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Isoniazid (Isoniazid) - Alanine Aminotransferase Increased - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Alanine Aminotransferase Increased (18)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Isoniazid where reactions include alanine aminotransferase increased. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Isoniazid side effects in male

Reported by a physician from Brazil on 2012-07-26

Patient: male

Reactions: Nausea, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased

Drug(s) suspected as cause:
Ethambutol Hydrochloride
    Dosage: unk
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2010-12-27

Rifampin
    Dosage: 450 mg, qd
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2011-01-01

Rifampin
    Dosage: 450 mg, qd

Isoniazid
    Dosage: unk
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2011-01-01

Efavirenz
    Dosage: unk
    Indication: HIV Infection
    Start date: 2010-11-25
    End date: 2011-01-01

Acyclovir
    Dosage: 4000 unk, unk
    Indication: Herpes Zoster
    Start date: 2010-12-18
    End date: 2010-12-25

Acetaminophen
    Dosage: unk
    Indication: Headache
    Start date: 2010-12-13

Pyrazinamide
    Dosage: 1200 mg, unk
    Indication: Tuberculosis
    Start date: 2010-10-16
    End date: 2010-12-27

Ethambutol Hydrochloride
    Dosage: unk

Tenofovir Disoproxil Fumarate
    Indication: HIV Infection

Bactrim
    Dosage: 400 mg, unk
    Indication: Prophylaxis
    Start date: 2010-12-13

Efavirenz
    Dosage: unk

Lamivudine
    Dosage: 300 mg, qd
    Indication: HIV Infection
    Start date: 2010-11-25

Azithromycin
    Dosage: 1500 unk, unk
    Indication: Prophylaxis
    Start date: 2010-11-04

Prednisone
    Dosage: 40 mg, unk
    Indication: Meningitis
    Start date: 2010-10-16



Possible Isoniazid side effects in 32 year old female

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11

Patient: 32 year old female

Reactions: Jaundice, Alanine Aminotransferase Increased, Acute Hepatic Failure, Drug Interaction, Kidney Transplant Rejection

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Isoniazid

Other drugs received by patient possibly interacting with the suspect drug:
Rifampicin
    Indication: Sarcoidosis

Immunosuppressive Agents
    Indication: Immunosuppression

Rifampicin

Prednisolone
    Indication: Immunosuppression

Other drugs received by patient: Moxifloxacin; Ethambutol Hydrochloride; Pyrazinamide; Ethambutol Hydrochloride



Possible Isoniazid side effects in 47 year old male

Reported by a health professional (non-physician/pharmacist) from France on 2012-07-11

Patient: 47 year old male

Reactions: Jaundice, Hepatic Encephalopathy, Alanine Aminotransferase Increased, Liver Transplant Rejection, Drug Interaction, Acute Hepatic Failure

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Isoniazid

Other drugs received by patient possibly interacting with the suspect drug:
Rifampicin
    Indication: Tuberculosis

Prednisolone
    Indication: Immunosuppression

Tacrolimus
    Indication: Immunosuppression

Other drugs received by patient: Rifampicin; Moxifloxacin; Ethambutol Hydrochloride; Ethambutol Hydrochloride



Possible Isoniazid side effects in 32 year old male

Reported by a physician from United States on 2012-06-20

Patient: 32 year old male, weighing 58.1 kg (127.7 pounds)

Reactions: Abdominal Pain, Fatigue, Nausea, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in male

Reported by a physician from Japan on 2012-06-15

Patient: male, weighing 64.0 kg (140.8 pounds)

Reactions: Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased

Drug(s) suspected as cause:
Stelara
    Start date: 2011-09-26

Stelara
    Start date: 2011-06-13

Stelara
    Start date: 2011-07-11

Stelara
    Indication: Psoriasis
    Start date: 2011-12-19

Isoniazid
    Indication: Prophylaxis
    Start date: 2011-05-23
    End date: 2011-12-19

Other drugs received by patient: Clobetasol Propionate; Cyclosporine; Maxacalcitol



Possible Isoniazid side effects in male

Reported by a physician from Japan on 2012-06-14

Patient: male, weighing 64.0 kg (140.8 pounds)

Reactions: Gamma-Glutamyltransferase Increased, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased

Drug(s) suspected as cause:
Isoniazid
    Indication: Prophylaxis
    Start date: 2011-05-23
    End date: 2011-12-19

Stelara
    Indication: Psoriasis
    Start date: 2011-12-19

Stelara
    Start date: 2011-07-11

Stelara
    Start date: 2011-06-13

Stelara
    Start date: 2011-09-26

Other drugs received by patient: Cyclosporine; Clobetasol Propionate; Maxacalcitol



Possible Isoniazid side effects in 21 year old female

Reported by a physician from United States on 2012-06-13

Patient: 21 year old female

Reactions: Liver Injury, Metabolic Acidosis, Vomiting, Rhabdomyolysis, Blood Creatine Phosphokinase Increased, Intentional Overdose, Alanine Aminotransferase Increased, Unresponsive To Stimuli, Blood PH Decreased, Posture Abnormal, Blood Bicarbonate Decreased, Convulsion, Loss of Consciousness, Aspartate Aminotransferase Increased, Suicide Attempt, Pupil Fixed

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Isoniazid
    Indication: Suicide Attempt

Ethambutol Hydrochloride

Rifampicin
    Indication: Suicide Attempt

Isoniazid
    Indication: Tuberculosis

Rifampicin
    Indication: Tuberculosis

Ethambutol Hydrochloride
    Indication: Suicide Attempt

Rifampicin

Isoniazid

Ethambutol Hydrochloride

Rifampicin

Ethambutol Hydrochloride
    Indication: Tuberculosis

Isoniazid



Possible Isoniazid side effects in 51 year old male

Reported by a health professional (non-physician/pharmacist) from Korea, Republic of on 2012-06-12

Patient: 51 year old male

Reactions: Blood Bilirubin Increased, Hypersensitivity, Headache, Pyrexia, Rash Pruritic, Diplopia, Malaise, Thrombocytopenia, Blood Alkaline Phosphatase Increased, Alanine Aminotransferase Increased, Vith Nerve Paralysis, Glycosuria, Rash Erythematous, Aspartate Aminotransferase Increased, Normochromic Normocytic Anaemia, Rash Maculo-Papular, Anisocytosis, Influenza Like Illness

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Isoniazid

Other drugs received by patient: Pyrazinamide; Rifampicin; Ethambutol Hydrochloride



Possible Isoniazid side effects in 39 year old male

Reported by a health professional (non-physician/pharmacist) from Tunisia on 2012-04-30

Patient: 39 year old male

Reactions: Dyspnoea, Alanine Aminotransferase Increased, Pyrexia, Drug Rash With Eosinophilia and Systemic Symptoms, Rash Pruritic, Generalised Oedema, Hallucination, Rash Maculo-Papular

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ethambutol Hydrochloride
    Dosage: 1600 mg, unk
    Start date: 2010-10-10

Ethambutol Hydrochloride
    Dosage: 1100 mg, unk
    Indication: Pulmonary Tuberculosis
    Start date: 2010-07-08

Isoniazid
    Dosage: 350 mg, unk
    Start date: 2010-04-13

Isoniazid
    Dosage: 300 mg, unk
    Indication: Pulmonary Tuberculosis
    Start date: 2010-07-08

Other drugs received by patient: Metformin HCL; Glimepiride; Rifampicin; Pyrazinamide



Possible Isoniazid side effects in 2 year old female

Reported by a physician from United States on 2012-04-16

Patient: 2 year old female

Reactions: Blood Bilirubin Increased, Liver Injury, Blood Alkaline Phosphatase Increased, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Failure To Thrive

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in 23 year old female

Reported by a physician from United States on 2012-04-13

Patient: 23 year old female

Reactions: Liver Injury, Jaundice, Aspartate Aminotransferase Increased, Alanine Aminotransferase Increased, Prothrombin Time Prolonged

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in 53 year old male

Reported by a physician from United States on 2012-04-13

Patient: 53 year old male

Reactions: Blood Alkaline Phosphatase Increased, Jaundice, Alanine Aminotransferase Increased, Aspartate Aminotransferase Increased

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in 63 year old male

Reported by a physician from United States on 2012-04-13

Patient: 63 year old male

Reactions: Liver Injury, Jaundice, Nausea, Alanine Aminotransferase Increased, Encephalopathy, Ascites, Fatigue, Renal Impairment, Aspartate Aminotransferase Increased, Abdominal Distension

Drug(s) suspected as cause:
Isoniazid



Possible Isoniazid side effects in 28 year old male

Reported by a health professional (non-physician/pharmacist) from Tunisia on 2012-04-02

Patient: 28 year old male, weighing 40.0 kg (88.0 pounds)

Reactions: Muscle Contractions Involuntary, Pain in Extremity, Myokymia, Alanine Aminotransferase Increased, Muscular Weakness, Erectile Dysfunction, Erythema, Myopathy, Myalgia, Antinuclear Antibody Positive, Joint Swelling, Arthralgia, Pulmonary Tuberculoma, White Blood Cell Count Increased

Drug(s) suspected as cause:
Isoniazid

Other drugs received by patient: Streptomycin; Rifampicin; Pyrazinamide



Possible Isoniazid side effects in 64 year old male

Reported by a physician from United States on 2012-01-10

Patient: 64 year old male

Reactions: Blood Alkaline Phosphatase Increased, Jaundice, Liver Injury, Blood Bilirubin Increased, Alanine Aminotransferase Increased, Ascites, Abdominal Discomfort, Fatigue, Hepatic Encephalopathy, Aspartate Aminotransferase Increased, Abdominal Distension

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Isoniazid
    Indication: Pulmonary Tuberculosis

Rifampicin
    Indication: Pulmonary Tuberculosis

Other drugs received by patient: Chlordiazepoxide; Lorazepam; Multi-Vitamins; Pyridoxine HCL; Thiamine HCL; Omeprazole; Sildenafil; Folic Acid; Felodipine; Propranolol; Aspirin



Possible Isoniazid side effects in 7 year old male

Reported by a health professional (non-physician/pharmacist) from United States on 2011-11-14

Patient: 7 year old male

Reactions: Abdominal Pain, Jaundice, Alanine Aminotransferase Increased, International Normalised Ratio Increased, Cachexia, Gamma-Glutamyltransferase Increased, Hepatotoxicity, Aspartate Aminotransferase Increased, Ammonia Increased, Acute Hepatic Failure

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Ethambutol Hydrochloride
    Indication: Tuberculosis

Rifampicin
    Indication: Tuberculosis

Pyrazinamide
    Indication: Tuberculosis

Isoniazid
    Indication: Tuberculosis

Other drugs received by patient: Ceftriaxone; Fluconazole; Pyridoxine HCL; Acetaminophen



Possible Isoniazid side effects in 8 month old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2011-10-20

Patient: 8 month old female

Reactions: Blood Bilirubin Increased, Immune Reconstitution Syndrome, Bovine Tuberculosis, Haemorrhage, Coagulopathy, Mental Status Changes, Hepatic Failure, Lymphadenitis, Hepatic Encephalopathy, Liver Function Test Abnormal, Brain Oedema, Hepatic Cirrhosis, Blood Lactate Dehydrogenase Increased, Alanine Aminotransferase Increased, Vaccination Failure, Condition Aggravated, Toxicity To Various Agents, Convulsion, Acute Hepatic Failure, Hepatitis B

Adverse event resulted in: death

Drug(s) suspected as cause:
Lopinavir / Ritonavir

Ritonavir
    Indication: HIV Infection

Ritonavir

Lamivudine
    Indication: HIV Infection

Lamivudine

Zidovudine

Ciprofloxacin
    Indication: Tuberculosis

Zidovudine
    Indication: HIV Infection

Amikacin
    Dosage: usp
    Indication: Tuberculosis

Cotrim
    Indication: Tuberculosis

Tice BCG
    Dosage: liquid intradermal
    Indication: Product Used FOR Unknown Indication

Isoniazid
    Indication: Tuberculosis

Hepatitis B Vaccine
    Dosage: received at 6, 10 and 14 weeks of life
    Indication: Product Used FOR Unknown Indication

Ethambutol Hydrochloride
    Indication: Tuberculosis

Pyrazinamide
    Indication: Tuberculosis

Rifampin
    Indication: Tuberculosis

Lopinavir / Ritonavir
    Indication: HIV Infection



Possible Isoniazid side effects in 8 month old female

Reported by a health professional (non-physician/pharmacist) from Canada on 2011-10-18

Patient: 8 month old female

Reactions: Blood Bilirubin Increased, Immune Reconstitution Syndrome, Bovine Tuberculosis, Haemorrhage, Coagulopathy, Mental Status Changes, Hepatic Failure, Lymphadenitis, Hepatic Encephalopathy, Liver Function Test Abnormal, Brain Oedema, Hepatic Cirrhosis, Alanine Aminotransferase Increased, Blood Lactate Dehydrogenase Increased, Vaccination Failure, Condition Aggravated, Toxicity To Various Agents, Convulsion, Acute Hepatic Failure, Hepatitis B

Adverse event resulted in: death

Drug(s) suspected as cause:
Norvir
    Indication: HIV Infection

Ethambutol Hydrochloride
    Indication: Tuberculosis

Pyrazinamide
    Indication: Tuberculosis

Norvir

Isoniazid
    Indication: Tuberculosis

Lamivudine

Ciprofloxacin
    Indication: Tuberculosis

Cotrim
    Indication: Tuberculosis

Zidovudine
    Indication: HIV Infection

Zidovudine

Kaletra

Hepatitis B Vaccine
    Dosage: received at 6, 10 and 14 weeks of life
    Indication: Product Used FOR Unknown Indication

Lamivudine
    Indication: HIV Infection

Rifampin
    Indication: Tuberculosis

Tice BCG
    Dosage: liquid intradermal
    Indication: Product Used FOR Unknown Indication

Amikacin
    Dosage: usp
    Indication: Tuberculosis

Kaletra
    Indication: HIV Infection

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