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Lamotrigine (Lamotrigine) - Blood Creatine Phosphokinase Increased - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Blood Creatine Phosphokinase Increased ()

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Lamotrigine where reactions include blood creatine phosphokinase increased. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Lamotrigine side effects in 26 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-02

Patient: 26 year old female

Reactions: Confusional State, Blood Creatine Phosphokinase Increased, Anaemia, Disseminated Intravascular Coagulation, Oropharyngeal Pain, Pyrexia, Headache, Somnolence, Renal Failure, Respiratory Arrest, Leukocytosis, Influenza Like Illness

Adverse event resulted in: death

Drug(s) suspected as cause:
Lamotrigine

Other drugs received by patient: Thioridazine HCL; Thyroxine (Thyroxine); Hydrocortone; Vigabatrin (Vigabatrin); Carbamazepine; Acetazolamide



Possible Lamotrigine side effects in 44 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-27

Patient: 44 year old female

Reactions: Antipsychotic Drug Level Increased, Blood Creatine Phosphokinase Increased, Rash, Pyrexia, Agranulocytosis, Dizziness, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Neutrophil Count Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lamotrigine

Other drugs received by patient possibly interacting with the suspect drug:
Clozapine
    Indication: Psychotic Disorder

Other drugs received by patient: Olanzapine



Possible Lamotrigine side effects in 23 year old female

Reported by a health professional (non-physician/pharmacist) from Poland on 2012-07-25

Patient: 23 year old female

Reactions: Electrocardiogram QT Prolonged, Pneumonia Aspiration, Blood Creatine Phosphokinase Increased, Rhabdomyolysis, Psychomotor Retardation, Atrioventricular Block Complete, Hypercapnia, Ventricular Arrhythmia, Coma, Hypokalaemia, Speech Disorder, Balance Disorder, Multiple Drug Overdose Intentional, Depression, Arrhythmia Supraventricular, Vomiting, Hypotension, Encephalopathy, Ataxia, Conduction Disorder, Hyponatraemia, Status Epilepticus, Body Temperature Decreased, Heart Rate Decreased, Respiratory Failure, Ventricular Tachycardia, Areflexia, Suicide Attempt, Pulse Absent, Ventricular Fibrillation, Memory Impairment

Adverse event resulted in: life threatening event, hospitalization

Drug(s) suspected as cause:
Baclofen
    Dosage: oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Lamotrigine
    Dosage: 10, 000 - 20, 000mg, oral
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication



Possible Lamotrigine side effects in 48 year old female

Reported by a pharmacist from United States on 2012-07-18

Patient: 48 year old female

Reactions: Agitation, Blood Creatine Phosphokinase Increased, Hyperthermia, Hallucination, Auditory, Unresponsive To Stimuli, Muscle Rigidity, Haematemesis, Social Avoidant Behaviour, Blood Creatinine Increased, Blood Glucose Increased, Lethargy, Blood Urea Increased, Restlessness, Catatonia, Foreign Body, Dehydration, Upper Gastrointestinal Haemorrhage, Withdrawal Syndrome, Leukocytosis

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Clozapine
    Indication: Agitation

Haloperidol
    Dosage: 5 mg, iv
    Indication: Agitation

Lamotrigine
    Dosage: 100 mg, bid, po
    Administration route: Oral
    Indication: Product Used FOR Unknown Indication

Paroxetine HCL
    Dosage: 40;20;30 mg, qd
    Indication: Product Used FOR Unknown Indication

Other drugs received by patient: Diphenhydramine HCL; Glimepiride; Diphenhydramine HCL; Famotidine; Pantoprazole



Possible Lamotrigine side effects in 36 year old

Reported by a physician from United States on 2012-07-11

Patient: 36 year old

Reactions: Blood Creatine Phosphokinase Increased, Mental Status Changes, Headache, Pyrexia, Hepatotoxicity, Neuroleptic Malignant Syndrome, Vomiting, Nausea, Autonomic Nervous System Imbalance, Alanine Aminotransferase Increased, International Normalised Ratio Increased, Urinary Tract Infection, Toxicity To Various Agents, Diarrhoea, Aspartate Aminotransferase Increased, Heart Rate Increased

Drug(s) suspected as cause:
Acetaminophen
    Dosage: unknown
    Indication: Urinary Tract Infection

Bupropion HCL
    Dosage: unknown
    Indication: Bipolar Disorder

Ciprofloxacin
    Dosage: unknown
    Indication: Urinary Tract Infection

Lamotrigine
    Dosage: unknown
    Indication: Bipolar Disorder

Lithiuim (Lithium)
    Dosage: unknown
    Indication: Bipolar Disorder

Loxazpine (Loxapine)
    Dosage: unknown
    Indication: Bipolar Disorder

Ondansetron
    Dosage: unknown
    Indication: Urinary Tract Infection

Sertraline Hydrochloride
    Dosage: unknown
    Indication: Bipolar Disorder

Trazodone HCL
    Dosage: unknown
    Indication: Bipolar Disorder

Venlafaxine HCL
    Dosage: unknown
    Indication: Bipolar Disorder



Possible Lamotrigine side effects in male

Reported by a physician from Germany on 2012-03-02

Patient: male, weighing 90.0 kg (198.0 pounds)

Reactions: Blood Creatine Phosphokinase Increased, Miosis, Tachycardia, Coma, Suicide Attempt, Endotracheal Intubation

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lamotrigine
    Dosage: 50mg see dosage text
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14

Lithium Carbonate
    Dosage: 450mg unknown
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14

Lorazepam
    Dosage: 1mg see dosage text
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14

Mirtazapine
    Dosage: 30mg see dosage text
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14

Zyprexa
    Dosage: 5mg see dosage text
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14



Possible Lamotrigine side effects in 56 year old male

Reported by a physician from United States on 2012-02-27

Patient: 56 year old male

Reactions: Agitation, Confusional State, Rhabdomyolysis, Blood Creatine Phosphokinase Increased, Aphasia, Mouth Injury, Mental Status Changes, Disorientation, Muscle Spasticity, Muscle Rigidity, Treatment Noncompliance, Speech Disorder, Overdose, Nose Deformity, Blood Sodium Increased, Patient Restraint, Blood Alkaline Phosphatase Increased, Alanine Aminotransferase Increased, Cognitive Disorder, Toxicity To Various Agents, Postictal State, Clonic Convulsion, Blood Glucose Decreased, Incoherent, Aspartate Aminotransferase Increased, Disturbance in Attention, Facial Bones Fracture, Face Injury

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lamotrigine

Other drugs received by patient: Clonazepam



Possible Lamotrigine side effects in 44 year old female

Reported by a physician from Germany on 2012-02-22

Patient: 44 year old female, weighing 60.0 kg (132.0 pounds)

Reactions: Blood Creatine Phosphokinase Increased, Body Temperature Increased, Incorrect Dose Administered, Hyperreflexia, Muscle Rigidity, Blood Creatine Phosphokinase MB Increased, Haemodialysis, Loss of Consciousness, Myoclonus, Grand MAL Convulsion, NO Therapeutic Response, Suicide Attempt, Blood Sodium Decreased

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lamotrigine
    Dosage: total dose up to 20 g
    Indication: Major Depression

Venlafaxine Hydrochloride
    Dosage: total dose up to 4.5 g
    Indication: Major Depression

Other drugs received by patient: Diazepam (Pill)



Possible Lamotrigine side effects in male

Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-27

Patient: male, weighing 90.0 kg (198.0 pounds)

Reactions: Blood Creatine Phosphokinase Increased, Tachycardia, Miosis, Coma, Suicide Attempt

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Lamotrigine
    Dosage: 50mg see dosage text
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14

Lithium Carbonate
    Dosage: 450mg unknown
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14

Lorazepam
    Dosage: 1mg see dosage text
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14

Mirtazapine
    Dosage: 30mg see dosage text
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14

Zyprexa
    Dosage: 5mg see dosage text
    Administration route: Oral
    Start date: 2011-09-14
    End date: 2011-09-14

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