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Isoniazid (Isoniazid) - Aspartate Aminotransferase Increased - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Aspartate Aminotransferase Increased (15)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Isoniazid where reactions include aspartate aminotransferase increased. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Isoniazid side effects in

Reported by a consumer/non-health professional from France on 2012-07-30

Patient:

Reactions: Drug Eruption, Death, Aspartate Aminotransferase Increased, Anaemia, Neutropenia, Leukopenia

Adverse event resulted in: death

Drug(s) suspected as cause:
Viread
    Dosage: 300 mg, qd
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2010-05-30

Rifampin
    Dosage: 600 mg, qd
    Administration route: Oral
    Indication: Tuberculosis
    Start date: 2010-05-22
    End date: 2010-08-10

Isentress
    Dosage: 800 mg, qd
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2010-05-30
    End date: 2010-08-31

Isoniazid
    Dosage: 400 mg, qd
    Administration route: Oral
    Indication: Tuberculosis
    Start date: 2010-05-22
    End date: 2010-08-10

Dapsone
    Dosage: 100 mg, qd
    Indication: Prophylaxis
    Start date: 2011-01-15

Pyrazinamide
    Dosage: 2 g, qd
    Administration route: Oral
    Indication: Tuberculosis
    Start date: 2010-05-22
    End date: 2010-07-26

Epivir
    Dosage: 300 mg, qd
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2010-06-30

Kaletra
    Dosage: 20
    Administration route: Oral
    Indication: HIV Infection
    Start date: 2010-11-22

Other drugs received by patient: Bactrim; Leucovorin Calcium; Leucovorin Calcium; Ivermectin; Acyclovir; Ciproflaxacin; Azithromycin; Pyridoxine HCL; Omeprazole



Possible Isoniazid side effects in male

Reported by a physician from Brazil on 2012-07-26

Patient: male

Reactions: Nausea, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased

Drug(s) suspected as cause:
Ethambutol Hydrochloride
    Dosage: unk
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2010-12-27

Rifampin
    Dosage: 450 mg, qd
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2011-01-01

Rifampin
    Dosage: 450 mg, qd

Isoniazid
    Dosage: unk
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2011-01-01

Efavirenz
    Dosage: unk
    Indication: HIV Infection
    Start date: 2010-11-25
    End date: 2011-01-01

Acyclovir
    Dosage: 4000 unk, unk
    Indication: Herpes Zoster
    Start date: 2010-12-18
    End date: 2010-12-25

Acetaminophen
    Dosage: unk
    Indication: Headache
    Start date: 2010-12-13

Pyrazinamide
    Dosage: 1200 mg, unk
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2010-12-27

Ethambutol Hydrochloride
    Dosage: unk

Tenofovir Disoproxil Fumarate
    Indication: HIV Infection

Bactrim
    Dosage: 400 mg, unk
    Indication: Prophylaxis
    Start date: 2010-12-13

Efavirenz
    Dosage: unk

Lamivudine
    Dosage: 300 mg, qd
    Indication: HIV Infection
    Start date: 2010-11-25

Azithromycin
    Dosage: 1500 unk, unk
    Indication: Prophylaxis
    Start date: 2010-11-04

Prednisone
    Dosage: 40 mg, unk
    Indication: Meningitis
    Start date: 2010-10-16



Possible Isoniazid side effects in 32 year old male

Reported by a physician from United States on 2012-06-20

Patient: 32 year old male, weighing 58.1 kg (127.7 pounds)

Reactions: Abdominal Pain, Fatigue, Nausea, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in male

Reported by a physician from Japan on 2012-06-15

Patient: male, weighing 64.0 kg (140.8 pounds)

Reactions: Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased

Drug(s) suspected as cause:
Stelara
    Start date: 2011-09-26

Stelara
    Start date: 2011-06-13

Stelara
    Start date: 2011-07-11

Stelara
    Indication: Psoriasis
    Start date: 2011-12-19

Isoniazid
    Indication: Prophylaxis
    Start date: 2011-05-23
    End date: 2011-12-19

Other drugs received by patient: Clobetasol Propionate; Cyclosporine; Maxacalcitol



Possible Isoniazid side effects in male

Reported by a physician from Japan on 2012-06-14

Patient: male, weighing 64.0 kg (140.8 pounds)

Reactions: Gamma-Glutamyltransferase Increased, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased

Drug(s) suspected as cause:
Isoniazid
    Indication: Prophylaxis
    Start date: 2011-05-23
    End date: 2011-12-19

Stelara
    Indication: Psoriasis
    Start date: 2011-12-19

Stelara
    Start date: 2011-07-11

Stelara
    Start date: 2011-06-13

Stelara
    Start date: 2011-09-26

Other drugs received by patient: Cyclosporine; Clobetasol Propionate; Maxacalcitol



Possible Isoniazid side effects in 21 year old female

Reported by a physician from United States on 2012-06-13

Patient: 21 year old female

Reactions: Liver Injury, Metabolic Acidosis, Vomiting, Rhabdomyolysis, Blood Creatine Phosphokinase Increased, Intentional Overdose, Alanine Aminotransferase Increased, Unresponsive To Stimuli, Blood PH Decreased, Posture Abnormal, Blood Bicarbonate Decreased, Convulsion, Loss of Consciousness, Aspartate Aminotransferase Increased, Suicide Attempt, Pupil Fixed

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Isoniazid
    Indication: Suicide Attempt

Ethambutol Hydrochloride

Rifampicin
    Indication: Suicide Attempt

Isoniazid
    Indication: Tuberculosis

Rifampicin
    Indication: Tuberculosis

Ethambutol Hydrochloride
    Indication: Suicide Attempt

Rifampicin

Isoniazid

Ethambutol Hydrochloride

Rifampicin

Ethambutol Hydrochloride
    Indication: Tuberculosis

Isoniazid



Possible Isoniazid side effects in 51 year old male

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-06-12

Patient: 51 year old male

Reactions: Blood Bilirubin Increased, Hypersensitivity, Headache, Pyrexia, Rash Pruritic, Diplopia, Malaise, Thrombocytopenia, Blood Alkaline Phosphatase Increased, Alanine Aminotransferase Increased, Vith Nerve Paralysis, Glycosuria, Rash Erythematous, Aspartate Aminotransferase Increased, Normochromic Normocytic Anaemia, Rash Maculo-Papular, Anisocytosis, Influenza Like Illness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Isoniazid

Other drugs received by patient: Pyrazinamide; Rifampicin; Ethambutol Hydrochloride



Possible Isoniazid side effects in 61 year old female

Reported by a physician from United States on 2012-05-15

Patient: 61 year old female

Reactions: Abdominal Pain, Jaundice, Blood Alkaline Phosphatase Increased, Pruritus, Lymphadenopathy, Blood Urine Present, Nausea, Faeces Discoloured, Fatigue, Drug-Induced Liver Injury, Aspartate Aminotransferase Increased, Decreased Appetite

Drug(s) suspected as cause:
Isoniazid

Other drugs received by patient: Pioglitazone; Amlodipine Besylate; Insulin Glargine; Aspirin; Hydrochlorothiazide; Insulin Aspart; Valsartan



Possible Isoniazid side effects in 2 year old female

Reported by a physician from United States on 2012-04-16

Patient: 2 year old female

Reactions: Blood Bilirubin Increased, Liver Injury, Blood Alkaline Phosphatase Increased, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Failure To Thrive

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in 63 year old male

Reported by a physician from United States on 2012-04-13

Patient: 63 year old male

Reactions: Liver Injury, Jaundice, Nausea, Alanine Aminotransferase Increased, Encephalopathy, Ascites, Fatigue, Renal Impairment, Aspartate Aminotransferase Increased, Abdominal Distension

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in 23 year old female

Reported by a physician from United States on 2012-04-13

Patient: 23 year old female

Reactions: Liver Injury, Jaundice, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Prothrombin Time Prolonged

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in 53 year old male

Reported by a physician from United States on 2012-04-13

Patient: 53 year old male

Reactions: Blood Alkaline Phosphatase Increased, Jaundice, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in 64 year old male

Reported by a physician from United States on 2012-01-10

Patient: 64 year old male

Reactions: Blood Alkaline Phosphatase Increased, Jaundice, Liver Injury, Blood Bilirubin Increased, Alanine Aminotransferase Increased, Ascites, Abdominal Discomfort, Fatigue, Hepatic Encephalopathy, Aspartate Aminotransferase Increased, Abdominal Distension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Isoniazid
    Indication: Pulmonary Tuberculosis

Rifampicin
    Indication: Pulmonary Tuberculosis

Other drugs received by patient: Chlordiazepoxide; Lorazepam; Multi-Vitamins; Pyridoxine HCL; Thiamine HCL; Omeprazole; Sildenafil; Folic Acid; Felodipine; Propranolol; Aspirin



Possible Isoniazid side effects in

Reported by a health professional (non-physician/pharmacist) from Uganda on 2011-11-17

Patient:

Reactions: Peptic Ulcer, Hypotension, Anaemia, Rash, Motor Neurone Disease, Lobar Pneumonia, Arrhythmia, Ascites, Diarrhoea, Aspartate Aminotransferase Increased, Mental Disorder, Neutropenia, Thrombocytopenia, Hypertension, Cardiac Failure Congestive

Drug(s) suspected as cause:
Rifampicin
    Indication: Tuberculosis

Ethambutol Hydrochloride
    Indication: Tuberculosis

Abacavir
    Dosage: 1 dose was observed by study staff and one self administered
    Indication: Antiretroviral Therapy

Lamivudine (Epivir Hbv)
    Dosage: 1 dose was observed by study staff and one self administered
    Indication: Antiretroviral Therapy

Isoniazid
    Indication: Tuberculosis

Zidovudine
    Dosage: 1 dose was observed by study staff and one self administered
    Indication: Antiretroviral Therapy

Pyrazinamide
    Indication: Tuberculosis



Possible Isoniazid side effects in 7 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-14

Patient: 7 year old male

Reactions: Abdominal Pain, Jaundice, Alanine Aminotransferase Increased, International Normalised Ratio Increased, Cachexia, Gamma-Glutamyltransferase Increased, Hepatotoxicity, Aspartate Aminotransferase Increased, Ammonia Increased, Acute Hepatic Failure

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ethambutol Hydrochloride
    Indication: Tuberculosis

Rifampicin
    Indication: Tuberculosis

Pyrazinamide
    Indication: Tuberculosis

Isoniazid
    Indication: Tuberculosis

Other drugs received by patient: Ceftriaxone; Fluconazole; Pyridoxine HCL; Acetaminophen

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