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Index of reports
> Cases with Liver Function Test Abnormal ()
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Letairis (Ambrisentan) where reactions include liver function test abnormal. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Letairis side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-21
Patient: male
Reactions: Jaundice, Renal Disorder, Nausea, Liver Function Test Abnormal, Hepatic Failure, Renal Failure Chronic, Liver Transplant
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in female
Reported by a physician from United States on 2012-08-15
Patient: female
Reactions: Fatigue, Malaise, Sickle Cell Anaemia With Crisis, Liver Function Test Abnormal, Sepsis, Hepatic Enzyme Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-14
Patient: male
Reactions: Jaundice, Renal Disorder, Liver Function Test Abnormal, Hepatic Failure, Renal Failure Chronic, Liver Transplant
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in female
Reported by a physician from United States on 2012-08-14
Patient: female
Reactions: Liver Function Test Abnormal, Escherichia Bacteraemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Dosage: 10 mg, unk
Administration route: Oral
Indication: Pulmonary Hypertension
Start date: 2011-07-27
End date: 2012-06-19
Letairis
Indication: Heart Disease Congenital
Possible Letairis side effects in 69 year old male
Reported by a physician from United States on 2012-08-10
Patient: 69 year old male
Reactions: Abdominal Pain, Jaundice, Vomiting, Viral Infection, Cryptogenic Cirrhosis, Nausea, Liver Function Test Abnormal, Abnormal Loss of Weight, non-Alcoholic Steatohepatitis, Decreased Appetite
Drug(s) suspected as cause:
Atorvastatin Calcium
Dosage: unk
End date: 2012-02-23
Azathioprine
Dosage: unk
Letairis
Dosage: 10 mg, unk
Administration route: Oral
Indication: Pulmonary Hypertension
Start date: 2010-10-12
End date: 2012-02-24
Letairis
Dosage: 5 mg, unk
Administration route: Oral
Indication: Pulmonary Fibrosis
Start date: 2012-03-16
End date: 2012-06-24
Letairis
Dosage: 10 unk
Administration route: Oral
Start date: 2012-06-24
Other drugs received by patient: Cyanocobalamin; Folic Acid; Pyridoxine; Codeine and Guaifenesin; Aspirin; NPH Insulin; Regular Human; Prednisone; Ascorbic Acid; Ipratropium; Potassium Chloride; Benzonatate; Furosemide; Metformin; Imuran; Doxycycline; Tocopheryl Acetate
Possible Letairis side effects in male
Reported by a physician from United States on 2012-08-06
Patient: male
Reactions: Death, Liver Function Test Abnormal, Ocular Icterus
Adverse event resulted in: death
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-31
Patient: female
Reactions: Liver Function Test Abnormal, Escherichia Bacteraemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in female
Reported by a physician from United States on 2012-07-30
Patient: female
Reactions: Pain in Extremity, Yellow Skin, Liver Function Test Abnormal, Cardiopulmonary Failure, Chromaturia, Septic Shock, Disease Progression
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Letairis
Dosage: 5 mg, unk
Administration route: Oral
Indication: Pulmonary Hypertension
Start date: 2009-01-21
End date: 2012-05-29
Letairis
Indication: Cardiac Disorder
Possible Letairis side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-30
Patient: male
Reactions: Liver Function Test Abnormal, Septic Shock
Drug(s) suspected as cause:
Letairis
Dosage: 5 mg, unk
Administration route: Oral
Indication: Pulmonary Hypertension
Letairis
Indication: Left Ventricular Dysfunction
Letairis
Indication: Sickle Cell Anaemia
Possible Letairis side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-30
Patient: female
Reactions: Liver Function Test Abnormal, Escherichia Bacteraemia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-20
Patient: female
Reactions: Pain in Extremity, Yellow Skin, Liver Function Test Abnormal, Cardiopulmonary Failure, Chromaturia, Septic Shock, Disease Progression
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Letairis
Indication: Cardiac Disorder
Letairis
Dosage: 5 mg, unk
Administration route: Oral
Indication: Pulmonary Hypertension
Start date: 2009-01-21
End date: 2012-05-29
Possible Letairis side effects in female
Reported by a consumer/non-health professional from United States on 2012-07-05
Patient: female
Reactions: Pain in Extremity, Yellow Skin, Liver Function Test Abnormal, Cardiopulmonary Failure, Chromaturia, Disease Progression
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Letairis
Dosage: 5 mg, unk
Administration route: Oral
Indication: Pulmonary Hypertension
Start date: 2009-01-21
End date: 2012-05-29
Letairis
Indication: Cardiac Disorder
Possible Letairis side effects in male
Reported by a physician from United States on 2012-05-14
Patient: male
Reactions: Death, Liver Function Test Abnormal, Ocular Icterus
Adverse event resulted in: death
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in male
Reported by a physician from United States on 2012-04-27
Patient: male
Reactions: Death, Renal Failure, Cyanosis, Hyperkalaemia, Liver Function Test Abnormal, Chest Pain, Lactic Acidosis, Cardiac Arrest
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Letairis
Dosage: 5 mg, unk
Administration route: Oral
Start date: 2009-04-01
End date: 2009-06-01
Letairis
Dosage: 10 unk, unk
Administration route: Oral
Indication: Pulmonary Hypertension
Start date: 2009-06-01
Other drugs received by patient: Fluoxetine; Hydrocodone Bitartrate and Acetaminophen; Furosemide; Flolan; Revatio; Potassium Chloride; Carvedilol; Digoxin; Simvastatin; Omeprazole
Possible Letairis side effects in 40 year old male
Reported by a pharmacist from United States on 2012-04-26
Patient: 40 year old male
Reactions: Agitation, Renal Failure, Cardio-Respiratory Arrest, Hyperkalaemia, Liver Function Test Abnormal, Lactic Acidosis
Drug(s) suspected as cause:
Letairis
Other drugs received by patient: Fluoxetine; Potassium Chloride; Furosemide; Revatio; Hydrocodone Bitartrate and Acetaminophen; Omeprazole; Digoxin; Simvastatin; Carvedilol
Possible Letairis side effects in male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-04-13
Patient: male
Reactions: Blood Bilirubin Increased, Liver Function Test Abnormal
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in male
Reported by a physician from United States on 2012-04-13
Patient: male
Reactions: Death, Liver Function Test Abnormal, Ocular Icterus
Adverse event resulted in: death
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in male
Reported by a physician from United States on 2012-04-13
Patient: male
Reactions: Blood Bilirubin Increased, Aspartate Aminotransferase Increased, Liver Function Test Abnormal
Drug(s) suspected as cause:
Letairis
Possible Letairis side effects in 74 year old female
Reported by a physician from United States on 2012-03-22
Patient: 74 year old female, weighing 60.5 kg (133.0 pounds)
Reactions: Dehydration, Liver Function Test Abnormal, Asthenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Dosage: (5 mg)
Indication: Pulmonary Arterial Hypertension
Tyvaso (6 Microgram, Aerosol FOR Inhalation) (Treprostinil Sodium, TRE
Dosage: (54 mcg), inhalation
Indication: Pulmonary Arterial Hypertension
Start date: 2009-11-05
Other drugs received by patient: Coumadin; Digoxin; Diuretics (Diuretics) (Unknown); Oxygen (Oxygen) (Unknown); Revatio (Sildenafil Citrate) (Unknown)
Possible Letairis side effects in 74 year old female
Reported by a physician from United States on 2012-03-22
Patient: 74 year old female, weighing 60.5 kg (133.0 pounds)
Reactions: Dehydration, Liver Function Test Abnormal, Asthenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Dosage: (5 mg)
Indication: Pulmonary Arterial Hypertension
Tyvaso (6 Microgram, Aerosol FOR Inhalation) (Treprostinil Sodium)
Dosage: (54 mcg), inhalation
Indication: Pulmonary Arterial Hypertension
Start date: 2009-11-05
Other drugs received by patient: Revatio (Sildenafil Citrate) (Unknown); Digoxin; Oxygen (Oxygen) (Unknown); Diuretics (Diuretics) (Unknown); Coumadin
Possible Letairis side effects in 50 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-25
Patient: 50 year old male
Reactions: Liver Function Test Abnormal
Drug(s) suspected as cause:
Letairis
Dosage: 10 mg, unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2008-10-14
Letairis
Dosage: 5 mg, unk
Administration route: Oral
Possible Letairis side effects in 50 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-01-05
Patient: 50 year old male
Reactions: Liver Function Test Abnormal
Drug(s) suspected as cause:
Letairis
Dosage: 5 mg, unk
Administration route: Oral
Letairis
Dosage: 10 mg, unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Start date: 2008-10-14
Possible Letairis side effects in 74 year old female
Reported by a physician from United States on 2011-12-22
Patient: 74 year old female, weighing 60.5 kg (133.0 pounds)
Reactions: Dehydration, Liver Function Test Abnormal, Asthenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Tyvaso
Dosage: (54 mcg),inhalation
Indication: Pulmonary Arterial Hypertension
Start date: 2009-11-05
Other drugs received by patient: Diuretics (Diuretics); Revatio; Oxygen (Oxygen); Coumadin; Digoxin
Possible Letairis side effects in 74 year old female
Reported by a physician from United States on 2011-12-22
Patient: 74 year old female, weighing 60.5 kg (133.0 pounds)
Reactions: Dehydration, Liver Function Test Abnormal, Asthenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Tyvaso
Dosage: (54 mcg),inhalation
Indication: Pulmonary Arterial Hypertension
Start date: 2009-11-05
Other drugs received by patient: Revatio; Digoxin; Diuretics (Diuretics); Oxygen (Oxygen); Coumadin
Possible Letairis side effects in 74 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-20
Patient: 74 year old female
Reactions: Liver Function Test Abnormal, Dehydration, Unevaluable Event, Asthenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Letairis
Dosage: unk
Indication: Pulmonary Arterial Hypertension
Tyvaso
Dosage: 54 ?g, unk
Indication: Pulmonary Arterial Hypertension
Start date: 2009-11-05
Other drugs received by patient: Revatio; Oxygen; Coumadin; Digoxin
Possible Letairis side effects in 50 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2011-12-19
Patient: 50 year old male
Reactions: Liver Function Test Abnormal
Drug(s) suspected as cause:
Letairis
Dosage: 5 mg, unk
Administration route: Oral
Letairis
Dosage: 10 mg, unk
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Letairis side effects in
Reported by a physician from United States on 2011-10-25
Patient:
Reactions: Torsade DE Pointes, Hypoxic-Ischaemic Encephalopathy, Liver Function Test Abnormal, Pulmonary Oedema, Platelet Count Decreased, Myocardial Infarction, Cardiac Arrest
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Letairis
Indication: Scleroderma
Letairis
Administration route: Oral
Indication: Pulmonary Hypertension
Start date: 2010-03-03
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