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Hydroxyurea (Hydroxyurea) - Cardiac Failure - Suspected Cause - Side Effect Reports

 
 



Index of reports > Cases with Cardiac Failure (8)

Below is the selection of side effect reports (a.k.a. adverse event reports) related to Hydroxyurea where reactions include cardiac failure. The selected reports were submitted to the FDA during the sample period of about a year.

Possible Hydroxyurea side effects in 73 year old male

Reported by a consumer/non-health professional from United States on 2012-07-30

Patient: 73 year old male, weighing 81.0 kg (178.1 pounds)

Reactions: Cardiac Failure, Cardiomyopathy, Pericardial Effusion, Generalised Oedema, Cardiomegaly

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Aspirin
    Dosage: 150mg
    Administration route: Oral
    Start date: 2003-01-27
    End date: 2003-03-20

Hydroxyurea
    Dosage: 500mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2009-09-21
    End date: 2009-09-22

Acetylsalicylic Acid W / Dipyridamole
    Dosage: 1 df daily dose
    Start date: 2003-01-27
    End date: 2005-03-20

Hydroxyurea
    Dosage: 500mg
    Administration route: Oral
    Start date: 2009-10-12
    End date: 2009-11-02

Anagrelide HCL
    Dosage: 2mg
    Administration route: Oral
    Start date: 2009-06-02
    End date: 2009-09-21

Anagrelide HCL
    Dosage: 1mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2009-11-09
    End date: 2009-11-17

Aspirin
    Dosage: 75mg
    Administration route: Oral
    Start date: 2009-12-30
    End date: 2010-07-08

Acetylsalicylic Acid W / Dipyridamole
    Dosage: 2 df daily dose
    Indication: Essential Thrombocythaemia
    Start date: 2005-03-20
    End date: 2009-09-21

Anagrelide HCL
    Dosage: dose of 1 mg and 3.5 mg
    Administration route: Oral
    Start date: 2000-06-28
    End date: 2009-03-02

Aspirin
    Dosage: 150mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2000-06-28
    End date: 2003-01-25

Other drugs received by patient: Citalopram Hydrobromide



Possible Hydroxyurea side effects in 73 year old male

Reported by a physician from Denmark on 2012-07-02

Patient: 73 year old male, weighing 81.0 kg (178.2 pounds)

Reactions: Anaemia, General Physical Health Deterioration, Cerebrovascular Accident, Cardiomyopathy, Generalised Oedema, Cardiomegaly, Pericardial Effusion, Cardiac Failure, Sepsis

Adverse event resulted in: death, hospitalization

Drug(s) suspected as cause:
Aspirin
    Dosage: 150 mg, qd
    Administration route: Oral
    Start date: 2003-01-27
    End date: 2003-03-01

Hydroxyurea
    Dosage: 500 mg, qd
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2009-09-21
    End date: 2009-09-22

Anagrelide HCL
    Dosage: .5 mg, bid
    Administration route: Oral
    Start date: 2009-11-09
    End date: 2009-11-17

Anagrelide HCL
    Dosage: alternating between a daily dose of 1 mg and 3.5 mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2000-06-28
    End date: 2009-06-02

Anagrelide HCL
    Dosage: .5 mg, qid
    Administration route: Oral
    Start date: 2009-06-02
    End date: 2009-09-21

Aspirin and Dipyridamole
    Dosage: 1 df, bid
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2003-01-27
    End date: 2005-03-01

Aspirin and Dipyridamole
    Dosage: 1 df, qd
    Administration route: Oral
    Start date: 2005-03-01
    End date: 2009-09-21

Aspirin
    Dosage: 150 mg, qd
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2000-06-28
    End date: 2003-01-25

Aspirin
    Dosage: 75 mg, qd
    Administration route: Oral
    Start date: 2009-12-30
    End date: 2010-07-08

Hydroxyurea
    Dosage: 500 mg, qd
    Administration route: Oral
    Start date: 2009-10-12
    End date: 2009-11-02

Other drugs received by patient: Danazol; Citalopram Hydrobromide



Possible Hydroxyurea side effects in 73 year old male

Reported by a consumer/non-health professional from United States on 2012-06-29

Patient: 73 year old male, weighing 81.0 kg (178.1 pounds)

Reactions: Cardiac Failure, Cardiomyopathy, Generalised Oedema, Cardiomegaly, Pericardial Effusion

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Acetylsalicylic Acid W / Dipyridamole
    Dosage: 2 df daily dose
    Indication: Essential Thrombocythaemia
    Start date: 2005-03-20
    End date: 2009-09-21

Acetylsalicylic Acid W / Dipyridamole
    Dosage: 1 df daily dose
    Start date: 2003-01-27
    End date: 2005-03-20

Anagrelide HCL
    Dosage: 1mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2009-11-09
    End date: 2009-11-17

Anagrelide HCL
    Dosage: dose of 1 mg and 3.5 mg
    Administration route: Oral
    Start date: 2000-06-28
    End date: 2009-03-02

Anagrelide HCL
    Dosage: 2mg
    Administration route: Oral
    Start date: 2009-06-02
    End date: 2009-09-21

Aspirin
    Dosage: 150mg
    Administration route: Oral
    Start date: 2003-01-27
    End date: 2003-03-20

Hydroxyurea
    Dosage: 500mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2009-09-21
    End date: 2009-09-22

Aspirin
    Dosage: 150mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2000-06-28
    End date: 2003-01-25

Aspirin
    Dosage: 75mg
    Administration route: Oral
    Start date: 2009-12-30
    End date: 2010-07-08

Hydroxyurea
    Dosage: 500mg
    Administration route: Oral
    Start date: 2009-10-12
    End date: 2009-11-02

Other drugs received by patient: Citalopram Hydrobromide



Possible Hydroxyurea side effects in 73 year old male

Reported by a consumer/non-health professional from United States on 2012-06-18

Patient: 73 year old male, weighing 81.0 kg (178.1 pounds)

Reactions: Cardiac Failure, Cardiomyopathy, Pericardial Effusion, Cardiomegaly, Generalised Oedema

Adverse event resulted in: hospitalization

Drug(s) suspected as cause:
Hydroxyurea
    Dosage: 500mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2009-09-21
    End date: 2009-09-22

Hydroxyurea
    Dosage: 500mg
    Administration route: Oral
    Start date: 2009-10-12
    End date: 2009-11-02

Aspirin
    Dosage: 150mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2000-06-28
    End date: 2003-01-25

Aspirin
    Dosage: 150mg
    Administration route: Oral
    Start date: 2003-01-27
    End date: 2003-03-20

Acetylsalicylic Acid W / Dipyridamole
    Dosage: 1 df daily dose
    Start date: 2003-01-27
    End date: 2005-03-20

Aspirin
    Dosage: 75mg
    Administration route: Oral
    Start date: 2009-12-30
    End date: 2010-07-08

Acetylsalicylic Acid W / Dipyridamole
    Dosage: 2 df daily dose
    Indication: Essential Thrombocythaemia
    Start date: 2005-03-20
    End date: 2009-09-21

Anagrelide HCL
    Dosage: 1mg
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2009-11-09
    End date: 2009-11-17

Anagrelide HCL
    Dosage: dose of 1 mg and 3.5 mg
    Administration route: Oral
    Start date: 2000-06-28
    End date: 2009-03-02

Anagrelide HCL
    Dosage: 2mg
    Administration route: Oral
    Start date: 2009-06-02
    End date: 2009-09-21

Other drugs received by patient: Citalopram Hydrobromide



Possible Hydroxyurea side effects in

Reported by a physician from Sweden on 2012-06-18

Patient:

Reactions: Tachyarrhythmia, Cardiac Failure, Supraventricular Tachyarrhythmia, Atrial Fibrillation, Cardiomyopathy, Arrhythmia

Adverse event resulted in: disablity

Drug(s) suspected as cause:
Hydroxyurea
    Dosage: 500 mg, unk
    Administration route: Oral
    Start date: 2008-08-11
    End date: 2008-11-30

Hydroxyurea
    Dosage: 500 mg, unk
    Administration route: Oral
    Start date: 2009-07-20
    End date: 2010-01-15

Hydroxyurea
    Dosage: 500 mg, unk
    Administration route: Oral
    Start date: 2005-10-17
    End date: 2007-10-21

Hydroxyurea
    Dosage: 500 mg, unk
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 1998-04-30
    End date: 2005-03-29

Hydroxyurea
    Dosage: 500 mg, unk
    Administration route: Oral
    Start date: 2005-03-30
    End date: 2005-10-16

Hydroxyurea
    Dosage: 500 mg, unk
    Administration route: Oral
    Start date: 2007-10-22
    End date: 2008-07-06

Anagrelide HCL
    Dosage: 0.5 mg, unk
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2005-03-30
    End date: 2005-10-17

Aspirin
    Dosage: 100 mg, unk
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2003-09-01

Hydroxyurea
    Dosage: 500 mg, unk
    Administration route: Oral
    Start date: 2008-12-01
    End date: 2009-01-25

Hydroxyurea
    Dosage: 500 mg, unk
    Administration route: Oral
    Start date: 2009-01-26
    End date: 2009-07-19

Hydroxyurea
    Dosage: 500 mg, unk
    Administration route: Oral
    Start date: 2008-07-08
    End date: 2008-08-10

Other drugs received by patient: Allopurinol; Metoprolol Succinate; Simvastatin



Possible Hydroxyurea side effects in 68 year old male

Reported by a consumer/non-health professional from Germany on 2012-04-13

Patient: 68 year old male

Reactions: Neoplasm Malignant, Cardiac Failure, Major Depression, Penis Carcinoma, Spinal Osteoarthritis, Leukocytosis, Haemorrhoidal Haemorrhage

Drug(s) suspected as cause:
Hydroxyurea
    Indication: Chronic Myeloid Leukaemia
    Start date: 2002-01-01
    End date: 2011-01-01

Nilotinib
    Start date: 2008-01-01

Thioguanine
    Start date: 2009-01-01
    End date: 2011-01-01

Imatinib Mesylate
    Dosage: also received in 2010
    Indication: Chronic Myeloid Leukaemia
    Start date: 2004-01-01



Possible Hydroxyurea side effects in 68 year old male

Reported by a physician from Germany on 2012-04-04

Patient: 68 year old male

Reactions: Cardiac Failure, Neoplasm Malignant, Major Depression, Spinal Osteoarthritis, Penis Carcinoma, Leukocytosis, Haemorrhoidal Haemorrhage

Drug(s) suspected as cause:
Thioguanine
    Start date: 2009-01-01
    End date: 2011-01-01

Hydroxyurea
    Indication: Chronic Myeloid Leukaemia
    Start date: 2002-01-01
    End date: 2011-01-01

Imatinib Mesylate
    Dosage: also received in 2010
    Indication: Chronic Myeloid Leukaemia
    Start date: 2004-01-01

Nilotinib
    Start date: 2008-01-01



Possible Hydroxyurea side effects in male

Reported by a physician from Germany on 2012-01-27

Patient: male

Reactions: Cardiac Failure

Adverse event resulted in: death

Drug(s) suspected as cause:
Hydroxyurea
    Dosage: 1500 mg daily, as req'd daily
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 1996-05-01
    End date: 1997-11-10

Anagrelide HCL
    Dosage: 1 mg, as req'd daily
    Administration route: Oral
    Indication: Essential Thrombocythaemia
    Start date: 2005-05-27
    End date: 2006-11-21

Hydroxyurea
    Dosage: 1000 mg daily, as req'd daily
    Administration route: Oral
    Start date: 2002-02-20
    End date: 2004-05-18

Anagrelide HCL
    Dosage: 1 mg daily for two days, then 1.5 mg for one day, repeating
    Administration route: Oral
    Start date: 2006-11-22

Interferon
    Dosage: 3 miu, 1x/week
    Indication: Essential Thrombocythaemia
    Start date: 1998-01-16
    End date: 2004-05-10

Other drugs received by patient: Novodigal / 00017701 /; Risperdal

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