercaptopurine
Administration route: Oral
Indication: Crohn's Disease
Mercaptopurine
Administration route: Oral
Start date: 2005-02-01
Remicade
Dosage: started in oct or nov-2005
Indication: Crohn's Disease
Start date: 2005-10-01
Remicade
Dosage: once every 6 to 7 weeks
End date: 2007-11-20
Other drugs received by patient: Steroids NOS; Allopurinol; Ambien; Wellbutrin; Doxycycline HCL; Protonix; Bentyl; Claritin; Mesalamine; Zoloft
Possible Mercaptopurine side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: female
Reactions: Malaise
Drug(s) suspected as cause:
Mercaptopurine
Possible Mercaptopurine side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-21
Patient: male, weighing 63.5 kg (139.7 pounds)
Reactions: Night Sweats, Cellulitis, Hepatosplenic T-Cell Lymphoma, Pyrexia, Thirst, Laryngitis, Leukocytoclastic Vasculitis, Epstein-Barr Virus Infection, Fatigue, Sinus Headache, Bacterial Infection, Vision Blurred, Pharyngitis
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Mercaptopurine
Dosage: 25mg am, 25mg pm
Indication: Crohn's Disease
Start date: 1999-11-01
End date: 2001-02-01
Mercaptopurine
Dosage: 25mg am, 25mg pm
Start date: 1998-05-01
Mercaptopurine
Dosage: 25mg am, 25mg pm
Start date: 1997-12-01
Mercaptopurine
Dosage: 25mg am, 25mg pm
Start date: 1997-07-01
Remicade
Start date: 2000-06-16
Remicade
Start date: 2000-02-03
Remicade
Start date: 2003-01-06
Remicade
Start date: 2002-11-15
Remicade
Start date: 2002-09-27
Remicade
Start date: 1999-12-03
Remicade
Start date: 1999-09-01
Remicade
Start date: 2002-06-21
Remicade
Indication: Crohn's Disease
Start date: 2000-08-17
Remicade
Start date: 2000-11-05
Remicade
Start date: 2002-08-09
Remicade
Start date: 2002-02-22
Remicade
Start date: 2002-02-11
Other drugs received by patient: Prilosec; Azathioprine Sodium; Imuran; Prednisone TAB; Corticosteroids; Fosamax
Possible Mercaptopurine side effects in female
Reported by a physician from United States on 2012-08-21
Patient: female, weighing 53.0 kg (116.6 pounds)
Reactions: Hepatosplenic T-Cell Lymphoma, Neutropenic Sepsis
Adverse event resulted in: death
Drug(s) suspected as cause:
Mercaptopurine
Mercaptopurine
Indication: Crohn's Disease
Mesalamine
Indication: Crohn's Disease
Remicade
Dosage: summer 2003
Indication: Crohn's Disease
Start date: 2001-01-15
End date: 2003-08-15
Other drugs received by patient: Metronidazole; Hydrocortisone; Prednisone TAB
Possible Mercaptopurine side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: female
Reactions: Night Sweats, Hot Flush
Drug(s) suspected as cause:
Mercaptopurine
Other drugs received by patient: Vitamin TAB
Possible Mercaptopurine side effects in male
Reported by a pharmacist from United States on 2012-08-21
Patient: male, weighing 81.7 kg (179.6 pounds)
Reactions: Neuropathy Peripheral, Lung Neoplasm, Hepatosplenic T-Cell Lymphoma, Nervous System Disorder, Muscle Rupture, Postoperative Abscess
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Mercaptopurine
Start date: 2002-01-01
Mercaptopurine
Indication: Crohn's Disease
Start date: 2002-10-01
Mercaptopurine
Dosage: decreased to 50 mg/day after 6-tg levels were found to be elevated
Start date: 2004-01-01
End date: 2006-08-01
Prednisone TAB
Indication: Crohn's Disease
Start date: 2003-08-01
Remicade
Dosage: in 2006, the patient received 3 doses; 24 total doses over total treatment period
Indication: Crohn's Disease
Start date: 2002-10-01
End date: 2006-08-01
Other drugs received by patient: Nexium; Folic Acid; Singulair; Asacol; Calcium; Nystatin; Balsalazide Disodium
Possible Mercaptopurine side effects in 8 year old female
Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-08-21
Patient: 8 year old female
Reactions: Mucoepidermoid Carcinoma
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cyclophosphamide
Indication: Acute Lymphocytic Leukaemia
Cytarabine
Indication: Acute Lymphocytic Leukaemia
Doxorubicin HCL
Indication: Acute Lymphocytic Leukaemia
Elspar
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Mercaptopurine
Indication: Acute Lymphocytic Leukaemia
Methotrexate
Methotrexate
Indication: Acute Lymphocytic Leukaemia
Prednisone TAB
Dosage: unk
Indication: Acute Lymphocytic Leukaemia
Vincristine
Indication: Acute Lymphocytic Leukaemia
Possible Mercaptopurine side effects in male
Reported by a physician from United Kingdom on 2012-08-21
Patient: male
Reactions: Pelvic Pain, Pyrexia, Anal Fistula, C-Reactive Protein Increased, Splenomegaly, Rectal Abscess, Lethargy, Hepatosplenic T-Cell Lymphoma, Crohn's Disease, Sepsis, Platelet Count Decreased, Diabetic Ketoacidosis, Neutropenia, Rectal Discharge, Leukopenia, Influenza Like Illness
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Azathioprine Sodium
Dosage: 2.5 mg/kg
Indication: Crohn's Disease
Azathioprine Sodium
Start date: 2002-01-01
End date: 2006-09-01
Azathioprine Sodium
Start date: 2001-06-01
Mercaptopurine
Indication: Crohn's Disease
Prednisolone
Indication: Product Used FOR Unknown Indication
Remicade
Indication: Crohn's Disease
End date: 2005-09-29
Remicade
Dosage: stopped in february - march (3rd infusion)
End date: 2006-02-01
Other drugs received by patient: Metronidazole; Vitamin B-12
Possible Mercaptopurine side effects in male
Reported by a physician from United States on 2012-08-21
Patient: male
Reactions: Multi-Organ Failure, Hepatosplenic T-Cell Lymphoma, Staphylococcal Abscess
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Mercaptopurine
Indication: Crohn's Disease
Remicade
Dosage: date also reported as 5-may-2005
Start date: 2005-04-01
Remicade
Dosage: second dose
Indication: Crohn's Disease
Start date: 2005-03-21
Remicade
Start date: 2000-01-01
Other drugs received by patient: Prednisone TAB; Mesalamine
Possible Mercaptopurine side effects in 66 year old female
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: 66 year old female, weighing 83.0 kg (182.6 pounds)
Reactions: Diplopia, Diarrhoea, Rash
Drug(s) suspected as cause:
Mercaptopurine
Administration route: Oral
Indication: Crohn's Disease
Start date: 2010-08-01
End date: 2010-03-01
Mercaptopurine
Administration route: Oral
Start date: 2011-03-01
End date: 2011-06-01
Mercaptopurine
Administration route: Oral
Start date: 2011-06-01
Metoprolol Succinate
Administration route: Oral
Indication: Blood Pressure Increased
Start date: 2006-01-01
End date: 2011-06-01
Other drugs received by patient: Omeprazole; Simvastatin; Amitriptyline HCL; Lisinopril
Possible Mercaptopurine side effects in male
Reported by a physician from United States on 2012-08-21
Patient: male, weighing 92.1 kg (202.6 pounds)
Reactions: T-Cell Lymphoma
Adverse event resulted in: death
Drug(s) suspected as cause:
Mercaptopurine
Start date: 1999-04-01
Mercaptopurine
Indication: Crohn's Disease
Start date: 1999-05-01
End date: 2002-05-12
Mesalamine
Indication: Crohn's Disease
Remicade
Remicade
Indication: Crohn's Disease
Start date: 1999-04-17
End date: 1999-04-17
Other drugs received by patient: Prednisone TAB
Possible Mercaptopurine side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-17
Patient: female
Reactions: Off Label Use, Ileostomy, Intestinal Operation, Pelvic Pouch Procedure, Pouchitis, Treatment Failure
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Humira
Dosage: 40 mg/0.8 ml pre-filled syringe
Start date: 2009-08-01
Humira
Indication: Pouchitis
Start date: 2012-06-06
Humira
Dosage: 40 mg/0.8 ml pre-filled syringe
Indication: Colitis Ulcerative
Start date: 2009-08-01
Humira
Start date: 2012-06-06
Mercaptopurine
Dosage: 40 mg/0.8 ml pre-filled syringe
Indication: Product Used FOR Unknown Indication
Remicade
Indication: Colitis Ulcerative
Possible Mercaptopurine side effects in 13 year old male
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-17
Patient: 13 year old male, weighing 40.0 kg (88.0 pounds)
Reactions: Pancreatitis Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Azathioprine Sodium
Indication: Colitis Ulcerative
Mercaptopurine
Indication: Colitis Ulcerative
Possible Mercaptopurine side effects in male
Reported by a physician from United States on 2012-08-17
Patient: male, weighing 31.5 kg (69.3 pounds)
Reactions: Pancreatitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cyclophosphamide
Dosage: 1000mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Cytarabine
Dosage: 75mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Mercaptopurine
Dosage: 60mgm2 cyclic
Administration route: Oral
Indication: T-Cell Type Acute Leukaemia
Methotrexate
Indication: T-Cell Type Acute Leukaemia
Nelarabine
Dosage: 650mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Start date: 2012-06-06
PEG-Asparaginase
Indication: T-Cell Type Acute Leukaemia
Vincristine
Dosage: 1.5mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Other drugs received by patient: Radiation
Possible Mercaptopurine side effects in female
Reported by a consumer/non-health professional from United States on 2012-08-16
Patient: female, weighing 37.2 kg (81.9 pounds)
Reactions: Respiratory Rate Increased, Tooth Loss, Pain, Off Label Use, Thinking Abnormal, Malaise, Euphoric Mood, Palpitations, Heart Rate Increased, Dizziness, Pancreatitis
Drug(s) suspected as cause:
Actiq
Indication: Pain
Actiq
Indication: Crohn's Disease
Mercaptopurine
Other drugs received by patient: Pentasa; Ciprofloxacin HCL; Flagyl
Possible Mercaptopurine side effects in
Reported by a health professional (non-physician/pharmacist) from Canada on 2012-08-13
Patient:
Reactions: Neoplasm Malignant
Drug(s) suspected as cause:
Budesonide
Indication: Crohn's Disease
Infliximab, Recombinant
Indication: Crohn's Disease
Mercaptopurine
Indication: Crohn's Disease
Possible Mercaptopurine side effects in 56 year old female
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-09
Patient: 56 year old female
Reactions: Angiocentric Lymphoma, Renal Mass
Drug(s) suspected as cause:
Mercaptopurine
Possible Mercaptopurine side effects in 9 year old female
Reported by a physician from Australia on 2012-08-08
Patient: 9 year old female, weighing 38.9 kg (85.6 pounds)
Reactions: Upper Respiratory Tract Infection, Alanine Aminotransferase Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Cyclophosphamide
Dosage: 1000mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Cytarabine
Dosage: 75mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Mercaptopurine
Dosage: 60mgm2 cyclic
Administration route: Oral
Indication: T-Cell Type Acute Leukaemia
Methotrexate
Indication: T-Cell Type Acute Leukaemia
Nelarabine
Dosage: 650mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Start date: 2012-05-10
PEG-Asparaginase
Indication: T-Cell Type Acute Leukaemia
Vincristine
Dosage: 1.5mgm2 cyclic
Indication: T-Cell Type Acute Leukaemia
Possible Mercaptopurine side effects in 12 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-08
Patient: 12 year old male
Reactions: non-Hodgkin's Lymphoma
Drug(s) suspected as cause:
Mercaptopurine
Indication: Crohn's Disease
Mesalamine
Indication: Crohn's Disease
Possible Mercaptopurine side effects in 18 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-08
Patient: 18 year old male
Reactions: Hodgkin's Disease Stage IV
Drug(s) suspected as cause:
Mercaptopurine
Indication: Colitis Ulcerative
Mesalamine
Indication: Colitis Ulcerative
Possible Mercaptopurine side effects in male
Reported by a physician from United States on 2012-08-07
Patient: male, weighing 75.2 kg (165.4 pounds)
Reactions: Clostridium Difficile Colitis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Dexamethasone
Dosage: 12 mg
Mercaptopurine
Dosage: 150 mg
Methotrexate
Dosage: 40 mg receives once weekly
Vincristine Sulfate
Dosage: 2 mg
Possible Mercaptopurine side effects in 5 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-07
Patient: 5 year old male
Reactions: Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased
Drug(s) suspected as cause:
Mercaptopurine
Dosage: 2800 milligram total
Administration route: Oral
Indication: B Precursor Type Acute Leukaemia
Start date: 2010-06-11
Methotrexate
Dosage: 110 milligram total
Administration route: Oral
Indication: B Precursor Type Acute Leukaemia
Start date: 2010-06-11
Prednisone
Dosage: 270 milligram total
Administration route: Oral
Indication: B Precursor Type Acute Leukaemia
Start date: 2010-06-11
Sprycel
Dosage: 1120 milligram total
Administration route: Oral
Indication: B Precursor Type Acute Leukaemia
Start date: 2010-06-11
Vincristine
Dosage: 2 milligram total
Indication: B Precursor Type Acute Leukaemia
Start date: 2010-06-11
Possible Mercaptopurine side effects in female
Reported by a physician from United States on 2012-08-07
Patient: female, weighing 44.9 kg (98.8 pounds)
Reactions: Small Intestinal Obstruction
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Humira
Humira
Indication: Product Used FOR Unknown Indication
Start date: 2011-07-01
Mercaptopurine
Indication: Product Used FOR Unknown Indication
Remicade
Indication: Inflammatory Bowel Disease
Start date: 2009-11-14
End date: 2010-07-02
Possible Mercaptopurine side effects in 8 year old female
Reported by a health professional (non-physician/pharmacist) from Turkey on 2012-08-06
Patient: 8 year old female
Reactions: Metastasis, Mucoepidermoid Carcinoma, Salivary Gland Cancer, Paralysis, Facial Nerve Disorder
Drug(s) suspected as cause:
Asparaginase
Dosage: berlin-frankfurt-munster protocol
Indication: Acute Lymphocytic Leukaemia
Cyclophosphamide
Dosage: berlin-frankfurt-munster protocol
Indication: Acute Lymphocytic Leukaemia
Cytarabine
Dosage: berlin-frankfurt-munster protocol
Indication: Acute Lymphocytic Leukaemia
Doxorubicin Hydrochloride
Dosage: berlin-frankfurt-munster protocol
Indication: Acute Lymphocytic Leukaemia
Mercaptopurine
Dosage: berlin-frankfurt-munster protocol
Indication: Acute Lymphocytic Leukaemia
End date: 2004-07-01
Methotrexate
Dosage: berlin-frankfurt-munster protocol
Indication: Acute Lymphocytic Leukaemia
End date: 2004-07-01
Methotrexate
Dosage: berlin-frankfurt-munster protocol
Prednisone
Dosage: berlin-frankfurt-munster protocol
Indication: Acute Lymphocytic Leukaemia
Vincristine
Dosage: berlin-frankfurt-munster protocol
Indication: Acute Lymphocytic Leukaemia
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