This is an index of side effect / adverse reaction reports (a.k.a. adverse event reports) related to Hycamtin (Topotecan) and submitted to the FDA during the sample period of about a year. The information is not vetted and should not be considered as verified clinical evidence.
Reports by Event Outcome
All Cases (157)
Death (52)
Life Threatening Events (11)
Disability (10)
Reports by Reaction Type
White Blood Cell Count Decreased (37),
Neutrophil Count Decreased (34),
Platelet Count Decreased (32),
Anaemia (28),
Death (24),
RED Blood Cell Count Decreased (21),
Nausea (13),
Decreased Appetite (11),
Febrile Neutropenia (11),
Fatigue (10),
Interstitial Lung Disease (8),
Blood Creatinine Increased (8)
Below are a few examples of reports where side effects / adverse reactions may be related to Hycamtin (Topotecan). For a complete list or a specific selection of reports, please use the links above.
Possible Hycamtin side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-27
Patient: male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in 50 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-24
Patient: 50 year old female, weighing 62.5 kg (137.5 pounds)
Reactions: Blood Alkaline Phosphatase Increased, White Blood Cell Count Decreased, Pain of Skin, Anaemia, Alanine Aminotransferase Increased, Gamma-Glutamyltransferase Increased, Aspartate Aminotransferase Increased, Platelet Count Decreased, Blood Creatinine Increased, Neutrophil Count Decreased
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Dexamethasone Sodium Phosphate; Granisetron
Possible Hycamtin side effects in 70 year old female
Reported by a physician from Japan on 2012-08-13
Patient: 70 year old female, weighing 45.0 kg (99.0 pounds)
Reactions: Hepatic Function Abnormal, Neutropenia
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Decadron Phosphate; Heparin Sodium; Urso 250
Possible Hycamtin side effects in 51 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-13
Patient: 51 year old female
Reactions: White Blood Cell Count Decreased, RED Blood Cell Count Decreased, Nausea, Anaemia, Platelet Count Decreased, Headache, Neutrophil Count Decreased, Decreased Appetite
Drug(s) suspected as cause:
Hycamtin
Dosage: 1mgm2 per day
Start date: 2011-12-19
End date: 2012-02-03
Hycamtin
Dosage: 1.25mgm2 per day
Indication: Ovarian Cancer Recurrent
Start date: 2011-11-28
End date: 2011-12-02
Possible Hycamtin side effects in 68 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-13
Patient: 68 year old female, weighing 38.0 kg (83.6 pounds)
Reactions: White Blood Cell Count Decreased, C-Reactive Protein Increased, RED Blood Cell Count Decreased, Nausea, Anaemia, Neutrophil Count Decreased, Decreased Appetite
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Decadron Phosphate; Clindamycin HCL; Zithromax; Rocephin; Minocycline HCL; Gran; Doripenem; Levofloxacin; Fosmicin S; Kytril
Possible Hycamtin side effects in 68 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-08-09
Patient: 68 year old female, weighing 38.0 kg (83.6 pounds)
Reactions: White Blood Cell Count Decreased, RED Blood Cell Count Decreased, Nausea, C-Reactive Protein Increased, Anaemia, Neutrophil Count Decreased, Decreased Appetite
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Kytril; Zithromax; Minocycline HCL; Levofloxacin; Rocephin; Doripenem; Clindamycin HCL; Fosmicin S; Decadron Phosphate; Gran
Possible Hycamtin side effects in female
Reported by a physician from Japan on 2012-08-09
Patient: female, weighing 46.0 kg (101.2 pounds)
Reactions: C-Reactive Protein Increased, Anaemia, Platelet Count Decreased, Neutrophil Count Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Transfusion; Paclitaxel; Gemcitabine Hydrochloride; Carboplatin
Possible Hycamtin side effects in
Reported by a physician from Greece on 2012-08-09
Patient:
Reactions: Off Label Use, Neuropathy Peripheral
Drug(s) suspected as cause:
Doxorubicin Hydrochloride
Dosage: on day 4; every 28 days
Indication: Pleural Mesothelioma Malignant
Hycamtin
Dosage: days 1-3; every 28 days
Indication: Pleural Mesothelioma Malignant
Other drugs received by patient: Opiates; Anti-Inflammatory Drugs; Bronchodilator, NOS; Antiemetic
Possible Hycamtin side effects in male
Reported by a consumer/non-health professional from United States on 2012-08-08
Patient: male
Reactions: Hospitalisation
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in 61 year old female
Reported by a consumer/non-health professional from United States on 2012-08-02
Patient: 61 year old female
Reactions: Dehydration
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Hydrochlorothiazide
Possible Hycamtin side effects in 80 year old female
Reported by a physician from Japan on 2012-08-01
Patient: 80 year old female, weighing 68.0 kg (149.6 pounds)
Reactions: White Blood Cell Count Decreased, Blood Urea Increased, RED Blood Cell Count Decreased, Anaemia, Platelet Count Decreased, Blood Creatinine Increased, Neutrophil Count Decreased
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Hycamtin
Dosage: .75mgm2 per day
Indication: Ovarian Cancer Recurrent
Start date: 2012-04-24
End date: 2012-04-28
Hycamtin
Dosage: .5mgm2 per day
Start date: 2012-05-22
End date: 2012-05-26
Other drugs received by patient: Dexamethasone Sodium Phosphate; Granisetron
Possible Hycamtin side effects in 62 year old male
Reported by a consumer/non-health professional from United States on 2012-07-31
Patient: 62 year old male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Zofran; Calcium; Klor-CON; Morphine Sulfate; Aspirin; Fluoxetine HCL; Fentanyl Citrate; Furosemide; Isosorbide; Magnesium; Metformin Hydrochloride; Pravastatin; Plavix; Miralax; Lisinopril; Gabapentin; Fenofibrate
Possible Hycamtin side effects in 51 year old male
Reported by a consumer/non-health professional from United States on 2012-07-27
Patient: 51 year old male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in 57 year old male
Reported by a consumer/non-health professional from United States on 2012-07-27
Patient: 57 year old male
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in 77 year old female
Reported by a physician from Japan on 2012-07-25
Patient: 77 year old female, weighing 46.0 kg (101.2 pounds)
Reactions: Diarrhoea, Dizziness, Headache, Blood Sodium Decreased
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in male
Reported by a consumer/non-health professional from United States on 2012-07-24
Patient: male
Reactions: Hospitalisation
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in female
Reported by a physician from Japan on 2012-07-23
Patient: female, weighing 50.0 kg (110.0 pounds)
Reactions: Dysgeusia, Platelet Count Decreased, Neutrophil Count Decreased
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in 80 year old female
Reported by a physician from Japan on 2012-07-16
Patient: 80 year old female, weighing 68.0 kg (149.6 pounds)
Reactions: White Blood Cell Count Decreased, Blood Urea Increased, RED Blood Cell Count Decreased, Anaemia, Platelet Count Decreased, Blood Creatinine Increased, Neutrophil Count Decreased
Adverse event resulted in: disablity
Drug(s) suspected as cause:
Hycamtin
Dosage: .75mgm2 per day
Indication: Ovarian Cancer Recurrent
Start date: 2012-04-24
End date: 2012-04-28
Hycamtin
Dosage: .5mgm2 per day
Start date: 2012-05-22
End date: 2012-05-26
Other drugs received by patient: Granisetron; Dexamethasone Sodium Phosphate
Possible Hycamtin side effects in 57 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-12
Patient: 57 year old female
Reactions: White Blood Cell Count Decreased, RED Blood Cell Count Decreased, Anaemia, Platelet Count Decreased, Abdominal Distension, Neutrophil Count Decreased, Constipation
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in 56 year old male
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-11
Patient: 56 year old male, weighing 67.3 kg (148.1 pounds)
Reactions: Small Cell Lung Cancer Metastatic
Adverse event resulted in: death
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Lortab; Procrit; Xanax; Morphine Sulfate
Possible Hycamtin side effects in 63 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-11
Patient: 63 year old female
Reactions: White Blood Cell Count Decreased, Blood Urea Increased, Nausea, Anaemia, Fatigue, RED Blood Cell Count Decreased, Neutrophil Count Decreased, Decreased Appetite
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in 71 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-10
Patient: 71 year old female
Reactions: Cholestasis
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-10
Patient: female
Reactions: Interstitial Lung Disease, Pancytopenia, Febrile Neutropenia
Adverse event resulted in: death, hospitalization
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Neutrogin; Dexamethasone Sodium Phosphate; Maxipime; Loxoprofen Sodium; Famotidine; Seltouch
Possible Hycamtin side effects in 68 year old female
Reported by a health professional (non-physician/pharmacist) from Japan on 2012-07-10
Patient: 68 year old female, weighing 38.0 kg (83.6 pounds)
Reactions: White Blood Cell Count Decreased, RED Blood Cell Count Decreased, C-Reactive Protein Increased, Nausea, Anaemia, Neutrophil Count Decreased, Decreased Appetite
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Doripenem; Gran; Decadron; Minocycline HCL; Levofloxacin; Zithromax; Fosmicin S; Kytril; Rocephin; Clindamycin HCL
Possible Hycamtin side effects in male
Reported by a consumer/non-health professional from United States on 2012-07-06
Patient: male
Reactions: Fatigue, Pneumonia, Haemorrhage, Hypotension, Blood Glucose Increased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in 59 year old female
Reported by a physician from Japan on 2012-07-05
Patient: 59 year old female, weighing 60.6 kg (133.3 pounds)
Reactions: White Blood Cell Count Decreased, RED Blood Cell Count Decreased, Anaemia, Platelet Count Decreased, Neutrophil Count Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Lansoprazole; Decadron; Cefepime; Flurbiprofen; Sandostatin
Possible Hycamtin side effects in female
Reported by a physician from Japan on 2012-07-05
Patient: female, weighing 46.0 kg (101.2 pounds)
Reactions: C-Reactive Protein Increased, Anaemia, Platelet Count Decreased, Neutrophil Count Decreased
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
Other drugs received by patient: Transfusion; Gemcitabine; Carboplatin; Paclitaxel
Possible Hycamtin side effects in female
Reported by a health professional (non-physician/pharmacist) from United States on 2012-07-03
Patient: female
Reactions: Death
Adverse event resulted in: death
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in 81 year old male
Reported by a consumer/non-health professional from United States on 2012-07-03
Patient: 81 year old male
Reactions: PRE-Existing Disease, Oral Candidiasis
Adverse event resulted in: death
Drug(s) suspected as cause:
Hycamtin
Possible Hycamtin side effects in female
Reported by a physician from Italy on 2012-06-29
Patient: female
Reactions: Anaemia, Thrombocytopenia, Renal Failure Acute
Adverse event resulted in: hospitalization
Drug(s) suspected as cause:
Hycamtin
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