This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Leukeran (Chlorambucil) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (24)
Reports by Reaction Type
Mouth Ulceration (4),
Squamous Cell Carcinoma of Skin (4),
Pyrexia (3),
Malaise (3),
Dehydration (3),
Hypophagia (3),
Respiratory Tract Infection Viral (2),
Ear Infection (2),
Respiratory Tract Infection (2),
Lymphadenopathy (1),
Nasopharyngitis (1),
Infection (1)
Possible Leukeran side effects in male
Reported by a physician from United Kingdom on 2012-08-22
Patient: male, weighing 83.0 kg (182.6 pounds)
Reactions: Extrasystoles
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Administration route: Oral
Indication: Chronic Lymphocytic Leukaemia
Start date: 2011-03-04
End date: 2011-05-25
Ofatumumab
Dosage: 2g weekly
Indication: Chronic Lymphocytic Leukaemia
Start date: 2012-07-05
Other drugs received by patient: Bisoprolol Fumarate
Possible Leukeran side effects in
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-16
Patient:
Reactions: Colon Cancer
Drug(s) suspected as cause:
Leukeran
NO Treatment Received
Indication: Renal Failure
Prednisolone
Possible Leukeran side effects in
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-08-16
Patient:
Reactions: Squamous Cell Carcinoma
Drug(s) suspected as cause:
Leukeran
NO Treatment Received
Indication: Renal Failure
Prednisolone
Possible Leukeran side effects in female
Reported by a physician from Sweden on 2012-08-10
Patient: female, weighing 63.0 kg (138.6 pounds)
Reactions: Febrile Neutropenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Possible Leukeran side effects in 62 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-07-02
Patient: 62 year old male
Reactions: Malaise, Intracranial Haematoma, Drug Administration Error, Headache, Hemiparesis, Intracranial Pressure Increased, Treatment Noncompliance
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Other drugs received by patient: Ramipril; Humalog; Thiamine HCL; Simvastatin; Furosemide (Furosemide)
Possible Leukeran side effects in 60 year old female
Reported by a individual with unspecified qualification from Belgium on 2012-06-21
Patient: 60 year old female, weighing 51.0 kg (112.2 pounds)
Reactions: Pyelonephritis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Dosage: (10 mg/m2,days 1-7 every 28 days) oral
Administration route: Oral
Indication: Chronic Lymphocytic Leukaemia
Start date: 2010-09-21
Ofatumumab (Ofatumumab) (Unknown)
Dosage: see image
Indication: Chronic Lymphocytic Leukaemia
Start date: 2010-09-21
Ofatumumab (Ofatumumab) (Unknown)
Dosage: see image
Indication: Chronic Lymphocytic Leukaemia
Start date: 2010-09-28
Possible Leukeran side effects in 58 year old male
Reported by a individual with unspecified qualification from Poland on 2012-06-14
Patient: 58 year old male
Reactions: Lymphadenopathy, Pyrexia, Haematotoxicity, Fatigue, Vertigo, Haemolytic Anaemia, Splenomegaly, Thrombocytopenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Other drugs received by patient: Potassium Chloride; Electrolyte Fluids; Spironol; Metformin Hydrochloride; Hygroton; Allopurinol; Sulfamethoxazole and Trimethoprim; Polprazol
Possible Leukeran side effects in 62 year old male
Reported by a individual with unspecified qualification from United Kingdom on 2012-06-06
Patient: 62 year old male
Reactions: Pleural Effusion, Empyema
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Possible Leukeran side effects in 76 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-31
Patient: 76 year old male
Reactions: Malaise, Pyrexia, Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Dosage: 18 milligram (18 milligram, 1 in 1 days) , oral
Administration route: Oral
Indication: Chronic Lymphocytic Leukaemia
Start date: 2012-03-23
Ofatumumab (Ofatumumab)(unknown)
Dosage: (1000 milligram) intravenous (not otherwise specified)
Indication: Chronic Lymphocytic Leukaemia
Start date: 2012-03-22
Prednisolone
Dosage: 20 milligram (20 milligram,l 1in 1 days) , oral
Administration route: Oral
Start date: 2012-04-23
End date: 2012-04-25
Other drugs received by patient: Chlorpheniramine (Chlorpheniramine)(unknown); Ranitidine; Allopurinol; Bendamustine (Bendamustine)(unknown); Acetaminophen; Metoclopramide; Aciclovir (Aciclovir)(unknown); G-CSF (G-Csf)(unknown)
Possible Leukeran side effects in 78 year old female
Reported by a individual with unspecified qualification from Germany on 2012-05-17
Patient: 78 year old female
Reactions: Dyspnoea
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Other drugs received by patient: Diuretic
Possible Leukeran side effects in 63 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-14
Patient: 63 year old male
Reactions: Hyperglycaemia, Pyrexia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Possible Leukeran side effects in 63 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-14
Patient: 63 year old male
Reactions: Respiratory Tract Infection
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Possible Leukeran side effects in 63 year old male
Reported by a individual with unspecified qualification from United Kingdom on 2012-05-14
Patient: 63 year old male
Reactions: Respiratory Tract Infection
Drug(s) suspected as cause:
Leukeran
Possible Leukeran side effects in 81 year old male
Reported by a health professional (non-physician/pharmacist) from United Kingdom on 2012-05-14
Patient: 81 year old male
Reactions: Malaise, Nasopharyngitis, Neutropenic Sepsis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Dosage: 10 mg/m2days 1-7 every 28 days (10 mg/m2) oral
Administration route: Oral
Indication: Chronic Lymphocytic Leukaemia
Start date: 2010-11-17
Ofatumumab (Ofatumumab)
Dosage: 300mgat day 1, 1000mg at day 8 followed by 1000mg every 28 days intravenous(not otherwise specified)
Indication: Chronic Lymphocytic Leukaemia
Start date: 2010-11-17
Possible Leukeran side effects in 61 year old female
Reported by a individual with unspecified qualification from Ukraine on 2012-05-14
Patient: 61 year old female
Reactions: Ear Infection, Respiratory Tract Infection Viral
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Dosage: (18 mg/m2) intravenous (not otherwise specified)
Indication: Chronic Lymphocytic Leukaemia Refractory
Start date: 2011-10-27
Ofatummab (Ofatummab)
Dosage: intravenous (not otherwise specified)
Indication: Chronic Lymphocytic Leukaemia Refractory
Start date: 2011-12-21
Rituxan
Dosage: (375 mg/m2) intravenous (not otherwise specified)
Indication: Chronic Lymphocytic Leukaemia Refractory
Start date: 2011-10-27
Possible Leukeran side effects in 61 year old female
Reported by a health professional (non-physician/pharmacist) from Ukraine on 2012-05-03
Patient: 61 year old female, weighing 74.0 kg (162.8 pounds)
Reactions: Ear Infection, Respiratory Tract Infection Viral
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Dosage: (18 mg/m2)
Indication: Chronic Lymphocytic Leukaemia Refractory
Start date: 2011-10-27
Ofatumumab (Ofatumumab)
Indication: Chronic Lymphocytic Leukaemia Refractory
Start date: 2011-12-21
Rituxan
Dosage: (375 mg/m2)
Indication: Chronic Lymphocytic Leukaemia Refractory
Start date: 2011-10-27
Possible Leukeran side effects in 80 year old female
Reported by a individual with unspecified qualification from United Kingdom on 2012-05-02
Patient: 80 year old female
Reactions: Viral Upper Respiratory Tract Infection, Pneumonitis
Drug(s) suspected as cause:
Leukeran
Dosage: 16 milligram, oral
Administration route: Oral
Indication: Chronic Lymphocytic Leukaemia
Start date: 2011-01-10
Study Medication (Other)
Dosage: 1000 milligram, 1 once, intravenous (not otherwise specified)
Indication: Chronic Lymphocytic Leukaemia
Start date: 2011-01-10
End date: 2011-07-05
Other drugs received by patient: CO-Trimoxazole (Sulfamethoxazole and Trimethoprim); Albuterol Sulfate
Possible Leukeran side effects in female
Reported by a consumer/non-health professional from United States on 2012-03-19
Patient: female
Reactions: Mouth Ulceration, Hypophagia, Dehydration
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Dosage: unk
Administration route: Oral
Start date: 2012-01-01
Matulane
Dosage: 150 mg, unk
Administration route: Oral
Start date: 2012-01-06
Velcade
Dosage: unk
Start date: 2012-01-01
Possible Leukeran side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-03-02
Patient: female
Reactions: Dehydration, Hypophagia, Mouth Ulceration
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Dosage: unk
Administration route: Oral
Start date: 2012-01-01
Matulane
Dosage: 150 mg, unk
Administration route: Oral
Start date: 2012-01-06
Velcade
Dosage: unk
Start date: 2012-01-01
Possible Leukeran side effects in 62 year old female
Reported by a physician from United States on 2012-02-10
Patient: 62 year old female
Reactions: Hypophagia, Dehydration, Mouth Ulceration
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Leukeran
Dosage: po
Administration route: Oral
Indication: Hodgkin's Disease
Start date: 2012-01-01
Matulane
Dosage: 150 mg;qd;po
Administration route: Oral
Indication: Hodgkin's Disease
Start date: 2012-01-06
Velcade
Dosage: iv
Indication: Hodgkin's Disease
Start date: 2012-01-01
Possible Leukeran side effects in 48 year old female
Reported by a individual with unspecified qualification from United States on 2011-12-22
Patient: 48 year old female
Reactions: Squamous Cell Carcinoma of Skin
Drug(s) suspected as cause:
Arava
Indication: Behcet's Syndrome
Start date: 2007-06-01
Cellcept
Indication: Behcet's Syndrome
Start date: 2001-01-01
End date: 2001-09-01
Colchicine
Indication: Behcet's Syndrome
Start date: 1999-10-01
End date: 2002-12-01
Colchicine
Start date: 2004-08-01
Cycloserine
Indication: Behcet's Syndrome
Start date: 2000-05-01
End date: 2001-01-06
Cytoxan
Start date: 2003-03-01
End date: 2003-04-01
Cytoxan
Start date: 2003-08-01
End date: 2003-08-01
Cytoxan
Start date: 2003-02-01
End date: 2003-02-01
Cytoxan
Start date: 2003-03-01
End date: 2003-03-01
Cytoxan
Start date: 2003-10-01
End date: 2004-05-01
Cytoxan
Indication: Behcet's Syndrome
Start date: 2002-12-01
End date: 2002-12-01
Cytoxan
Start date: 2003-05-01
End date: 2003-07-01
Cytoxan
Start date: 2003-01-01
End date: 2003-01-01
Cytoxan
Start date: 2003-09-01
End date: 2003-09-01
Dapsone
Indication: Behcet's Syndrome
Start date: 1999-09-01
End date: 2000-05-01
Dapsone
Start date: 2003-06-01
End date: 2005-09-01
Enbrel
Indication: Behcet's Syndrome
Start date: 2004-09-01
End date: 2005-02-01
Imuran
Start date: 2007-01-01
End date: 2007-03-01
Imuran
Indication: Behcet's Syndrome
Start date: 2005-02-01
End date: 2005-04-01
Leukeran
Indication: Behcet's Syndrome
Start date: 2001-11-01
End date: 2002-04-01
Leukeran
Start date: 2002-06-01
End date: 2002-09-01
Leukeran
Start date: 2002-04-01
End date: 2002-06-01
Methotrexate
Indication: Behcet's Syndrome
Start date: 1998-10-01
End date: 1999-07-01
Plaquenil
Start date: 2002-06-01
End date: 2004-08-01
Plaquenil
Indication: Behcet's Syndrome
Start date: 1999-07-01
End date: 2002-05-01
Plaquenil
Start date: 2004-08-01
Prednisone TAB
Indication: Behcet's Syndrome
Remicade
Indication: Behcet's Syndrome
Start date: 2005-04-01
End date: 2005-05-01
Remicade
Start date: 2005-05-01
End date: 2005-07-01
Remicade
Start date: 2005-07-01
End date: 2005-09-01
Remicade
Start date: 2005-09-01
End date: 2006-02-01
Rituxan
Start date: 2006-07-05
End date: 2006-07-05
Rituxan
Indication: Behcet's Syndrome
Start date: 2006-06-01
End date: 2006-06-01
Other drugs received by patient: Sertraline Hydrochloride; Terbutaline Sulfate; Pregabalin; Acyclovir; Theophylline; Erythromycin; Esomeprazole Magnesium; Pentoxifylline; Fentanyl-100; Imiquimod; Fluticasone Propionate / Salmeterol; Folic Acid; Ipratropium Bromide and Albuterol Sulfate; Furosemide; Immune Globulin NOS; Imiquimod
Possible Leukeran side effects in 48 year old female
Reported by a physician from United States on 2011-12-13
Patient: 48 year old female
Reactions: Squamous Cell Carcinoma of Skin
Drug(s) suspected as cause:
Arava
Dosage: 20 mg, daily
Start date: 2007-06-01
Cellcept
Dosage: 1000 mg, 2x/day
Indication: Behcet's Syndrome
Start date: 2001-01-01
End date: 2001-09-01
Colchicine
Dosage: 6 mg, 2x/day
Indication: Behcet's Syndrome
Start date: 1999-10-01
End date: 2002-12-01
Colchicine
Dosage: 6 mg, 2x/day
Start date: 2004-08-01
Cyclosporine
Dosage: unk
Indication: Behcet's Syndrome
Start date: 2000-05-01
End date: 2001-01-06
Cytoxan
Dosage: 500 mg, unk
Start date: 2003-01-01
Cytoxan
Dosage: 1250 mg, unk
Start date: 2003-03-01
Cytoxan
Dosage: 500 mg, unk
Start date: 2003-05-01
Cytoxan
Dosage: 1000 mg, unk
Start date: 2003-09-01
Cytoxan
Dosage: 750 mg, unk
Start date: 2003-08-01
Cytoxan
Dosage: 250 mg, unk
Start date: 2002-12-01
Cytoxan
Dosage: 500 mg, unk
End date: 2004-05-01
Cytoxan
Dosage: 750 mg, unk
Start date: 2003-02-01
Cytoxan
Dosage: 1000 mg, unk
Start date: 2003-03-01
Cytoxan
Dosage: 500 mg, unk
Start date: 2003-07-01
Cytoxan
Dosage: 1250 mg, unk
Start date: 2003-04-01
Dapsone
Dosage: 50 mg, daily
Start date: 2003-06-01
End date: 2005-09-01
Dapsone
Dosage: 100 mg, 2x/day
Indication: Behcet's Syndrome
Start date: 1999-09-01
End date: 2000-05-01
Enbrel
Dosage: 25 mg, 2x/week
Indication: Ankylosing Spondylitis
Start date: 2004-09-01
End date: 2005-02-01
Imuran
Dosage: 150 mg, daily
Indication: Behcet's Syndrome
Start date: 2005-02-01
End date: 2005-04-01
Imuran
Dosage: 150 mg, daily
Start date: 2007-01-01
End date: 2007-03-01
Leukeran
Dosage: 2 mg, unk
Start date: 2002-06-01
End date: 2002-09-01
Leukeran
Dosage: 4 mg, daily
Indication: Behcet's Syndrome
Start date: 2001-11-01
Leukeran
Dosage: 3 mg, unk
Start date: 2002-04-01
Methotrexate
Dosage: titrated from 7.5 mg up to 20 mg weekly
Indication: Behcet's Syndrome
Start date: 1998-10-01
End date: 1999-07-01
Plaquenil
Dosage: 300 mg, qd
Indication: Behcet's Syndrome
Start date: 1999-07-01
End date: 2002-01-01
Plaquenil
Dosage: 200 mg, 2x/day
Start date: 2004-08-01
Plaquenil
Dosage: 200 mg, daily
Start date: 2002-06-01
Prednisone TAB
Dosage: 10 mg, daily, occasional pulses
Indication: Behcet's Syndrome
Remicade
Dosage: 400 mg, unk
Start date: 2005-05-01
Remicade
Dosage: 300 mg, unk
Start date: 2005-07-01
Remicade
Dosage: 400 mg, unk
Start date: 2005-11-01
Remicade
Dosage: 400 mg, unk
Start date: 2006-01-01
End date: 2006-02-01
Remicade
Dosage: 200 mg, unk
Indication: Behcet's Syndrome
Start date: 2005-04-01
Remicade
Dosage: 400 mg, unk
Start date: 2005-09-01
Rituxan
Dosage: 1000 mg, unk
Indication: Behcet's Syndrome
Start date: 2006-06-01
Rituxan
Dosage: 1000 mg, unk
Start date: 2006-07-05
Other drugs received by patient: Fentanyl; Galenic / Fluticasone / Salmeterol /; Acyclovir; Folic Acid; Terbutaline Sulfate; Albuterol Sulfate and Ipratropium Bromide; Theophylline; Erythromycin; Esomeprazole Magnesium; Sertraline Hydrochloride; Furosemide; Pentoxifylline; Pregabalin
Possible Leukeran side effects in 48 year old female
Reported by a physician from United States on 2011-10-28
Patient: 48 year old female
Reactions: Renal Failure, Nausea, Mouth Ulceration, Anaemia, Squamous Cell Carcinoma of Skin, Neutropenia, Rash, Accidental Exposure
Drug(s) suspected as cause:
Arava
Dosage: 20 mg daily
Indication: Behcet's Syndrome
Cellcept
Dosage: 1000 mg twice daily
Indication: Behcet's Syndrome
Colchicine
Dosage: 6 mg twice daily, 6 mg twice daily
Indication: Behcet's Syndrome
Cyclosporine
Indication: Behcet's Syndrome
End date: 2001-01-06
Cytoxan
Dosage: 250 mg, 250 mg, 500 mg, 750 mg, 1000 mg, 1250 mg, intravenous
Indication: Behcet's Syndrome
Dapsone
Dosage: titrated up to 100 mg twice daily, titrated up to 50 mg daily
Indication: Behcet's Syndrome
Enbrel
Dosage: 25 mg twice weekly
Indication: Behcet's Syndrome
Imuran
Dosage: titrated up to 150 mg daily
Indication: Behcet's Syndrome
Leukeran
Dosage: titrated up to 4 mg daily, 3 mg daily, 3 mg daily
Indication: Behcet's Syndrome
Methotrexate
Dosage: 7.5 mg per week, titrated up to 20 mg per week
Indication: Behcet's Syndrome
Plaquenil
Dosage: 300 mg daily, 200 mg daily, 200 mg twice daily, oral
Administration route: Oral
Indication: Behcet's Syndrome
Prednisone
Dosage: 10 mg daily
Indication: Behcet's Syndrome
Remicade
Dosage: 200 mg, 300 mg, 400 mg, intravenous
Indication: Behcet's Syndrome
Rituxan
Dosage: 1000 mg, 1000 mg, intravenous
Indication: Behcet's Syndrome
End date: 2006-07-05
Other drugs received by patient: Terbutaline Sulfate; (Esomeprazole); Pregabalin; Acyclovir; (Fentanyl); Erythromycin; Sertraline Hydrochloride; Theophylline; Pentoxifylline; Furosemide; Folic Acid; Fluticasone Propionate / Salmeterol; Ipratropium Bromide and Albuterol Sulfate
Possible Leukeran side effects in 48 year old female
Reported by a physician from United States on 2011-10-19
Patient: 48 year old female
Reactions: Squamous Cell Carcinoma of Skin
Drug(s) suspected as cause:
Arava
Indication: Behcet's Syndrome
Colchicine
Indication: Behcet's Syndrome
Cyclosporine
Indication: Behcet's Syndrome
Cytoxan
Indication: Behcet's Syndrome
Dapsone
Indication: Behcet's Syndrome
Enbrel
Indication: Behcet's Syndrome
Imuran
Indication: Behcet's Syndrome
Leukeran
Indication: Behcet's Syndrome
Methotrexate
Indication: Behcet's Syndrome
Mycophenolate Mofetil (Cellcept)
Indication: Behcet's Syndrome
Plaquenil
Indication: Behcet's Syndrome
Prednisone
Indication: Behcet's Syndrome
Remicade
Indication: Behcet's Syndrome
Rituxan
Indication: Behcet's Syndrome
Other drugs received by patient: Pregabalin; Acyclovir; Folic Acid; Furosemide; Terbutaline Sulfate; Erythromycin; Esomeprazole Sodium; Pentoxifylline; Theophylline; Fentanyl-100; Fluticasone Propionate / Salmeterol; Sertraline Hydrochloride
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