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Index of reports
> Cases with Blood Creatine Phosphokinase Increased ()
Below is the selection of side effect reports (a.k.a. adverse event reports) related to Lamotrigine where reactions include blood creatine phosphokinase increased. The selected reports were submitted to the FDA during the sample period of about a year.
Possible Lamotrigine side effects in 26 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-08-02
Patient: 26 year old female
Reactions: Confusional State, Blood Creatine Phosphokinase Increased, Anaemia, Disseminated Intravascular Coagulation, Oropharyngeal Pain, Pyrexia, Headache, Somnolence, Renal Failure, Respiratory Arrest, Leukocytosis, Influenza Like Illness
Adverse event resulted in: death
Drug(s) suspected as cause:
Lamotrigine
Other drugs received by patient: Thioridazine HCL; Thyroxine (Thyroxine); Hydrocortone; Vigabatrin (Vigabatrin); Carbamazepine; Acetazolamide
Possible Lamotrigine side effects in 44 year old female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-27
Patient: 44 year old female
Reactions: Antipsychotic Drug Level Increased, Blood Creatine Phosphokinase Increased, Rash, Pyrexia, Agranulocytosis, Dizziness, Musculoskeletal Stiffness, Neuroleptic Malignant Syndrome, Neutrophil Count Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Lamotrigine
Other drugs received by patient possibly interacting with the suspect drug:
Clozapine
Indication: Psychotic Disorder
Other drugs received by patient: Olanzapine
Possible Lamotrigine side effects in 23 year old female
Reported by a health professional (non-physician/pharmacist) from Poland on 2012-07-25
Patient: 23 year old female
Reactions: Electrocardiogram QT Prolonged, Pneumonia Aspiration, Blood Creatine Phosphokinase Increased, Rhabdomyolysis, Psychomotor Retardation, Atrioventricular Block Complete, Hypercapnia, Ventricular Arrhythmia, Coma, Hypokalaemia, Speech Disorder, Balance Disorder, Multiple Drug Overdose Intentional, Depression, Arrhythmia Supraventricular, Vomiting, Hypotension, Encephalopathy, Ataxia, Conduction Disorder, Hyponatraemia, Status Epilepticus, Body Temperature Decreased, Heart Rate Decreased, Respiratory Failure, Ventricular Tachycardia, Areflexia, Suicide Attempt, Pulse Absent, Ventricular Fibrillation, Memory Impairment
Adverse event resulted in: life threatening event, hospitalization
Drug(s) suspected as cause:
Baclofen
Dosage: oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Lamotrigine
Dosage: 10, 000 - 20, 000mg, oral
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Possible Lamotrigine side effects in 48 year old female
Reported by a pharmacist from United States on 2012-07-18
Patient: 48 year old female
Reactions: Agitation, Blood Creatine Phosphokinase Increased, Hyperthermia, Hallucination, Auditory, Unresponsive To Stimuli, Muscle Rigidity, Haematemesis, Social Avoidant Behaviour, Blood Creatinine Increased, Blood Glucose Increased, Lethargy, Blood Urea Increased, Restlessness, Catatonia, Foreign Body, Dehydration, Upper Gastrointestinal Haemorrhage, Withdrawal Syndrome, Leukocytosis
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Clozapine
Indication: Agitation
Haloperidol
Dosage: 5 mg, iv
Indication: Agitation
Lamotrigine
Dosage: 100 mg, bid, po
Administration route: Oral
Indication: Product Used FOR Unknown Indication
Paroxetine HCL
Dosage: 40;20;30 mg, qd
Indication: Product Used FOR Unknown Indication
Other drugs received by patient: Diphenhydramine HCL; Glimepiride; Diphenhydramine HCL; Famotidine; Pantoprazole
Possible Lamotrigine side effects in 36 year old
Reported by a physician from United States on 2012-07-11
Patient: 36 year old
Reactions: Blood Creatine Phosphokinase Increased, Mental Status Changes, Headache, Pyrexia, Hepatotoxicity, Neuroleptic Malignant Syndrome, Vomiting, Nausea, Autonomic Nervous System Imbalance, Alanine Aminotransferase Increased, International Normalised Ratio Increased, Urinary Tract Infection, Toxicity To Various Agents, Diarrhoea, Aspartate Aminotransferase Increased, Heart Rate Increased
Drug(s) suspected as cause:
Acetaminophen
Dosage: unknown
Indication: Urinary Tract Infection
Bupropion HCL
Dosage: unknown
Indication: Bipolar Disorder
Ciprofloxacin
Dosage: unknown
Indication: Urinary Tract Infection
Lamotrigine
Dosage: unknown
Indication: Bipolar Disorder
Lithiuim (Lithium)
Dosage: unknown
Indication: Bipolar Disorder
Loxazpine (Loxapine)
Dosage: unknown
Indication: Bipolar Disorder
Ondansetron
Dosage: unknown
Indication: Urinary Tract Infection
Sertraline Hydrochloride
Dosage: unknown
Indication: Bipolar Disorder
Trazodone HCL
Dosage: unknown
Indication: Bipolar Disorder
Venlafaxine HCL
Dosage: unknown
Indication: Bipolar Disorder
Possible Lamotrigine side effects in male
Reported by a physician from Germany on 2012-03-02
Patient: male, weighing 90.0 kg (198.0 pounds)
Reactions: Blood Creatine Phosphokinase Increased, Miosis, Tachycardia, Coma, Suicide Attempt, Endotracheal Intubation
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Lamotrigine
Dosage: 50mg see dosage text
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
Lithium Carbonate
Dosage: 450mg unknown
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
Lorazepam
Dosage: 1mg see dosage text
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
Mirtazapine
Dosage: 30mg see dosage text
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
Zyprexa
Dosage: 5mg see dosage text
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
Possible Lamotrigine side effects in 56 year old male
Reported by a physician from United States on 2012-02-27
Patient: 56 year old male
Reactions: Agitation, Confusional State, Rhabdomyolysis, Blood Creatine Phosphokinase Increased, Aphasia, Mouth Injury, Mental Status Changes, Disorientation, Muscle Spasticity, Muscle Rigidity, Treatment Noncompliance, Speech Disorder, Overdose, Nose Deformity, Blood Sodium Increased, Patient Restraint, Blood Alkaline Phosphatase Increased, Alanine Aminotransferase Increased, Cognitive Disorder, Toxicity To Various Agents, Postictal State, Clonic Convulsion, Blood Glucose Decreased, Incoherent, Aspartate Aminotransferase Increased, Disturbance in Attention, Facial Bones Fracture, Face Injury
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Lamotrigine
Other drugs received by patient: Clonazepam
Possible Lamotrigine side effects in 44 year old female
Reported by a physician from Germany on 2012-02-22
Patient: 44 year old female, weighing 60.0 kg (132.0 pounds)
Reactions: Blood Creatine Phosphokinase Increased, Body Temperature Increased, Incorrect Dose Administered, Hyperreflexia, Muscle Rigidity, Blood Creatine Phosphokinase MB Increased, Haemodialysis, Loss of Consciousness, Myoclonus, Grand MAL Convulsion, NO Therapeutic Response, Suicide Attempt, Blood Sodium Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Lamotrigine
Dosage: total dose up to 20 g
Indication: Major Depression
Venlafaxine Hydrochloride
Dosage: total dose up to 4.5 g
Indication: Major Depression
Other drugs received by patient: Diazepam (Pill)
Possible Lamotrigine side effects in male
Reported by a health professional (non-physician/pharmacist) from Germany on 2011-10-27
Patient: male, weighing 90.0 kg (198.0 pounds)
Reactions: Blood Creatine Phosphokinase Increased, Tachycardia, Miosis, Coma, Suicide Attempt
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Lamotrigine
Dosage: 50mg see dosage text
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
Lithium Carbonate
Dosage: 450mg unknown
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
Lorazepam
Dosage: 1mg see dosage text
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
Mirtazapine
Dosage: 30mg see dosage text
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
Zyprexa
Dosage: 5mg see dosage text
Administration route: Oral
Start date: 2011-09-14
End date: 2011-09-14
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